[go: up one dir, main page]

BR9910122A - Compostos amidina - Google Patents

Compostos amidina

Info

Publication number
BR9910122A
BR9910122A BR9910122-0A BR9910122A BR9910122A BR 9910122 A BR9910122 A BR 9910122A BR 9910122 A BR9910122 A BR 9910122A BR 9910122 A BR9910122 A BR 9910122A
Authority
BR
Brazil
Prior art keywords
amidine compounds
prodrug
inhibitors
salt
useful
Prior art date
Application number
BR9910122-0A
Other languages
English (en)
Inventor
Susumu Katoh
Katsuyuki Yokota
Mikio Hayashi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of BR9910122A publication Critical patent/BR9910122A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS AMIDINA"<D>. Composto de fórmula (I) onde R¹, R² e R³ são iguais ou diferentes e cada um é átomo de hidrogênio, hidróxi, alquila inferior ou arila R é um grupo de fórmula ou onde cada símbolo é como indicado no pedido, um sal deste ou uma prodroga deste. O composto da presente invenção, um sal deste e uma prodroga deste são úteis como inibidores do fator Xa e inibidores da coagulação sanq³ínea, e também úteis para profilaxia e/ou tratamento de doenças ocasionadas por coagulação sang³ínea ou por trombo.
BR9910122-0A 1998-04-10 1999-04-09 Compostos amidina BR9910122A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11623398 1998-04-10
JP23786998 1998-08-25
PCT/JP1999/001900 WO1999052895A1 (fr) 1998-04-10 1999-04-09 Composes d'amidine

Publications (1)

Publication Number Publication Date
BR9910122A true BR9910122A (pt) 2001-10-16

Family

ID=26454606

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910122-0A BR9910122A (pt) 1998-04-10 1999-04-09 Compostos amidina

Country Status (23)

