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AR114027A2 - Construcciones de adn recombinante y métodos para modular la expresión de un gen diana - Google Patents

Construcciones de adn recombinante y métodos para modular la expresión de un gen diana

Info

Publication number
AR114027A2
AR114027A2 ARP180103208A ARP180103208A AR114027A2 AR 114027 A2 AR114027 A2 AR 114027A2 AR P180103208 A ARP180103208 A AR P180103208A AR P180103208 A ARP180103208 A AR P180103208A AR 114027 A2 AR114027 A2 AR 114027A2
Authority
AR
Argentina
Prior art keywords
methods
recombinant dna
target gene
expression
modulate
Prior art date
Application number
ARP180103208A
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English (en)
Original Assignee
Monsanto Technology Llc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41466319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR114027(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Monsanto Technology Llc filed Critical Monsanto Technology Llc
Publication of AR114027A2 publication Critical patent/AR114027A2/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente da a conocer construcciones de ADN recombinante y métodos para manipular la expresión de un gen diana que es regulada por un pequeño ARN, interfiriendo con la unión del pequeño ARN a su gen diana. Más específicamente, la presente describe construcciones de ADN recombinante que codifican bloqueantes de la escisión, bloqueantes de la escisión modificados en 5’, e inhibidores de la traducción que sirven para modular la expresión de un gen diana y métodos para utilizarlos. También se describen miARN diana útiles para diseñar las construcciones de ADN recombinante que incluyen genes que no responden al miARN, señuelos de miARN, bloqueantes de la escisión, bloqueantes de la escisión modificados en 5’ e inhibidores de la traducción, como así también métodos para utilizarlos y células transgénicas eucariotas y organismos que contienen dichas construcciones.
ARP180103208A 2008-07-01 2018-11-05 Construcciones de adn recombinante y métodos para modular la expresión de un gen diana AR114027A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7724408P 2008-07-01 2008-07-01
PCT/US2009/049392 WO2010002984A1 (en) 2008-07-01 2009-07-01 Recombinant dna constructs and methods for modulating expression of a target gene

Publications (1)

Publication Number Publication Date
AR114027A2 true AR114027A2 (es) 2020-07-15

Family

ID=41466319

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180103208A AR114027A2 (es) 2008-07-01 2018-11-05 Construcciones de adn recombinante y métodos para modular la expresión de un gen diana

Country Status (10)

Country Link
US (2) US9040774B2 (es)
EP (2) EP2924118A1 (es)
CN (1) CN106995819B (es)
AR (1) AR114027A2 (es)
AU (3) AU2009267007B2 (es)
BR (1) BRPI0913657A2 (es)
CA (1) CA2729713C (es)
ES (1) ES2563485T3 (es)
UY (1) UY32066A (es)
WO (1) WO2010002984A1 (es)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1976567B1 (en) 2005-12-28 2020-05-13 The Scripps Research Institute Natural antisense and non-coding rna transcripts as drug targets
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
WO2009125401A2 (en) 2008-04-10 2009-10-15 Rosetta Genomics Ltd. Compositions and methods for enhancing oil content in plants
WO2010040112A2 (en) 2008-10-03 2010-04-08 Curna, Inc. Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
EP2370581B1 (en) 2008-12-04 2016-08-03 CuRNA, Inc. Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
MX358603B (es) 2008-12-04 2018-08-28 Curna Inc Tratamiento de enfermedades relacionadas con un gen supresor de tumor mediante inhibicion del transcrito antisentido natural para el gen.
