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EE200000587A - Uued 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis - Google Patents

Uued 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis

Info

Publication number
EE200000587A
EE200000587A EEP200000587A EEP200000587A EE200000587A EE 200000587 A EE200000587 A EE 200000587A EE P200000587 A EEP200000587 A EE P200000587A EE P200000587 A EEP200000587 A EE P200000587A EE 200000587 A EE200000587 A EE 200000587A
Authority
EE
Estonia
Prior art keywords
novel
preparation
treatment
pharmaceutical composition
composition containing
Prior art date
Application number
EEP200000587A
Other languages
English (en)
Inventor
Lazarevski Gorjana
Kobrehel Gabrijela
Kelneric Zeljko
Original Assignee
PLIVA, farmaceutska industrija, dionicko dru�tvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PLIVA, farmaceutska industrija, dionicko dru�tvo filed Critical PLIVA, farmaceutska industrija, dionicko dru�tvo
Publication of EE200000587A publication Critical patent/EE200000587A/et
Publication of EE04283B1 publication Critical patent/EE04283B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
EEP200000587A 1998-04-06 1999-04-02 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis EE04283B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (2)

Publication Number Publication Date
EE200000587A true EE200000587A (et) 2002-04-15
EE04283B1 EE04283B1 (et) 2004-04-15

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000587A EE04283B1 (et) 1998-04-06 1999-04-02 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis

Country Status (26)

Country Link
US (1) US6110965A (et)
EP (1) EP1070077B1 (et)
JP (1) JP2002510701A (et)
KR (1) KR100600463B1 (et)
CN (1) CN1141312C (et)
AR (1) AR019261A1 (et)
AT (1) ATE241638T1 (et)
AU (1) AU3046499A (et)
BG (1) BG64600B1 (et)
BR (1) BR9910115A (et)
CA (1) CA2327775C (et)
DE (1) DE69908338T2 (et)
DK (1) DK1070077T3 (et)
EE (1) EE04283B1 (et)
ES (1) ES2200512T3 (et)
HR (1) HRP980189B1 (et)
HU (1) HUP0101817A3 (et)
IL (2) IL138837A0 (et)
NO (1) NO317982B1 (et)
PL (1) PL193742B1 (et)
PT (1) PT1070077E (et)
RU (1) RU2211222C2 (et)
SI (1) SI1070077T1 (et)
SK (1) SK284169B6 (et)
UA (1) UA70941C2 (et)
WO (1) WO1999051616A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
MXPA02009587A (es) * 2000-03-28 2003-05-14 Biochemie Gmbh Particulas granuladas con sabor enmascarado.
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
GEP20063812B (en) * 2001-08-21 2006-05-10 Pfizer Prod Inc Single dose azithromycin for treating respirator infections
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
WO2003070254A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
JP4530851B2 (ja) 2002-07-08 2010-08-25 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ステロイド／非ステロイド抗炎症活性分子、抗新生物活性分子および抗ウイルス活性分子用担体としての新規な化合物、組成物
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2006087644A2 (en) 2005-01-13 2006-08-24 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Macrolides with anti-inflammatory activity
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
JP5126685B2 (ja) * 2006-05-01 2013-01-23 大正製薬株式会社 マクロライド誘導体
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
WO2010086349A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
PT2673285T (pt) * 2010-12-09 2017-10-19 Wockhardt Ltd Resumo
CA3120148A1 (en) * 2018-11-19 2020-05-28 Zikani Therapeutics, Inc. C10-alkylene substituted 13-membered macrolides and uses thereof
US20230250124A1 (en) * 2019-10-29 2023-08-10 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5166967A (en) * 1990-08-27 1992-11-24 Fabian Carl E Markers for dental x-ray film and packets for simplified film mounting
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
ATE154806T1 (de) * 1993-05-19 1997-07-15 Pfizer Zwischenprodukt für azithromycin
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) * 1995-12-08 2000-01-20 Руссель Юклаф Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция

Also Published As

Publication number Publication date
BR9910115A (pt) 2000-12-26
UA70941C2 (uk) 2004-11-15
US6110965A (en) 2000-08-29
CA2327775C (en) 2007-08-07
NO317982B1 (no) 2005-01-17
NO20005015D0 (no) 2000-10-05
EP1070077A1 (en) 2001-01-24
HUP0101817A3 (en) 2003-07-28
CN1301268A (zh) 2001-06-27
HRP980189A2 (en) 2000-12-31
BG104913A (en) 2001-08-31
WO1999051616A1 (en) 1999-10-14
SI1070077T1 (en) 2004-02-29
DK1070077T3 (da) 2003-09-22
IL138837A (en) 2006-10-05
KR100600463B1 (ko) 2006-07-13
DE69908338T2 (de) 2004-04-08
PL193742B1 (pl) 2007-03-30
JP2002510701A (ja) 2002-04-09
HK1036457A1 (en) 2002-01-04
IL138837A0 (en) 2001-10-31
DE69908338D1 (de) 2003-07-03
EE04283B1 (et) 2004-04-15
EP1070077B1 (en) 2003-05-28
AR019261A1 (es) 2002-02-13
HUP0101817A2 (hu) 2001-11-28
CN1141312C (zh) 2004-03-10
ES2200512T3 (es) 2004-03-01
AU3046499A (en) 1999-10-25
ATE241638T1 (de) 2003-06-15
KR20010034754A (ko) 2001-04-25
HRP980189B1 (en) 2004-04-30
RU2211222C2 (ru) 2003-08-27
NO20005015L (no) 2000-12-04
BG64600B1 (bg) 2005-08-31
SK284169B6 (sk) 2004-10-05
PT1070077E (pt) 2003-10-31
PL343441A1 (en) 2001-08-13
SK15022000A3 (sk) 2001-03-12
CA2327775A1 (en) 1999-10-14

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090402