[go: up one dir, main page]

EA200801199A1 - Ингибиторы киназы - Google Patents

Ингибиторы киназы

Info

Publication number
EA200801199A1
EA200801199A1 EA200801199A EA200801199A EA200801199A1 EA 200801199 A1 EA200801199 A1 EA 200801199A1 EA 200801199 A EA200801199 A EA 200801199A EA 200801199 A EA200801199 A EA 200801199A EA 200801199 A1 EA200801199 A1 EA 200801199A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kinase inhibitors
formula
pharmaceutically acceptable
acceptable salt
present
Prior art date
Application number
EA200801199A
Other languages
English (en)
Other versions
EA015189B1 (ru
Inventor
Джолие Анне Бастиан
Хесус Андрес Блас Де Блас
Альфонсо Де Дьес
Кевин Джон Худзиак
Течао Ли
Беатрис Лопес Де Уралде-Гармениа
Мэри Маргарет Мэйдер
Майкл Рэй Майерс
Марк Эндрю Побанс
Чуань Ших
Боюй Чжун
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43298635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200801199(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200801199A1 publication Critical patent/EA200801199A1/ru
Publication of EA015189B1 publication Critical patent/EA015189B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение предлагает ингибиторы киназы формулы Iгде R, R, X и Z являются такими, как описано в данной заявке, или их фармацевтически приемлемую соль.
EA200801199A 2005-10-28 2006-10-25 Ингибиторы киназы EA015189B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73160405P 2005-10-28 2005-10-28
EP06380151 2006-06-02
US82196306P 2006-08-10 2006-08-10
PCT/US2006/041644 WO2007053394A1 (en) 2005-10-28 2006-10-25 Kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200801199A1 true EA200801199A1 (ru) 2008-08-29
EA015189B1 EA015189B1 (ru) 2011-06-30

Family

ID=43298635

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801199A EA015189B1 (ru) 2005-10-28 2006-10-25 Ингибиторы киназы

Country Status (19)

Country Link
US (1) US7652015B2 (ru)
EP (1) EP1943243B1 (ru)
KR (1) KR101004156B1 (ru)
AR (1) AR056582A1 (ru)
AT (1) ATE493403T1 (ru)
AU (1) AU2006309044B2 (ru)
BR (1) BRPI0616901A2 (ru)
CA (1) CA2627673A1 (ru)
DK (1) DK1943243T3 (ru)
DO (1) DOP2006000234A (ru)
EA (1) EA015189B1 (ru)
PE (1) PE20070795A1 (ru)
PL (1) PL1943243T3 (ru)
PT (1) PT1943243E (ru)
RS (1) RS51949B (ru)
SI (1) SI1943243T1 (ru)
TN (1) TNSN08191A1 (ru)
TW (1) TWI325423B (ru)
WO (1) WO2007053394A1 (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
WO2011124930A1 (en) 2010-04-08 2011-10-13 Respivert Limited P38 map kinase inhibitors
US8933228B2 (en) 2010-06-17 2015-01-13 Respivert, Ltd. Respiratory formulations and compounds for use therein
AU2012289254A1 (en) 2011-07-26 2014-03-13 Grünenthal GmbH Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands
WO2014033449A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
WO2014033446A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
EP2890695A2 (en) 2012-08-29 2015-07-08 Respivert Limited Kinase inhibitors
WO2014076484A1 (en) 2012-11-16 2014-05-22 Respivert Limited Kinase inhibitors
WO2014162121A1 (en) 2013-04-02 2014-10-09 Topivert Pharma Limited Kinase inhibitors based upon n-alkyl pyrazoles
KR102283876B1 (ko) 2013-04-02 2021-07-29 옥슬러 액퀴지션즈 리미티드 키나제 저해제로서 유용한 우레아 유도체
CN113717162A (zh) 2013-12-20 2021-11-30 奥苏拉收购有限公司 用作激酶抑制剂的脲衍生物
SMT202100031T1 (it) 2014-03-07 2021-03-15 Biocryst Pharm Inc Pirazoli trifluorometil-sostituiti come inibitori della callicreina plasmatica umana
MA40775A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
BR112018067552A2 (pt) 2016-04-06 2019-01-08 Topivert Pharma Ltd inibidores de cinase
JP7012152B2 (ja) 2017-10-05 2022-02-10 フルクラム セラピューティクス，インコーポレイテッド Ｆｓｈｄの治療のためにｄｕｘ４および下流遺伝子発現を低減するｐ３８キナーゼ阻害剤
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
ES2924933T3 (es) 2017-10-27 2022-10-11 Boehringer Ingelheim Int Derivados de piridina y usos terapéuticos de los mismos como inhibidores de TRPC6
MX2023001818A (es) 2020-08-13 2023-03-13 Boehringer Ingelheim Int Compuestos para usarse en tratamiento de deterioro cognitivo asociado con la esquizofrenia.
AU2021360172A1 (en) 2020-10-13 2023-03-30 Boehringer Ingelheim International Gmbh Process of reworking

