BR9911178A - Derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems - Google Patents
Derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefemsInfo
- Publication number
- BR9911178A BR9911178A BR9911178-0A BR9911178A BR9911178A BR 9911178 A BR9911178 A BR 9911178A BR 9911178 A BR9911178 A BR 9911178A BR 9911178 A BR9911178 A BR 9911178A
- Authority
- BR
- Brazil
- Prior art keywords
- ocor
- hydrogen
- compounds
- cooch
- coor
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Patente de Invenção:<B>"DERIVADOS DE 3-(2-OXO-[1,3']BIPIRROLIDINIL-3-ILIDENOMETIL)-CEFEMS"<D>. A presente invenção refere-se a novos compostos de fórmula (I) em que R^ 1^ é hidrogênio, C~ 1-6~-alquila, opcionalmente substituída por flúor, ou C~ 3-6~-cicloalquila; R^ 2^ é hidrogênio ou um grupo selecionado de -CH~ 2~C(=CHR)-COOR, -CH~ 2~OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CR~ 2~COCH~ 2~OCOR e (II); R^ 3^ é hidrogênio ou grupo selecionado de -CH~ 2~C(=CH~ 2~)-COOR, -COOCH~ 2~C(=CHR)-COOR, -COOCH~ 2~OCOR, -COOCH(R)OCOR, -COOCH(R)OCOOR, -COOCH(OCOR)OCOR, -COOCH~ 2~COCH~ 2~OCOR, e (III); com a condição de que um de R^ 2^ e R^ 3^ seja hidrogênio e o outro de R^ 2^ e R^ 3^ seja diferente de hidrogênio, R é hidrogênio ou C~ 1-6~-alquila; R^ 4^ é hidrogênio ou hidróxi, R^ 5^é hidrogênio ou <SYM>-hidroxialquila; e X é CH ou N, assim como a sais farmaceuticamente aceitáveis dos referidos compostos e hidratos dos referidos compostos e de seus sais, e ao uso de compostos de fórmula (I) e de sais farmaceuticamente aceitáveis dos referidos compostos e hidratos dos referidos compostos e de seus sais para a fabricação de preparações farmacêuticas contendo tais compostos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110888 | 1998-06-15 | ||
| EP98117099 | 1998-09-10 | ||
| PCT/EP1999/003907 WO1999065920A1 (en) | 1998-06-15 | 1999-06-07 | Derivatives of 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9911178A true BR9911178A (pt) | 2001-03-13 |
| BR9911178B1 BR9911178B1 (pt) | 2013-10-29 |
| BRPI9911178B8 BRPI9911178B8 (pt) | 2017-03-07 |
Family
ID=26149347
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9911178A BRPI9911178C1 (pt) | 1998-06-15 | 1999-06-07 | derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos |
| BRPI9911178A BRPI9911178B8 (pt) | 1998-06-15 | 1999-06-07 | derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9911178A BRPI9911178C1 (pt) | 1998-06-15 | 1999-06-07 | derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1087980B1 (pt) |
| JP (1) | JP3872955B2 (pt) |
| KR (1) | KR100411915B1 (pt) |
| CN (1) | CN1136222C (pt) |
| AR (1) | AR018675A1 (pt) |
| AT (1) | ATE231871T1 (pt) |
| AU (1) | AU754732B2 (pt) |
| BE (1) | BE2014C034I2 (pt) |
| BR (2) | BRPI9911178C1 (pt) |
| CA (1) | CA2334568C (pt) |
| CO (1) | CO5080758A1 (pt) |
| DE (1) | DE69905162T2 (pt) |
| DK (1) | DK1087980T3 (pt) |
| ES (1) | ES2190222T3 (pt) |
| FR (1) | FR14C0044I2 (pt) |
| GT (1) | GT199900084A (pt) |
| HU (1) | HUP0105426A3 (pt) |
| ID (1) | ID27686A (pt) |
| IL (1) | IL139872A0 (pt) |
| LU (1) | LU92564I2 (pt) |
| MA (1) | MA26650A1 (pt) |
| NO (1) | NO20006350L (pt) |
| PA (1) | PA8475701A1 (pt) |
| PE (1) | PE20000645A1 (pt) |
| PL (1) | PL344994A1 (pt) |
| SV (1) | SV1999000075A (pt) |
| TN (1) | TNSN99114A1 (pt) |
| WO (1) | WO1999065920A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6267100A (en) * | 1999-07-07 | 2001-01-30 | F. Hoffmann-La Roche Ag | Vinylpyrrolidinone derivatives with substituted thiazole ring |
