[go: up one dir, main page]

CU24385B1 - Compuestos éteres de arilo útiles para tratar cancer de célula renal - Google Patents

Compuestos éteres de arilo útiles para tratar cancer de célula renal

Info

Publication number
CU24385B1
CU24385B1 CU2016000030A CU20160030A CU24385B1 CU 24385 B1 CU24385 B1 CU 24385B1 CU 2016000030 A CU2016000030 A CU 2016000030A CU 20160030 A CU20160030 A CU 20160030A CU 24385 B1 CU24385 B1 CU 24385B1
Authority
CU
Cuba
Prior art keywords
compounds
formula
useful
renal cell
arilo
Prior art date
Application number
CU2016000030A
Other languages
English (en)
Other versions
CU20160030A7 (es
Inventor
Darryl David Dixon
Jonas Grina
John A Josey
James P Rizzi
Stephen T Schlachter
Eli M Wallace
Bin Wang
Paul Wehn
Rui Xu
Hanbiao Yang
Original Assignee
Peloton Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peloton Therapeutics Inc filed Critical Peloton Therapeutics Inc
Publication of CU20160030A7 publication Critical patent/CU20160030A7/es
Publication of CU24385B1 publication Critical patent/CU24385B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/06—Sulfinamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/263—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings the aromatic rings being non-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/285—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/275—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings having all ether-oxygen atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/29—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

<p>La invención se relaciona con compuestos de éteres de arilo de Fórmula I</p> <p>ESPACIO PARA FÓRMULA I</p> <p>o una sal farmacéuticamente aceptable del mismo preparada a partir de una base inorgánica, base orgánica, base inorgánica, base orgánica, ácido inorgánico o ácido orgánica, donde: R1; R2; R3; R4; y R5 son como se definen en el pliego reivindicatorio.</p> <p>Dichos compuestos de fórmula I son capaces de modular la actividad del factor 2 alfa inducible por hipoxia (HIF-2alfa), una proteína que juega un papel importante en la vía de respuesta hipóxica en tumores. Esta vía es una fuerza impulsora para la progresión del cáncer. De esta manera, los compuestos de fórmula I de la presente invención son útiles en el tratamiento del cáncer, tal como en el tratamiento del carcinoma celular renal.</p>
CU2016000030A 2013-09-09 2014-09-05 Compuestos éteres de arilo útiles para tratar cancer de célula renal CU24385B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361875674P 2013-09-09 2013-09-09
US201461978421P 2014-04-11 2014-04-11
PCT/US2014/054375 WO2015035223A1 (en) 2013-09-09 2014-09-05 Aryl ethers and uses thereof

Publications (2)

Publication Number Publication Date
CU20160030A7 CU20160030A7 (es) 2016-07-29
CU24385B1 true CU24385B1 (es) 2019-03-04

Family

ID=52628976

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2016000030A CU24385B1 (es) 2013-09-09 2014-09-05 Compuestos éteres de arilo útiles para tratar cancer de célula renal

Country Status (33)

