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IL138837A0 - 15-membered lactam ketolides with antibacterial activity - Google Patents

15-membered lactam ketolides with antibacterial activity

Info

Publication number
IL138837A0
IL138837A0 IL13883799A IL13883799A IL138837A0 IL 138837 A0 IL138837 A0 IL 138837A0 IL 13883799 A IL13883799 A IL 13883799A IL 13883799 A IL13883799 A IL 13883799A IL 138837 A0 IL138837 A0 IL 138837A0
Authority
IL
Israel
Prior art keywords
ketolides
antibacterial activity
membered lactam
lactam
membered
Prior art date
Application number
IL13883799A
Other languages
English (en)
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of IL138837A0 publication Critical patent/IL138837A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL13883799A 1998-04-06 1999-04-02 15-membered lactam ketolides with antibacterial activity IL138837A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (1)

Publication Number Publication Date
IL138837A0 true IL138837A0 (en) 2001-10-31

Family

ID=10946724

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13883799A IL138837A0 (en) 1998-04-06 1999-04-02 15-membered lactam ketolides with antibacterial activity
IL138837A IL138837A (en) 1998-04-06 2000-10-03 Derivatives of 6-O-methyl-A8-Aza-A8-homo- and 6-O-methyl-A9-aza-A9-homoarthromycin A, their preparation and antibacterial preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138837A IL138837A (en) 1998-04-06 2000-10-03 Derivatives of 6-O-methyl-A8-Aza-A8-homo- and 6-O-methyl-A9-aza-A9-homoarthromycin A, their preparation and antibacterial preparations containing them

Country Status (26)

Country Link
US (1) US6110965A (xx)
EP (1) EP1070077B1 (xx)
JP (1) JP2002510701A (xx)
KR (1) KR100600463B1 (xx)
CN (1) CN1141312C (xx)
AR (1) AR019261A1 (xx)
AT (1) ATE241638T1 (xx)
AU (1) AU3046499A (xx)
BG (1) BG64600B1 (xx)
BR (1) BR9910115A (xx)
CA (1) CA2327775C (xx)
DE (1) DE69908338T2 (xx)
DK (1) DK1070077T3 (xx)
EE (1) EE04283B1 (xx)
ES (1) ES2200512T3 (xx)
HR (1) HRP980189B1 (xx)
HU (1) HUP0101817A3 (xx)
IL (2) IL138837A0 (xx)
NO (1) NO317982B1 (xx)
PL (1) PL193742B1 (xx)
PT (1) PT1070077E (xx)
RU (1) RU2211222C2 (xx)
SI (1) SI1070077T1 (xx)
SK (1) SK284169B6 (xx)
UA (1) UA70941C2 (xx)
WO (1) WO1999051616A1 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
NZ521368A (en) * 2000-03-28 2004-05-28 Biochemie Ges M Granulated particles of an active compound, with a film-forming coating resulting in the masked taste of said active compound
GB0025688D0 (en) 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
BR0211830A (pt) * 2001-08-21 2004-09-08 Pfizer Prod Inc Dose única de azitromicina
NZ535355A (en) 2002-02-15 2007-09-28 Merckle Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
BR0312634A (pt) 2002-07-08 2005-05-10 Pliva Istrazivacki Inst D O O Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias
HRP20050002A2 (en) 2002-07-08 2006-03-31 Pliva-Istra�iva�ki institut d.o.o. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
ATE476438T1 (de) 2005-01-13 2010-08-15 Glaxosmithkline Zagreb Makrolide mit entzündungshemmender wirkung
US7547679B2 (en) 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
RU2455308C2 (ru) * 2006-05-01 2012-07-10 Тайсо Фармасьютикал Ко., Лтд. Макролидные производные
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
SG172782A1 (en) * 2009-01-30 2011-08-29 Glaxo Group Ltd Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
PL2673285T3 (pl) * 2010-12-09 2017-12-29 Wockhardt Limited Związki ketolidowe
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途
WO2021084411A1 (en) * 2019-10-29 2021-05-06 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5166967A (en) * 1990-08-27 1992-11-24 Fabian Carl E Markers for dental x-ray film and packets for simplified film mounting
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
ES2104386T3 (es) * 1993-05-19 1997-10-01 Pfizer Compuesto intermedio para la acitromicina.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) * 1995-12-08 2000-01-20 Руссель Юклаф Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция

Also Published As

Publication number Publication date
HUP0101817A2 (hu) 2001-11-28
HUP0101817A3 (en) 2003-07-28
BR9910115A (pt) 2000-12-26
CN1141312C (zh) 2004-03-10
CN1301268A (zh) 2001-06-27
HRP980189A2 (en) 2000-12-31
PT1070077E (pt) 2003-10-31
DE69908338D1 (de) 2003-07-03
EE200000587A (et) 2002-04-15
ES2200512T3 (es) 2004-03-01
PL193742B1 (pl) 2007-03-30
KR20010034754A (ko) 2001-04-25
NO317982B1 (no) 2005-01-17
HK1036457A1 (en) 2002-01-04
BG104913A (en) 2001-08-31
JP2002510701A (ja) 2002-04-09
EP1070077A1 (en) 2001-01-24
KR100600463B1 (ko) 2006-07-13
US6110965A (en) 2000-08-29
BG64600B1 (bg) 2005-08-31
AU3046499A (en) 1999-10-25
SK15022000A3 (sk) 2001-03-12
EE04283B1 (et) 2004-04-15
DE69908338T2 (de) 2004-04-08
SI1070077T1 (en) 2004-02-29
NO20005015D0 (no) 2000-10-05
IL138837A (en) 2006-10-05
NO20005015L (no) 2000-12-04
RU2211222C2 (ru) 2003-08-27
CA2327775A1 (en) 1999-10-14
PL343441A1 (en) 2001-08-13
AR019261A1 (es) 2002-02-13
WO1999051616A1 (en) 1999-10-14
HRP980189B1 (en) 2004-04-30
UA70941C2 (uk) 2004-11-15
DK1070077T3 (da) 2003-09-22
CA2327775C (en) 2007-08-07
ATE241638T1 (de) 2003-06-15
SK284169B6 (sk) 2004-10-05
EP1070077B1 (en) 2003-05-28

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees