ITPD20040053A1 - Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi - Google Patents

Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi

Info

Publication number: ITPD20040053A1
Authority: IT; Italy
Prior art keywords: hyaluronic acid; osteoarthrosis; repair; protection; acid derivatives
Prior art date: 2004-02-27

Application number

IT000053A

Other languages

English (en)

Inventor

Anthony P Hollander

Alessandra Pavesio

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-27

Filing date

2004-02-27

Publication date

2004-05-27

2004-02-27 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

2004-02-27 Priority to IT000053A priority Critical patent/ITPD20040053A1/it

2004-05-27 Publication of ITPD20040053A1 publication Critical patent/ITPD20040053A1/it

2005-02-25 Priority to PCT/EP2005/050817 priority patent/WO2005082433A1/en

2005-02-25 Priority to CA2555559A priority patent/CA2555559C/en

2005-02-25 Priority to US10/590,250 priority patent/US7842487B2/en

2005-02-25 Priority to JP2007500225A priority patent/JP2007524489A/ja

2005-02-25 Priority to ES05716808T priority patent/ES2329485T3/es

2005-02-25 Priority to EP05716808A priority patent/EP1722835B1/en

2005-02-25 Priority to AT05716808T priority patent/ATE438421T1/de

2005-02-25 Priority to DE602005015824T priority patent/DE602005015824D1/de

2005-02-25 Priority to AU2005216648A priority patent/AU2005216648A1/en

2005-02-25 Priority to PT05716808T priority patent/PT1722835E/pt

2005-02-25 Priority to SI200530812T priority patent/SI1722835T1/sl

2005-02-25 Priority to HK07103236.1A priority patent/HK1096047B/en

2005-02-25 Priority to DK05716808T priority patent/DK1722835T3/da

2005-02-25 Priority to PL05716808T priority patent/PL1722835T3/pl

2009-10-29 Priority to CY20091101122T priority patent/CY1109550T1/el

2010-11-30 Priority to US12/956,158 priority patent/US20110104284A1/en

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
239000012620 biological material Substances 0.000 title abstract 2
210000001188 articular cartilage Anatomy 0.000 title 1
201000008482 osteoarthritis Diseases 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
210000001612 chondrocyte Anatomy 0.000 abstract 2
210000000845 cartilage Anatomy 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Botany (AREA)
Zoology (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Materials For Medical Uses (AREA)
Cosmetics (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IT000053A 2004-02-27 2004-02-27 Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi ITPD20040053A1 (it)

Priority Applications (17)

Application Number	Priority Date	Filing Date	Title
IT000053A ITPD20040053A1 (it)	2004-02-27	2004-02-27	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
PL05716808T PL1722835T3 (pl)	2004-02-27	2005-02-25	Trójwymiarowa matryca na bazie pochodnej kwasu hialuronowego
EP05716808A EP1722835B1 (en)	2004-02-27	2005-02-25	Hyaluronic acid derivative-based three-dimensional matrix
DE602005015824T DE602005015824D1 (de)	2004-02-27	2005-02-25	Dreidimensionale matrix basiert auf hyaluronsäure-derivaten
US10/590,250 US7842487B2 (en)	2004-02-27	2005-02-25	Hyarulonic acid derivative based three dimensional matrix
JP2007500225A JP2007524489A (ja)	2004-02-27	2005-02-25	三次元マトリクスに基づくヒアルロン酸誘導体
ES05716808T ES2329485T3 (es)	2004-02-27	2005-02-25	Matriz tridimensional a base de un derivado de acido hialuronico.
PCT/EP2005/050817 WO2005082433A1 (en)	2004-02-27	2005-02-25	Hyaluronic acid derivative based three-dimensional matrix
AT05716808T ATE438421T1 (de)	2004-02-27	2005-02-25	Dreidimensionale matrix basiert auf hyaluronsäure-derivaten
CA2555559A CA2555559C (en)	2004-02-27	2005-02-25	Hyaluronic acid derivative based three-dimensional matrix
AU2005216648A AU2005216648A1 (en)	2004-02-27	2005-02-25	Hyaluronic acid derivative based three-dimensional matrix
PT05716808T PT1722835E (pt)	2004-02-27	2005-02-25	Matriz tridimensional baseada num derivado de ácido hialurónico
SI200530812T SI1722835T1 (sl)	2004-02-27	2005-02-25	Tridimenzionalni matriks na osnovi derivata hialuronske kisline
HK07103236.1A HK1096047B (en)	2004-02-27	2005-02-25	Hyaluronic acid derivative-based three-dimensional matrix
DK05716808T DK1722835T3 (da)	2004-02-27	2005-02-25	Hyaluronsyre-derivatbaseret tredimensional matrix
CY20091101122T CY1109550T1 (el)	2004-02-27	2009-10-29	Παραγωγο υαλουρονικου οξεος με βαση τρισδιαστατη μητρα
US12/956,158 US20110104284A1 (en)	2004-02-27	2010-11-30	Hyaluronic acid derivative based three-dimensional matrix