Country Link
US (7) US9908845B2 (es)
EP (4) EP3417852B1 (es)
JP (4) JP6486940B2 (es)
KR (1) KR102153772B1 (es)
CN (2) CN110372550B (es)
AU (1) AU2014318025B2 (es)
BR (1) BR112016005262B1 (es)
CA (1) CA2919397C (es)
CU (1) CU24385B1 (es)
CY (2) CY1122144T1 (es)
DK (1) DK3043784T3 (es)
EA (1) EA032124B1 (es)
ES (3) ES2784454T3 (es)
FI (1) FIC20253001I1 (es)
FR (1) FR25C1018I1 (es)
HR (2) HRP20201701T8 (es)
HU (3) HUE052080T2 (es)
IL (1) IL243888B (es)
LT (3) LT3417851T (es)
MX (1) MX2016002974A (es)
MY (1) MY199426A (es)
NL (1) NL301327I2 (es)
NO (1) NO2025022I1 (es)
PE (1) PE20160434A1 (es)
PL (2) PL3417851T3 (es)
PT (2) PT3417851T (es)
RS (2) RS60953B1 (es)
SG (1) SG11201601616SA (es)
SI (2) SI3043784T1 (es)
SM (1) SMT201900479T1 (es)
TW (2) TWI657071B (es)
UY (1) UY35731A (es)
WO (1) WO2015035223A1 (es)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2968234B1 (en) 2013-03-15 2018-06-27 Chromocell Corporation Sodium channel modulators for the treatment of pain
CN110372550B (zh) * 2013-09-09 2021-08-24 佩洛通治疗公司 芳基醚及其用途
AU2014318979B2 (en) 2013-09-10 2019-03-28 Chromocell Corporation Sodium channel modulators for the treatment of pain and diabetes
EP3083639B1 (en) 2013-12-16 2019-05-29 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
WO2016057242A1 (en) * 2014-10-10 2016-04-14 The Board Of Regents Of The University Of Texas System HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS
WO2016144825A1 (en) * 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
WO2016145045A1 (en) * 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating glioblastoma
WO2016145236A1 (en) * 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Hif-2-alpha inhibitor polymorphs
WO2016144826A1 (en) * 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
US10278942B2 (en) * 2015-03-11 2019-05-07 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
US10335388B2 (en) 2015-04-17 2019-07-02 Peloton Therapeutics, Inc. Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof
CN105566406A (zh) * 2015-12-30 2016-05-11 江西胜富化工有限公司 一种氟代脱氧呋喃核糖的制备方法
WO2018031680A1 (en) * 2016-08-10 2018-02-15 Fronthera U.S. Pharmaceuticals Llc Novel compounds, uses and methods for their preparation
TW201825490A (zh) * 2017-01-11 2018-07-16 大陸商江蘇豪森藥業集團有限公司 吡咯並［２，３－ｃ］吡啶類衍生物、其製備方法及其在醫藥上的應用
WO2018160772A1 (en) 2017-02-28 2018-09-07 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Method of treating obesity, insulin resistance, non-alcoholic fatty liver disease including non-alcoholic steatohepatitis
TWI642658B (zh) 2017-11-01 2018-12-01 國立臺灣師範大學 茚並異喹啉衍生物的製備方法
US10953036B2 (en) 2017-11-20 2021-03-23 University Of Georgia Research Foundation, Inc. Compositions and methods of modulating HIF-2A to improve muscle generation and repair
JP2021519282A (ja) * 2018-03-28 2021-08-10 ペロトン セラピューティクス， インコーポレイテッド ＨＩＦ−２−αの阻害薬による消化器系の炎症軽減方法
CA3100399A1 (en) 2018-05-18 2019-11-21 Ryvu Therapeutics S.A. Thiophene derivatives
EP3849541A4 (en) 2018-09-11 2022-06-22 Nikang Therapeutics, Inc. 2,3-DIHYDROBENZO[B]THIOPHENE DERIVATIVES AS HYPOXIA-INDUCABLE FACTOR-2 (ALPHA) INHIBITORS
EP3866927A4 (en) * 2018-10-17 2022-07-27 Nikang Therapeutics, Inc. Indane derivatives as hypoxia inducible factor-2(alpha) inhibitors
KR20210091191A (ko) 2018-10-30 2021-07-21 펠로톤 테라퓨틱스, 인크. 치환된 인단을 포함하는 고체 분산물 및 제약 조성물 및 그의 제조 및 사용 방법
CN109776607B (zh) * 2019-02-21 2021-06-04 青岛海洋生物医药研究院 芳基磷氧类和芳基磷硫类化合物及其制备方法和应用
MX2021012549A (es) * 2019-04-18 2022-01-18 Nikang Therapeutics Inc Derivados de tetrahidro-1h-ciclopenta[cd]indeno como inhibidores del factor inducible por hipoxia-2(alfa).
UY38794A (es) 2019-07-23 2021-02-26 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas
WO2021055728A1 (en) 2019-09-18 2021-03-25 Merck Sharp & Dohme Corp. Small molecule inhibitors of kras g12c mutant
