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BR9910115A - Cetolìdeos da classe dos lactamas de 5 elementos - Google Patents

Cetolìdeos da classe dos lactamas de 5 elementos

Info

Publication number
BR9910115A
BR9910115A BR9910115-7A BR9910115A BR9910115A BR 9910115 A BR9910115 A BR 9910115A BR 9910115 A BR9910115 A BR 9910115A BR 9910115 A BR9910115 A BR 9910115A
Authority
BR
Brazil
Prior art keywords
group
class
ketolides
aza
methyl
Prior art date
Application number
BR9910115-7A
Other languages
English (en)
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Zeljko Kelneric
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of BR9910115A publication Critical patent/BR9910115A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Patente de Invenção: <B>"CETOLìDEOS DA CLASSE DOS LACTAMAS DE 5 ELEMENTOS"<D>. A presente invenção refere-se a novos cetoazalídeos de 15 elementos da classe de 6-O-metil-8a-aza-8a-homo- e 6-O-metil-9a-aza-9a-homoeritromicina A com a fórmula geral (I): em que: A representa um grupo NH e B, ao mesmo tempo, representa um grupo C=O, ou A representa um grupo C=O e B, ao mesmo tempo, representa um grupo NH, R¹ representa um grupo OH, um grupo L-cladinosila da fórmula (II): ou junto com R² representa cetona, R² representa hidrogênio ou junto com R¹ representa cetona, R³ representa hidrogênio ou um grupo C~ 1~-C~ 4~ alcanoíla, a intermediários e a um processo para sua preparação, a seus sais de adição farmaceuticamente aceitáveis com ácidos inorgânicos ou orgânicos, a um processo para a preparação de composições farmacêuticas, bem como ao uso das composições farmacêuticas no tratamento de infecções bacterianas.
BR9910115-7A 1998-04-06 1999-04-02 Cetolìdeos da classe dos lactamas de 5 elementos BR9910115A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (1)

Publication Number Publication Date
BR9910115A true BR9910115A (pt) 2000-12-26

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910115-7A BR9910115A (pt) 1998-04-06 1999-04-02 Cetolìdeos da classe dos lactamas de 5 elementos

Country Status (26)

Country Link
US (1) US6110965A (pt)
EP (1) EP1070077B1 (pt)
JP (1) JP2002510701A (pt)
KR (1) KR100600463B1 (pt)
CN (1) CN1141312C (pt)
AR (1) AR019261A1 (pt)
AT (1) ATE241638T1 (pt)
AU (1) AU3046499A (pt)
BG (1) BG64600B1 (pt)
BR (1) BR9910115A (pt)
CA (1) CA2327775C (pt)
DE (1) DE69908338T2 (pt)
DK (1) DK1070077T3 (pt)
EE (1) EE04283B1 (pt)
ES (1) ES2200512T3 (pt)
HR (1) HRP980189B1 (pt)
HU (1) HUP0101817A3 (pt)
IL (2) IL138837A0 (pt)
NO (1) NO317982B1 (pt)
PL (1) PL193742B1 (pt)
PT (1) PT1070077E (pt)
RU (1) RU2211222C2 (pt)
SI (1) SI1070077T1 (pt)
SK (1) SK284169B6 (pt)
UA (1) UA70941C2 (pt)
WO (1) WO1999051616A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
MXPA02009587A (es) * 2000-03-28 2003-05-14 Biochemie Gmbh Particulas granuladas con sabor enmascarado.
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
GEP20063812B (en) * 2001-08-21 2006-05-10 Pfizer Prod Inc Single dose azithromycin for treating respirator infections
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
WO2003070254A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
JP4530851B2 (ja) 2002-07-08 2010-08-25 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ステロイド／非ステロイド抗炎症活性分子、抗新生物活性分子および抗ウイルス活性分子用担体としての新規な化合物、組成物
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2006087644A2 (en) 2005-01-13 2006-08-24 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Macrolides with anti-inflammatory activity
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
JP5126685B2 (ja) * 2006-05-01 2013-01-23 大正製薬株式会社 マクロライド誘導体
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
WO2010086349A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
PT2673285T (pt) * 2010-12-09 2017-10-19 Wockhardt Ltd Resumo
CA3120148A1 (en) * 2018-11-19 2020-05-28 Zikani Therapeutics, Inc. C10-alkylene substituted 13-membered macrolides and uses thereof
US20230250124A1 (en) * 2019-10-29 2023-08-10 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5166967A (en) * 1990-08-27 1992-11-24 Fabian Carl E Markers for dental x-ray film and packets for simplified film mounting
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
ATE154806T1 (de) * 1993-05-19 1997-07-15 Pfizer Zwischenprodukt für azithromycin
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) * 1995-12-08 2000-01-20 Руссель Юклаф Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция

Also Published As

Publication number Publication date
UA70941C2 (uk) 2004-11-15
US6110965A (en) 2000-08-29
CA2327775C (en) 2007-08-07
NO317982B1 (no) 2005-01-17
NO20005015D0 (no) 2000-10-05
EP1070077A1 (en) 2001-01-24
HUP0101817A3 (en) 2003-07-28
CN1301268A (zh) 2001-06-27
HRP980189A2 (en) 2000-12-31
BG104913A (en) 2001-08-31
EE200000587A (et) 2002-04-15
WO1999051616A1 (en) 1999-10-14
SI1070077T1 (en) 2004-02-29
DK1070077T3 (da) 2003-09-22
IL138837A (en) 2006-10-05
KR100600463B1 (ko) 2006-07-13
DE69908338T2 (de) 2004-04-08
PL193742B1 (pl) 2007-03-30
JP2002510701A (ja) 2002-04-09
HK1036457A1 (en) 2002-01-04
IL138837A0 (en) 2001-10-31
DE69908338D1 (de) 2003-07-03
EE04283B1 (et) 2004-04-15
EP1070077B1 (en) 2003-05-28
AR019261A1 (es) 2002-02-13
HUP0101817A2 (hu) 2001-11-28
CN1141312C (zh) 2004-03-10
ES2200512T3 (es) 2004-03-01
AU3046499A (en) 1999-10-25
ATE241638T1 (de) 2003-06-15
KR20010034754A (ko) 2001-04-25
HRP980189B1 (en) 2004-04-30
RU2211222C2 (ru) 2003-08-27
NO20005015L (no) 2000-12-04
BG64600B1 (bg) 2005-08-31
SK284169B6 (sk) 2004-10-05
PT1070077E (pt) 2003-10-31
PL343441A1 (en) 2001-08-13
SK15022000A3 (sk) 2001-03-12
CA2327775A1 (en) 1999-10-14

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 10 (VIII) DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.