RU2620970C2 (ru) 2008-12-04 2017-05-30 КьюРНА,Инк., Лечение связанных с эритропоэтином (еро) заболеваний путем ингибирования природного антисмыслового транскрипта к еро
EP3009150B1 (en) 2009-02-12 2019-11-13 CuRNA, Inc. Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
WO2010107733A2 (en) 2009-03-16 2010-09-23 Curna, Inc. Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
ES2627763T3 (es) 2009-03-17 2017-07-31 Curna, Inc. Tratamiento de enfermedades relacionadas con el homólogo tipo delta 1 (dlk1) por inhibición de transcrito antisentido natural a dlk1
US9155754B2 (en) 2009-05-06 2015-10-13 Curna, Inc. Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1
EP2427552B1 (en) 2009-05-06 2016-11-16 CuRNA, Inc. Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
CA2761248C (en) 2009-05-08 2023-03-14 Joseph Collard Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
DK2432881T3 (en) 2009-05-18 2018-02-26 Curna Inc TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
WO2010135695A2 (en) 2009-05-22 2010-11-25 Curna, Inc. TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
ES2618576T3 (es) 2009-05-28 2017-06-21 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen antivírico mediante la inhibición de una transcripción antisentido natural a un gen antivírico
KR101702689B1 (ko) 2009-06-16 2017-02-06 큐알엔에이, 인크. Ｐｏｎ1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(ｐｏｎ1) 관련된 질환의 치료
KR101801404B1 (ko) 2009-06-16 2017-12-20 큐알엔에이, 인크. 콜라겐 유전자에 대한 천연 안티센스 전사체의 억제에 의한 콜라겐 유전자 관련된 질환의 치료
JP6073133B2 (ja) 2009-06-24 2017-02-01 クルナ・インコーポレーテッド 腫瘍壊死因子受容体２（ｔｎｆｒ２）に対する天然アンチセンス転写物の抑制によるｔｎｆｒ２関連疾患の治療
ES2583691T3 (es) 2009-06-26 2016-09-21 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen del síndrome de Down mediante la inhibición de una transcripción antisentido natural a un gen del síndrome de Down
US20120252869A1 (en) 2009-07-24 2012-10-04 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
KR101802536B1 (ko) 2009-08-05 2017-11-28 큐알엔에이, 인크. 인슐린 유전자 (ｉｎｓ)에 대한 자연 안티센스 전사체의 저해에 의한 인슐린 유전자 (ｉｎｓ) 관련된 질환의 치료
WO2011019815A2 (en) 2009-08-11 2011-02-17 Curna, Inc. Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq)
CN102482670B (zh) 2009-08-21 2018-06-15 库尔纳公司 通过抑制‘hsp70-相互作用蛋白的c末端’(chip)的天然反义转录物而治疗chip相关疾病
CA2771172C (en) 2009-08-25 2021-11-30 Opko Curna, Llc Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
ES2664591T3 (es) 2009-09-25 2018-04-20 Curna, Inc. Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
WO2011049587A1 (en) 2009-10-23 2011-04-28 Monsanto Technology Llc Transgenic soybean plants and chromosomes
NO2513310T3 (es) 2009-12-16 2018-03-31
EP2515947B1 (en) 2009-12-23 2021-10-06 CuRNA, Inc. Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
JP5934106B2 (ja) 2009-12-23 2016-06-15 カッパーアールエヌエー，インコーポレイテッド 肝細胞増殖因子（ｈｇｆ）に対する天然アンチセンス転写物の阻害によるｈｇｆ関連性疾患の治療
EP2519634B1 (en) 2009-12-29 2016-06-01 CuRNA, Inc. TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
JP5993744B2 (ja) 2009-12-29 2016-09-14 カッパーアールエヌエー，インコーポレイテッド 核呼吸因子１（ｎｒｆ１）に対する天然アンチセンス転写物の阻害による核呼吸因子１関連疾患の治療
US20120289583A1 (en) 2009-12-31 2012-11-15 Curna, Inc. Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
NO2521784T3 (es) 2010-01-04 2018-05-05
CA2786056C (en) 2010-01-06 2023-03-14 Curna, Inc. Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
EP2524039B1 (en) 2010-01-11 2017-11-29 CuRNA, Inc. Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
WO2011091390A2 (en) 2010-01-25 2011-07-28 Opko Curna, Llc Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1
WO2011103528A2 (en) 2010-02-22 2011-08-25 Opko Curna Llc Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
MX2012010479A (es) 2010-03-08 2012-10-09 Monsanto Technology Llc Moleculas polinucleotidicas para regulacion genetica en plantas.