US11576889B2 (en) 2019-09-23 2023-02-14 The Board Of Regents Of The University Of Texas System Methods of identifying and treating patients with HIF-2 inhibitor resistance
CA3158793A1 (en) 2019-10-28 2021-05-06 Merck Sharp & Dohme Corp. Small molecule inhibitors of kras g12c mutant
CN115551500A (zh) 2019-10-31 2022-12-30 大鹏药品工业株式会社 4-氨基丁-2-烯酰胺衍生物及其盐
CN112812136B (zh) * 2019-11-15 2022-04-12 武汉光谷亚太医药研究院有限公司 新型2,3-二氢化茚衍生化合物、制备方法和应用
TW202136248A (zh) 2019-11-25 2021-10-01 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
JP7769629B2 (ja) * 2019-11-26 2025-11-13 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 低酸素誘導性因子（ｈｉｆ）阻害剤としての濃縮チオフェン誘導体
WO2021106231A1 (en) 2019-11-29 2021-06-03 Taiho Pharmaceutical Co., Ltd. A compound having inhibitory activity against kras g12d mutation
CA3163338A1 (en) * 2019-12-04 2021-06-10 Arcus Biosciences, Inc. Inhibitors of hif-2alpha
CN111214484B (zh) * 2020-01-21 2021-04-06 北京工商大学 一种共轭聚合物和聚集诱导发光小分子共掺的纳米粒子及其制备方法和应用
CN113387848B (zh) * 2020-03-12 2022-11-22 上海交通大学 一种制备磺酰胺类化合物的合成工艺
JP7474861B2 (ja) 2020-03-19 2024-04-25 アーカス バイオサイエンシーズ，インコーポレーテッド Ｈｉｆ－２アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
US11420936B2 (en) 2020-04-16 2022-08-23 Nikang Therapeutics, Inc. Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
US20230181536A1 (en) 2020-04-24 2023-06-15 Taiho Pharmaceutical Co., Ltd. Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
EP4139299B1 (en) 2020-04-24 2025-12-17 Taiho Pharmaceutical Co., Ltd. Kras g12d protein inhibitors
TWI891782B (zh) 2020-05-06 2025-08-01 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基三唑化合物
WO2021249463A1 (zh) * 2020-06-11 2021-12-16 贝达药业股份有限公司 双环化合物及其应用
CN115667190B (zh) * 2020-06-17 2024-10-11 贝达药业股份有限公司 双环类化合物及其应用
JP7327855B2 (ja) 2020-06-26 2023-08-16 ラクオリア創薬株式会社 レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬
KR20230031926A (ko) 2020-07-15 2023-03-07 다이호야쿠힌고교 가부시키가이샤 종양의 치료에 사용되는 피리미딘 화합물을 포함하는 조합
WO2022063115A1 (zh) * 2020-09-24 2022-03-31 贝达药业股份有限公司 双环化合物及其应用
WO2022082329A1 (en) * 2020-10-19 2022-04-28 Nikang Therapeutics, Inc. Processes of preparing 3-fluoro-5- ( ( (1s, 2ar) -1, 3, 3, 4, 4-pentafluoro-2a-hydroxy-2, 2a, 3, 4-tetrahydro-1h-cyclopenta [cd] inden-7-yl) oxy) -benzonitrile
WO2022082337A1 (en) 2020-10-19 2022-04-28 Nikang Therapeutics, Inc. Process of preparing 3-fluoro-5 ( ( (1r, 2ar) -3, 3, 4, 4-tetrafluoro-1, 2a-dihydroxy-2, 2a, 3, 4-tetrahydro-1h-cyclopenta [cd] inden-7-yl) oxy) benzonitrile
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
CN112724167B (zh) * 2021-01-13 2022-11-11 湖北恒安芙林药业股份有限公司 一种克立硼罗的制备方法
US11827614B2 (en) 2021-05-21 2023-11-28 Merck Sharp & Dohme Llc Synthetic pathway to belzutifan and crystalline phases of synthetic intermediates
EP4347041A1 (en) 2021-05-28 2024-04-10 Taiho Pharmaceutical Co., Ltd. Small molecule inhibitors of kras mutated proteins
CN113651735B (zh) * 2021-08-27 2022-04-15 中国药科大学 一种HIF-2α抑制剂PT2385的制备方法
US12145901B1 (en) 2021-09-17 2024-11-19 Arcus Biosciences, Inc. Process for preparing tetralin compounds
TW202329928A (zh) * 2021-10-18 2023-08-01 美商尼坎醫療公司 用於治療膀胱癌的低氧誘導因子－２（α）抑制劑
WO2023160552A1 (zh) * 2022-02-22 2023-08-31 南京明德新药研发有限公司 一类螺环类化合物及其应用
CN116178223B (zh) * 2022-04-15 2024-12-03 上海皓鸿生物医药科技有限公司 一种Belzutifan及其中间体的制备方法
CN114656379B (zh) * 2022-04-27 2024-06-04 成都道合尔医药技术有限公司 一种立他司特中间体的合成方法
CN115611847B (zh) * 2022-10-13 2024-04-30 南方科技大学坪山生物医药研究院 一种Belzutifan的中间体的制备方法
JP2025539091A (ja) * 2022-11-14 2025-12-03 エフ． ホフマン－ラ ロシュ アーゲー ＨＩＦ－２α阻害剤としてのアリールチオエーテル
CR20250419A (es) 2023-04-06 2025-10-07 Pfizer Compuestos de derivados de ácido indazol propiónico sustituidos y usos de estos
TW202515582A (zh) 2023-08-24 2025-04-16 日商大塚製藥股份有限公司 西區嘧啶(cedazuridine)之固定劑量組合
US12466840B2 (en) 2023-10-20 2025-11-11 Merck Sharp & Dohme Llc Small molecule inhibitors of KRAS proteins
CN118005840B (zh) * 2024-04-08 2024-06-14 西南石油大学 一种热增稠自破胶压裂液稠化剂及其制备方法和应用

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE705530C (de) 1932-01-23 1941-04-30 Chem Fab Von Heyden Akt Ges Verfahren zur Darstellung von Polychlorsubstitutionsprodukten des Diphenylaethers
FR1574139A (es) 1968-05-06 1969-07-11
US3905971A (en) * 1971-03-29 1975-09-16 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
JPS4872169A (es) 1971-12-28 1973-09-29
GB1448696A (en) * 1973-05-29 1976-09-08 Pfizer 2-phqnyl-astriazine-3,4-2h,4h-diones
GB2017087B (en) 1978-03-03 1982-09-02 Roussel Lab Ltd Process for the preparation of xanthone derivatives
US4214103A (en) 1978-11-30 1980-07-22 Great Lakes Chemical Corporation Purification of brominated organic products
DE2938595A1 (de) 1979-09-24 1981-04-23 Celamerck Gmbh & Co Kg, 6507 Ingelheim Verfahren zur herstellung von diphenylaethern
US4505929A (en) 1980-06-12 1985-03-19 The Dow Chemical Company Sulfur-substituted diphenyl ethers having antiviral activity
US4426385A (en) * 1980-10-16 1984-01-17 Union Carbide Corporation Insecticidal bicyclooxyphenyl ureas
DE3110894A1 (de) * 1981-03-20 1982-09-30 Celamerck Gmbh & Co Kg, 6507 Ingelheim Neue nitroaniline
DE3239449A1 (de) 1981-10-27 1983-05-05 CIBA-GEIGY AG, 4002 Basel Phenoxyphenyl- und pyridyloxyphenyl-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
JPS58124758A (ja) 1982-01-20 1983-07-25 Fujisawa Pharmaceut Co Ltd ベンゼンスルホンアミド誘導体
DE3209878A1 (de) 1982-03-18 1983-09-29 Celamerck Gmbh & Co Kg, 6507 Ingelheim Verfahren zur herstellung von diphenylaethern
US4665097A (en) 1983-03-31 1987-05-12 Union Carbide Corporation Novel bicyclooxyaryl thioureas and process for preparation
US4664097A (en) 1984-05-09 1987-05-12 The Wistar Institute Of Anatomy & Biology Nuclear transplantation in the mammalian embryo by microsurgery and cell fusion
US4705955A (en) * 1985-04-02 1987-11-10 Curt Mileikowsky Radiation therapy for cancer patients
JPS635136A (ja) 1986-06-26 1988-01-11 Mitsubishi Electric Corp 内燃機関のアイドル回転数制御装置
JPS6351363A (ja) 1986-08-21 1988-03-04 Tekukemu:Kk アミノ基を有するジフエニ−ル化合物の製造方法
US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
IL105777A0 (en) * 1992-06-04 1993-09-22 Great Lakes Chemical Corp Method for the isolation of a partially brominated diphenyl ether product
DK0640618T3 (da) 1993-08-27 2000-04-03 Hoffmann La Roche Tetrahydronaphthalen-peptidderivater
DE4431219A1 (de) * 1994-09-02 1996-03-07 Bayer Ag Selektive Herbizide auf Basis von Aryluracilen
DE69635874T2 (de) 1995-12-06 2006-12-14 Japan Science And Technology Agency, Kawaguchi Verfahren zur Herstellung von optisch aktiven Alkoholen
US6887820B1 (en) 1995-12-06 2005-05-03 Japan Science And Technology Corporation Method for producing optically active compounds
WO1998042671A1 (de) 1997-03-20 1998-10-01 Basf Aktiengesellschaft Substituierte 2-benz(o)ylpyridin derivate, deren herstellung und deren verwendung als herbizide
NZ517426A (en) 1999-08-27 2004-04-30 Sugen Inc Phosphate mimics and methods of treatment using phosphatase inhibitors
DE60234100D1 (de) 2001-04-24 2009-12-03 Vlaams Interuniv Inst Biotech Verwendung von "hypoxia inducible factor 2alpha" zur behandlung von "neonatal respiratory distress syndrome"