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1043995T1 (de) * 1997-12-22 2001-06-07 Bayer Corp., Pittsburgh INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYLSUBSTITUIERTEN HARNSTOFFEN
ATE400567T1 (de) * 2004-06-23 2008-07-15 Lilly Co Eli Kinaseinhibitoren

Also Published As

Publication number Publication date
EP1943243A1 (en) 2008-07-16
RS51949B (sr) 2012-02-29
EP1943243B1 (en) 2010-12-29
BRPI0616901A2 (pt) 2011-07-05
TW200800184A (en) 2008-01-01
CA2627673A1 (en) 2007-05-10
TNSN08191A1 (en) 2009-10-30
DK1943243T3 (da) 2011-03-07
US20080269244A1 (en) 2008-10-30
US7652015B2 (en) 2010-01-26
WO2007053394A1 (en) 2007-05-10
TWI325423B (en) 2010-06-01
ATE493403T1 (de) 2011-01-15
AR056582A1 (es) 2007-10-10
AU2006309044B2 (en) 2011-10-13
PT1943243E (pt) 2011-01-11
KR20080053394A (ko) 2008-06-12
PL1943243T3 (pl) 2011-05-31
SI1943243T1 (sl) 2011-04-29
DOP2006000234A (es) 2007-05-31
EA015189B1 (ru) 2011-06-30
KR101004156B1 (ko) 2010-12-27
PE20070795A1 (es) 2007-08-24
AU2006309044A1 (en) 2007-05-10

Similar Documents

Publication Publication Date Title
TNSN08191A1 (en) Kinase inhibitors
CY1109006T1 (el) Παραγωγα πουρινης ως αναστολεις κινασης
SMT201300109B (it) Imidazopiridazincarbonitrili utili come inibitori di chinasi
DK1761520T3 (da) Kinaseinhibitorer
NO20080761L (no) Acykliske Ikur inhibitorer
WO2005074603A3 (en) Aminobenzoxazoles as therapeutic agents
EA200801381A1 (ru) Производные пиримидина
NO20070557L (no) Ftalazinderivater som PARP-inhibitorer
ATE479687T1 (de) Kinaseinhibitoren
EA200971051A1 (ru) Ингибиторы p70 s6 киназы
EA201070786A1 (ru) Бензофуропиримидиноны
WO2005110410A3 (en) Kinase inhibitors as therapeutic agents
NO20070529L (no) Kinazolindionderivater som parp-inhibitorer
EA200801291A1 (ru) Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
EA200701396A1 (ru) Триазолофталазины в качестве ингибиторов pde-2
EA200601686A1 (ru) Замещенные производные морфолина и тиоморфолина
ECSP088369A (es) Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicóticos y neurodegenerativos
SE0400284D0 (sv) Novel compounds
CY1109234T1 (el) Αναστολεις κινασης
EA200801200A1 (ru) ПРОИЗВОДНЫЕ ПИРАЗОЛИЗОХИНОЛИНМОЧЕВИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ p38 КИНАЗЫ
EA200801413A1 (ru) Гетероциклические сетр ингибиторы
NO20082185L (no) Heterocykliske CETP-inhibitorer
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
ATE517623T1 (de) Verwendung von methylphenidat-derivaten
EA200702590A1 (ru) Ингибиторы растворимой аденилатциклазы

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU