[go: up one dir, main page]

BR9916188A - Derivados de cromano - Google Patents

Derivados de cromano

Info

Publication number
BR9916188A
BR9916188A BR9916188-5A BR9916188A BR9916188A BR 9916188 A BR9916188 A BR 9916188A BR 9916188 A BR9916188 A BR 9916188A BR 9916188 A BR9916188 A BR 9916188A
Authority
BR
Brazil
Prior art keywords
atoms
hal
derivatives
croatian
alkyl containing
Prior art date
Application number
BR9916188-5A
Other languages
English (en)
Other versions
BR9916188B1 (pt
Inventor
Heinz-Hermann Dr Bokel
Peter Dr Mackert
Christoph Dr Muermann
Norbert Dr Schweickert
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9916188A publication Critical patent/BR9916188A/pt
Publication of BR9916188B1 publication Critical patent/BR9916188B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE CROMANO"<D>. Derivados de cromano de fórmula I na qual R¹ é acila contendo de 1 - 6 átomos de C, -CO-R^ 5^ ou um grupo protetor amino, R² é H ou alquila contendo 1-6 átomos de C, R³, R^ 4^ em cada caso independentemente um do outro são H, alquila contendo 1-6 átomos de C, CN, Hal ou COOR², R^ 5^ é fenila que é não-substituída ou monossubstituída ou dissubstituída por alquila contendo 1-6 átomos de C, OR² ou Hal, X é H, H ou O, Hal é F, Cl, Br ou I, e seus sais, são apropriados como intermediários na síntese de medicamentos.
BRPI9916188-5A 1998-12-17 1999-12-01 derivados de cromano. BR9916188B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19858341A DE19858341A1 (de) 1998-12-17 1998-12-17 Chromanderivate
PCT/EP1999/009333 WO2000035901A1 (de) 1998-12-17 1999-12-01 Chromanderivate

Publications (2)

Publication Number Publication Date
BR9916188A true BR9916188A (pt) 2001-09-04
BR9916188B1 BR9916188B1 (pt) 2011-10-18

Family

ID=7891486

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9916188-5A BR9916188B1 (pt) 1998-12-17 1999-12-01 derivados de cromano.

Country Status (26)

Country Link
US (1) US6646136B1 (pt)
EP (1) EP1140890B1 (pt)
JP (1) JP4790910B2 (pt)
KR (1) KR100676017B1 (pt)
CN (1) CN1140522C (pt)
AR (1) AR021900A1 (pt)
AT (1) ATE233253T1 (pt)
AU (1) AU760501B2 (pt)
BR (1) BR9916188B1 (pt)
CA (1) CA2355098C (pt)
CZ (1) CZ300544B6 (pt)
DE (2) DE19858341A1 (pt)
DK (1) DK1140890T3 (pt)
ES (1) ES2193779T3 (pt)
HK (1) HK1043119B (pt)
HU (1) HU229060B1 (pt)
ID (1) ID29273A (pt)
NO (1) NO328132B1 (pt)
PL (1) PL194157B1 (pt)
PT (1) PT1140890E (pt)
RU (1) RU2233277C2 (pt)
SK (1) SK285837B6 (pt)
TW (1) TWI222866B (pt)
UA (1) UA72235C2 (pt)
WO (1) WO2000035901A1 (pt)
ZA (1) ZA200105840B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092250A2 (en) * 2000-06-02 2001-12-06 Cor Therapeutics, Inc. Synthesis of 2-acyl substituted chromanes and intermediates thereof
DE10044091A1 (de) * 2000-09-07 2002-04-04 Merck Patent Gmbh Chromanonderivate
NZ536190A (en) 2002-04-17 2007-08-31 Cytokinetics Inc Compounds for treating cellular proliferative diseases by modulating the activity of the mitotic kinesin KSP
DE60326248D1 (de) * 2002-07-17 2009-04-02 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
WO2004024086A2 (en) * 2002-09-13 2004-03-25 Cytokinetics, Inc. Compounds, compositions and methods
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods
CN100424034C (zh) * 2006-08-25 2008-10-08 华中科技大学 一种磷石膏复合砖及其生产方法
RU2404174C2 (ru) * 2008-12-08 2010-11-20 ГОУ ВПО "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" 4-иминометил-3-(7-ацетоксихромон-3-ил) бензойная кислота, обладающая антибактериальной активностью
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck
CN108690017B (zh) * 2018-05-04 2021-06-18 新乡学院 一种铑催化的莫西沙星侧链中间体的制备方法
CN113979983B (zh) * 2021-11-03 2023-10-03 中国人民解放军空军军医大学 一种非达司他关键中间体的不对称合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
DE2745306A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide mittel
CA2022693A1 (en) * 1989-08-05 1991-02-06 Rolf Gericke Chroman derivatives
DE4102103A1 (de) * 1991-01-25 1992-08-20 Bayer Ag Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
RU2039739C1 (ru) * 1993-03-01 1995-07-20 Пятигорский фармацевтический институт Замещенные фениламиды -3-(4`-оксо- 4н-1`-бензопиранил-3`)-пропен -2-карбоновой кислоты, обладающие антиаллергической активностью
DE69524528T2 (de) * 1994-10-14 2002-08-01 Merck Patent Gmbh ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman

Also Published As

Publication number Publication date
PL348191A1 (en) 2002-05-06
SK8162001A3 (en) 2001-11-06
DE59904407D1 (en) 2003-04-03
ZA200105840B (en) 2002-10-16
EP1140890B1 (de) 2003-02-26
KR100676017B1 (ko) 2007-01-29
EP1140890A1 (de) 2001-10-10
HK1043119B (zh) 2004-12-24
AU2094600A (en) 2000-07-03
UA72235C2 (uk) 2005-02-15
PT1140890E (pt) 2003-07-31
AR021900A1 (es) 2002-09-04
CN1329606A (zh) 2002-01-02
NO20012964L (no) 2001-06-15
PL194157B1 (pl) 2007-05-31
CZ20012145A3 (cs) 2001-09-12
NO328132B1 (no) 2009-12-14
HUP0104819A3 (en) 2003-01-28
ES2193779T3 (es) 2003-11-01
US6646136B1 (en) 2003-11-11
DK1140890T3 (da) 2003-06-02
DE19858341A1 (de) 2000-06-21
ID29273A (id) 2001-08-16
NO20012964D0 (no) 2001-06-15
ATE233253T1 (de) 2003-03-15
SK285837B6 (sk) 2007-09-06
HK1043119A1 (en) 2002-09-06
JP4790910B2 (ja) 2011-10-12
CA2355098A1 (en) 2000-06-22
HU229060B1 (hu) 2013-07-29
CN1140522C (zh) 2004-03-03
WO2000035901A1 (de) 2000-06-22
RU2233277C2 (ru) 2004-07-27
JP2002532488A (ja) 2002-10-02
KR20010086111A (ko) 2001-09-07
BR9916188B1 (pt) 2011-10-18
CZ300544B6 (cs) 2009-06-10
TWI222866B (en) 2004-11-01
AU760501B2 (en) 2003-05-15
HUP0104819A2 (en) 2002-06-29
CA2355098C (en) 2009-10-13

Similar Documents

Publication Publication Date Title
BR9910122A (pt) Compostos amidina
BR9916188A (pt) Derivados de cromano
BR9900710A (pt) Composições condicionadoras de cabelos.
BR0215294A (pt) 4-arilquinazolinas e o seu uso como inibidores de nhe-3
BR9714787A (pt) Compostos de 4- fenilpiperidina e processo para sua preparação
ATE260275T1 (de) Substituierte thien-3-yl- sulfonylamino(thio)carbonyl-triazolin(thi)one
BR9913405A (pt) Composto heterocìclico que contenha oxigênio, e, inibidor de fosfodiesterase (pde) iv.
BR9807132A (pt) Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2
BR0008763A (pt) Derivados de piridopiranoazepinas, a preparação dos mesmos e a respectiva aplicação em terapêutica
BR9814832A (pt) Composto, e, herbicida
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
DE60025744D1 (de) Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1
AR026351A1 (es) Derivados de pirrol como inhibidores de la fosfodiesterasa vii
DE69813605D1 (de) Benzofuranderivate
DE69819525D1 (de) Acridine derivate zur verbesserung der oralen bioverfügbarkeit von taxol
BR9912575A (pt) Processo para a preparação de um composto, e, composto.
BR0015487A (pt) Compostos de imidazol como inibidores de fosfodiesterase vii
TW427979B (en) A condensed piperidine compound
BR9910058A (pt) Compostos azapolicìclicos aril-condensados
BR0113584A (pt) Derivados de cromanona
DK0807627T3 (da) Anilidforbindelser som ACAT-inhibitorer
BR9813719A (pt) Agentes terapêuticos
BRPI0414460A (pt) compostos derivados de carboxamida do tipo de amida, composição farmacêutica e respectivo uso
BR9908589A (pt) Derivados de 2,4-diamino-1,3,5-triazina 6 substituìda com pelo menos dois átomos de carbono assimétricos substituìdos, sua preparação e seu emprego como herbicidas
BR9913282A (pt) 3-aril-pirazóis substituìdos

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/10/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 18.10.2021