ECSP088965A - Derivados de 2-tioxantina que actúan como inhibidores de la mpo - Google Patents
Derivados de 2-tioxantina que actúan como inhibidores de la mpoInfo
- Publication number
- ECSP088965A ECSP088965A EC2008008965A ECSP088965A ECSP088965A EC SP088965 A ECSP088965 A EC SP088965A EC 2008008965 A EC2008008965 A EC 2008008965A EC SP088965 A ECSP088965 A EC SP088965A EC SP088965 A ECSP088965 A EC SP088965A
- Authority
- EC
- Ecuador
- Prior art keywords
- thioxantine
- mpo
- inhibitors
- derivatives
- act
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Resumen: La presente invención se relaciona con un compuesto de acuerdo a la Fórmula (I) donde R1 es seleccionado de C1-C6 alquil, y dicho C1-C6 alquil es sustituido con C1-C6 alcoxi; y al menos uno de dicho C1-C6 alquil o dicho C1-C6 alcoxi es ramificado; o un sal farmacéuticamente aceptable del mismo, solvato o solvato de una sal del mismo, con composiciones que contienen el compuesto y el uso del mismo en terapia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81091906P | 2006-06-05 | 2006-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088965A true ECSP088965A (es) | 2009-01-30 |
Family
ID=38801720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008965A ECSP088965A (es) | 2006-06-05 | 2008-12-12 | Derivados de 2-tioxantina que actúan como inhibidores de la mpo |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7943625B2 (es) |
| EP (1) | EP2029598A4 (es) |
| JP (1) | JP2009539828A (es) |
| KR (1) | KR20090014189A (es) |
| CN (1) | CN101460498A (es) |
| AR (1) | AR061134A1 (es) |
| AU (1) | AU2007256005B2 (es) |
| BR (1) | BRPI0712310A2 (es) |
| CA (1) | CA2653774A1 (es) |
| CL (1) | CL2007001590A1 (es) |
| EC (1) | ECSP088965A (es) |
| IL (1) | IL195287A0 (es) |
| MX (1) | MX2008014991A (es) |
| NO (1) | NO20085269L (es) |
| RU (1) | RU2435772C2 (es) |
| TW (1) | TW200804383A (es) |
| UA (1) | UA94606C2 (es) |
| UY (1) | UY30387A1 (es) |
| WO (1) | WO2007142576A1 (es) |
| ZA (1) | ZA200809800B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| SE0302756D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| TW200804383A (en) * | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090053176A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Combination 937 |
| US20110144049A1 (en) * | 2009-10-21 | 2011-06-16 | Serebruany Victor L | Treating Cardiac Arrhythmias, Heart Failure, Peripheral Artery Disease and Stroke with Cyclopentyl-Triazolo-Pyrimidine or Derivative Thereof |
| WO2012151576A1 (en) * | 2011-05-05 | 2012-11-08 | Robert Sackstein | Methods of treating complications and disorders associated with g-csf administration |
| BR112014011254A2 (pt) | 2011-11-11 | 2017-05-16 | Pfizer | 2-tiopirimidinonas |
| US9221821B2 (en) | 2012-06-05 | 2015-12-29 | Forest Laboratories Holdings, Limited | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds |
| WO2015134210A1 (en) | 2014-03-03 | 2015-09-11 | Principia Biopharma, Inc. | BENZIMIDAZOLE DERIVATIVES AS RLK and ITK INHIBITORS |
| WO2015196245A1 (en) * | 2014-06-25 | 2015-12-30 | Adelaide Research & Innovation Pty Ltd | Modulation of osteogenesis and or angiogenesis by modulating peroxidase functionality |
| US9616063B2 (en) | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| AU2016257179A1 (en) | 2015-05-05 | 2017-11-02 | Pfizer Inc. | 2-thiopyrimidinones |
| WO2016191172A1 (en) | 2015-05-22 | 2016-12-01 | Principia Biopharma Inc. | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
| PE20180521A1 (es) | 2015-06-03 | 2018-03-14 | Principia Biopharma Inc | Inhibidores de tirosina-cinasas |
| JP2025528217A (ja) | 2022-08-18 | 2025-08-26 | アストラゼネカ・アクチエボラーグ | ミエロペルオキシダーゼの阻害剤 |