| DE60123513T2 (de) | 2000-04-19 | 2007-05-10 | Basilea Pharmaceutica Ag | Verfahren zur Herstellung von D-Asparaginderivaten |
| US6504025B2 (en) | 2000-05-24 | 2003-01-07 | Basilea Pharmaceutica Ag | Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives |
| JP5230934B2 (ja) * | 2003-03-27 | 2013-07-10 | バジリア ファルマスーチカ アーゲー | 結晶形態のセファロスポリン |
| EP1656930A1 (en) | 2004-11-10 | 2006-05-17 | Basilea Pharmaceutica AG | Stabilized freeze-dried formulation for cephalosporin derivatives |
| AR071318A1 (es) | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
| WO2010072672A1 (en) | 2008-12-24 | 2010-07-01 | Basilea Pharmaceutica Ag | New crystal polymorphs of ceftobiprole |
| JP2012528103A (ja) * | 2009-05-25 | 2012-11-12 | サンド・アクチエンゲゼルシヤフト | セフトビプロールメドカリルの製造方法 |
| CN104892635B (zh) | 2010-05-10 | 2017-12-05 | 巴斯利尔药物国际有限公司 | 制备3‑甲酰基‑头孢霉毒核衍生物的氧化方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2281090T3 (es) * | 1996-11-06 | 2007-09-16 | Basilea Pharmaceutica Ag | Derivados de vinilpirrolidona-cefalosporina. |
| TW415949B (en) * | 1996-12-19 | 2000-12-21 | Hoffmann La Roche | Vinyl pyrrolidine cephalosporin derivatives with basic substituents |
-
1999
- 1999-06-07 BR BRPI9911178A patent/BRPI9911178C1/pt unknown
- 1999-06-07 PL PL99344994A patent/PL344994A1/xx unknown
- 1999-06-07 BR BRPI9911178A patent/BRPI9911178B8/pt not_active IP Right Cessation
- 1999-06-07 ID IDW20002565A patent/ID27686A/id unknown
- 1999-06-07 KR KR10-2000-7014203A patent/KR100411915B1/ko not_active Expired - Lifetime
- 1999-06-07 WO PCT/EP1999/003907 patent/WO1999065920A1/en not_active Ceased
- 1999-06-07 JP JP2000554745A patent/JP3872955B2/ja not_active Expired - Lifetime
- 1999-06-07 HU HU0105426A patent/HUP0105426A3/hu unknown
- 1999-06-07 CN CNB998073474A patent/CN1136222C/zh not_active Expired - Lifetime
- 1999-06-07 EP EP99927894A patent/EP1087980B1/en not_active Expired - Lifetime
- 1999-06-07 AU AU45081/99A patent/AU754732B2/en not_active Expired
- 1999-06-07 CA CA002334568A patent/CA2334568C/en not_active Expired - Lifetime
- 1999-06-07 AT AT99927894T patent/ATE231871T1/de active
- 1999-06-07 IL IL13987299A patent/IL139872A0/xx unknown
- 1999-06-07 DK DK99927894T patent/DK1087980T3/da active
- 1999-06-07 DE DE69905162T patent/DE69905162T2/de not_active Expired - Lifetime
- 1999-06-07 ES ES99927894T patent/ES2190222T3/es not_active Expired - Lifetime
- 1999-06-11 AR ARP990102825A patent/AR018675A1/es active IP Right Grant
- 1999-06-11 CO CO99036886A patent/CO5080758A1/es unknown
- 1999-06-11 PE PE1999000521A patent/PE20000645A1/es not_active Application Discontinuation
- 1999-06-14 GT GT199900084A patent/GT199900084A/es unknown
- 1999-06-14 PA PA19998475701A patent/PA8475701A1/es unknown
- 1999-06-15 TN TNTNSN99114A patent/TNSN99114A1/fr unknown
- 1999-06-15 SV SV1999000075A patent/SV1999000075A/es not_active Application Discontinuation
- 1999-06-15 MA MA25625A patent/MA26650A1/fr unknown
-
2000
- 2000-12-13 NO NO20006350A patent/NO20006350L/no not_active Application Discontinuation
-
2014
- 2014-05-15 BE BE2014C034C patent/BE2014C034I2/fr unknown
- 2014-06-11 FR FR14C0044C patent/FR14C0044I2/fr active Active
- 2014-10-01 LU LU92564C patent/LU92564I2/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer |
Free format text: BASILEA PHARMACEUTICA AG (CH) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEIDO UMA VEZ QUE O MESMO NAO ATENDE O DISPOSTO NOS ARTIGOS 8O E 13 DA LEI 9279/96. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/10/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/06/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 07/06/2019 |