CN1364521A - Nano climacteria medicine and its preparing method - Google Patents
Nano climacteria medicine and its preparing method Download PDFInfo
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- CN1364521A CN1364521A CN 01100681 CN01100681A CN1364521A CN 1364521 A CN1364521 A CN 1364521A CN 01100681 CN01100681 CN 01100681 CN 01100681 A CN01100681 A CN 01100681A CN 1364521 A CN1364521 A CN 1364521A
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Abstract
The nano climatcteric medicine is prepared with nano Radix Bupleuri, nano Astragalus membranaceus, nano Radix Paeoniae Alba, nano yeradetajo, nano ginseng and other 17 kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to the nano climacteria medicine of a kind of dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting QI and nourishing blood, spleen-benefiting mind-tranquilizing, the invention still further relates to the method for this medication preparation.
Climacteric rather is a kind of classical Chinese patent medicine, mainly contains effects such as dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting QI and nourishing blood, spleen-benefiting mind-tranquilizing, is used for that the shortness of breath and palpitation that climacteric causes, irritated irritability, dizzy insomnia, a battle array febrile perspiration go out, breast mammary swelling pain, menoxenia.But the peaceful disintegrate of traditional climacteric is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano climacteria medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano climacteria medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bupleurum 18-42 part nano astragalus 18-42 part nanometer Radix Paeoniae Alba 24-56 part
Nanometric Herba Ecliptae 24-56 part nano ginseng 6-14 part nanometer Radix Codonopsis 18-42 part
Nanometer Radix Curcumae 18-42 part nano cyperus tuber 24-56 part nano Chinese angelica 24-56 part
Nanometer Herba Menthae 6-14 part nanometer Rhizoma Chuanxiong 12-28 part nanometer Radix Scrophulariae 24-56 part
Nano Poria 18-42 part nanometer Rhizoma Pinelliae Preparatum 18-42 part nanometer Rhizoma Acori Graminei 18-42 part
Nanometer Cortex Moutan 24-56 part nanometer Pericarpium Citri Reticulatae 18-42 part nanometer Rhizoma Zingiberis 6-14 part
Nanometer Rhizoma Atractylodis Macrocephalae 18-42 part nano red sage 18-42 part nanometer Semen Vaccariae 18-42 part
Nanometer Fructus Ligustri Lucidi 24-56 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bupleurum 24-36 part nano astragalus 24-36 part nanometer Radix Paeoniae Alba 32-48 part
Nanometric Herba Ecliptae 32-48 part nano ginseng 8-12 part nanometer Radix Codonopsis 24-36 part
Nanometer Radix Curcumae 24-36 part nano cyperus tuber 32-48 part nano Chinese angelica 32-48 part
Nanometer Herba Menthae 8-12 part nanometer Rhizoma Chuanxiong 16-24 part nanometer Radix Scrophulariae 32-48 part
Nano Poria 24-36 part nanometer Rhizoma Pinelliae Preparatum 24-36 part nanometer Rhizoma Acori Graminei 24-36 part
Nanometer Cortex Moutan 32-48 part nanometer Pericarpium Citri Reticulatae 24-36 part nanometer Rhizoma Zingiberis 8-12 part
Nanometer Rhizoma Atractylodis Macrocephalae 24-36 part nano red sage 24-36 part nanometer Semen Vaccariae 24-36 part
Nanometer Fructus Ligustri Lucidi 32-48 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 30 parts of nanometer Radix Paeoniae Albas of 30 parts of nano astragalus of nano bupleurum
30 parts of 10 parts of nanometer Radix Codonopsis of 40 parts of nano ginsengs of nanometric Herba Ecliptae
40 parts of 40 parts of nano Chinese angelicas of 30 parts of nano cyperus tubers of nanometer Radix Curcumae
40 parts of 20 portions of nanometer Radix Scrophulariaes of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Herba Menthae
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nano Poria
10 parts of 30 parts of nanometer Rhizoma Zingiberiss of 40 parts of nanometer Pericarpium Citri Reticulataes of nanometer Cortex Moutan
30 parts of 30 parts of nanometer Semen Vaccariae of 30 parts of nano red sages of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of nanometer Fructus Ligustri Lucidi
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour:
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the peaceful preparation nano powder of climacteric with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano climacteria medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the peaceful preparation material of common climacteric is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano climacteria medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as the shortness of breath and palpitation that climacteric causes, irritated irritability, dizzy insomnia, a battle array febrile perspiration go out, breast mammary swelling pain, menoxenia, and it is peaceful that clinical efficacy significantly is better than traditional climacteric.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts of 30 parts of nanometer Radix Paeoniae Albas of 30 parts of nano astragalus of nano bupleurum
30 parts of 10 parts of nanometer Radix Codonopsis of 40 parts of nano ginsengs of nanometric Herba Ecliptae
40 parts of 40 parts of nano Chinese angelicas of 30 parts of nano cyperus tubers of nanometer Radix Curcumae
40 parts of 20 portions of nanometer Radix Scrophulariaes of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Herba Menthae
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nano Poria
10 parts of 30 parts of nanometer Rhizoma Zingiberiss of 40 parts of nanometer Pericarpium Citri Reticulataes of nanometer Cortex Moutan
30 parts of 30 parts of nanometer Semen Vaccariae of 30 parts of nano red sages of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of nanometer Fructus Ligustri Lucidi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts of 30 parts of nanometer Radix Paeoniae Albas of 30 parts of nano astragalus of nano bupleurum
