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AR044706A2 - Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp - Google Patents

Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp

Info

Publication number
AR044706A2
AR044706A2 ARP040102071A ARP040102071A AR044706A2 AR 044706 A2 AR044706 A2 AR 044706A2 AR P040102071 A ARP040102071 A AR P040102071A AR P040102071 A ARP040102071 A AR P040102071A AR 044706 A2 AR044706 A2 AR 044706A2
Authority
AR
Argentina
Prior art keywords
aminoquinolins
procedures
prepare
cetp inhibitors
compound
Prior art date
Application number
ARP040102071A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR044706A2 publication Critical patent/AR044706A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un procedimiento para preparar un compuesto de fórmula (1), que comprende combinar el compuesto de fórmula (2), con un haluro de 3,5-bis(trifluorometil)bencilo en presencia de una base.
ARP040102071A 2001-04-30 2004-06-15 Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp AR044706A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30

Publications (1)

Publication Number Publication Date
AR044706A2 true AR044706A2 (es) 2005-09-21

Family

ID=23103272

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP020101575A AR035963A1 (es) 2001-04-30 2002-04-29 Compuestos derivados de trifluormetilbenceno utiles como intermedios de los inhibidores de la proteina de transferencia del ester de colesterilo y procedimientos para su preparacion
ARP020101576A AR036331A1 (es) 2001-04-30 2002-04-29 Compuestos utiles como intermediarios en la elaboracion de inhibidores de cetp y procedimiento para obtener dichos intermediarios e inhibidores
ARP040102071A AR044706A2 (es) 2001-04-30 2004-06-15 Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP020101575A AR035963A1 (es) 2001-04-30 2002-04-29 Compuestos derivados de trifluormetilbenceno utiles como intermedios de los inhibidores de la proteina de transferencia del ester de colesterilo y procedimientos para su preparacion
ARP020101576A AR036331A1 (es) 2001-04-30 2002-04-29 Compuestos utiles como intermediarios en la elaboracion de inhibidores de cetp y procedimiento para obtener dichos intermediarios e inhibidores

Country Status (24)

Country Link
US (3) US6689897B2 (es)
EP (2) EP1425270B1 (es)
JP (2) JP3924250B2 (es)
KR (2) KR100591998B1 (es)
CN (3) CN1267411C (es)
AR (3) AR035963A1 (es)
AT (2) ATE316957T1 (es)
AU (1) AU2002253448B2 (es)
BR (2) BR0209291A (es)
CA (2) CA2445623A1 (es)
CZ (2) CZ20032898A3 (es)
DE (2) DE60209004T2 (es)
DK (2) DK1383734T3 (es)
ES (2) ES2259080T3 (es)
HU (2) HU225777B1 (es)
IL (2) IL157544A0 (es)
MX (2) MXPA03009935A (es)
PL (2) PL366700A1 (es)
PT (1) PT1425270E (es)
RU (2) RU2259355C2 (es)
TW (1) TWI250974B (es)
WO (2) WO2002088069A2 (es)
YU (2) YU84303A (es)
ZA (2) ZA200306599B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
CA2500582A1 (en) 2002-10-04 2004-04-22 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
ATE461700T1 (de) 2002-12-20 2010-04-15 Pfizer Prod Inc Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
EP1594843B1 (en) 2003-02-18 2013-05-22 Takasago International Corporation METHOD FOR PRODUCING AN OPTICALLY ACTIVE beta-amino acid derivative
CA2515789A1 (en) * 2003-03-17 2004-09-30 Kaneka Corporation Method for producing(r)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
CN101342162A (zh) 2003-09-26 2009-01-14 日本烟草产业株式会社 抑制残余脂蛋白产生的方法
HRP20090581T1 (hr) * 2003-10-08 2009-12-31 Eli Lilly And Company Spojevi i postupci za liječenje dislipidemije
WO2005046662A2 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
AR048528A1 (es) * 2004-04-07 2006-05-03 Millennium Pharm Inc Compuestos derivados de quinolina como antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias y composiciones farmacéuticas que los contienen.
MXPA06014716A (es) * 2004-06-24 2007-03-12 Lilly Co Eli Compuestos y metodos para el tratamiento de dislipidemia.
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
WO2006091674A1 (en) 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
WO2006137774A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the production of (alkoxycarbonylamino)alkyl sulfonates
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
AR077208A1 (es) 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
BR112013026280A2 (pt) 2011-04-12 2024-04-30 Chong Kun Dang Pharmaceutical Corp Derivados de cicloalquenil arila para inibidor da cetp
ES2683350T3 (es) * 2011-07-08 2018-09-26 Novartis Ag Método para tratar la aterosclerosis en sujetos con alto nivel de triglicéridos
JP6166385B2 (ja) 2013-01-31 2017-07-19 チョン クン ダン ファーマシューティカル コーポレーション コレステロールエステル転送蛋白質（ｃｅｔｐ）抑制剤としてのビアリールまたは複素環式ビアリール置換シクロヘキセン誘導体化合物
US9458180B2 (en) * 2013-11-11 2016-10-04 Lonza Ltd. Method for preparation of cyano compounds of the 13th group with a lewis acid
KR102572626B1 (ko) * 2014-08-12 2023-08-30 뉴암스테르담 파마 비.브이. 테트라하이드로퀴놀린 유도체 제조용의 합성 중간체를 제조하기 위한 방법
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205037B (es) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
CA2336691C (en) 1998-07-10 2009-02-10 Massachusetts Institute Of Technology Ligands for metals and metal-catalyzed processes
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.

Also Published As

Publication number Publication date
US20030216576A1 (en) 2003-11-20
WO2002088069A2 (en) 2002-11-07
IL157546A0 (en) 2004-03-28
JP2004527556A (ja) 2004-09-09
JP2004531541A (ja) 2004-10-14
DK1383734T3 (da) 2006-05-15
YU84403A (sh) 2006-08-17
HUP0304041A2 (hu) 2004-04-28
JP3924250B2 (ja) 2007-06-06
YU84303A (sh) 2006-05-25
HK1062294A1 (en) 2004-10-29
CZ20032898A3 (cs) 2004-07-14
CZ20032900A3 (cs) 2004-06-16
US6689897B2 (en) 2004-02-10
AR035963A1 (es) 2004-07-28
CN1267411C (zh) 2006-08-02
IL157544A0 (en) 2004-03-28
DE60210265D1 (de) 2006-05-18
DE60210265T2 (de) 2006-10-12
EP1425270A2 (en) 2004-06-09
CA2445623A1 (en) 2002-11-07
CN1529696A (zh) 2004-09-15
KR20040030603A (ko) 2004-04-09
RU2259355C2 (ru) 2005-08-27
DE60209004T2 (de) 2006-09-28
HUP0304039A2 (hu) 2004-03-29
KR100591998B1 (ko) 2006-06-22
PL366584A1 (en) 2005-02-07
CN1505609A (zh) 2004-06-16
EP1425270B1 (en) 2006-03-29
TWI250974B (en) 2006-03-11
RU2003131871A (ru) 2005-04-10
CN1297541C (zh) 2007-01-31
JP3924251B2 (ja) 2007-06-06
HUP0304041A3 (en) 2005-08-29
EP1383734A2 (en) 2004-01-28
US6706881B2 (en) 2004-03-16
ATE316957T1 (de) 2006-02-15
KR100639745B1 (ko) 2006-10-30
DE60209004D1 (de) 2006-04-13
AU2002253448B2 (en) 2007-07-05
RU2003131870A (ru) 2005-01-27
EP1383734B1 (en) 2006-02-01
ZA200306600B (en) 2004-08-25
RU2265010C2 (ru) 2005-11-27
HU225777B1 (en) 2007-08-28
ATE321755T1 (de) 2006-04-15
HUP0304039A3 (en) 2005-10-28
KR20040015200A (ko) 2004-02-18
WO2002088069A9 (en) 2003-12-04
US20020177716A1 (en) 2002-11-28
CA2445693A1 (en) 2002-11-07
WO2002088085A3 (en) 2004-03-25
MXPA03009936A (es) 2004-01-29
US20030073843A1 (en) 2003-04-17
WO2002088085A2 (en) 2002-11-07
DK1425270T3 (da) 2006-07-03
WO2002088069A3 (en) 2003-02-20
MXPA03009935A (es) 2004-01-29
US6600045B2 (en) 2003-07-29
ES2259080T3 (es) 2006-09-16
ZA200306599B (en) 2004-10-22
PL366700A1 (en) 2005-02-07
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
PT1425270E (pt) 2006-07-31
ES2256461T3 (es) 2006-07-16
CN1680292A (zh) 2005-10-12
BR0209291A (pt) 2004-07-13
CN100357265C (zh) 2007-12-26

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