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BRPI0507374A - moduladores do receptor de histamina-3 - Google Patents

moduladores do receptor de histamina-3

Info

Publication number
BRPI0507374A
BRPI0507374A BRPI0507374-0A BRPI0507374A BRPI0507374A BR PI0507374 A BRPI0507374 A BR PI0507374A BR PI0507374 A BRPI0507374 A BR PI0507374A BR PI0507374 A BRPI0507374 A BR PI0507374A
Authority
BR
Brazil
Prior art keywords
disorders
compound
formula
disorder
congestion
Prior art date
Application number
BRPI0507374-0A
Other languages
English (en)
Inventor
Ramalakshmi Yegn Chadrasekaran
Travis T Wager
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0507374A publication Critical patent/BRPI0507374A/pt

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

MODULADORES DO RECEPTOR DE HISTAMINA-3. A presente invenção é dirigida a um composto da fórmula l conforme definido aqui ou um farmaceuticamente aceitável do mesmo; uma composição farmacêutica contendo um composto da fórmula l, um método de tratamento de um distúrbio ou condição que pode ser tratada através de modulação dos receptores de histamina H3, o método compreendendo administração,a um mamífero que precisa de tal tratamento, de um composto da fórmula l conforme descrito acima e um método de tratamento de um distúrbio ou condição selecionada do grupo consistindo em depressão, distúrbios do humor, esquizofrenia, distúrbios de ansiedade, Mal de alzheimer, distúrbio de hiperatividade de déficit de atenção (ADHD), distúrbios psicóticos, distúrbios do sono obesidade, insónia, epilepsia, enfermidades do movimento, doenças respiratórias, alergia, respostas das vias aéreas alergia induzidas, rinite alérgica, congestão nasal congestão alérgica, congestão, hipotensão, doença cardiovascular, doenças do trato Gl, hiper e hipo motilidade e secreção ácida do troto gastrointestinal, método compeendendo administração, a um mamífero que precisa de tal tratamento, de um composto da fórmula l conforme descrito acima.
BRPI0507374-0A 2004-02-02 2005-01-24 moduladores do receptor de histamina-3 BRPI0507374A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54115104P 2004-02-02 2004-02-02
PCT/IB2005/000172 WO2005080361A1 (en) 2004-02-02 2005-01-24 Histamine-3 receptor modulators

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BRPI0507374A true BRPI0507374A (pt) 2007-07-10

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BRPI0507374-0A BRPI0507374A (pt) 2004-02-02 2005-01-24 moduladores do receptor de histamina-3

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US (1) US7115600B2 (pt)
EP (1) EP1720847A1 (pt)
JP (1) JP2007519707A (pt)
AR (1) AR047587A1 (pt)
BR (1) BRPI0507374A (pt)
CA (1) CA2555071A1 (pt)
TW (1) TW200529806A (pt)
WO (1) WO2005080361A1 (pt)

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US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
RU2449989C2 (ru) * 2006-06-23 2012-05-10 Эбботт Лэборетриз Производные циклопропиламина в качестве модуляторов h3-гистаминового рецептора
JP4585610B2 (ja) * 2007-01-22 2010-11-24 ファイザー・プロダクツ・インク 治療用化合物のトシル酸塩およびその医薬組成物
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US8383657B2 (en) * 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
US20090221648A1 (en) * 2007-12-21 2009-09-03 Abbott Laboratories Compositions for treatment of cognitive disorders
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