US7230031B2 (en) 2002-01-30 2007-06-12 Kissei Pharmaceutical Co., Ltd. Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
CA2463464A1 (en) 2003-04-28 2004-10-28 Auckland Uniservices Limited Methods of treatment and compositions therefor
SE0301906D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab New compounds
NZ548128A (en) 2003-12-29 2010-05-28 Banyu Pharma Co Ltd Novel 2-heteroaryl-substituted benzimidazole derivative
EP1749006A2 (en) 2004-05-28 2007-02-07 Speedel Experimenta AG Heterocyclic compounds and their use as aldosterone synthase inhibitors
BRPI0514675A (pt) * 2004-09-10 2008-06-17 Pfizer Prod Inc ligantes de éter difenìlico terapêuticos
BRPI0519013A2 (pt) 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
DE602006008576D1 (de) 2005-01-31 2009-10-01 Merck & Co Inc Antidiabetische bicyclische verbindungen
TW200714597A (en) 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
AU2006303368B2 (en) 2005-10-19 2011-05-26 F. Hoffmann-La Roche Ag Non-Nucleoside Reverse Transcriptase Inhibitors
AU2006323700B2 (en) * 2005-12-05 2011-02-17 Otsuka Pharmaceutical Co., Ltd. Diarylether derivatives as antitumor agents
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
GB0526445D0 (en) * 2005-12-23 2006-02-08 Novartis Ag Organic compounds
DK1976828T3 (en) 2005-12-29 2017-03-06 Celtaxsys Inc DIAMINE DERIVATIVES AS INhibitors of Leukotriene A4 HYDROLASE
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
US20070244071A1 (en) 2006-03-07 2007-10-18 Mount Sinai Hospital Treatment of proliferative diseases
ATE552245T1 (de) * 2006-05-15 2012-04-15 Merck Sharp & Dohme Antidiabetische bicyclische verbindungen
ES2399928T3 (es) * 2006-08-23 2013-04-04 Neurogen Corporation Análogos de 2-fenoxipirimidinona
MX2009010559A (es) 2007-03-30 2009-10-22 Nippon Shinyaku Co Ltd Derivados de heteroarilo.
CN101058535B (zh) 2007-05-25 2010-07-21 复旦大学 二(7-羟基-2,3-二氢-1-1h-茚基)醚类及其类似物、合成方法及应用
RS51501B (sr) * 2007-06-06 2011-04-30 Torrent Pharmaceuticals Ltd Nova jedinjenja
WO2008157273A1 (en) 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
CN101407467A (zh) * 2007-10-12 2009-04-15 中国人民解放军军事医学科学院毒物药物研究所 N-取代芳烃苯胺/多取代二芳基醚类化合物,其制备方法及抗肿瘤应用
US8299262B2 (en) * 2007-12-05 2012-10-30 Basf Se Pyridylmethyl-sulfonamide compounds
WO2009093133A1 (en) 2008-01-25 2009-07-30 Medichem, S.A. Method for determining the enantiomeric purity of indane derivatives
AU2009221375A1 (en) 2008-03-05 2009-09-11 F. Hoffmann-La Roche Ag 2-Aminoquinolines
US8188098B2 (en) 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
AR074210A1 (es) * 2008-11-24 2010-12-29 Boehringer Ingelheim Int Derivados de pirimidina como inhibidores de ptk2-quinasa
US8691866B2 (en) 2008-12-10 2014-04-08 The General Hospital Corporation HIF inhibitors and use thereof
CU24099B1 (es) * 2009-01-12 2015-06-30 Pfizer Ltd Derivados de sulfonamida para el tratamiento del dolor
CA2754685A1 (en) 2009-03-11 2010-09-16 Pfizer Inc. Substituted indazole amides
WO2010137620A1 (ja) 2009-05-27 2010-12-02 武田薬品工業株式会社 フェノキシエチルアミン誘導体
