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MX9704059A - Derivado de amidinonaftilo novedoso o sal del mismo. - Google Patents

Derivado de amidinonaftilo novedoso o sal del mismo.

Info

Publication number
MX9704059A
MX9704059A MX9704059A MX9704059A MX9704059A MX 9704059 A MX9704059 A MX 9704059A MX 9704059 A MX9704059 A MX 9704059A MX 9704059 A MX9704059 A MX 9704059A MX 9704059 A MX9704059 A MX 9704059A
Authority
MX
Mexico
Prior art keywords
group
formula
represented
hydrogen atom
group represented
Prior art date
Application number
MX9704059A
Other languages
English (en)
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of MX9704059A publication Critical patent/MX9704059A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de amidinonaftilo representado por la siguiente formula general (I), que tiene una accion inhibidora de la acumulacion de plaquetas basada en la accion inhibidora del factor X de coagulacion sanguínea activado, y es util como un agente contra trombos y similares, una sal del mismo, un intermediario del mismo, y una composicion farmacéutica que comprende al derivado de amidinonaftilo. Un derivado de amidinonaftilo representado por la siguiente formula general (I), o una sal farmacéuticamente aceptable del mismo: (Ver Formula) (los símbolos en la formula tienen los siguientes significados: R1; un átomo de hidrogeno o un grupo representado por la formula -A-W-R4, A: un grupo representado por la formula (Ver Formula) un grupo representado por la formula, o un grupo representado por la formula -SO2-, X: un átomo de oxígeno o un átomo de azufre, W: un enlace sencillo o un grupo representado por la formula -NR5-; R4: un grupo hidroxilo, un grupo alcoxi inferior, etcétera; R5: un átomo de hidrogeno, un grupo carbamoilo, un grupo alcoxi inferior-carbonilo, etcétera; R2: un grupo alquilo inferior, R3: un átomo de hidrogeno, un átomo de halogeno, un grupo carboxilo; B: un grupo alquileno inferior o un grupo carbonilo; y n: 0 o 1.
MX9704059A 1994-12-02 1995-12-01 Derivado de amidinonaftilo novedoso o sal del mismo. MX9704059A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP19881695 1995-08-03
PCT/JP1995/002458 WO1996016940A1 (en) 1994-12-02 1995-12-01 Novel amidinonaphthyl derivative or salt thereof

Publications (1)

Publication Number Publication Date
MX9704059A true MX9704059A (es) 1997-08-30

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704059A MX9704059A (es) 1994-12-02 1995-12-01 Derivado de amidinonaftilo novedoso o sal del mismo.

Country Status (20)

Country Link
US (1) US5869501A (es)
EP (1) EP0798295B1 (es)
JP (1) JP3004362B2 (es)
KR (1) KR100383161B1 (es)
CN (1) CN1087736C (es)
AT (1) ATE233240T1 (es)
AU (1) AU688628B2 (es)
CA (1) CA2206532C (es)
DE (1) DE69529770T2 (es)
ES (1) ES2193202T3 (es)
FI (1) FI115051B (es)
HU (1) HUT77313A (es)
MX (1) MX9704059A (es)
NO (1) NO309566B1 (es)
NZ (1) NZ296210A (es)
PL (1) PL184824B1 (es)
PT (1) PT798295E (es)
RU (1) RU2154633C2 (es)
TW (1) TW300888B (es)
WO (1) WO1996016940A1 (es)

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Also Published As

Publication number Publication date
FI972326A7 (fi) 1997-06-02
PL184824B1 (pl) 2002-12-31
CA2206532A1 (en) 1996-06-06
CA2206532C (en) 2006-07-11
ATE233240T1 (de) 2003-03-15
FI115051B (fi) 2005-02-28
US5869501A (en) 1999-02-09
PL320486A1 (en) 1997-09-29
PT798295E (pt) 2003-07-31
NZ296210A (en) 1998-05-27
AU688628B2 (en) 1998-03-12
EP0798295A1 (en) 1997-10-01
DE69529770T2 (de) 2003-12-24
TW300888B (es) 1997-03-21
RU2154633C2 (ru) 2000-08-20
FI972326A0 (fi) 1997-06-02
JP3004362B2 (ja) 2000-01-31
HUT77313A (hu) 1998-03-30
EP0798295B1 (en) 2003-02-26
WO1996016940A1 (en) 1996-06-06
NO972482L (no) 1997-08-01
EP0798295A4 (en) 1998-03-04
NO309566B1 (no) 2001-02-19
NO972482D0 (no) 1997-05-30
CN1167484A (zh) 1997-12-10
KR100383161B1 (ko) 2003-12-24
AU3994295A (en) 1996-06-19
CN1087736C (zh) 2002-07-17
DE69529770D1 (de) 2003-04-03
ES2193202T3 (es) 2003-11-01

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