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BRPI0406591A - Composição, métodos para o tratamento de uma doença neurodegenerativa, disquinesia, distonia, mioclonias ou tremores, psicose, de uma doença neuropsiquiátria, de uma condição doentia e enxaqueca, composto, métodos de inibição da atividade de um receptor de monoamina e da ativação de um receptor de monoamina métodos de identificação de polimorfismo genético e de um paciente apropriado para tratamento com o composto - Google Patents

Composição, métodos para o tratamento de uma doença neurodegenerativa, disquinesia, distonia, mioclonias ou tremores, psicose, de uma doença neuropsiquiátria, de uma condição doentia e enxaqueca, composto, métodos de inibição da atividade de um receptor de monoamina e da ativação de um receptor de monoamina métodos de identificação de polimorfismo genético e de um paciente apropriado para tratamento com o composto

Info

Publication number
BRPI0406591A
BRPI0406591A BR0406591-3A BRPI0406591A BRPI0406591A BR PI0406591 A BRPI0406591 A BR PI0406591A BR PI0406591 A BRPI0406591 A BR PI0406591A BR PI0406591 A BRPI0406591 A BR PI0406591A
Authority
BR
Brazil
Prior art keywords
methods
compound
treatment
disease
psychosis
Prior art date
Application number
BR0406591-3A
Other languages
English (en)
Inventor
David M Weiner
Robert E Davis
Mark R Brann
Original Assignee
Acadia Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32776052&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0406591(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Acadia Pharm Inc filed Critical Acadia Pharm Inc
Publication of BRPI0406591A publication Critical patent/BRPI0406591A/pt
Publication of BRPI0406591B1 publication Critical patent/BRPI0406591B1/pt
Publication of BRPI0406591B8 publication Critical patent/BRPI0406591B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"COMPOSIçãO, MéTODOS PARA O TRATAMENTO DE UMA DOENçA NEURODEGENERATIVA, DISQUINESIA, DISTONIA, MIOCLONIAS OU TREMORES, PSICOSE, DE UMA DOENçA NEUROPSIQUIáTRICA, DE UMA CONDIçãO DOENTIA E ENXAQUECA, COMPOSTO, MéTODOS DE INIBIçãO DA ATIVIDADE DE UM RECEPTOR DE MONOAMINA E DA ATIVAçãO DE UM RECEPTOR DE MONOAMINA, MéTODOS DE IDENTIFICAçãO DE POLIMORFISMO GENéTICO E DE UM PACIENTE APROPRIADO PARA TRATAMENTO COM O COMPOSTO". Dados farmacológicos de comportamento com o composto da fórmula (I), agonista inverso receptor de 5HT2A/2C inovador e seletivo, demonstram a eficácia in vivo em modelos de psicose e disquinesias. Isso inclui a atividade na reversão de comportamentos locomotores induzidos por MK-801, o que sugere que este composto pode ser antipsicótico eficaz, e a atividade em modelo de primatas MPTP de disquínesias, o que sugere a eficácia como agente antidisquinesia. Estes dados sustentam a hipótese de que o agonismo inverso de receptor de 5HT2A/2C pode conferir eficácia antipsicótica e antidisquinética em seres humanos e indicam um uso do composto da fórmula (I) e agentes relacionados como terapêuticos inovadores para o Mal de Parkinson, doenças neurodegenerativas humanas relacionadas e psicose.
BRPI0406591A 2003-01-16 2004-01-15 composto e composição farmacêutica BRPI0406591B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44140603P 2003-01-16 2003-01-16
US47934603P 2003-06-17 2003-06-17
PCT/US2004/001234 WO2004064738A2 (en) 2003-01-16 2004-01-15 Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases

Publications (3)

Publication Number Publication Date
BRPI0406591A true BRPI0406591A (pt) 2005-12-20
BRPI0406591B1 BRPI0406591B1 (pt) 2018-12-18
BRPI0406591B8 BRPI0406591B8 (pt) 2021-05-25

Family

ID=32776052

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0406591A BRPI0406591B8 (pt) 2003-01-16 2004-01-15 composto e composição farmacêutica

Country Status (21)

Country Link
US (17) US7601740B2 (pt)
EP (2) EP2009000B1 (pt)
JP (2) JP5184777B2 (pt)
KR (1) KR101095939B1 (pt)
CN (3) CN1816524B (pt)
AT (2) ATE407117T1 (pt)
AU (1) AU2004206886B2 (pt)
BR (1) BRPI0406591B8 (pt)
CA (1) CA2512639C (pt)
CY (1) CY1108642T1 (pt)
DE (1) DE602004016288D1 (pt)
DK (2) DK1587789T3 (pt)
ES (2) ES2367135T3 (pt)
MX (1) MXPA05007568A (pt)
NZ (1) NZ541146A (pt)
PT (1) PT1587789E (pt)
RU (2) RU2332401C2 (pt)
SG (1) SG170617A1 (pt)
SI (2) SI1587789T1 (pt)
WO (1) WO2004064738A2 (pt)
ZA (1) ZA200505680B (pt)

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US20060199842A1 (en) 2006-09-07
DK2009000T3 (da) 2011-09-05
CN101780080A (zh) 2010-07-21
CY1108642T1 (el) 2014-04-09
AU2004206886A1 (en) 2004-08-05
US20220241265A1 (en) 2022-08-04
KR101095939B1 (ko) 2011-12-19
US20060264466A1 (en) 2006-11-23
US7732462B2 (en) 2010-06-08
US8377959B2 (en) 2013-02-19
CA2512639C (en) 2012-10-30
SG170617A1 (en) 2011-05-30
EP2009000B1 (en) 2011-06-08
US8008323B2 (en) 2011-08-30
CA2512639A1 (en) 2004-08-05
US8618130B2 (en) 2013-12-31
SI1587789T1 (sl) 2009-02-28
AU2004206886B2 (en) 2010-09-02
US20100227886A1 (en) 2010-09-09
US20160250200A1 (en) 2016-09-01
HK1083759A1 (en) 2006-07-14
US20200323836A1 (en) 2020-10-15
BRPI0406591B8 (pt) 2021-05-25
SI2009000T1 (sl) 2011-09-30
MXPA05007568A (es) 2005-09-21
US9211289B2 (en) 2015-12-15
US7601740B2 (en) 2009-10-13
EP1587789A2 (en) 2005-10-26
US7659285B2 (en) 2010-02-09
NZ541146A (en) 2009-04-30
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US20100227885A1 (en) 2010-09-09
US7994193B2 (en) 2011-08-09
RU2465267C2 (ru) 2012-10-27

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