AU2010256384B2 (en) 2009-06-05 2016-08-25 Joan M. Caron Methods and compositions for the treatment of cancer
US8461164B2 (en) 2009-08-31 2013-06-11 Dow Agrosciences, Llc. Pteridines and their use as agrochemicals
US8716286B2 (en) 2009-10-30 2014-05-06 Glaxo Group Limited Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione
US8853277B2 (en) * 2009-11-30 2014-10-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC)
WO2011105603A1 (ja) 2010-02-26 2011-09-01 株式会社日本触媒 フタロシアニン誘導体
GB201005589D0 (en) * 2010-04-01 2010-05-19 Respivert Ltd Novel compounds
JP5787977B2 (ja) * 2010-04-08 2015-09-30 レスピバート・リミテツド Ｐ３８ｍａｐキナーゼ阻害剤
WO2011133659A2 (en) 2010-04-20 2011-10-27 Emory University Inhibitors of hif and angiogenesis
US8853423B2 (en) 2010-06-17 2014-10-07 Seragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
KR101760158B1 (ko) 2010-07-29 2017-07-20 아스텔라스세이야쿠 가부시키가이샤 축환 피리딘 화합물
EP2502917A1 (en) 2011-03-17 2012-09-26 Santhera Pharmaceuticals (Schweiz) AG Solid state crystalline forms of 4-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole
WO2012170442A1 (en) 2011-06-06 2012-12-13 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
UY34200A (es) 2011-07-21 2013-02-28 Bayer Ip Gmbh 3-(fluorovinil)pirazoles y su uso
US8962608B2 (en) 2011-09-22 2015-02-24 Merck Sharp & Dohme Corp. Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
EP2768826A1 (de) 2011-10-17 2014-08-27 Bayer Intellectual Property GmbH Substituierte oxadiazolylpyridinone und - pyridazinone als hif - hemmer
CN104093716B (zh) * 2011-10-31 2017-06-23 克赛农制药股份有限公司 联芳醚磺酰胺化合物及其作为治疗剂的用途
EP2807154B1 (en) 2012-01-28 2015-12-23 Merck Patent GmbH Azaheterocyclic compounds
WO2013133325A1 (ja) 2012-03-06 2013-09-12 武田薬品工業株式会社 三環性化合物
PT2865663T (pt) 2012-06-21 2017-06-02 Eisai R&D Man Co Ltd Derivado de indanossulfamida inovador
WO2014031933A2 (en) 2012-08-24 2014-02-27 Philip Jones Heterocyclic modulators of hif activity for treatment of disease
EP2888256A4 (en) 2012-08-24 2016-02-17 Univ Texas HETEROCYCLIC HIF ACTIVITY MODULATORS FOR THE TREATMENT OF DISEASES
US20140128365A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
WO2014078479A2 (en) 2012-11-14 2014-05-22 The Board Of Regents Of The University Of Texas System INHIBITION OF HIF-2α HETERODIMERIZATION WITH HIF1β (ARNT)
MX2015006591A (es) * 2012-11-28 2015-08-05 Boehringer Ingelheim Int Nuevos acidos indaniloxi dihidrobenzofuranil aceticos.
US20140163025A1 (en) * 2012-12-07 2014-06-12 Boehringer Ingelheim International Gmbh Indanyloxydihydrobenzofuranylacetic acids
CN110372550B (zh) * 2013-09-09 2021-08-24 佩洛通治疗公司 芳基醚及其用途
EP3083639B1 (en) 2013-12-16 2019-05-29 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
WO2016145045A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating glioblastoma
WO2016144826A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
WO2016145236A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Hif-2-alpha inhibitor polymorphs
US10278942B2 (en) 2015-03-11 2019-05-07 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
US10335388B2 (en) 2015-04-17 2019-07-02 Peloton Therapeutics, Inc. Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof

Also Published As

Publication number Publication date
EP3043784A4 (en) 2017-04-05
FIC20253001I1 (fi) 2025-05-05
PE20160434A1 (es) 2016-05-25
SI3417851T1 (sl) 2020-11-30
RS58960B1 (sr) 2019-08-30
CN105530923A (zh) 2016-04-27
IL243888B (en) 2020-11-30
JP6918039B2 (ja) 2021-08-11
ES2823477T3 (es) 2021-05-07
EP3417851A1 (en) 2018-12-26
NL301327I2 (nl) 2025-07-17
CA2919397C (en) 2021-05-18
US20160251307A1 (en) 2016-09-01
KR20160055199A (ko) 2016-05-17
PL3043784T3 (pl) 2019-10-31
SI3043784T1 (sl) 2019-08-30
CA2919397A1 (en) 2015-03-12
US20190119214A1 (en) 2019-04-25
US9896418B2 (en) 2018-02-20
ES2739433T3 (es) 2020-01-31
JP2019089855A (ja) 2019-06-13
PT3043784T (pt) 2019-08-02
TWI657071B (zh) 2019-04-21
US9969689B2 (en) 2018-05-15
CN110372550A (zh) 2019-10-25
SG11201601616SA (en) 2016-04-28
BR112016005262B1 (pt) 2021-11-30
LT3043784T (lt) 2019-08-12
CN110372550B (zh) 2021-08-24
PL3417851T3 (pl) 2020-12-14
HRP20201701T8 (hr) 2022-01-07
AU2014318025B2 (en) 2020-02-06
MY199426A (en) 2023-10-27
RS60953B1 (sr) 2020-11-30
LT3417851T (lt) 2020-11-25
CY1122144T1 (el) 2020-11-25
UY35731A (es) 2015-04-30
EP3586835B1 (en) 2023-11-22
HUE045462T2 (hu) 2019-12-30
HRP20191298T1 (hr) 2019-10-18
KR102153772B1 (ko) 2020-09-09
EA032124B1 (ru) 2019-04-30
SMT201900479T1 (it) 2019-09-09
US20180155279A1 (en) 2018-06-07
ES2784454T3 (es) 2020-09-25
JP2019070043A (ja) 2019-05-09
EP3043784A1 (en) 2016-07-20
HK1221667A1 (en) 2017-06-09
US10144711B2 (en) 2018-12-04
CY1123433T1 (el) 2021-12-31
HUS2500021I1 (hu) 2025-05-28
US20200190031A1 (en) 2020-06-18
EP3417851B1 (en) 2020-07-22
NO2025022I1 (no) 2025-05-12
USRE49948E1 (en) 2024-04-30
JP6746733B2 (ja) 2020-08-26
TW201936572A (zh) 2019-09-16
US9908845B2 (en) 2018-03-06
IL243888A0 (en) 2016-04-21
JP2019089856A (ja) 2019-06-13
CU20160030A7 (es) 2016-07-29
HRP20201701T1 (hr) 2021-04-02
EP3586835A1 (en) 2020-01-01
BR112016005262A2 (pt) 2017-08-01
EP3043784B9 (en) 2019-11-20
LTPA2025519I1 (es) 2025-06-10
JP2016534134A (ja) 2016-11-04
EP3417852A1 (en) 2018-12-26
PT3417851T (pt) 2020-10-12
EP3043784B1 (en) 2019-05-15
MX2016002974A (es) 2016-06-02
EA201690549A1 (ru) 2016-11-30
WO2015035223A1 (en) 2015-03-12
US20170217892A1 (en) 2017-08-03
US10597366B2 (en) 2020-03-24
US20170217891A1 (en) 2017-08-03
HUE052080T2 (hu) 2021-04-28
TW201605775A (zh) 2016-02-16
NZ716281A (en) 2021-08-27
JP6486940B2 (ja) 2019-03-20
AU2014318025A1 (en) 2016-02-18
CN105530923B (zh) 2019-07-23
EP3417852B1 (en) 2020-02-19
DK3043784T3 (da) 2019-07-15
FR25C1018I1 (fr) 2025-07-18

