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BRPI0813237B8 - composto, método para preparar o composto, medicamento, e, uso do composto - Google Patents

composto, método para preparar o composto, medicamento, e, uso do composto

Info

Publication number
BRPI0813237B8
BRPI0813237B8 BRPI0813237A BRPI0813237A BRPI0813237B8 BR PI0813237 B8 BRPI0813237 B8 BR PI0813237B8 BR PI0813237 A BRPI0813237 A BR PI0813237A BR PI0813237 A BRPI0813237 A BR PI0813237A BR PI0813237 B8 BRPI0813237 B8 BR PI0813237B8
Authority
BR
Brazil
Prior art keywords
compound
medicine
preparing
pyrimidines
dihydro
Prior art date
Application number
BRPI0813237A
Other languages
English (en)
Inventor
Siegfried Goldmann
Li Jing
Liu Yisong
Original Assignee
Sunshine Lake Pharma Co Ltd
Zhongneng Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40155886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0813237(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sunshine Lake Pharma Co Ltd, Zhongneng Zhang filed Critical Sunshine Lake Pharma Co Ltd
Publication of BRPI0813237A2 publication Critical patent/BRPI0813237A2/pt
Publication of BRPI0813237B1 publication Critical patent/BRPI0813237B1/pt
Publication of BRPI0813237B8 publication Critical patent/BRPI0813237B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

composto, método para preparar o composto, composição, medicamento, e, uso do composto. tiazolil-di-hidro-pirimidinas bromo-fenil-substituídas e suas combinações com outros agentes antivirais para combater infecções por hbv.
BRPI0813237A 2007-06-18 2008-06-18 composto, método para preparar o composto, medicamento, e, uso do composto BRPI0813237B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200710119019 2007-06-18
PCT/CN2008/001187 WO2008154817A1 (en) 2007-06-18 2008-06-18 Bromo-phenyl substituted thiazolyl dihydropyrimidines

Publications (3)

Publication Number Publication Date
BRPI0813237A2 BRPI0813237A2 (pt) 2014-12-23
BRPI0813237B1 BRPI0813237B1 (pt) 2020-01-07
BRPI0813237B8 true BRPI0813237B8 (pt) 2021-05-25

Family

ID=40155886

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813237A BRPI0813237B8 (pt) 2007-06-18 2008-06-18 composto, método para preparar o composto, medicamento, e, uso do composto

Country Status (14)

Country Link
US (4) USRE45004E1 (pt)
EP (2) EP2159224B1 (pt)
JP (2) JP5361879B2 (pt)
KR (1) KR101173892B1 (pt)
CN (2) CN101328171A (pt)
AU (1) AU2008265397C1 (pt)
BR (1) BRPI0813237B8 (pt)
CA (1) CA2691056C (pt)
DK (2) DK2159224T3 (pt)
ES (2) ES2442907T3 (pt)
PL (2) PL2514750T3 (pt)
PT (2) PT2159224E (pt)
RU (1) RU2443703C2 (pt)
WO (1) WO2008154817A1 (pt)

