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AR057056A1 - Proceso para la sintesis de imidazol bencilaminas - Google Patents

Proceso para la sintesis de imidazol bencilaminas

Info

Publication number
AR057056A1
AR057056A1 ARP060102367A ARP060102367A AR057056A1 AR 057056 A1 AR057056 A1 AR 057056A1 AR P060102367 A ARP060102367 A AR P060102367A AR P060102367 A ARP060102367 A AR P060102367A AR 057056 A1 AR057056 A1 AR 057056A1
Authority
AR
Argentina
Prior art keywords
imidazol
bencilaminas
synthesis
methyl
halogen
Prior art date
Application number
ARP060102367A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37149980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057056(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR057056A1 publication Critical patent/AR057056A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicacion 1: Un proceso para la preparacion de 5-(4-metil-1H-imidazol-1-il)-3-(trifluoro-metil)-bencenamina (I), el cual comprende hacer reaccionar 4-metil-1H-imidazol, o una sal del mismo, y un compuesto de formula (1) en donde: X es halogeno, sulfonato, o NO2; e Y es NH2, NO2, halogeno, o CN, en la presencia de una base adecuada o de un catalizador de metal de transicion adecuado o una combinacion de los mismos, en un solvente apropiado.
ARP060102367A 2005-06-09 2006-06-07 Proceso para la sintesis de imidazol bencilaminas AR057056A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68897605P 2005-06-09 2005-06-09

Publications (1)

Publication Number Publication Date
AR057056A1 true AR057056A1 (es) 2007-11-14

Family

ID=37149980

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102367A AR057056A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de imidazol bencilaminas

Country Status (25)

Country Link
US (2) US7781597B2 (es)
EP (3) EP2292607B1 (es)
JP (2) JP5225078B2 (es)
KR (2) KR101283109B1 (es)
CN (6) CN102174021B (es)
AR (1) AR057056A1 (es)
AT (1) ATE540931T1 (es)
AU (3) AU2006258050B2 (es)
BR (1) BRPI0611683A2 (es)
CA (4) CA2833394C (es)
DK (2) DK2266961T3 (es)
ES (3) ES2465522T3 (es)
GT (1) GT200600202AA (es)
HU (1) HUE028024T2 (es)
IN (2) IN2014DN08578A (es)
JO (1) JO2758B1 (es)
MX (1) MX2007015609A (es)
MY (1) MY146795A (es)
PE (3) PE20100716A1 (es)
PL (3) PL1896426T3 (es)
PT (3) PT1896426E (es)
RU (1) RU2446162C2 (es)
SI (2) SI2292607T1 (es)
TW (1) TWI380981B (es)
WO (1) WO2006135640A2 (es)

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MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
WO2008154528A2 (en) 2007-06-13 2008-12-18 E. I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
SI2182945T1 (sl) 2007-06-27 2015-12-31 E.I. Du Pont De Nemours And Company Metoda za zatiranje škodljivcev pri živalih
TWI461411B (zh) 2007-08-17 2014-11-21 Du Pont 製備５－鹵烷基－４，５－二氫異唑衍生物之方法
KR20100075996A (ko) 2007-10-03 2010-07-05 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물
TWI455919B (zh) 2008-04-09 2014-10-11 Du Pont 製備３－三氟甲基查耳酮（ｃｈａｌｃｏｎｅ）之方法
US20100016590A1 (en) 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
KR20120111743A (ko) 2008-11-05 2012-10-10 테바 파마슈티컬 인더스트리즈 리미티드 닐로티닙 ＨＣｌ 결정형
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) * 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
US9156852B2 (en) 2011-12-30 2015-10-13 Hanmi Pharm. Co., Ltd Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases
CN102592837B (zh) * 2012-03-12 2014-01-15 河北师范大学 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
CN104592122B (zh) * 2014-12-09 2018-01-23 凯莱英医药集团（天津）股份有限公司 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) * 2015-03-04 2018-04-03 埃斯特维华义制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) * 2017-05-09 2019-08-27 吉林凯莱英医药化学有限公司 芳香化合物的硝化方法
WO2019130254A1 (en) * 2018-01-01 2019-07-04 Laurus Labs Ltd An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh) 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
TWI787523B (zh) 2018-06-15 2022-12-21 漢達生技醫藥股份有限公司 達沙替尼十二烷基硫酸鹽之結晶
CN112105603B (zh) * 2019-04-06 2024-01-30 特里纳普克公司 磺酰基二唑和n-(氟磺酰基)唑及其制备方法
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836B (zh) * 2021-02-23 2024-05-31 四川青木制药有限公司 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法
CN116478319B (zh) * 2022-11-07 2025-07-01 华北电力大学 一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用
CN115626880B (zh) * 2022-11-15 2023-11-14 常州大学 3-硝基-5-氰基三氟甲苯的合成方法
CN118108670B (zh) * 2023-12-28 2025-07-01 江苏希迪制药有限公司 尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法

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GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
PE20040522A1 (es) * 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
CN1939910A (zh) * 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
GT200600207A (es) * 2005-06-09 2007-01-15 Novartis Ag Proceso para la síntesis de compuestos orgánicos
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds

Also Published As

Publication number Publication date
US20100280257A1 (en) 2010-11-04
KR101249199B1 (ko) 2013-04-03
RU2446162C2 (ru) 2012-03-27
CA2942046A1 (en) 2006-12-21
US7781597B2 (en) 2010-08-24
AU2010241374A1 (en) 2010-12-02
TW200716563A (en) 2007-05-01
WO2006135640A3 (en) 2007-08-02
CN102174020A (zh) 2011-09-07
RU2007148238A (ru) 2009-07-20
PL1896426T3 (pl) 2012-06-29
PT2266961E (pt) 2016-02-05
ES2380489T8 (es) 2012-06-22
JP2013035855A (ja) 2013-02-21
CN102174019B (zh) 2013-02-13
EP2292607A2 (en) 2011-03-09
CN102174020B (zh) 2012-11-07
PT2292607E (pt) 2014-06-24
ES2465522T3 (es) 2014-06-06
IN2014DN08588A (es) 2015-07-10
US8008504B2 (en) 2011-08-30
DK2266961T3 (en) 2016-01-25
CN102180836B (zh) 2012-11-21
CA2833394A1 (en) 2006-12-21
GT200600202AA (es) 2014-06-09
EP2292607A3 (en) 2011-04-27
CN102174021A (zh) 2011-09-07
DK2292607T3 (da) 2014-06-30
EP2292607B1 (en) 2014-04-09
CN102180836A (zh) 2011-09-14
PL2292607T3 (pl) 2014-09-30
BRPI0611683A2 (pt) 2010-09-28
JP2008546645A (ja) 2008-12-25
MY146795A (en) 2012-09-28
ATE540931T1 (de) 2012-01-15
EP2266961A2 (en) 2010-12-29
EP2266961B1 (en) 2015-10-21
TWI380981B (zh) 2013-01-01
EP1896426B1 (en) 2012-01-11
CA2833394C (en) 2016-03-29
AU2011201044A1 (en) 2011-03-31
MX2007015609A (es) 2008-02-25
CN102174019A (zh) 2011-09-07
CA2611280A1 (en) 2006-12-21
CA2886482C (en) 2017-09-05
PE20100715A1 (es) 2010-10-25
KR20120099028A (ko) 2012-09-06
IN2014DN08578A (es) 2015-07-10
AU2010241374B2 (en) 2011-11-03
AU2006258050A1 (en) 2006-12-21
WO2006135640A2 (en) 2006-12-21
ES2558696T3 (es) 2016-02-08
KR20080014010A (ko) 2008-02-13
SI2292607T1 (sl) 2014-09-30
PE20070109A1 (es) 2007-04-02
HUE028024T2 (en) 2016-11-28
ES2380489T3 (es) 2012-05-14
US20080200692A1 (en) 2008-08-21
PT1896426E (pt) 2012-04-12
CA2611280C (en) 2014-01-28
CN101189212B (zh) 2011-05-18
PE20100716A1 (es) 2010-10-25
CN101189212A (zh) 2008-05-28
KR101283109B1 (ko) 2013-07-05
CA2886482A1 (en) 2006-12-21
EP1896426A2 (en) 2008-03-12
CN102174021B (zh) 2013-02-27
EP2266961A3 (en) 2011-07-27
JO2758B1 (en) 2014-03-15
SI2266961T1 (sl) 2016-02-29
AU2006258050B2 (en) 2010-12-09
PL2266961T3 (pl) 2016-04-29
CN102180796A (zh) 2011-09-14
JP5225078B2 (ja) 2013-07-03

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