Country Link
US (2) US6562828B1 (pt)
EP (1) EP1070714B1 (pt)
KR (1) KR100416111B1 (pt)
CN (1) CN1305470A (pt)
AR (1) AR015269A1 (pt)
AT (1) ATE272630T1 (pt)
AU (1) AU752588B2 (pt)
BR (1) BR9910122A (pt)
CA (1) CA2327488A1 (pt)
CO (1) CO5021130A1 (pt)
DE (1) DE69919149D1 (pt)
HU (1) HUP0101137A3 (pt)
ID (1) ID28266A (pt)
IL (1) IL138899A0 (pt)
NO (1) NO20005083L (pt)
NZ (1) NZ508101A (pt)
PE (1) PE20000422A1 (pt)
PL (1) PL343424A1 (pt)
RU (1) RU2201927C2 (pt)
SG (1) SG74717A1 (pt)
SK (1) SK15072000A3 (pt)
TR (1) TR200002904T2 (pt)
WO (1) WO1999052895A1 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0813525T3 (da) 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
CA2347095A1 (en) * 1998-10-16 2000-04-27 Takeda Chemical Industries, Ltd. Nitrogen-containing condensed heterocyclic derivatives, their production and agent
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
AU2001249399A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Isoquinolone inhibitors of factor xa
AU2001249398A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Bicyclic sulfonyl amino inhibitors of factor xa
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US20030187023A1 (en) * 2000-07-17 2003-10-02 Keiji Kubo Sulfone derivatives, process for their production and use thereof
DE10110325A1 (de) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenylderivate 2
WO2003060475A2 (en) 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
JPWO2003095446A1 (ja) * 2002-05-09 2005-09-15 持田製薬株式会社 １−（４−ピリジル）−４−ピペリドンの製造方法
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
CA2507026A1 (en) * 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited Imidazole derivatives, their production and use
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
EP1479676A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Benzimidazole-derivatives as factor xa inhibitors
US7741341B2 (en) * 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
JP4355917B2 (ja) 2003-10-29 2009-11-04 信越化学工業株式会社 含窒素有機化合物、レジスト材料及びパターン形成方法
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
DE102004016605A1 (de) * 2004-04-03 2005-10-20 Merck Patent Gmbh Thiocarbamoylproline
TWI396686B (zh) * 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
FR2870846B1 (fr) 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
CN101014595A (zh) * 2004-08-11 2007-08-08 杏林制药株式会社 新型环状氨基苯甲酸衍生物
EP1847527A4 (en) 2005-02-02 2009-04-08 Ajinomoto Kk NEW BENZAMIDINE DERIVATIVE
EP1862464A4 (en) * 2005-03-23 2010-08-25 Kyorin Seiyaku Kk NEW CYCLIC AMINOPHENYL ALKANIC ACID DERIVATIVE
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
RU2424231C2 (ru) * 2005-11-14 2011-07-20 Вайтаи Фармасьютиклз, Инк. Ингибиторы аспартат-протеазы
EP1790646A1 (fr) * 2005-11-24 2007-05-30 Sanofi-Aventis Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
JPWO2010005087A1 (ja) * 2008-07-11 2012-01-05 味の素株式会社 アミジン誘導体
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
KR101499696B1 (ko) * 2013-10-16 2015-03-09 한국식품연구원 젓갈 유래 엔테로코쿠스속 미생물 및 이를 이용하여 s-아데노실-l-메티오닌을 대량 생산하는 방법
CN103965113A (zh) * 2014-05-06 2014-08-06 四川大学 1-羟乙基-2-取代苯氧甲基苯并咪唑类化合物及其制备方法
CA3074989A1 (en) * 2017-10-04 2019-04-11 Japan Tobacco Inc. Nitrogen-containing heteroaryl compound and pharmaceutical use thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725388A (en) 1970-06-25 1973-04-03 Boehringer Sohn Ingelheim N-acyl-7-(n{41 -cycloalkyl-ureido-n{40 -sulfonyl)-isoquinolines and -benzazepines and alkali metal salts thereof
US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
JPS59139357A (ja) 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SG64322A1 (en) 1991-05-10 1999-04-27 Rhone Poulenc Rorer Int Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5721237A (en) 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
DE4127404A1 (de) 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP3048698B2 (ja) 1991-09-19 2000-06-05 第一製薬株式会社 アミジノ基置換芳香族化合物及びその塩
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JP3457694B2 (ja) * 1993-02-04 2003-10-20 第一製薬株式会社 インフルエンザ感染予防・治療薬
JP3388803B2 (ja) 1993-05-20 2003-03-24 第一製薬株式会社 光学活性７−アミジノナフタレン誘導体の製造法
IL111011A0 (en) 1993-09-22 1994-11-28 Wellcome Found Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them
JPH07179407A (ja) 1993-11-12 1995-07-18 Green Cross Corp:The 新規縮合環系化合物またはその塩、およびその医薬用途
US6815461B1 (en) 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
JPH0820532A (ja) 1994-07-05 1996-01-23 Dai Ichi Seiyaku Co Ltd 抗膵炎剤
MX9704059A (es) * 1994-12-02 1997-08-30 Yamanouchi Pharma Co Ltd Derivado de amidinonaftilo novedoso o sal del mismo.
US5693515A (en) 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
JPH092977A (ja) 1995-06-21 1997-01-07 Dai Ichi Seiyaku Co Ltd 経口投与用医薬組成物
DE19530996A1 (de) * 1995-08-23 1997-02-27 Boehringer Mannheim Gmbh Cyclische Guanidine, Verfahren zu ihrer Herstellung und Arzneimittel
PL193686B1 (pl) 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
CZ81997A3 (en) 1996-03-20 1997-10-15 Immuno Ag Pharmaceutical preparation for treating disorders connected with blood clotting, process of its preparation and use
EP0918768B1 (en) 1996-05-31 2002-01-09 C &amp; C Research Laboratories Aromatic amidine derivatives useful as selective thrombin inhibitors
HU224315B1 (hu) 1996-06-05 2005-07-28 Gyógyszerkutató Intézet Kft. Véralvadásgátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
JPH1017549A (ja) 1996-07-02 1998-01-20 Banyu Pharmaceut Co Ltd 二環性芳香族アミジン誘導体
HN1998000118A (es) 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
JP2003512423A (ja) 1999-10-27 2003-04-02 スノル・モレキュラー・コーポレーション 組織因子アンタゴニスト及びその使用方法
US20020173507A1 (en) 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses

Also Published As

Publication number Publication date
NO20005083D0 (no) 2000-10-09
NO20005083L (no) 2000-12-08
CO5021130A1 (es) 2001-03-27
PL343424A1 (en) 2001-08-13
AU3167799A (en) 1999-11-01
NZ508101A (en) 2002-12-20
KR100416111B1 (ko) 2004-01-31
US20040006099A1 (en) 2004-01-08
SK15072000A3 (sk) 2001-08-06
AR015269A1 (es) 2001-04-18
AU752588B2 (en) 2002-09-26
RU2201927C2 (ru) 2003-04-10
CA2327488A1 (en) 1999-10-21
SG74717A1 (en) 2000-08-22
EP1070714A4 (en) 2002-10-30
CN1305470A (zh) 2001-07-25
US6562828B1 (en) 2003-05-13
WO1999052895A1 (fr) 1999-10-21
IL138899A0 (en) 2001-11-25
HUP0101137A2 (hu) 2001-10-28
DE69919149D1 (de) 2004-09-09
ATE272630T1 (de) 2004-08-15
EP1070714B1 (en) 2004-08-04
EP1070714A1 (en) 2001-01-24
EP1070714A9 (en) 2005-10-19
TR200002904T2 (tr) 2001-02-21
KR20010042606A (ko) 2001-05-25
HUP0101137A3 (en) 2003-03-28
PE20000422A1 (es) 2000-05-19
ID28266A (id) 2001-05-10

Similar Documents

Publication Publication Date Title
BR9910122A (pt) Compostos amidina
BR9913654A (pt) Inibidores de p-38alfa quinase
NO20024424D0 (no) Glykopyranosyloksybenzylbenzenderivater, medisinske sammensetninger inneholdende slike, samt intermediater tilfremstilling av derivatene
DE60119894D1 (de) Piperidinverbindungen und diese enthaltenden medikamente
CY1107853T1 (el) Χρησεις αντισπασμωδικων αμινοξεων για τη θεραπευτικη αγωγη διπολικων διαταραχων
BR0108610A (pt) Compostos azapolicìclicos condensados com arila
ATE396988T1 (de) Chinolin- und chianzolinderivate zur behandlung von tumoren
IT1314184B1 (it) Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
DK0541798T3 (da) Hidtil ukendt diaminforbindelse og cerebralbeskyttende middel indeholdende denne
IT1311922B1 (it) Composti farmaceutici.
PE20010751A1 (es) Quinolin-2-ona como inhibidores de las proteinas resistentes a multiples farmacos
DE60221505D1 (de) FAKTOR Xa BENZAMIDIN INHIBITOREN
BR0208499A (pt) ácido 3-heterociclilpropanohidroxâmico como inibidores de procolágeno c-proteinase
DK656789A (da) Benzoheterocykliske forbindelser
BR9910058A (pt) Compostos azapolicìclicos aril-condensados
DE69707372D1 (de) Verwendung eines Phosphorsäurediesters zur Herstellung eines Arzneimittels zur Behandlung von Akne
ATE513821T1 (de) Thiadiazolin-derivate zur behandlung von krebs
ATE239741T1 (de) Derivate der phosphonsäure zur inhibierung von carboxypeptidase b
BR9813719A (pt) Agentes terapêuticos
BR9916188A (pt) Derivados de cromano
DE60021075D1 (de) Verwendung von 1,4-benzothiazepinderivaten als medikamente zur überwindung der toleranz für carcinostatika
BR9802544A (pt) Derivados de hexahidro-1,4-diazepina os seus sais.
DE602005017007D1 (de) Verbindungen vom hydrazidtyp und deren verwendung in pharmazeutischen zusammensetzungen zur behandlung von herzkreislauferkrankungen
DE60124717D1 (de) Aryl-sulfonamide als serotonin-antagonisten für de behandlung von fettleibigkeit
WO2003013499A3 (en) Drugs for vasculopaties

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.