DE60119894D1 - Piperidinverbindungen und diese enthaltenden medikamente - Google Patents
Piperidinverbindungen und diese enthaltenden medikamenteInfo
- Publication number
- DE60119894D1 DE60119894D1 DE60119894T DE60119894T DE60119894D1 DE 60119894 D1 DE60119894 D1 DE 60119894D1 DE 60119894 T DE60119894 T DE 60119894T DE 60119894 T DE60119894 T DE 60119894T DE 60119894 D1 DE60119894 D1 DE 60119894D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- piperidine compounds
- chem
- medicaments containing
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000012175 | 2000-01-20 | ||
| PCT/JP2001/000287 WO2001053288A1 (en) | 2000-01-20 | 2001-01-18 | Novel piperidine compounds and drugs containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60119894D1 true DE60119894D1 (de) | 2006-06-29 |
Family
ID=18539928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60119894T Expired - Lifetime DE60119894D1 (de) | 2000-01-20 | 2001-01-18 | Piperidinverbindungen und diese enthaltenden medikamente |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6784192B2 (de) |
| EP (1) | EP1254904B1 (de) |
| KR (1) | KR20020080378A (de) |
| CN (1) | CN1395575A (de) |
| AT (1) | ATE327230T1 (de) |
| AU (1) | AU779442B2 (de) |
| BR (1) | BR0107732A (de) |
| CA (1) | CA2398388A1 (de) |
| DE (1) | DE60119894D1 (de) |
| HU (1) | HUP0204496A3 (de) |
| IL (1) | IL150650A0 (de) |
| MX (1) | MXPA02007036A (de) |
| NO (1) | NO20023457L (de) |
| NZ (1) | NZ520041A (de) |
| RU (1) | RU2259365C2 (de) |
| WO (1) | WO2001053288A1 (de) |
| ZA (1) | ZA200205399B (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| RU2299207C2 (ru) * | 2001-08-30 | 2007-05-20 | Кова Ко., Лтд. | Соединения циклического амина |
| AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| AU2004218115A1 (en) * | 2003-03-07 | 2004-09-16 | Astellas Pharma Inc. | Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl |
| KR20070050961A (ko) * | 2004-09-01 | 2007-05-16 | 아스텔라스세이야쿠 가부시키가이샤 | 피페리딘 유도체 또는 이의 제약학적으로 허용되는 염 |
| US20060210613A1 (en) * | 2005-03-15 | 2006-09-21 | Carliss Richard D | Therapeutic wound care product |
| CA2608116A1 (en) | 2005-05-10 | 2006-11-16 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
| US20090131412A1 (en) * | 2005-06-07 | 2009-05-21 | Dainippon Sumitomo Pharma Co., Ltd. | Novel 2-quinolone derivative |
| ATE441641T1 (de) | 2005-06-28 | 2009-09-15 | Sanofi Aventis | Isochinolinderivate als inhibitoren von rho- kinase |
| ES2372067T3 (es) | 2005-07-26 | 2012-01-13 | Sanofi | Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa. |
| EP2385047B1 (de) | 2005-07-26 | 2013-05-29 | Sanofi | Piperidinylsubstituierte Isochinolonderivate |
| CA2619594C (en) | 2005-08-18 | 2014-04-08 | Nissan Chemical Industries, Ltd. | Thiophene compound having sulfonyl group and process for producing the same |
| CA2620269A1 (en) * | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| US7786130B2 (en) | 2005-08-29 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
| WO2007027528A2 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| CL2007001597A1 (es) * | 2006-06-05 | 2008-05-16 | Novartis Ag Xenon Pharmaceutic | Compuestos derivados de 2-oxo-piridin-1(2h)-il-tiazol, imidazol o tiofen-carboxamida; composicion farmaceutica; y uso para el tratamiento de una enfermedad mediada por la estearoil-coa-desaturasa, tal como sindrome metabolico, hipertension y diabetes |
| WO2008077553A1 (en) * | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives |
| DE602007013295D1 (de) | 2006-12-27 | 2011-04-28 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| WO2008077552A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
| HRP20100705T1 (hr) | 2006-12-27 | 2011-01-31 | Sanofi-Aventis | Cikloalkilaminski supstituirani izokinolinski i izokinolinonski derivati |
| CN101595094B (zh) | 2006-12-27 | 2013-02-20 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹诺酮衍生物 |
| RU2455302C2 (ru) | 2006-12-27 | 2012-07-10 | Санофи-Авентис | ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| JP5405316B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| WO2008113006A1 (en) * | 2007-03-14 | 2008-09-18 | Xenon Pharmaceuticals Inc. | Methods of using quinolinone compounds in treating sodium channel-mediated diseases or conditions |
| WO2008147518A1 (en) | 2007-05-23 | 2008-12-04 | Merck & Co., Inc. | Pyridyl piperidine orexin receptor antagonists |