EP2553098B1 (en) 2010-04-02 2017-10-11 CuRNA, Inc. Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3
RU2610661C2 (ru) 2010-04-09 2017-02-14 Курна, Инк. Лечение заболеваний, связанных с фактором роста фибробластов 21 (fgf21), путем ингибирования природного антисмыслового транскрипта к fgf21
KR101915115B1 (ko) 2010-05-03 2018-11-05 큐알엔에이, 인크. 시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
TWI586356B (zh) 2010-05-14 2017-06-11 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
ES2664585T3 (es) 2010-05-26 2018-04-20 Curna, Inc. Tratamiento de enfermedades relacionadas con metionina sulfóxido reductasa (MSRA) mediante inhibición del transcrito antisentido natural a MSRA
DK2576783T3 (en) 2010-05-26 2018-03-12 Curna Inc TREATMENT OF ATONAL HOMOLOGY 1- (ATOH1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS AT ATOH1
JP6023705B2 (ja) 2010-06-23 2016-11-09 カッパーアールエヌエー，インコーポレイテッド ナトリウムチャネル、電位依存性、αサブユニット（ＳＣＮＡ）に対する天然アンチセンス転写物の阻害によるＳＣＮＡ関連疾患の治療
CN103068982B (zh) 2010-07-14 2017-06-09 库尔纳公司 通过抑制盘状大同系物(dlg)的天然反义转录物而治疗dlg相关疾病
US9222100B2 (en) 2010-08-24 2015-12-29 Monsanto Technology Llc Methods and DNA constructs for autoregulating transgene silencing
JP5986998B2 (ja) 2010-10-06 2016-09-06 カッパーアールエヌエー，インコーポレイテッド シアリダーゼ４（ｎｅｕ４）への天然アンチセンス転写物の阻害によるｎｅｕ４関連疾患の治療
WO2012054723A2 (en) 2010-10-22 2012-04-26 Opko Curna Llc Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
EP2633057B1 (en) * 2010-10-29 2016-09-28 Syngenta Participations AG Overexpression of plant mirnas for parasite control
US10000752B2 (en) 2010-11-18 2018-06-19 Curna, Inc. Antagonat compositions and methods of use
ES2657590T3 (es) 2010-11-23 2018-03-06 Curna, Inc. Tratamiento de enfermedades relacionadas con nanog mediante inhibición del transcrito antisentido natural a nanog
BR112013015745B1 (pt) 2010-12-03 2021-01-19 Ms Technologies, Llc polinucleotídeos referente ao evento de tolerância a herbicida 8291.45.36.2, cassete de expressão, sonda, bem como processos para identificação do evento, determinação da zigosidade, produção de uma planta de soja transgênica e produção de uma proteína em uma célula de planta
EP2645848B1 (en) 2010-12-03 2018-05-16 Dow AgroSciences LLC Stacked herbicide tolerance event 8264.44.06.1, related transgenic soybean lines, and detection thereof
JP6024901B2 (ja) * 2010-12-06 2016-11-16 国立大学法人弘前大学 植物の形質転換個体の取得方法
EP2510781A1 (en) * 2011-04-15 2012-10-17 Institut National De La Recherche Agronomique Novel methods of modifying plant phenotype
WO2012149316A2 (en) 2011-04-28 2012-11-01 Iowa State University Research Foundation, Inc. miRNA396 AND GROWTH REGULATING FACTORS FOR CYST NEMATODE TOLERANCE IN PLANTS
EP2718439B1 (en) 2011-06-09 2017-08-09 CuRNA, Inc. Treatment of frataxin (fxn) related diseases by inhibition of natural antisense transcript to fxn
CN103826443B (zh) 2011-07-13 2017-12-19 陶氏益农公司 叠加的除草剂耐受性事件8264.42.32.1、相关转基因大豆系及其检测方法
CN103826439A (zh) * 2011-07-22 2014-05-28 巴斯夫植物科学有限公司 植物转化方法
KR101991980B1 (ko) 2011-09-06 2019-06-21 큐알엔에이, 인크. 소형 분자로 전압-개폐된 나트륨 채널 (SCNxA)의 알파 아단위에 관련된 질환의 치료
EP3296402B1 (en) 2011-09-13 2020-04-15 Monsanto Technology LLC Methods and compositions for weed control
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
US9840715B1 (en) 2011-09-13 2017-12-12 Monsanto Technology Llc Methods and compositions for delaying senescence and improving disease tolerance and yield in plants
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
CA2845581A1 (en) * 2011-09-13 2013-03-21 E. I. Du Pont De Nemours And Company Soybean atps promoter and its use in constitutive expression of transgenic genes in plants
CN110066794A (zh) 2011-09-13 2019-07-30 孟山都技术公司 用于杂草控制的方法和组合物
MX362810B (es) 2011-09-13 2019-02-13 Monsanto Technology Llc Metodos y composiciones para controlar malezas.
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
MX362812B (es) 2011-09-13 2019-02-13 Monsanto Technology Llc Metodos y composiciones para el control de malezas.
US9920326B1 (en) 2011-09-14 2018-03-20 Monsanto Technology Llc Methods and compositions for increasing invertase activity in plants
CN110438125A (zh) 2012-03-15 2019-11-12 科纳公司 通过抑制脑源神经营养因子(bdnf)的天然反义转录物治疗bdnf相关疾病
WO2013175480A1 (en) 2012-05-24 2013-11-28 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
WO2014033723A1 (en) 2012-09-03 2014-03-06 A.B. Seeds Ltd. Method of improving abiotic stress tolerance of plants and plants generated thereby
CA2888264A1 (en) 2012-10-18 2014-04-24 Monsanto Technology Llc Methods and compositions for plant pest control
US20150307894A1 (en) 2012-11-28 2015-10-29 Monsanto Technology Llc Transgenic Plants With Enhanced Traits
MX375327B (es) 2013-01-01 2025-03-06 A B Seeds Ltd Métodos para introducir dsrna en semillas de plantas para modular la expresión genética.
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
US10000767B2 (en) 2013-01-28 2018-06-19 Monsanto Technology Llc Methods and compositions for plant pest control
WO2014164797A2 (en) 2013-03-13 2014-10-09 Monsanto Technology Llc Methods and compositions for weed control
CN105074008A (zh) 2013-03-13 2015-11-18 孟山都技术有限公司 用于杂草控制的方法和组合物
US20140283211A1 (en) 2013-03-14 2014-09-18 Monsanto Technology Llc Methods and Compositions for Plant Pest Control
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
CA2918387C (en) 2013-07-19 2021-11-02 Monsanto Technology Llc Compositions and methods for controlling leptinotarsa
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
WO2015054106A1 (en) 2013-10-07 2015-04-16 Monsanto Technology Llc Transgenic plants with enhanced traits
NZ719544A (en) 2013-11-04 2022-09-30 Beeologics Inc Compositions and methods for controlling arthropod parasite and pest infestations