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000053A ITPD20040053A1 (it)	2004-02-27	2004-02-27	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi

Publications (1)

Publication Number	Publication Date
ITPD20040053A1 true ITPD20040053A1 (it)	2004-05-27

Family

ID=34897807

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT000053A ITPD20040053A1 (it)	2004-02-27	2004-02-27	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi

Country Status (15)

Country	Link
US (2)	US7842487B2 (it)
EP (1)	EP1722835B1 (it)
JP (1)	JP2007524489A (it)
AT (1)	ATE438421T1 (it)
AU (1)	AU2005216648A1 (it)
CA (1)	CA2555559C (it)
CY (1)	CY1109550T1 (it)
DE (1)	DE602005015824D1 (it)
DK (1)	DK1722835T3 (it)
ES (1)	ES2329485T3 (it)
IT (1)	ITPD20040053A1 (it)
PL (1)	PL1722835T3 (it)
PT (1)	PT1722835E (it)
SI (1)	SI1722835T1 (it)
WO (1)	WO2005082433A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITPD20060219A1 (it)	2006-05-31	2007-12-01	Fidia Farmaceutici	Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
ES2298052B1 (es)	2006-08-03	2009-09-28	Bioiberica S.A.	Procedimiento para la proliferacion de celulas.
EP3424514B1 (en) *	2007-08-06	2022-05-11	Mesoblast, Inc.	Tnap+ mesenchymal precursor cells for use in treating connective tissue diseases
AU2013203054B2 (en) *	2007-08-06	2017-05-18	Mesoblast, Inc.	Methods of generating, repairing and/or maintaining connective tissue in vivo
KR20170104643A (ko)	2008-06-25	2017-09-15	메소블라스트, 아이엔씨.	추간판의 치료 및/또는 재구성
JP2011041472A (ja) *	2009-08-19	2011-03-03	Tokai Univ	細胞混合物からなる細胞移植治療用スフェロイド及びその作製方法
CA2862499C (en) *	2012-01-24	2020-10-27	Cd Diagnostics, Inc.	System for detecting infection in synovial fluid
ITUA20164153A1 (it) *	2016-06-07	2017-12-07	Jointherapeutics S R L	Composizioni polisaccaridiche impiegabili nella riparazione tissutale
IT201700110784A1 (it) *	2017-10-03	2019-04-03	Fidia Farm Spa	Composizioni farmaceutiche contenenti Acido Ialuronico e Carnosina e relativo uso
US12357465B2 (en)	2018-01-02	2025-07-15	Cartiheal (2009) Ltd.	Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1219587B (it) *	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
US7789841B2 (en) *	1997-02-06	2010-09-07	Exogen, Inc.	Method and apparatus for connective tissue treatment
ITPD980149A1 (it) *	1998-06-17	1999-12-17	Fidia Advanced Biopolymers Srl	Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
ITPD980169A1 (it) *	1998-07-06	2000-01-06	Fidia Advanced Biopolymers Srl	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
DE19855890A1 (de) *	1998-12-03	2000-06-08	Nerlich Michael	Poröse Kompositmatrix, deren Herstellung und Verwendung
IT1302534B1 (it) *	1998-12-21	2000-09-05	Fidia Advanced Biopolymers Srl	Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
IT1317359B1 (it) *	2000-08-31	2003-06-16	Fidia Advanced Biopolymers Srl	Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
IT1317358B1 (it) *	2000-08-31	2003-06-16	Fidia Advanced Biopolymers Srl	Derivati cross-linkati dell'acido ialuronico.
CZ20031828A3 (cs) *	2000-12-28	2003-11-12	Fidia Advanced Biopolymers S. P. A.	Použití biologického materiálu s obsahem buněk
ITPD20010032A1 (it)	2001-02-09	2002-08-09	Fidia Advanced Biopolymers Srl	Innesti ingegnerizzati per la riparazione di difetti osteocondrali
ITPD20020064A1 (it) *	2002-03-12	2003-09-12	Fidia Advanced Biopolymers Srl	Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US7931687B2 (en) *	2002-05-13	2011-04-26	Articular Engineering, Llc	Tissue engineered osteochondral implant