| CA2696948C (en) | 2007-09-14 | 2013-04-30 | Jose Maria Cid-Nunez | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones |
| WO2009101917A1 (ja) * | 2008-02-13 | 2009-08-20 | Eisai R & D Management Co., Ltd. | ビシクロアミン誘導体 |
| CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
| CA2728128C (en) * | 2008-06-24 | 2016-06-07 | Sanofi-Aventis | 6-substituted isoquinolines and isoquinolinones |
| RU2538588C2 (ru) * | 2008-06-24 | 2015-01-10 | Санофи-Авентис | ЗАМЕЩЕННЫЕ ИЗИХИНОЛИНЫ И ИЗОХИНОЛИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| PT2303845E (pt) * | 2008-06-24 | 2013-11-25 | Sanofi Sa | Derivados de isoquinolina e isoquinolina substituída com bi- e policíclicos como inibidores de rho-cinase |
| JP2012506374A (ja) | 2008-10-21 | 2012-03-15 | メルク・シャープ・エンド・ドーム・コーポレイション | ２，５−二置換ピペリジンオレキシン受容体アンタゴニスト |
| WO2010048016A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,3-disubstituted piperidine orexin receptor antagonists |
| RU2415128C2 (ru) * | 2009-05-07 | 2011-03-27 | Общество с ограниченной ответственностью "Центр по химии лекарственных средств" (ООО "ЦХЛС-ВНИХФИ") | Гидрохлорид n-1-[(4-фторфенил)-2-(1-этил-4-пиперидил)-этил]-4-нитробензамид, проявляющий антиаритмическую и антифибрилляторную активность |
| CN102439015B (zh) | 2009-05-12 | 2015-05-13 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 |
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| WO2011016234A1 (en) | 2009-08-04 | 2011-02-10 | Raqualia Pharma Inc. | Picolinamide derivatives as ttx-s blockers |
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| CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
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|---|---|---|---|---|
| FR2459240A1 (fr) * | 1979-06-21 | 1981-01-09 | Cm Ind | Aminopiperidines anorexigenes, procede pour leur preparation, intermediaires dans ledit procede et medicaments qui les contiennent |
| FR2467849A1 (fr) * | 1979-10-17 | 1981-04-30 | Clin Midy | 4-amino-1-(2-pyridyl)piperidines n-substituees et leur procede de preparation |
| DE3438394A1 (de) * | 1984-10-19 | 1986-04-30 | Merck Patent Gmbh, 6100 Darmstadt | Pyridinderivate |
| PH23283A (en) | 1986-02-26 | 1989-06-30 | Eisai Co Ltd | Piperidine derivative, pharmaceutical composition containing the same and method of use thereof |
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-
2001
- 2001-01-18 WO PCT/JP2001/000287 patent/WO2001053288A1/ja not_active Ceased
- 2001-01-18 DE DE60119894T patent/DE60119894D1/de not_active Expired - Lifetime
- 2001-01-18 IL IL15065001A patent/IL150650A0/xx unknown
- 2001-01-18 HU HU0204496A patent/HUP0204496A3/hu unknown
- 2001-01-18 CN CN01803949A patent/CN1395575A/zh active Pending
- 2001-01-18 US US10/181,560 patent/US6784192B2/en not_active Expired - Fee Related
- 2001-01-18 NZ NZ520041A patent/NZ520041A/en unknown
- 2001-01-18 AU AU27058/01A patent/AU779442B2/en not_active Ceased
- 2001-01-18 MX MXPA02007036A patent/MXPA02007036A/es active IP Right Grant
- 2001-01-18 BR BR0107732-5A patent/BR0107732A/pt not_active IP Right Cessation
- 2001-01-18 EP EP01901412A patent/EP1254904B1/de not_active Expired - Lifetime
- 2001-01-18 CA CA002398388A patent/CA2398388A1/en not_active Abandoned
- 2001-01-18 KR KR1020027009265A patent/KR20020080378A/ko not_active Withdrawn
- 2001-01-18 RU RU2002122095/04A patent/RU2259365C2/ru not_active IP Right Cessation
- 2001-01-18 AT AT01901412T patent/ATE327230T1/de not_active IP Right Cessation
-
2002
- 2002-07-05 ZA ZA200205399A patent/ZA200205399B/en unknown
- 2002-07-18 NO NO20023457A patent/NO20023457L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1254904A1 (de) | 2002-11-06 |
| US6784192B2 (en) | 2004-08-31 |
| EP1254904B1 (de) | 2006-05-24 |
| AU779442B2 (en) | 2005-01-27 |
| NO20023457L (no) | 2002-09-13 |
| ZA200205399B (en) | 2003-09-04 |
| HUP0204496A2 (en) | 2003-05-28 |
| EP1254904A4 (de) | 2003-03-19 |
| NZ520041A (en) | 2004-11-26 |
| IL150650A0 (en) | 2003-02-12 |
| NO20023457D0 (no) | 2002-07-18 |
| HUP0204496A3 (en) | 2004-07-28 |
| RU2259365C2 (ru) | 2005-08-27 |
| CN1395575A (zh) | 2003-02-05 |
| US20030220368A1 (en) | 2003-11-27 |
| BR0107732A (pt) | 2003-03-11 |
| KR20020080378A (ko) | 2002-10-23 |
| WO2001053288A1 (en) | 2001-07-26 |
| ATE327230T1 (de) | 2006-06-15 |
| MXPA02007036A (es) | 2002-12-13 |
| CA2398388A1 (en) | 2001-07-26 |
| AU2705801A (en) | 2001-07-31 |
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