RU2687369C2 (ru) * 2013-11-04 2019-05-13 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Универсальная донорная система для направленного воздействия на гены
UA119253C2 (uk) 2013-12-10 2019-05-27 Біолоджикс, Інк. Спосіб боротьби із вірусом у кліща varroa та у бджіл
US10683513B2 (en) * 2013-12-31 2020-06-16 Dow Agrosciences Llc Tissue-specific expression and hybrid plant production
UA121462C2 (uk) 2014-01-15 2020-06-10 Монсанто Текнолоджі Елелсі Спосіб та композиція для боротьби із бур'янами з використанням полінуклеотидів epsps
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
EP3420809A1 (en) 2014-04-01 2019-01-02 Monsanto Technology LLC Compositions and methods for controlling insect pests
EP3158067B1 (en) 2014-06-23 2020-08-12 Monsanto Technology LLC Compositions and methods for regulating gene expression via rna interference
EP3161138A4 (en) 2014-06-25 2017-12-06 Monsanto Technology LLC Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
WO2016018887A1 (en) 2014-07-29 2016-02-04 Monsanto Technology Llc Compositions and methods for controlling insect pests
CA2974101A1 (en) 2015-01-22 2016-07-28 Monsanto Technology Llc Compositions and methods for controlling leptinotarsa
WO2016196738A1 (en) 2015-06-02 2016-12-08 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
CN108024517A (zh) 2015-06-03 2018-05-11 孟山都技术公司 用于将核酸引入到植物中的方法和组合物
US11364285B2 (en) * 2016-04-01 2022-06-21 Purdue Research Foundation Methods, compositions, and molecular targets that exploit synergies and symbioses in the termite gut
JP2019524147A (ja) * 2016-08-17 2019-09-05 モンサント テクノロジー エルエルシー 収穫可能収量を増加させるためのジベレリン代謝操作を介して低草高植物を得るための方法及び組成物
CA3040328A1 (en) 2016-10-19 2018-04-26 Monsanto Technology Llc Compositions and methods for altering flowering and plant architecture to improve yield potential
EP3557980A4 (en) 2016-12-22 2020-06-17 Monsanto Technology LLC Crop manipulation based on genome editing and production of brachytic plants
EP3573448A4 (en) 2017-01-28 2020-09-02 Inari Agriculture, Inc. NEW PLANT CELLS, PLANTS AND SEEDS
CN111132552A (zh) * 2017-02-24 2020-05-08 旗舰创业创新五公司 用于调节内共生体的组合物和相关方法
ES3050594T3 (en) 2017-09-15 2025-12-22 Covercress Inc Low fiber pennycress meal and methods of making
US11603536B2 (en) 2017-09-29 2023-03-14 Inari Agriculture Technology, Inc. Methods for efficient maize genome editing
US11802288B1 (en) 2018-01-29 2023-10-31 Inari Agriculture Technology, Inc. Methods for efficient soybean genome editing
US11220694B1 (en) 2018-01-29 2022-01-11 Inari Agriculture, Inc. Rice cells and rice plants
US11926835B1 (en) 2018-01-29 2024-03-12 Inari Agriculture Technology, Inc. Methods for efficient tomato genome editing
MX2020008561A (es) 2018-02-15 2021-01-08 Monsanto Technology Llc Gestión mejorada de maíz a través de sistemas semienanos.
EP3752621A4 (en) 2018-02-15 2021-12-01 Monsanto Technology LLC COMPOSITIONS AND METHODS OF IMPROVING THE HARVEST YIELD THROUGH TRAIT STACKING
EP3751987A4 (en) 2018-02-15 2021-11-10 Monsanto Technology LLC IMPROVED METHODS FOR MANUFACTURING HYBRID CORN SEEDS
AR114124A1 (es) 2018-02-15 2020-07-22 Monsanto Technology Llc Composiciones y métodos para mejorar el rendimiento de cultivos a través de apilamiento de rasgos
US11866719B1 (en) 2018-06-04 2024-01-09 Inari Agriculture Technology, Inc. Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
CN108795927A (zh) * 2018-07-02 2018-11-13 河南农业大学 普通小麦基因TaSPX3编码序列的克隆及其应用
US12274205B2 (en) 2018-12-12 2025-04-15 Monsanto Technology Llc Delayed harvest of short stature corn plants
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
CN111518810B (zh) * 2020-05-18 2023-06-09 四川农业大学 玉米zma-miR164e及其靶基因在调控籽粒大小中的应用
CN111593058B (zh) * 2020-05-25 2022-01-25 扬州大学 Bna-miR169n基因及其在控制甘蓝型油菜抗旱性中的应用
CN112226458B (zh) * 2020-09-23 2022-07-12 南昌大学 一种利用水稻osa-miR5511基因提高水稻产量的方法
CN114480473A (zh) * 2020-10-23 2022-05-13 中国科学院分子植物科学卓越创新中心 调控植物对菌核病抗病性的新型基因及其应用
US12527250B2 (en) 2020-11-23 2026-01-20 Monsanto Technology Llc Methods for improved hybrid corn seed production
CN112626082B (zh) * 2020-12-28 2022-07-29 山东农业大学 玉米基因ZmSCL14在调控植物根部发育中的应用
TW202300650A (zh) 2021-03-26 2023-01-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 真核系統中環狀多核糖核苷酸的產生
TW202305130A (zh) 2021-03-26 2023-02-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 原核系統中環狀多核糖核苷酸之產生
EP4314277A1 (en) 2021-03-26 2024-02-07 Flagship Pioneering Innovations VII, LLC Compositions and methods for producing circular polyribonucleotides
WO2022232407A2 (en) 2021-04-30 2022-11-03 Monsanto Technology Llc Plant regulatory elements and uses thereof
EP4377457A1 (en) 2021-07-26 2024-06-05 Flagship Pioneering Innovations VI, LLC Trem compositions and uses thereof
EP4405469A4 (en) * 2021-09-24 2025-09-10 Univ Pennsylvania COMPOSITIONS FOR THE TREATMENT OF CHARCOT-MARIE-TOOTH DISEASE
KR20240110818A (ko) 2021-11-01 2024-07-16 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 유기체를 변형하기 위한 폴리뉴클레오티드
EP4430196A4 (en) 2021-11-12 2025-10-22 Monsanto Technology Llc COMPOSITIONS AND METHODS FOR ALTERING PLANT DETERMINACY
US20250230452A1 (en) 2022-01-20 2025-07-17 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
EP4508221A1 (en) * 2022-04-12 2025-02-19 Monsanto Technology LLC Plant regulatory elements and uses thereof for autoexcision
WO2024229359A2 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Artificial tymovirales satellite rnas
AR132589A1 (es) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Arn satélite de solemoviridae artificiales
AR132587A1 (es) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Arn satélite de martellivirales artificiales
AR132586A1 (es) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Arn satélite de amalgavirus artificiales
WO2024229385A1 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Artificial ghabrivirales satellite rnas
WO2024229395A1 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Partitiviral satellite rna amplification systems for plants
AR133211A1 (es) 2023-05-03 2025-09-10 Flagship Pioneering Innovations Vii Llc Arn satélite artificiales de tombusviridae
AR132591A1 (es) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Arn satélite de secoviridae artificiales
WO2024229403A1 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Endornaviral satellite rna amplification systems for plants
