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CL2012001303A1 - Compuestos derivados de pirrolo[2,3-d]pirimidina sustituidas, inhibidores de la proteína quinasa raf; procedimiento de preparación; composición farmacéutica que los comprende; kit farmacéutico; y su uso para tratar melanoma, glioma, cáncer de pulmón, cáncer de hígado, alzheimer, parkinson, epilepsia, dolor neuropatico, aterosclerosis. - Google Patents

Compuestos derivados de pirrolo[2,3-d]pirimidina sustituidas, inhibidores de la proteína quinasa raf; procedimiento de preparación; composición farmacéutica que los comprende; kit farmacéutico; y su uso para tratar melanoma, glioma, cáncer de pulmón, cáncer de hígado, alzheimer, parkinson, epilepsia, dolor neuropatico, aterosclerosis.

Info

Publication number
CL2012001303A1
CL2012001303A1 CL2012001303A CL2012001303A CL2012001303A1 CL 2012001303 A1 CL2012001303 A1 CL 2012001303A1 CL 2012001303 A CL2012001303 A CL 2012001303A CL 2012001303 A CL2012001303 A CL 2012001303A CL 2012001303 A1 CL2012001303 A1 CL 2012001303A1
Authority
CL
Chile
Prior art keywords
glioma
protein kinase
kinase inhibitors
epilepsy
parkinson
Prior art date
Application number
CL2012001303A
Other languages
English (en)
Inventor
Chao Zhang
Songyuan Shi
Wayne Spevak
Hanna Cho
Pranha N Ibrahim
Ying Zhang
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of CL2012001303A1 publication Critical patent/CL2012001303A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Compuestos derivados de pirimidinas sustituidas, inhibidores de la proteína quinasa RAF; procedimiento de preparación; composición farmacéutica que los comprende; kit farmacéutico; y método para tratar enfermedades tales como melanoma, glioma, cáncer de pulmón, cáncer de hígado, entre otras.
CL2012001303A 2009-11-18 2012-05-18 Compuestos derivados de pirrolo[2,3-d]pirimidina sustituidas, inhibidores de la proteína quinasa raf; procedimiento de preparación; composición farmacéutica que los comprende; kit farmacéutico; y su uso para tratar melanoma, glioma, cáncer de pulmón, cáncer de hígado, alzheimer, parkinson, epilepsia, dolor neuropatico, aterosclerosis. CL2012001303A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26251009P 2009-11-18 2009-11-18
US38331010P 2010-09-15 2010-09-15

Publications (1)

Publication Number Publication Date
CL2012001303A1 true CL2012001303A1 (es) 2012-10-05

Family

ID=44060002

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001303A CL2012001303A1 (es) 2009-11-18 2012-05-18 Compuestos derivados de pirrolo[2,3-d]pirimidina sustituidas, inhibidores de la proteína quinasa raf; procedimiento de preparación; composición farmacéutica que los comprende; kit farmacéutico; y su uso para tratar melanoma, glioma, cáncer de pulmón, cáncer de hígado, alzheimer, parkinson, epilepsia, dolor neuropatico, aterosclerosis.

Country Status (21)

Country Link
US (2) US8673928B2 (es)
EP (1) EP2501236B1 (es)
JP (2) JP2013511541A (es)
KR (1) KR20120097512A (es)
CN (2) CN105906631A (es)
AU (2) AU2010321883A1 (es)
BR (1) BR112012011792A2 (es)
CA (1) CA2781287C (es)
CL (1) CL2012001303A1 (es)
CO (1) CO6551689A2 (es)
ES (1) ES2627911T3 (es)
IL (1) IL219567A0 (es)
MA (1) MA33811B1 (es)
MX (1) MX2012005827A (es)
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MX2012005827A (es) 2012-06-19
PE20121335A1 (es) 2012-10-12
JP2013511541A (ja) 2013-04-04
WO2011063159A1 (en) 2011-05-26
JP2016185958A (ja) 2016-10-27
CA2781287A1 (en) 2011-05-26
SG10201407718WA (en) 2015-01-29
AU2010321883A1 (en) 2012-05-31
CA2781287C (en) 2018-07-31
US8673928B2 (en) 2014-03-18
CN102740698A (zh) 2012-10-17
CO6551689A2 (es) 2012-10-31
AU2016200485B2 (en) 2017-09-28
MA33811B1 (fr) 2012-12-03
AU2016200485A1 (en) 2016-02-18
EP2501236B1 (en) 2017-03-29
US20110152258A1 (en) 2011-06-23
BR112012011792A2 (pt) 2015-10-13
KR20120097512A (ko) 2012-09-04
ES2627911T3 (es) 2017-08-01
EP2501236A1 (en) 2012-09-26
EP2501236A4 (en) 2013-05-15
US20140288070A1 (en) 2014-09-25
CN105906631A (zh) 2016-08-31
US9617267B2 (en) 2017-04-11
NZ599872A (en) 2014-08-29
RU2012125070A (ru) 2013-12-27
JP6194389B2 (ja) 2017-09-06
MY156210A (en) 2016-01-29
PH12012500981A1 (en) 2017-08-23

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