AR088774A1 - Compuesto de 7-[3,5-dihidroxi-2-(3hidroxi-5-fenil-pent-1-enil)-ciclopentil]-n-etil-hept-5-enamida (bimatoprost) y su uso para preparar una composicion farmaceutica para inducir el crecimiento de pelo en un humano - Google Patents
Compuesto de 7-[3,5-dihidroxi-2-(3hidroxi-5-fenil-pent-1-enil)-ciclopentil]-n-etil-hept-5-enamida (bimatoprost) y su uso para preparar una composicion farmaceutica para inducir el crecimiento de pelo en un humanoInfo
- Publication number
- AR088774A1 AR088774A1 ARP120100482A ARP120100482A AR088774A1 AR 088774 A1 AR088774 A1 AR 088774A1 AR P120100482 A ARP120100482 A AR P120100482A AR P120100482 A ARP120100482 A AR P120100482A AR 088774 A1 AR088774 A1 AR 088774A1
- Authority
- AR
- Argentina
- Prior art keywords
- bimatoprost
- pent
- hept
- phenyl
- human
- Prior art date
Links
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 title abstract 2
- 229960002470 bimatoprost Drugs 0.000 title abstract 2
- 230000003779 hair growth Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AQOKCDNYWBIDND-UHFFFAOYSA-N 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-enyl)cyclopentyl]-n-ethylhept-5-enamide Chemical compound CCNC(=O)CCCC=CCC1C(O)CC(O)C1C=CC(O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un compuesto de 7-[3,5-dihidroxi-2-(3-hidroxi-5-fenil-pent-1-enil)-ciclopentil]-N-etil-hept-5-enamida (bimatoprost) caracterizado porque tiene la estructura de la fórmula (1) o derivado, isómero o enantiómero del mismo; en donde, R¹ es hidrógeno o R¹ᵃC(O)-; R² es hidrógeno o R²ᵃC(O)-; R³ es hidrógeno o R³ᵃC(O)-; R¹ᵃ, R²ᵃ R³ᵃ son independientemente alquilo C₁₋₁₀ sustituido o no sustituido, cicloalquilo C₃₋₈ sustituido o no sustituido, o arilo sustituido o no sustituido; y R⁴ y R⁵ son independientemente hidrógeno, alquilo C₁₋₁₀ sustituido o no sustituido, o cicloalquilo C₃₋₈ sustituido o no sustituido; siempre que, sin embargo, por lo menos uno entre R¹, R² y R³ no es hidrógeno. Reivindicación 21: Uso de un compuesto de acuerdo con la reivindicación 1, caracterizado porque es para preparar una composición farmacéutica para inducir el crecimiento de pelo en un humano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161442400P | 2011-02-14 | 2011-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088774A1 true AR088774A1 (es) | 2014-07-10 |
Family
ID=45755562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100482A AR088774A1 (es) | 2011-02-14 | 2012-02-14 | Compuesto de 7-[3,5-dihidroxi-2-(3hidroxi-5-fenil-pent-1-enil)-ciclopentil]-n-etil-hept-5-enamida (bimatoprost) y su uso para preparar una composicion farmaceutica para inducir el crecimiento de pelo en un humano |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20130324606A1 (es) |
| EP (1) | EP2675786B1 (es) |
| JP (1) | JP5885271B2 (es) |
| KR (1) | KR101935068B1 (es) |
| CN (1) | CN103459368B (es) |
| AR (1) | AR088774A1 (es) |
| AU (1) | AU2012217922B2 (es) |
| BR (1) | BR112013020719B1 (es) |
| CA (1) | CA2827446C (es) |
| RU (1) | RU2599249C2 (es) |
| TW (1) | TWI642653B (es) |
| WO (1) | WO2012112451A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2681668C (en) * | 2006-03-23 | 2014-04-01 | Michael S. Singer | Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| RU2567792C2 (ru) | 2009-11-09 | 2015-11-10 | Аллерган, Инк. | Композиции и способы стимулирования роста волос |
| US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
| US8859616B2 (en) * | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| EP2912046A1 (en) * | 2012-10-29 | 2015-09-02 | Allergan, Inc. | Phosphate esters of bimatoprost and the prostamides |
| US20150313825A1 (en) | 2012-11-21 | 2015-11-05 | Topokine Therapeutics, Inc. | Methods and compositions for locally increasing body fat |
| WO2014158373A1 (en) * | 2013-03-14 | 2014-10-02 | Allergan, Inc. | Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith |
| NO2753788T3 (es) | 2013-05-10 | 2018-06-16 | ||
| WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| US11478437B2 (en) | 2016-07-05 | 2022-10-25 | Jenivision Inc. | Formulations for hair growth |
| JP7141025B1 (ja) * | 2021-11-11 | 2022-09-22 | エルデシエロ プライベート リミテッド | 化合物、組成物、方法、及び製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| EP0495421B1 (en) | 1991-01-15 | 1996-08-21 | Alcon Laboratories, Inc. | Use of carrageenans in topical ophthalmic compositions |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5972991A (en) | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| US5352708A (en) | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5574066A (en) * | 1992-10-28 | 1996-11-12 | Allergan | Intraocular pressure reducing 15-acyl prostaglandins |
| JP2818381B2 (ja) * | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| JPH10259179A (ja) * | 1996-09-19 | 1998-09-29 | Santen Pharmaceut Co Ltd | 多置換アリールオキシ基を有するプロスタグランジン類およびその用途 |
| US6395787B1 (en) * | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
| US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| AU2006295305B2 (en) * | 2005-09-16 | 2013-01-31 | Allergan, Inc. | Compositions and methods for the intraocular transport of therapeutic agents |
| EP2425816A3 (en) * | 2007-01-31 | 2014-04-30 | Allergan, Inc. | A pharmaceutical composition for use in treating an ocular disease or condition and a method for producing the composition |
| US20090111761A1 (en) * | 2007-10-31 | 2009-04-30 | Pamela Lipkin | Prostaglandin Analog Compositions And Methods To Treat Epithelial-Related Conditions |
| AR076731A1 (es) | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
| RU2567792C2 (ru) | 2009-11-09 | 2015-11-10 | Аллерган, Инк. | Композиции и способы стимулирования роста волос |
-
2012
- 2012-02-13 WO PCT/US2012/024881 patent/WO2012112451A1/en not_active Ceased
- 2012-02-13 EP EP12705582.0A patent/EP2675786B1/en not_active Not-in-force
- 2012-02-13 US US13/985,263 patent/US20130324606A1/en not_active Abandoned
- 2012-02-13 CN CN201280014860.XA patent/CN103459368B/zh not_active Expired - Fee Related
- 2012-02-13 US US13/371,851 patent/US8865766B2/en active Active
- 2012-02-13 CA CA2827446A patent/CA2827446C/en active Active
- 2012-02-13 KR KR1020137024231A patent/KR101935068B1/ko not_active Expired - Fee Related
- 2012-02-13 AU AU2012217922A patent/AU2012217922B2/en not_active Ceased
- 2012-02-13 RU RU2013141849/04A patent/RU2599249C2/ru active
- 2012-02-13 JP JP2013554528A patent/JP5885271B2/ja not_active Expired - Fee Related
- 2012-02-13 BR BR112013020719-1A patent/BR112013020719B1/pt not_active IP Right Cessation
- 2012-02-14 TW TW101104790A patent/TWI642653B/zh not_active IP Right Cessation
- 2012-02-14 AR ARP120100482A patent/AR088774A1/es not_active Application Discontinuation
-
2014
- 2014-09-16 US US14/488,093 patent/US9499478B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012217922B2 (en) | 2017-05-04 |
| KR101935068B1 (ko) | 2019-01-03 |
| US8865766B2 (en) | 2014-10-21 |
| US20150005377A1 (en) | 2015-01-01 |
| KR20140015364A (ko) | 2014-02-06 |
| AU2012217922A1 (en) | 2013-09-05 |
| RU2599249C2 (ru) | 2016-10-10 |
| US9499478B2 (en) | 2016-11-22 |
| TWI642653B (zh) | 2018-12-01 |
| US20120295972A1 (en) | 2012-11-22 |
| JP5885271B2 (ja) | 2016-03-15 |
| CN103459368B (zh) | 2016-06-08 |
| US20130324606A1 (en) | 2013-12-05 |
| CA2827446C (en) | 2020-06-23 |
| RU2013141849A (ru) | 2015-03-27 |
| EP2675786B1 (en) | 2018-12-26 |
| CN103459368A (zh) | 2013-12-18 |
| TW201247613A (en) | 2012-12-01 |
| CA2827446A1 (en) | 2012-08-23 |
| BR112013020719A2 (pt) | 2016-08-09 |
| JP2014513051A (ja) | 2014-05-29 |
| EP2675786A1 (en) | 2013-12-25 |
| WO2012112451A1 (en) | 2012-08-23 |
| BR112013020719B1 (pt) | 2018-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |