[go: up one dir, main page]

AR059016A4 - Derivados de aril-isoxazol-4-il-imidazo[1,2-a]piridina, metodo de preparacion, medicamentos que los contienen y usos en el tratamiento de trastornos cognitivos. - Google Patents

Derivados de aril-isoxazol-4-il-imidazo[1,2-a]piridina, metodo de preparacion, medicamentos que los contienen y usos en el tratamiento de trastornos cognitivos.

Info

Publication number
AR059016A4
AR059016A4 ARM070100173A ARM070100173A AR059016A4 AR 059016 A4 AR059016 A4 AR 059016A4 AR M070100173 A ARM070100173 A AR M070100173A AR M070100173 A ARM070100173 A AR M070100173A AR 059016 A4 AR059016 A4 AR 059016A4
Authority
AR
Argentina
Prior art keywords
lower alkyl
links
heteroaryl
isoxazol
imidazo
Prior art date
Application number
ARM070100173A
Other languages
English (en)
Inventor
Andrew Thomas
Bernd Buettelmann
Bo Han
Henner Knust
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37965110&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR059016(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR059016A4 publication Critical patent/AR059016A4/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados de aril-isoxazol-4-il-imidazo[1,2-a]piridina de la formula (1) en la que R1 es hidrogeno, halogeno, hidroxi, alquilo inferior, benciloxi u -O-(CH2)-(CO)-heteroarilo de 5 o 6 eslabones opcionalmente sustituido por arilo o por alquilo inferior; R2 es H, halogeno, alquilo inferior, alquinilo inferior, amino,-NHC(O)-R' o -(CO)-R'; R' es H, halogeno, ciano, alquilo inferior, alquinilo inferior, amino, -NHC(O)-Ra, -(CO)-Ra, -heterocicloalquilo de 5 o 6 eslabones en la posicion 1, opcionalmente sustituido por =O o es un heteroarilo de 5 o 6 eslabones en la posicion 1; R4 es hidrogeno o -heteroarilo de 5 o 6 eslabones; R5 es alquilo inferior o cicloalquilo; Ra es alcoxi inferior o NR'Rö, en el que R' y Rö con independencia entre sí son hidrogeno, alquilo inferior opcionalmente sustituido por hidroxi, alquinilo inferior, -(CH2)n-cicloalquilo, -(CH2)n-heterocicloalquilo de 5 o 6 eslabones o -(CH2)n-heteroarilo de 5 o 6 eslabones; n es un numero de 0 a 3; así como a las sales de adicion de ácido farmacéuticamente aceptables de los mismos. Se ha encontrado que este grupo de compuestos presentan una gran afinidad y selectividad para los sitios de fijacion del receptor GABA A alfa5 y pueden ser utiles como mejoradores cognitivos o para el tratamiento de trastornos cognitivos, por ejemplo la enfermedad de Alzheimer.
ARM070100173A 2006-01-17 2007-01-16 Derivados de aril-isoxazol-4-il-imidazo[1,2-a]piridina, metodo de preparacion, medicamentos que los contienen y usos en el tratamiento de trastornos cognitivos. AR059016A4 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06100426 2006-01-17

Publications (1)

Publication Number Publication Date
AR059016A4 true AR059016A4 (es) 2008-03-05

Family

ID=37965110

Family Applications (1)

Application Number Title Priority Date Filing Date
ARM070100173A AR059016A4 (es) 2006-01-17 2007-01-16 Derivados de aril-isoxazol-4-il-imidazo[1,2-a]piridina, metodo de preparacion, medicamentos que los contienen y usos en el tratamiento de trastornos cognitivos.

Country Status (15)

Country Link
US (1) US7585874B2 (es)
EP (1) EP1979350A1 (es)
JP (1) JP4913157B2 (es)
KR (1) KR101062583B1 (es)
CN (1) CN101370807B (es)
AR (1) AR059016A4 (es)
AU (1) AU2007207053B2 (es)
BR (1) BRPI0706560A2 (es)
CA (1) CA2636112A1 (es)
IL (1) IL192636A0 (es)
NO (1) NO20082956L (es)
RU (1) RU2426732C2 (es)
TW (1) TWI338691B (es)
WO (1) WO2007082806A1 (es)
ZA (1) ZA200805839B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009005478A (es) 2006-11-27 2009-08-12 Lundbeck & Co As H Derivados de heteroarilamida.
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
ATE519760T1 (de) 2007-06-22 2011-08-15 Hoffmann La Roche Isoxazolimidazolderivate
EP2767536B1 (en) 2007-12-04 2015-09-02 F. Hoffmann-La Roche AG Isoxazolo-pyridine derivatives
PH12012500355A1 (en) * 2009-09-24 2019-11-29 Hoffmann La Roche Imidazopyridine or imidazopyrimidine derivatives as phosphodiesterase 10a inhibitors
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
US9301962B2 (en) 2010-05-14 2016-04-05 Baylor College Of Medicine Male contraceptive compositions and methods of use
EP2569434B1 (en) 2010-05-14 2019-09-04 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia and related disorders
AU2011252808B2 (en) 2010-05-14 2015-05-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
EP2925756B1 (en) * 2012-11-29 2017-02-01 F. Hoffmann-La Roche AG Imidazopyridine derivatives
WO2014159392A1 (en) 2013-03-14 2014-10-02 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
KR20170094001A (ko) * 2013-04-29 2017-08-16 에프. 호프만-라 로슈 아게 2-페닐 또는 2-헤트아릴 이미다졸[1,2-a]피리딘 유도체
US9975896B2 (en) 2013-07-25 2018-05-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
EP3066101B1 (en) 2013-11-08 2020-07-29 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
CN106029653A (zh) 2014-01-31 2016-10-12 达纳-法伯癌症研究所股份有限公司 二氨基嘧啶苯砜衍生物及其用途
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
HK1225383A1 (zh) 2014-01-31 2017-09-08 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
CN106456653A (zh) 2014-02-28 2017-02-22 腾沙治疗公司 高胰岛素血症相关病症的治疗
MX2017001757A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
BR112017002369A2 (pt) 2014-08-08 2017-12-05 Dana Farber Cancer Inst Inc derivados de diazepana e usos dos mesmos
EP3212654B1 (en) 2014-10-27 2020-04-08 Tensha Therapeutics, Inc. Bromodomain inhibitors
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS
PE20181086A1 (es) 2015-09-11 2018-07-05 Dana Farber Cancer Inst Inc Acetamida tienotrizolodiazepinas y usos de las mismas
RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
MX2018006499A (es) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos.
PL3697785T3 (pl) * 2017-10-18 2023-08-07 Jubilant Epipad LLC Związki imidazopirydynowe jako inhibitory pad

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE258554T1 (de) * 1999-10-08 2004-02-15 Gruenenthal Gmbh Bicyclische imidazo-3-yl-aminderivate
IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
WO2002002557A2 (en) * 2000-06-30 2002-01-10 Neurogen Corporation 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
US6596731B2 (en) * 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
PL366624A1 (en) 2001-07-05 2005-02-07 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as mch selective antagonists
GB0212048D0 (en) * 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
JPWO2004035522A1 (ja) * 2002-08-30 2006-02-16 株式会社 ビーエフ研究所 プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤
WO2004076452A1 (en) * 2003-02-26 2004-09-10 Merck Sharp & Dohme Limited 5,8-DIFLUOROIMIDAZO[1,2-a]PYRIDINES AS GABA-A α2/α3 LIGANDS FOR TREATING ANXIETY AND/OR DEPRESSION
WO2005123672A2 (en) 2004-06-14 2005-12-29 Takeda San Diego, Inc. Kinase inhibitors

Also Published As

Publication number Publication date
CA2636112A1 (en) 2007-07-26
TW200736257A (en) 2007-10-01
AU2007207053A1 (en) 2007-07-26
JP4913157B2 (ja) 2012-04-11
NO20082956L (no) 2008-08-06
CN101370807A (zh) 2009-02-18
WO2007082806A1 (en) 2007-07-26
IL192636A0 (en) 2009-02-11
CN101370807B (zh) 2011-08-31
AU2007207053B2 (en) 2012-05-24
JP2009523752A (ja) 2009-06-25
KR20080075924A (ko) 2008-08-19
US20070179178A1 (en) 2007-08-02
RU2008126807A (ru) 2010-02-27
TWI338691B (en) 2011-03-11
EP1979350A1 (en) 2008-10-15
ZA200805839B (en) 2009-09-30
US7585874B2 (en) 2009-09-08
KR101062583B1 (ko) 2011-09-06
BRPI0706560A2 (pt) 2011-03-29
RU2426732C2 (ru) 2011-08-20

Similar Documents

Publication Publication Date Title
AR059016A4 (es) Derivados de aril-isoxazol-4-il-imidazo[1,2-a]piridina, metodo de preparacion, medicamentos que los contienen y usos en el tratamiento de trastornos cognitivos.
PE20071009A1 (es) Compuestos derivados de fenoxipiperidinas como antagonistas de histamina h3
AR064608A1 (es) Derivados de pirazolo-quinazolina sustituidos, composiciones farmaceuticas que los contienen. proceso para su preparacion y uso de los mismos como agentes anticancer.
AR038419A1 (es) Derivados de piridina y quinolina
UY28374A1 (es) Agentes terapéuticos
AR058728A1 (es) Derivados de aril-isoxazol-4-il-imidazo[1,5-a]piridina, metodo de preparacion,medicamentos que los contienen y usos en el tratamiento de trastornos cognitivos.
AR044402A1 (es) Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.
AR046272A1 (es) Inhibidores de dipeptidil peptidasa iv
AR048567A1 (es) Derivados de benzoxazinona, su preparacion y composiciones farmaceuticas.
AR043658A1 (es) Derivados 8-substituidos-6,7,8,9-tetrahidropirimido[1,2-a]pirimidin-4-ona
AR065587A1 (es) Aminoamidas como antagonistas de orexina
AR045155A1 (es) Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos
AR035945A1 (es) Derivados de piperacina, su uso en la preparacion de medicamentos, procedimiento para la preparacion de dichos compuestos, composiciones farmaceuticas que comprenden dichos compuestos, y metodo para preparar dichas composiciones
AR045156A1 (es) Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos
AR046077A1 (es) Derivados de n4- oxicarbonilcitimidina, procedimientos de eleaboracion y usos de los mismos
HRP20090565T1 (hr) Novi triciklički derivati, postupak njihove priprave i farmaceutski pripravci koji ih sadrže
CA3103932A1 (en) Pyridinyl pyrazoles as modulators of roryt
ECSP088257A (es) Derivados de amida
ES2912223T3 (es) Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida
AR070910A1 (es) Derivados de sulfonamida sustituida
GB0507601D0 (en) Compounds
AR075160A1 (es) Derivados de aril y/o heteroaril piperidinas sustituidas, medicamentos que las contienen, proceso para prepararlas y uso de las mismas para el tratamiento de trastornos neurologicos y neuropsiquiatricos.
UY28839A1 (es) Agentes terapeuticos
AR054813A1 (es) Derivados de pirroloquinolinas y sus usos como inhibidores de proteinas quinasas
AR036166A1 (es) Compuestos de octahidro-2h-pirido[1,2-a]piracina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Legal Events

Date Code Title Description
FA Abandonment or withdrawal