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AR083849A1 - Antagonistas de mdm2 de espiro-oxindol - Google Patents

Antagonistas de mdm2 de espiro-oxindol

Info

Publication number
AR083849A1
AR083849A1 ARP110104223A ARP110104223A AR083849A1 AR 083849 A1 AR083849 A1 AR 083849A1 AR P110104223 A ARP110104223 A AR P110104223A AR P110104223 A ARP110104223 A AR P110104223A AR 083849 A1 AR083849 A1 AR 083849A1
Authority
AR
Argentina
Prior art keywords
group
hydrogen
optionally substituted
alkyl
espiro
Prior art date
Application number
ARP110104223A
Other languages
English (en)
Original Assignee
Univ Michigan
Ascenta Therapeutics Inc
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Ascenta Therapeutics Inc, Sanofi Sa filed Critical Univ Michigan
Publication of AR083849A1 publication Critical patent/AR083849A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los compuestos y composiciones proporcionados en la presente se relacionan con espiro-oxindoles que funcionan como antagonistas de la interacción entre p53 y MDM2 y su uso como agentes terapéuticos para el tratamiento de cáncer y otras enfermedades.Reivindicación 1: Un compuesto que tiene la fórmula (1), en donde: R1a, R1b, R1c y R1d se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, fluoro y cloro; R2 se selecciona del grupo que consiste en aralquilo y el grupo de formula (2), en donde: R25a, R25b, R25c, R25d y R25e se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, fluoro y cloro; R3 se selecciona del grupo que consiste en alquilo C1-8 opcionalmente sustituido y arilo opcionalmente sustituido; R4 se selecciona del grupo que consiste en hidrógeno y alquilo C1-6 opcionalmente sustituido; R5 se selecciona del grupo que consiste en el grupo de formulas (3), en donde: R14 se selecciona del grupo que consiste en hidrógeno y alquilo C1-4 opcionalmente sustituido; X se selecciona del grupo que consiste en O, S y NR’; Y se selecciona del grupo que consiste en O, S y NR’’; R’ se selecciona del grupo que consiste en hidrógeno y alquilo C1-4 opcionalmente sustituido; y R’’ se selecciona del grupo que consiste en hidrógeno, alquilo C1-4 opcionalmente sustituido y -COCH3, en donde el compuesto está sustancialmente libre de otro u otros estereoisómeros, o una sal farmacéuticamente aceptable del mismo.
ARP110104223A 2010-11-12 2011-11-11 Antagonistas de mdm2 de espiro-oxindol AR083849A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US201161451968P 2011-03-11 2011-03-11
US201161451958P 2011-03-11 2011-03-11
US201161470992P 2011-04-01 2011-04-01

Publications (1)

Publication Number Publication Date
AR083849A1 true AR083849A1 (es) 2013-03-27

Family

ID=46048358

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104223A AR083849A1 (es) 2010-11-12 2011-11-11 Antagonistas de mdm2 de espiro-oxindol

Country Status (27)

Country Link
US (2) US8680132B2 (es)
EP (1) EP2638046A4 (es)
JP (1) JP2014500870A (es)
KR (1) KR101929188B1 (es)
CN (1) CN103298818B (es)
AR (1) AR083849A1 (es)
AU (1) AU2011326395B2 (es)
CA (1) CA2817585A1 (es)
CO (1) CO6721010A2 (es)
CR (1) CR20130271A (es)
DO (1) DOP2013000104A (es)
EA (1) EA201390682A1 (es)
EC (1) ECSP13012678A (es)
GT (1) GT201300118A (es)
IL (1) IL226275A0 (es)
MA (1) MA34732B1 (es)
MX (1) MX2013005238A (es)
NI (1) NI201300041A (es)
NZ (1) NZ611866A (es)
PE (1) PE20140408A1 (es)
PH (1) PH12013500955A1 (es)
SG (1) SG190230A1 (es)
TW (1) TWI535723B (es)
UA (1) UA109464C2 (es)
UY (1) UY33725A (es)
WO (1) WO2012065022A2 (es)
ZA (1) ZA201304042B (es)

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