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AR015269A1 - Compuesto amidinico y composicion farmaceutica, inhibidor de la coagulacion sanguinea e inhibidor del factor xa que lo comprenden - Google Patents

Compuesto amidinico y composicion farmaceutica, inhibidor de la coagulacion sanguinea e inhibidor del factor xa que lo comprenden

Info

Publication number
AR015269A1
AR015269A1 ARP990101626A ARP990101626A AR015269A1 AR 015269 A1 AR015269 A1 AR 015269A1 AR P990101626 A ARP990101626 A AR P990101626A AR P990101626 A ARP990101626 A AR P990101626A AR 015269 A1 AR015269 A1 AR 015269A1
Authority
AR
Argentina
Prior art keywords
atom
amino
alkyl
lower alkyl
hydroxy
Prior art date
Application number
ARP990101626A
Other languages
English (en)
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of AR015269A1 publication Critical patent/AR015269A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un compuesto amidínico de formula (I) en donde R es un grupo de formula (II) en donde R4 es un átomo de hidrogeno, hidroxi, alquilo inferior, alcoxiinferior o un átomo de halogeno; R5 es un átomo de hidrogeno, ciano, carboxi o alcoxicarbonilo inferior; R6 es un átomo de hidrogeno, cicloalquilo, hidroxi,carboxi, alcoxicarbonilo inferior, arilalquiloxicarbonilo, en donde dicho arilalquiloxicarbonilo está opcionalmente sustituido por un átomo de halogeno, nitro,alquilo, alcoxi o trifluorometilo, nni tro, amino, alquilamino inferior, dialquil(inferior)amino, arilo, heteroarilo, en donde dicho arilo o heteroarilo estáopcionalmente sustituido por entre 1 y 3 sustituyentes seleccionados del grupo que integran alquilo, hidroxi, alcoxi inferior, carbo xi, alcoxicarboniloinferior, arilalquiloxicarbonilo, nitro amino, acilamino, amidino e hidroxiamidino; un heterociclo saturado de entre 5 y 7 miembros que tiene por lo menos unátomo de nitrogeno, en donde dicho heterociclo saturado está opcionalmente sustituido por un alquilo inferior, acilo, dialquil(inferior)amino, alcanoilo(inferior) o imidoilo, o el compuesto de formula (III) en donde Ak es alquilo inferior y Hal es un átomo de halogeno; X2 es un átomo de oxígeno, átomo deazufre, -SO2-,-SO2 -NH- o un enlace simple; X3 es -(CH2)m- en donde m es 0 o un entero entre 1 y 3; X4 es -CO-, -C(=NH)-, -SO2-, -CONH-, -CSNH-, -SO2NH-,-(CH2)rCONH-, -(CH2)rCH(OH)-, o un compuesto del grupo (IV) en donde r es 0 o un entero entre 1 y 3, o un enlaace sim ple; X5 es un alquileno C1-6, teniendo elalquenileno C2-6, o un enlace simple; R7 es un átomo de hidrogeno, alquilo inferior o -C(:R9)R10 en donde R9 es un átomo de oxígeno, átomo de azufre, NH, NR11en donde NR11 es alquilo inferior, arilalquilo, en donde dicho arilalquilo está opcionalmente sustituido por entre 1 y 3 sustituyentes seleccionados del grupoque integran átomo de halogeno, alquilo inferior, hidroxi, alcoxi inferior, haloalquilo, ciano, nitro, amino y aciloxi, o hidroxi, y R10 es alq uilo inferior,alcoxi inferior, amino, alquilamino inferior o dialquil(inferior)amino; R8 es un átomo de hidrogeno, alquilo inferior, cicloalquilo, en donde el cicloalquilo
ARP990101626A 1998-04-10 1999-04-09 Compuesto amidinico y composicion farmaceutica, inhibidor de la coagulacion sanguinea e inhibidor del factor xa que lo comprenden AR015269A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11623398 1998-04-10
JP23786998 1998-08-25

Publications (1)

Publication Number Publication Date
AR015269A1 true AR015269A1 (es) 2001-04-18

Family

ID=26454606

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101626A AR015269A1 (es) 1998-04-10 1999-04-09 Compuesto amidinico y composicion farmaceutica, inhibidor de la coagulacion sanguinea e inhibidor del factor xa que lo comprenden

Country Status (23)

Country Link
US (2) US6562828B1 (es)
EP (1) EP1070714B1 (es)
KR (1) KR100416111B1 (es)
CN (1) CN1305470A (es)
AR (1) AR015269A1 (es)
AT (1) ATE272630T1 (es)
AU (1) AU752588B2 (es)
BR (1) BR9910122A (es)
CA (1) CA2327488A1 (es)
CO (1) CO5021130A1 (es)
DE (1) DE69919149D1 (es)
HU (1) HUP0101137A3 (es)
ID (1) ID28266A (es)
IL (1) IL138899A0 (es)
NO (1) NO20005083L (es)
NZ (1) NZ508101A (es)
PE (1) PE20000422A1 (es)
PL (1) PL343424A1 (es)
RU (1) RU2201927C2 (es)
SG (1) SG74717A1 (es)
SK (1) SK15072000A3 (es)
TR (1) TR200002904T2 (es)
WO (1) WO1999052895A1 (es)

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Also Published As

Publication number Publication date
NO20005083D0 (no) 2000-10-09
NO20005083L (no) 2000-12-08
CO5021130A1 (es) 2001-03-27
PL343424A1 (en) 2001-08-13
AU3167799A (en) 1999-11-01
NZ508101A (en) 2002-12-20
KR100416111B1 (ko) 2004-01-31
US20040006099A1 (en) 2004-01-08
SK15072000A3 (sk) 2001-08-06
AU752588B2 (en) 2002-09-26
RU2201927C2 (ru) 2003-04-10
CA2327488A1 (en) 1999-10-21
SG74717A1 (en) 2000-08-22
EP1070714A4 (en) 2002-10-30
CN1305470A (zh) 2001-07-25
US6562828B1 (en) 2003-05-13
WO1999052895A1 (fr) 1999-10-21
IL138899A0 (en) 2001-11-25
HUP0101137A2 (hu) 2001-10-28
DE69919149D1 (de) 2004-09-09
BR9910122A (pt) 2001-10-16
ATE272630T1 (de) 2004-08-15
EP1070714B1 (en) 2004-08-04
EP1070714A1 (en) 2001-01-24
EP1070714A9 (en) 2005-10-19
TR200002904T2 (tr) 2001-02-21
KR20010042606A (ko) 2001-05-25
HUP0101137A3 (en) 2003-03-28
PE20000422A1 (es) 2000-05-19
ID28266A (id) 2001-05-10

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