2004
- 2004-02-27 IT IT000053A patent/ITPD20040053A1/it unknown
2005
- 2005-02-25 SI SI200530812T patent/SI1722835T1/sl unknown
- 2005-02-25 JP JP2007500225A patent/JP2007524489A/ja active Pending
- 2005-02-25 WO PCT/EP2005/050817 patent/WO2005082433A1/en not_active Ceased
- 2005-02-25 PT PT05716808T patent/PT1722835E/pt unknown
- 2005-02-25 DE DE602005015824T patent/DE602005015824D1/de not_active Expired - Lifetime
- 2005-02-25 ES ES05716808T patent/ES2329485T3/es not_active Expired - Lifetime
- 2005-02-25 AT AT05716808T patent/ATE438421T1/de active
- 2005-02-25 PL PL05716808T patent/PL1722835T3/pl unknown
- 2005-02-25 AU AU2005216648A patent/AU2005216648A1/en not_active Abandoned
- 2005-02-25 EP EP05716808A patent/EP1722835B1/en not_active Expired - Lifetime
- 2005-02-25 CA CA2555559A patent/CA2555559C/en not_active Expired - Lifetime
- 2005-02-25 US US10/590,250 patent/US7842487B2/en active Active
- 2005-02-25 DK DK05716808T patent/DK1722835T3/da active
2009
- 2009-10-29 CY CY20091101122T patent/CY1109550T1/el unknown
2010
- 2010-11-30 US US12/956,158 patent/US20110104284A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE602005015824D1 (de)	2009-09-17
HK1096047A1 (en)	2007-05-25
EP1722835A1 (en)	2006-11-22
ATE438421T1 (de)	2009-08-15
US20080317808A1 (en)	2008-12-25
EP1722835B1 (en)	2009-08-05
DK1722835T3 (da)	2009-11-09
SI1722835T1 (sl)	2009-12-31
US20110104284A1 (en)	2011-05-05
CA2555559A1 (en)	2005-09-09
JP2007524489A (ja)	2007-08-30
ES2329485T3 (es)	2009-11-26
CA2555559C (en)	2013-03-12
PL1722835T3 (pl)	2010-01-29
WO2005082433A1 (en)	2005-09-09
CY1109550T1 (el)	2014-08-13
US7842487B2 (en)	2010-11-30
PT1722835E (pt)	2009-11-13
AU2005216648A1 (en)	2005-09-09

Publication	Publication Date	Title
Tuan	2006	Stemming cartilage degeneration: adult mesenchymal stem cells as a cell source for articular cartilage tissue engineering
CY1109550T1 (el)	2014-08-13	Παραγωγο υαλουρονικου οξεος με βαση τρισδιαστατη μητρα
AR025693A1 (es)	2002-12-11	Composiciones de condrocitos, preparacion y usos
EP2512432B1 (fr)	2018-07-18	Compositions injectables a usage intra-articulaire associant un agent de viscosupplementation et un milieu de croissance des fibroblastes
EP2061527B8 (en)	2018-07-25	Repair of cartilage tissue
NZ527565A (en)	2005-04-29	Methods and devices for tissue repair
EP1740121A4 (en)	2011-06-01	MIXTURE FOR REPAIRING CARTIL WITH ALLOGENIC CHONDROCYTES
Suchaoin et al.	2016	Novel bioadhesive polymers as intra-articular agents: Chondroitin sulfate-cysteine conjugates
IT1301994B1 (it)	2000-07-20	Derivati dell'acido ialuronico.
ATE242018T1 (de)	2003-06-15	Poröse kompositmatrix, deren herstellung und verwendung
ECSP055531A (es)	2005-03-10	"nuevos derivados de glicósido de tiofeno, metodos para la preparacion de los mismos, medicamentos que comprenden dichos compuestos, y su uso"
GB2440292A (en)	2008-01-23	Implantable materials and methods for inhibiting tissue adhesion formation
AU2003304250A1 (en)	2005-01-13	Method of isolating cells from umbilical cord
ATE553186T1 (de)	2012-04-15	Bandscheibenreparatur und verfahren dafür
TW200510012A (en)	2005-03-16	Aqua gel comprising temperature effect
SE0203526D0 (sv)	2002-11-28	New use of dextran sulfate
CN101085357A (zh)	2007-12-12	一种用于关节腔内注射治疗软骨缺损的非病毒纳米核酸转运复合物及其制备方法
DE60141166D1 (de)	2010-03-11	Verwendung eines biologischen materials mit dreidimensionalen gerüsten aus hyaluronsäure-derivaten
ITMI20021666A1 (it)	2004-01-26	Derivati dell'acido ialuronico
Conrozier et al.	2014	Role of high concentrations of mannitol on the stability of hyaluronan in an oxidative stress model induced by xanthine/xanthine oxydase
ATE449101T1 (de)	2009-12-15	Salze von clopidogrel mit polyanionen und ihre verwendung zur herstellung pharmazeutischer formulierungen
Zavala et al.	2020	Injectable functionalized-gelatin derived from cold-adapted species balances between arthroscopic extrudability prerequisite, chondrocompatibility and biomechanical requirements for precise arthroscopic restoration
MX2021011695A (es)	2022-03-03	Implantes alogenicos para el tratamiento de lesiones de cartilago.
Ando	2004	Novel bone and cartilage tissue engineering using a scaffold-free, synovium-derived implant: In vitro performance
Rederstorff et al.	2011	A self-setting hydrogel doped with an exopolysaccharide from marine origin as a scaffold for cartilage tissue engineering