| CN120265633A (zh) * | 2022-12-09 | 2025-07-04 | 深圳信立泰药业股份有限公司 | 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途 |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3135753A (en) * | 1961-05-10 | 1964-06-02 | Burroughs Wellcome Co | Alkylthiopurines and method |
| SE7810947L (sv) | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
| GB8418430D0 (en) * | 1984-07-19 | 1984-08-22 | Beecham Wuelfing Gmbh & Co Kg | Treatment |
| US4710503A (en) | 1985-02-07 | 1987-12-01 | Euroceltique S.A. | 6-thioxanthine derivatives |
| WO1989006125A1 (en) | 1987-12-31 | 1989-07-13 | Smithkline Beckman Corporation | 4-aralkyl-5-substituted-1,2,4-triazole-5-thiols |
| DK440989A (da) | 1988-09-12 | 1990-03-13 | Smithkline Beecham Corp | Dopamin-beta-hydroxylase inhibitorer |
| JPH02160235A (ja) | 1988-12-13 | 1990-06-20 | Konica Corp | ハロゲン化銀カラー写真画像の形成方法 |
| AU5436790A (en) * | 1989-04-19 | 1990-11-16 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Sulfer-containing xanthine derivatives as adenosin antagonists |
| EP0430300A3 (en) | 1989-12-01 | 1992-03-25 | Takeda Chemical Industries, Ltd. | Xanthine derivatives, their production and use |
| US5100906A (en) | 1990-04-19 | 1992-03-31 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers |
| FR2665636B1 (fr) * | 1990-08-10 | 1994-10-07 | Adir | Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer. |
| US6046019A (en) * | 1991-07-09 | 2000-04-04 | Goumeniouk; Alexander P. | Diagnostic kits and methods for making granulocyte cell counts |
| US6469017B1 (en) | 1998-01-16 | 2002-10-22 | Cell Therapeutics, Inc. | Method of inhibiting interleukin-12 signaling |
| GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| PL314605A1 (en) * | 1993-11-26 | 1996-09-16 | Pfizer | Isoxazolin compounds as anti-inflammatory agents |
| US5489598A (en) * | 1994-06-08 | 1996-02-06 | Warner-Lambert Company | Cytoprotection utilizing aryltriazol-3-thiones |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| CA2206287C (en) * | 1994-12-13 | 2001-03-20 | Mark Chasin | Aryl thioxanthines |
| WO1996018400A1 (en) | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| US5756511A (en) * | 1995-04-03 | 1998-05-26 | Cell Therapeutics, Inc. | Method for treating symptoms of a neurodegenerative condition |
| US6294541B1 (en) * | 1996-06-06 | 2001-09-25 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| DE19707655A1 (de) * | 1997-02-26 | 1998-08-27 | Hoechst Ag | Kombinationspräparat zur Anwendung bei Demenz |
| US5976823A (en) * | 1997-03-19 | 1999-11-02 | Integrated Biomedical Technology, Inc. | Low range total available chlorine test strip |
| WO1999012546A1 (en) | 1997-09-05 | 1999-03-18 | Kyowa Hakko Kogyo Co., Ltd. | Remedial agent for neural degeneration |
| WO1999014204A1 (en) | 1997-09-16 | 1999-03-25 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
| AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| US6319928B1 (en) * | 1998-11-30 | 2001-11-20 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| DZ3019A1 (fr) | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
| JP2002541078A (ja) | 1999-04-02 | 2002-12-03 | ユーロ−セルティーク，エス．エー． | ホスホジエステラーゼｉｖ阻害活性を有するプリン誘導体 |
| GB2362101A (en) | 2000-05-12 | 2001-11-14 | Astrazeneca Ab | Treatment of chronic obstructive pulmonary disease |
| FR2811989A1 (fr) | 2000-07-18 | 2002-01-25 | Sanofi Synthelabo | Derives de polyfluoroalkytriazole, leur preparation et leur application en therapeutique |
| US6855817B2 (en) | 2000-07-21 | 2005-02-15 | Mark B. Lyles | Materials and methods for binding nucleic acids to surfaces |
| FR2819723B1 (fr) * | 2001-01-23 | 2006-11-17 | Arnaud Mainnemare | Composition halogene, son procede de preparation et ses utilisations |
| WO2002066447A1 (en) | 2001-02-21 | 2002-08-29 | Ono Pharmaceutical Co., Ltd. | 4h-1,2,4-triazole-3(2h)-thione deratives as sphingomyelinase inhibitors |
| SE0103766D0 (sv) * | 2001-11-09 | 2001-11-09 | Astrazeneca Ab | Novel assay |