CN117003844B (zh) * 2023-08-10 2024-05-14 西部(重庆)科学城种质创制大科学中心 马铃薯块茎调控基因StRAP2.7b及其应用
CN117025631B (zh) * 2023-08-10 2024-11-01 中国烟草总公司郑州烟草研究院 烟草萜类物质合成相关转录因子NtGATA8及其编码基因、载体和应用
CN118620907B (zh) * 2024-04-01 2025-05-23 安徽农业大学 一种增强植物抵抗蚜虫的rta1基因及其应用
CN118460601B (zh) * 2024-05-30 2024-12-03 江西农业大学 一种miRNA在调控植物耐盐胁迫中的应用
CN118620915A (zh) * 2024-08-12 2024-09-10 海南大学三亚南繁研究院 转录因子PeAP2-85及其改善西番莲果实品质的应用
CN119780433B (zh) * 2024-12-13 2025-07-29 首都医科大学附属北京友谊医院 一种以otud7b为靶点在制备诊断和/或防治主动脉夹层产品中的应用
CN119506347B (zh) * 2025-01-21 2025-04-18 中国科学院昆明植物研究所 一种草地早熟禾基因编辑方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
US5004863B2 (en) 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
DK0413019T3 (da) 1989-02-24 2001-11-12 Monsanto Technology Llc Syntetiske plantegener og fremgangsmåde til fremstilling af disse
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
JP3209744B2 (ja) 1990-01-22 2001-09-17 デカルブ・ジェネティクス・コーポレーション 結実能力のある遺伝子変換コーン
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US5837848A (en) 1990-03-16 1998-11-17 Zeneca Limited Root-specific promoter
US6403865B1 (en) 1990-08-24 2002-06-11 Syngenta Investment Corp. Method of producing transgenic maize using direct transformation of commercially important genotypes
US5633435A (en) 1990-08-31 1997-05-27 Monsanto Company Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases
WO1992020809A1 (en) 1991-05-15 1992-11-26 Agracetus, Inc. Method of creating a transformed rice plant
US5518908A (en) 1991-09-23 1996-05-21 Monsanto Company Method of controlling insects
US5593874A (en) 1992-03-19 1997-01-14 Monsanto Company Enhanced expression in plants
WO1994000977A1 (fr) 1992-07-07 1994-01-20 Japan Tobacco Inc. Procede de transformation d'une monocotyledone
GB9311147D0 (en) * 1993-05-28 1993-07-14 Long Ashton Research Station Regulation of plant growth
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
US5631152A (en) 1994-10-26 1997-05-20 Monsanto Company Rapid and efficient regeneration of transgenic plants
US5888732A (en) 1995-06-07 1999-03-30 Life Technologies, Inc. Recombinational cloning using engineered recombination sites
ATE298368T1 (de) 1995-12-27 2005-07-15 Japan Tobacco Inc Kälteindusierbare promotorsequenzen
EA199800212A1 (ru) 1996-06-21 1998-10-29 Монсанто Компани Способы получения устойчивотрансформируемой высокопродуктивной пшеницы посредством трансформации, опосредованной agrobacterium, и комбинации, получаемые ими
US6140078A (en) 1996-09-05 2000-10-31 Unilever Patent Holdings Salt-inducible promoter derivable from a lactic acid bacterium, and its use in a lactic acid bacterium for production of a desired protein
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
BR9807488A (pt) 1997-01-20 2000-03-21 Plant Genetic Systems Nv Promotores de planta induzidos por agentes patogênicos.
US5981840A (en) 1997-01-24 1999-11-09 Pioneer Hi-Bred International, Inc. Methods for agrobacterium-mediated transformation
IL135776A0 (en) 1997-10-24 2001-05-20 Life Technologies Inc Recombinational cloning using nucleic acids having recombination sites
US5914451A (en) 1998-04-06 1999-06-22 Monsanto Company Efficiency soybean transformation protocol
US6307123B1 (en) 1998-05-18 2001-10-23 Dekalb Genetics Corporation Methods and compositions for transgene identification
JP2000083680A (ja) 1998-07-16 2000-03-28 Nippon Paper Industries Co Ltd 光誘導型プロモ―タ―の制御下に置かれた不定芽再分化遺伝子を選抜マ―カ―遺伝子とする植物への遺伝子導入方法及びこれに用いる植物への遺伝子導入用ベクタ―
AR032578A1 (es) * 1998-08-10 2003-11-19 Monsanto Technology Llc Metodos para controlar los niveles de giberelina
US6717034B2 (en) 2001-03-30 2004-04-06 Mendel Biotechnology, Inc. Method for modifying plant biomass
AU774441B2 (en) 1998-12-18 2004-06-24 Monsanto Technology Llc Method for the regeneration of cotton
JP2002534129A (ja) 1999-01-14 2002-10-15 モンサント テクノロジー エルエルシー ダイズ形質転換方法
US6194636B1 (en) 1999-05-14 2001-02-27 Dekalb Genetics Corp. Maize RS324 promoter and methods for use thereof
US6207879B1 (en) 1999-05-14 2001-03-27 Dekalb Genetics Corporation Maize RS81 promoter and methods for use thereof
US6232526B1 (en) 1999-05-14 2001-05-15 Dekalb Genetics Corp. Maize A3 promoter and methods for use thereof
AU2575701A (en) 1999-12-07 2001-06-18 Monsanto Company Sugarbeet regeneration and transformation
EP2210948A3 (en) 1999-12-10 2010-10-06 Life Technologies Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
US7151204B2 (en) 2001-01-09 2006-12-19 Monsanto Technology Llc Maize chloroplast aldolase promoter compositions and methods for use thereof
JP2003000260A (ja) * 2001-06-19 2003-01-07 Honda Motor Co Ltd 植物の半矮性化に関与するｓｄ１遺伝子、並びにその利用
IL161100A0 (en) 2001-09-28 2004-08-31 Max Planck Gesellschaft Identification of novel genes coding for small temporal rnas
US7166771B2 (en) 2002-06-21 2007-01-23 Monsanto Technology Llc Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs
US20040106198A1 (en) 2002-07-16 2004-06-03 Large Scale Biology Corporation Inhibition of peptide cleavage in plants
US20040115642A1 (en) 2002-12-12 2004-06-17 Changlin Fu Single-step methods for gene cloning
US20040123347A1 (en) 2002-12-20 2004-06-24 Hinchey Brendan S. Water-deficit-inducible plant promoters
US7682829B2 (en) 2003-05-30 2010-03-23 Monsanto Technology Llc Methods for corn transformation
US20050144669A1 (en) 2003-07-01 2005-06-30 Whitehead Institute For Biomedical Research MicroRNAs in plants
EP1818405B2 (en) 2004-04-09 2025-03-19 Monsanto Technology, LLC Compositions and methods for control of insect infestations in plants
AU2005333165B2 (en) 2004-11-12 2012-07-19 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20060200878A1 (en) 2004-12-21 2006-09-07 Linda Lutfiyya Recombinant DNA constructs and methods for controlling gene expression
US8314290B2 (en) 2004-12-21 2012-11-20 Monsanto Technology Llc Temporal regulation of gene expression by MicroRNAs
US8404927B2 (en) * 2004-12-21 2013-03-26 Monsanto Technology Llc Double-stranded RNA stabilized in planta
US7414125B2 (en) * 2005-03-30 2008-08-19 The Regents Of The University Of California Cloning and characterization of microRNAs from rice
WO2007003023A2 (en) 2005-06-30 2007-01-11 Alellyx S.A. Method for increasing plant resistance to sugarcane mosaic virus and sugarcane mosaic virus resistant plants
WO2007047016A2 (en) 2005-10-13 2007-04-26 Monsanto Technology, Llc Methods for producing hybrid seed
ES2655700T3 (es) 2006-08-31 2018-02-21 Monsanto Technology, Llc ARN pequeños en fase
EP2664673A3 (en) 2006-10-05 2014-02-19 E. I. du Pont de Nemours and Company Maize microRNA sequences
US8946511B2 (en) 2006-10-12 2015-02-03 Monsanto Technology Llc Plant microRNAs and methods of use thereof
WO2008049183A1 (en) 2006-10-27 2008-05-02 Alellyx S.A. Method for modifying plant architecture and enhancing plant biomass and/or sucrose yield
CN105219694A (zh) 2007-03-09 2016-01-06 孟山都技术公司 用于转化的植物胚外植体的制备和用途

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