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AR070578A1 - Imidazolidinas fenil- sustituidas, medicamentos que comprenden dichos compuestos y su uso para producir medicamentos - Google Patents

Imidazolidinas fenil- sustituidas, medicamentos que comprenden dichos compuestos y su uso para producir medicamentos

Info

Publication number
AR070578A1
AR070578A1 ARP090100398A ARP090100398A AR070578A1 AR 070578 A1 AR070578 A1 AR 070578A1 AR P090100398 A ARP090100398 A AR P090100398A AR P090100398 A ARP090100398 A AR P090100398A AR 070578 A1 AR070578 A1 AR 070578A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
aryl
independently
compounds
Prior art date
Application number
ARP090100398A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR070578A1 publication Critical patent/AR070578A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos son adecuados, por ejemplo, como fármacos antiobesidad y para el tratamiento del síntoma cardiometabolico. Reivindicacion 1: Un compuesto de la formula 1 en el que R1 es CN, NO2 o halogeno; R2 es CF3 o halogeno; A, B son cada uno independientemente CH, N; R3, R4 son cada uno independientemente: hidrogeno, alquilo C1-12, arilo C6-12-, alquilen C1-12-arilo C6-12, donde alquilo C1-12, arilo C6-12, alquilen C1-12-arilo C6-12 pueden estar cada uno hasta trisustituidos independientemente por: halogeno, CN, CF3; R5, R6, R7 son cada uno independientemente: H, F, CI, Br, CN, CF3, SF5, OCF3, NO2, S(O)m[alquilo C1-6], S(O)m[cicloalquilo C3-9], S(O)mCF3, alquilo C1-6, alcoxi C1-6, alquenilo C2-6, [alquenil C2-6]-oxi, alquinilo C2-6, [alquinil C2-6]-oxi, OH, SH, W-COO-[alquilo C1-12], -O(C=O)-arilo C6-12, W-COOH, W-CONH2, W-CO-NH[alquilo C1-6], W-CO-N[alquilo C1-6]2, W-CO-NH[cicloalquilo C3-9], W-CO-N[cicloalquilo C3-9]2, W-CO-NH-CN, W-CO-NH-CHR8-CO-R9-W-CO-R10, W-CO-NH-C(=NH)NH2, W-CO-NH-C(=NH)NH[alquilo C1-6], W-CO-NH-C(=NH)N[alquilo C1-6]2, acilo C1-8, aciloxi C1-7, W-C(=NH)NH2, W-C(=NH)NHOH, W-C(=N-SO2-NH2)NH2, W-C(=N-SO2-CF3)NH2, W-C[=N-SO2-alquil C1-6]NH2, W-C[=N-SO2-cicloalquil C3-9]NH2, W-C(=N-SO2-arilo)NH2, NH2, NH-alquilo C1-12, N-[alquilo C1-12]2 , W-NH-C(=NH)NH2, W-NH-C(=NH)NH[alquilo C1-6], W-NH-C(=NH)N[alquilo C1-6]2, W-NH-CO-NH2, W-NH-CO-NH[alquilo C1-6], W-NH-CO-N[alquilo C1-6]2, W-NH-CO-NH[cicloalquilo C3-9], W-NH-CO-N[cicloalquilo C3-9]2, W-NH-CO-NH-[alquilo C1-6]-CO-O-[alquilo C1-6], W-NH-CO-NH-[alquil C1-6]-CO-NH2, W-NH-CO-NH-SO2-alquilo C1-6, W-NH-CO-NH-SO2[cicloalquilo C3-9], W-NH-CO-NH-CO-alquilo C1-6, W-NH-CO-NH-CO-[cicloalquilo C3-9], W-NH-C(=NH)-NH-C(=NH)-NH2, W-NH-C(=NH)-NH-C(=NH)-NH[alquilo C1-6], W-NH-C(=NH)-NH-C(=NH)-N[alquilo C1-6]2, W-NH-W-SO2-NH2, W-NH-W-SO2-NH[aIquilo C1-6], W-NH-W-SO2-N[alquilo C1-6]2, W-NH-W-SO2-NH[cicloalquilo C3-9], W-NH-W-SO2-N[cicloalquilo C3-9]2, W-NH-W-SO2-NH-CO-O[alquilo C1-6], W-NH-W-SO2-NH-CO-NH2, W-O-SO2-NH2, W-O-W-COOH, W-O-W-CONH2, W-SO2-NH2, W-SO2-NH[alquilo C1-6], W-SO2-N[alquilo C1-6]2, W-SO-NH[cicloalquilo C3-9], W-SO2-N[cicloalquilo C3-9]2, W-SO3H, W-NH-W-SO3H, W-SO2-NH-CO-NH2, W-SO2-NH-CO-NH[alquilo C1-6], W-SO2-NH-CO-N[alquilo C1-6]2, W-SO2-NH-CO-NH[cicIoalquilo C3-9], W-SO2-NH-CO-N[cicloalquilo C3-9]2, W-P(O)(OH)[O-alquilo C1-6], W-P(O)[O-alquilo C1-6]2, W-P(O)(OH)(O-CH2-arilo), W-P(O)(O-CH2-arilo)2, W-P(O)(OH)2, arilo C6-12, O-arilo C6-12, O-alquilen C1-12-arilo C6-12, S(O)m-arilo C6-12, tri[alquil C1-12]sililo, donde el alquilo tiene de 1 a 6 átomos de carbono; m es 0, 1, 2; W es un enlace o alquilo C1-6; R8 es H, alquilo C1-6, donde el grupo alquilo puede estar sustituido por: OH, SH, SCH3, arilo, 4-hidroxiarilo, heteroarilo, NH2, NH-C(=NH)NH2, COOH, CO-Oalquilo C1-6, CONH2; R9 es OH, NH2, NH-alquilo C1-12, N[alquilo C1-12]2, NH-cicloalquilo C3-9, N[cicloalquilo C3-9]2; R10 es NH-alquil C1-6-SO3H, NH-alquil C1-6-SO2NH2, NH-alquil C1-6-SO2-alquilo C1-6, NH-alquil C1-6-SO2-cicloalquilo C3-9, NH-alquil 1-6-SO2-CF3, grupo de formulas (2) y sus sales fisiologicamente compatibles.
ARP090100398A 2008-02-07 2009-02-05 Imidazolidinas fenil- sustituidas, medicamentos que comprenden dichos compuestos y su uso para producir medicamentos AR070578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290133 2008-02-07

Publications (1)

Publication Number Publication Date
AR070578A1 true AR070578A1 (es) 2010-04-21

Family

ID=39506661

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100398A AR070578A1 (es) 2008-02-07 2009-02-05 Imidazolidinas fenil- sustituidas, medicamentos que comprenden dichos compuestos y su uso para producir medicamentos

Country Status (7)

Country Link
US (1) US20110178134A1 (es)
EP (1) EP2242745A1 (es)
AR (1) AR070578A1 (es)
CL (1) CL2009000256A1 (es)
TW (1) TW200946510A (es)
UY (1) UY31645A1 (es)
WO (1) WO2009097995A1 (es)

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US20110178134A1 (en) 2011-07-21
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