30 parts of 10 parts of nanometer Radix Codonopsis of 40 parts of nano ginsengs of nanometric Herba Ecliptae
40 parts of 40 parts of nano Chinese angelicas of 30 parts of nano cyperus tubers of nanometer Radix Curcumae
40 parts of 20 portions of nanometer Radix Scrophulariaes of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Herba Menthae
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nano Poria
10 parts of 30 parts of nanometer Rhizoma Zingiberiss of 40 parts of nanometer Pericarpium Citri Reticulataes of nanometer Cortex Moutan
30 parts of 30 parts of nanometer Semen Vaccariae of 30 parts of nano red sages of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of nanometer Fructus Ligustri Lucidi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the peaceful powder needle injection of nanometer climacteric, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts of 30 parts of nanometer Radix Paeoniae Albas of 30 parts of nano astragalus of nano bupleurum
30 parts of 10 parts of nanometer Radix Codonopsis of 40 parts of nano ginsengs of nanometric Herba Ecliptae
40 parts of 40 parts of nano Chinese angelicas of 30 parts of nano cyperus tubers of nanometer Radix Curcumae
40 parts of 20 portions of nanometer Radix Scrophulariaes of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Herba Menthae
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nano Poria
10 parts of 30 parts of nanometer Rhizoma Zingiberiss of 40 parts of nanometer Pericarpium Citri Reticulataes of nanometer Cortex Moutan
30 parts of 30 parts of nanometer Semen Vaccariae of 30 parts of nano red sages of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of nanometer Fructus Ligustri Lucidi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the peaceful membrane of nanometer climacteric, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano climacteria medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bupleurum 18-42 part nano astragalus 18-42 part nanometer Radix Paeoniae Alba 24-56 part
Nanometric Herba Ecliptae 24-56 part nano ginseng 6-14 part nanometer Radix Codonopsis 18-42 part
Nanometer Radix Curcumae 18-42 part nano cyperus tuber 24-56 part nano Chinese angelica 24-56 part
Nanometer Herba Menthae 6-14 part nanometer Rhizoma Chuanxiong 12-28 part nanometer Radix Scrophulariae 24-56 part
Nano Poria 18-42 part nanometer Rhizoma Pinelliae Preparatum 18-42 part nanometer Rhizoma Acori Graminei 18-42 part
Nanometer Cortex Moutan 24-56 part nanometer Pericarpium Citri Reticulatae 18-42 part nanometer Rhizoma Zingiberis 6-14 part
Nanometer Rhizoma Atractylodis Macrocephalae 18-42 part nano red sage 18-42 part nanometer Semen Vaccariae 18-42 part
Nanometer Fructus Ligustri Lucidi 24-56 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano climacteria medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bupleurum 24-36 part nano astragalus 24-36 part nanometer Radix Paeoniae Alba 32-48 part
Nanometric Herba Ecliptae 32-48 part nano ginseng 8-12 part nanometer Radix Codonopsis 24-36 part
Nanometer Radix Curcumae 24-36 part nano cyperus tuber 32-48 part nano Chinese angelica 32-48 part
Nanometer Herba Menthae 8-12 part nanometer Rhizoma Chuanxiong 16-24 part nanometer Radix Scrophulariae 32-48 part
Nano Poria 24-36 part nanometer Rhizoma Pinelliae Preparatum 24-36 part nanometer Rhizoma Acori Graminei 24-36 part
Nanometer Cortex Moutan 32-48 part nanometer Pericarpium Citri Reticulatae 24-36 part nanometer Rhizoma Zingiberis 8-12 part
Nanometer Rhizoma Atractylodis Macrocephalae 24-36 part nano red sage 24-36 part nanometer Semen Vaccariae 24-36 part
Nanometer Fructus Ligustri Lucidi 32-48 part
3, nano climacteria medicine according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 30 parts of nanometer Radix Paeoniae Albas of 30 parts of nano astragalus of nano bupleurum
30 parts of 10 parts of nanometer Radix Codonopsis of 40 parts of nano ginsengs of nanometric Herba Ecliptae
40 parts of 40 parts of nano Chinese angelicas of 30 parts of nano cyperus tubers of nanometer Radix Curcumae
40 parts of 20 portions of nanometer Radix Scrophulariaes of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Herba Menthae
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nano Poria
10 parts of 30 parts of nanometer Rhizoma Zingiberiss of 40 parts of nanometer Pericarpium Citri Reticulataes of nanometer Cortex Moutan
30 parts of 30 parts of nanometer Semen Vaccariae of 30 parts of nano red sages of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of nanometer Fructus Ligustri Lucidi
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano climacteria medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano climacteria medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100681 CN1364521A (en) | 2001-01-17 | 2001-01-17 | Nano climacteria medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100681 CN1364521A (en) | 2001-01-17 | 2001-01-17 | Nano climacteria medicine and its preparing method |
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| CN1364521A true CN1364521A (en) | 2002-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100681 Pending CN1364521A (en) | 2001-01-17 | 2001-01-17 | Nano climacteria medicine and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017124826A1 (en) * | 2016-01-22 | 2017-07-27 | 王平平 | Traditional chinese medicinal product for treating liver qi stagnation type premenstrual tension and syndrome |
-
2001
- 2001-01-17 CN CN 01100681 patent/CN1364521A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017124826A1 (en) * | 2016-01-22 | 2017-07-27 | 王平平 | Traditional chinese medicinal product for treating liver qi stagnation type premenstrual tension and syndrome |
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