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AU2008265397C1 (en) 2007-06-18 2013-08-29 Sunshine Lake Pharma Co., Ltd. Bromo-phenyl substituted thiazolyl dihydropyrimidines
WO2010069147A1 (zh) * 2008-12-17 2010-06-24 张中能 二氢嘧啶类化合物、其组合物及其应用
CN101744823B (zh) * 2008-12-17 2013-06-19 广东东阳光药业有限公司 一种二氢嘧啶类化合物的固体分散体及其药用制剂
CN101575318B (zh) 2009-06-25 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 二氢嘧啶类化合物及其用于制备治疗和/或预防病毒性疾病的药物的用途
AR089671A1 (es) * 2012-01-06 2014-09-10 Janssen R & D Ireland 1,4-dihidropirimidinas 4,4-disustituidas y su uso como medicamentos para el tratamiento de la hepatitis b
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
PL2888241T3 (pl) 2012-08-24 2017-12-29 Sunshine Lake Pharma Co., Ltd. 2,4,5,6-Podstawione pochodne 3,6-dihydropirymidyny jako inhibitory polimerazy wirusa zapalenia wątroby typu B (HBV) do leczenia np. przewlekłego zapalenia wątroby
CN103664897B (zh) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664925B (zh) * 2012-09-07 2018-01-23 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
BR112015004113A2 (pt) 2012-09-10 2017-07-04 Hoffmann La Roche 6-aminoácido heteroarila diidropirimidinas para o tratamento e profilaxia da infecção pelo vírus da hepatite b
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
TWI561520B (en) * 2012-09-27 2016-12-11 Sunshine Lake Pharma Co Ltd Crystalline forms of dihydropyrimidine derivatives
CA2907490A1 (en) * 2013-03-20 2014-09-25 Indiana University Research And Technology Corporation Fluorescent-hap: a diagnostic stain for hbv cores in cells
MX2016006564A (es) 2013-11-19 2017-09-12 Sunshine Lake Pharma Co Ltd Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos.
KR102284938B1 (ko) * 2013-11-27 2021-08-02 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
MX2016012573A (es) 2014-03-28 2018-02-19 Sunshine Lake Pharma Co Ltd Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
CA2948580A1 (en) * 2014-05-09 2015-11-12 Adam Zlotnick Methods and compositions for treating hepatitis b virus infections
TW201629054A (zh) 2015-02-07 2016-08-16 廣東東陽光藥業有限公司 二氫嘧啶衍生物的複合物及其在藥物中的應用
MX377531B (es) 2015-11-03 2025-03-10 Hoffmann La Roche Terapia de combinación de un inhibidor del ensamble de la cápside del hbv y un interferón.
WO2018036941A1 (en) 2016-08-24 2018-03-01 F. Hoffmann-La Roche Ag Combination therapy of an hbv capsid assembly inhibitor and a nucleos(t)ide analogue
ES2874656T3 (es) 2017-02-23 2021-11-05 Fujian Cosunter Pharmaceutical Co Ltd Compuesto tricíclico y aplicaciones del mismo
ES2895023T3 (es) * 2017-03-31 2022-02-17 Fujifilm Corp Compuesto de 4-piridona o sal del mismo y composición farmacéutica y formulación que los incluyen
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
CN107501257B (zh) * 2017-08-17 2020-05-29 山东大学 二氢嘧啶-三氮唑类衍生物及其制备方法与应用
WO2019223791A1 (zh) 2018-05-25 2019-11-28 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
CA3109746C (en) 2018-08-23 2023-07-11 Fujian Cosunter Pharmaceutical Co., Ltd. Crystal form of tri-cycle compound and application thereof
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CA3159096A1 (en) 2019-11-22 2021-05-27 Chia Tai Tianqing Pharmaceutical Group Co., Ltd Crystal form of nucleoprotein inhibitor and use thereof
US20240246978A1 (en) 2021-02-05 2024-07-25 Hepagene Therapeutics (HK) Limited Phenyldihydropyrimidine compound and use thereof
CN117136187A (zh) * 2021-06-24 2023-11-28 上海齐鲁制药研究中心有限公司 新型抗乙肝化合物

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Also Published As

Publication number Publication date
KR101173892B1 (ko) 2012-08-16
EP2514750A1 (en) 2012-10-24
EP2514750B1 (en) 2013-11-20
JP5361879B2 (ja) 2013-12-04
BRPI0813237B1 (pt) 2020-01-07
JP2010530374A (ja) 2010-09-09
ES2442907T3 (es) 2014-02-14
AU2008265397C1 (en) 2013-08-29
HK1174035A1 (en) 2013-05-31
EP2159224B1 (en) 2012-08-01
JP2013231036A (ja) 2013-11-14
DK2514750T5 (en) 2014-02-17
EP2159224A1 (en) 2010-03-03
US8236797B2 (en) 2012-08-07
EP2159224A4 (en) 2011-08-03
AU2008265397B9 (en) 2011-08-04
CA2691056A1 (en) 2008-12-24
CN102066369A (zh) 2011-05-18
ES2391597T3 (es) 2012-11-28
CN102066369B (zh) 2013-05-29
US20100240655A1 (en) 2010-09-23
AU2008265397B2 (en) 2011-07-21
RU2443703C2 (ru) 2012-02-27
PL2159224T3 (pl) 2012-12-31
PT2159224E (pt) 2012-10-24
USRE44987E1 (en) 2014-07-01
DK2514750T3 (da) 2013-12-02
BRPI0813237A2 (pt) 2014-12-23
PT2514750E (pt) 2014-01-23
US8343969B2 (en) 2013-01-01
US20120282221A1 (en) 2012-11-08
PL2514750T3 (pl) 2014-05-30
WO2008154817A1 (en) 2008-12-24
USRE45004E1 (en) 2014-07-08
RU2010101212A (ru) 2011-07-27
AU2008265397A1 (en) 2008-12-24
JP5970421B2 (ja) 2016-08-17
DK2159224T3 (da) 2012-08-20
CN101328171A (zh) 2008-12-24
KR20100038104A (ko) 2010-04-12
CA2691056C (en) 2014-03-11

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SUNSHINE LAKE PHARMA CO., LTD. (CN)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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