| JP4095446B2 (ja) | 2001-05-08 | 2008-06-04 | アストラゼネカ・アクチエボラーグ | 酵素ミエロペルオキシダーゼの阻害剤を検出するための検定 |
| ES2193839B1 (es) | 2001-06-22 | 2005-02-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de 6-fenildihidropirrolpirimidindiona. |
| ES2208063B1 (es) | 2002-04-01 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de la 4-(pirrolopirimidin-6-il)bencenosulfonamida. |
| AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| RU2223273C1 (ru) * | 2002-08-16 | 2004-02-10 | Давлетьярова Альпия Васильевна | Производные 1,3-диметил-8-(2-гидроксипропил-1) тиоксантина, проявляющие биологическую активность |
| SE0301232D0 (sv) | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| SE0302756D0 (sv) | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
| MXPA06004789A (es) | 2003-10-31 | 2006-07-03 | Cv Therapeutics Inc | Antagonistas del receptor de adenosina a2b. |
| BRPI0507604A (pt) | 2004-02-14 | 2007-07-03 | Smithkline Beecham Corp | medicamentos com atividade de receptor hm74a |
| WO2006045564A1 (en) | 2004-10-22 | 2006-05-04 | Smithkline Beecham Corporation | Xanthine derivatives with hm74a receptor activity |
| SE0402591D0 (sv) | 2004-10-25 | 2004-10-25 | Astrazeneca Ab | Novel use |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| TW200804383A (en) * | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
-
2007
- 2007-05-30 TW TW096119344A patent/TW200804383A/zh unknown
- 2007-05-31 AR ARP070102350A patent/AR061134A1/es not_active Application Discontinuation
- 2007-06-01 CL CL2007001590A patent/CL2007001590A1/es unknown
- 2007-06-01 US US11/756,967 patent/US7943625B2/en not_active Expired - Fee Related
- 2007-06-04 CA CA002653774A patent/CA2653774A1/en not_active Abandoned
- 2007-06-04 AU AU2007256005A patent/AU2007256005B2/en not_active Ceased
- 2007-06-04 US US12/300,673 patent/US20090131459A1/en not_active Abandoned
- 2007-06-04 CN CNA2007800209903A patent/CN101460498A/zh active Pending
- 2007-06-04 BR BRPI0712310-8A patent/BRPI0712310A2/pt not_active IP Right Cessation
- 2007-06-04 RU RU2008145971/04A patent/RU2435772C2/ru not_active IP Right Cessation
- 2007-06-04 JP JP2009514228A patent/JP2009539828A/ja active Pending
- 2007-06-04 MX MX2008014991A patent/MX2008014991A/es active IP Right Grant
- 2007-06-04 UA UAA200813045A patent/UA94606C2/ru unknown
- 2007-06-04 WO PCT/SE2007/000537 patent/WO2007142576A1/en not_active Ceased
- 2007-06-04 UY UY30387A patent/UY30387A1/es unknown
- 2007-06-04 KR KR1020087029646A patent/KR20090014189A/ko not_active Withdrawn
- 2007-06-04 EP EP07748200A patent/EP2029598A4/en not_active Withdrawn
-
2008
- 2008-11-13 IL IL195287A patent/IL195287A0/en unknown
- 2008-11-17 ZA ZA200809800A patent/ZA200809800B/xx unknown
- 2008-12-12 EC EC2008008965A patent/ECSP088965A/es unknown
- 2008-12-16 NO NO20085269A patent/NO20085269L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009539828A (ja) | 2009-11-19 |
| MX2008014991A (es) | 2008-12-05 |
| EP2029598A1 (en) | 2009-03-04 |
| NO20085269L (no) | 2009-03-05 |
| RU2435772C2 (ru) | 2011-12-10 |
| UY30387A1 (es) | 2008-01-31 |
| CA2653774A1 (en) | 2007-12-13 |
| US20080221133A1 (en) | 2008-09-11 |
| CN101460498A (zh) | 2009-06-17 |
| UA94606C2 (ru) | 2011-05-25 |
| CL2007001590A1 (es) | 2008-01-25 |
| US7943625B2 (en) | 2011-05-17 |
| TW200804383A (en) | 2008-01-16 |
| KR20090014189A (ko) | 2009-02-06 |
| US20090131459A1 (en) | 2009-05-21 |
| WO2007142576A1 (en) | 2007-12-13 |
| BRPI0712310A2 (pt) | 2012-01-17 |
| RU2008145971A (ru) | 2010-07-20 |
| EP2029598A4 (en) | 2010-02-17 |
| AU2007256005B2 (en) | 2011-03-17 |
| IL195287A0 (en) | 2009-08-03 |
| AR061134A1 (es) | 2008-08-06 |
| ZA200809800B (en) | 2010-04-28 |
| AU2007256005A1 (en) | 2007-12-13 |
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