Similar Documents

Publication Publication Date Title
CU24385B1 (es) Compuestos éteres de arilo útiles para tratar cancer de célula renal
JO3363B1 (ar) مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
CR20200276A (es) Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059)
CY1120031T1 (el) Αποπτωτικοι υποκινητες ν-ακυλοσουλφοναμιδης
PE20181803A1 (es) Inhibidores de mcl-1 macrociclicos para tratar el cancer
AR095347A1 (es) Compuestos orgánicos
AR098912A1 (es) Inhibidores de syk
PE20180258A1 (es) Inhibidores de bromodominio
CO6390038A2 (es) Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedades inmunes
EA201690316A1 (ru) Соединения для применения в качестве иммуномодуляторов
BR112015032921A8 (pt) compostos de benzofuranila e benzoxazolila substituídos e utilizações dos mesmos
UY36285A (es) Compuestos que inhiben la proteína mcl-1
ECSP13012448A (es) Nuevas aminopirazoloquinazolinas.
UY33817A (es) ?nuevas oxindolpirimidinas bencílicas?.
CR20130534A (es) Nuevos derivados de imidazol útiles para el tratamiento de artritis
EA201791094A1 (ru) Аналоги простых эфиров фосфолипидов в качестве носителей лекарственных средств, нацеленных на раковые клетки
MX2012012527A (es) Compuestos quimicos.
AR085155A1 (es) Procesos para preparar compuestos de quinolina y composiciones farmaceuticas que contienen dichos compuestos
ECSP13012596A (es) Proceso de elaboración para derivados de pirimidina
MX2016004964A (es) Compuesto heterociclico fusionado, metodo de preparacion del mismo, composicion farmaceutica, y usos del mismo.
BR112012029647A2 (pt) novos derivados de pirimidinas
PE20150966A1 (es) Compuestos heteroaromaticos y su uso como ligandos d1 de dopamina
CU24402B1 (es) 2,6 purinas di-sustituidas útiles en el tratamiento de trastornos proliferativos tales como cáncer
AR088774A1 (es) Compuesto de 7-[3,5-dihidroxi-2-(3hidroxi-5-fenil-pent-1-enil)-ciclopentil]-n-etil-hept-5-enamida (bimatoprost) y su uso para preparar una composicion farmaceutica para inducir el crecimiento de pelo en un humano
EA201591024A1 (ru) Димерные соединения