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AR049543A1 - Derivados de la 1-amino-ftalazina, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de la 1-amino-ftalazina, su preparacion y su aplicacion en terapeutica

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Publication number
AR049543A1
AR049543A1 ARP050101458A ARP050101458A AR049543A1 AR 049543 A1 AR049543 A1 AR 049543A1 AR P050101458 A ARP050101458 A AR P050101458A AR P050101458 A ARP050101458 A AR P050101458A AR 049543 A1 AR049543 A1 AR 049543A1
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AR
Argentina
Prior art keywords
alkylene
aryl
alkyl
group
heteroaryl
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ARP050101458A
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English (en)
Inventor
Jean Michel Augereau
Michel Geslin
Gilles Courtemanche
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Sanofi Aventis
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Publication of AR049543A1 publication Critical patent/AR049543A1/es

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Abstract

La presente se refiere a derivados de la 1-amino-ftalazina, procedimiento de preparacion y aplicacion en terapéutica. Reivindicacion 1: Compuesto que responde a la formula general (1), donde: A representa un grupo alquileno C1-4, eventualmente sustituido por uno o más grupos R9 idénticos o diferentes uno del otro; B representa un grupo alquileno C1-4, eventualmente sustituido por uno o más grupos R10 idénticos o diferentes uno del otro; R9 y R10 representan cada uno, independientemente uno del otro, un átomo de hidrogeno o un grupo alquilo C1-5; o bien R9 y R10 forman juntos un enlace simple o un grupo alquileno C1-4; L representa un enlace simple o un grupo alquileno C1-2, CH=CH- o -CsC-; estando los grupos alquileno C1-2 y - CH=CH- eventualmente sustituidos por uno o más sustituyentes alquilo C1-2; o bien L representa un grupo cicloprop-1,2-diilo; R1 representa un arilo o un heteroarilo; estando los grupos arilo y heteroarilo eventualmente sustituido por uno o más radicales Z idénticos o diferentes uno del otro; R2 y R3 representan independientemente uno del otro un átomo de hidrogeno o un grupo alquilo C1-3 o fluoroalquilo C1-3; o bien R2 y R3 forman juntos, con el átomo de carbono que los lleva, un grupo cicloprop-1,1-diilo; R4 representa un átomo de hidrogeno o un grupo alquilo C1-5, fluoroalquilo C1-3, cicloalquilo C3-6, cicloalquilo C3-6-alquileno C1-3, alquilo C1-3-O-alquileno C1-3, HO-alquileno C1-3, alquilo C1-3-X-alquileno C1-3 en donde X representa S, SO o SO2; o bien R4 representa un grupo RaRbN-alquileno C1-3, arilo, arilo-alquileno C1-3, arilo-O, arilo-O-alquileno C1-3, arilo-alquileno C1-3-O-alquileno C1-3, heteroarilo o heteroarilo-alquileno C1-3; estando los grupos arilo, arilo-alquileno C1-3, arilo-O, arilo-O-alquileno C1-3, heteroarilo o heteroarilo-alquileno C1-3 eventualmente sustituidos por uno o más radicales Z idénticos o diferentes uno del otro; R5 representa un átomo de hidrogeno o de halogeno o un grupo alquilo C1-5, fluoroalquilo C1-3, alcoxi C1-5, fluoroalcoxi C1-3, HO-alquileno C1-3, -CN, alquilo C1-3-X- en donde X representa S, SO o SO2; o bien R5 representa un grupo RaRbN-, RaRbN-alquileno C1-3, arilo, arilo-alquileno C1-3, arilo-O, o heteroarilo; estando los grupos arilo, arilo-alquileno C1-3, arilo-O, y heteroarilo eventualmente sustituidos por uno o más radicales Z idénticos o diferentes uno del otro; R6 representa un átomo de hidrogeno o de halogeno o un grupo alquilo C1-5, fluoroalquilo C1-3, alcoxi C1-5, fluoroalcoxi C1-3, -CN, RaRbN-, RaRbN-alquileno C1-3, arilo o heteroarilo; estando los grupos arilo y heteroarilo eventualmente sustituidos por uno o más radicales Z idénticos o diferentes uno del otro; R7 representa un átomo de hidrogeno o de halogeno o un grupo alquilo C1-5, fluoroalquilo C1-3, alcoxi C1-5, fluoroalcoxi C1-3, -HO-alquileno C1-3, -CN, alquilo C1-3-X- en donde X representa S, SO o SO2; o bien R7 representa un grupo RaRbN-, RaRbN-alquileno C1-3, RaRbNC(O)-, alquilo C1-3-C(O)-, arilo, arilo-O- o heteroarilo; estando los grupos arilo, arilo-O y heteroarilo eventualmente sustituidos por uno o más radicales Z idénticos o diferentes uno del otro; R8 representa un átomo de hidrogeno o de halogeno o un grupo alquilo C1-5, alcoxi C1-5, fluoroalcoxi C1-3; Z representa un átomo de hidrogeno o de halogeno o un grupo alquilo C1-5, fluoroalquilo C1-3, cicloalquilo C3-6, cicloalquilo C3-6-alquileno C1-3, un fenilo, alcoxi C1-5, fluoroalcoxi C1-3, alquilo C1-3-O-alquileno C1-3, HO-alquileno C1-3, NO2, -CN, alquilo C1-3-X, alquilo C1-3-X-alquileno C1-3 en donde X representa S, SO o SO2; o bien Z representa un grupo RaRbN-, RaRbN-alquileno C1-3, RaRbNC(O)-, alquilo C1-3-C(O)-, alquilo C1-4-CO2- , cicloalquilo C3-6-C(O); o bien Z representa un radical oxo; o bien dos radicales Z adyacentes forman juntos un grupo alquilenodioxi C1-3; Ra y Rb representan cada uno, independientemente uno del otro, un átomo de hidrogeno o un grupo alquilo C1-3 o alquilo C1-3-C(O); o bien Ra y Rb forman juntos, con el átomo de nitrogeno que los lleva, un heterociclo eventualmente sustituido por uno o más grupo alquilo C1-3 u oxo; entendiéndose que cuando R2, R3, R5, R6, R7 y R8 representan todos un átomo de hidrogeno, A y B representan ambos un grupo etilenilo (-CH2CH2) y L es un enlace simple, R1 y R4 no pueden representar ambos un grupo fenilo no sustituido; en el estado de base o de sal de adicion de un ácido, así como también en el estado de hidrato o de solvato, así como también sus enantiomeros, diastereoisomeros y sus mezclas.
ARP050101458A 2004-04-13 2005-04-14 Derivados de la 1-amino-ftalazina, su preparacion y su aplicacion en terapeutica AR049543A1 (es)

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FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique

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NO20065184L (no) 2007-01-11
ATE372998T1 (de) 2007-09-15
US7423030B2 (en) 2008-09-09
MA28575B1 (fr) 2007-05-02
MXPA06011829A (es) 2007-01-16
TW200607800A (en) 2006-03-01
EP1737840A1 (fr) 2007-01-03
CA2562100A1 (fr) 2005-11-03
UY28855A1 (es) 2005-11-30
KR20070007361A (ko) 2007-01-15
GT200500089A (es) 2005-10-31
WO2005103033A1 (fr) 2005-11-03
BRPI0509910A (pt) 2007-09-18
US20070099895A1 (en) 2007-05-03
RU2006139952A (ru) 2008-05-20
DE602005002470D1 (de) 2007-10-25
IL178402A0 (en) 2007-02-11
DOP2005000062A (es) 2006-10-15
PE20060336A1 (es) 2006-05-15
FR2868780B1 (fr) 2008-10-17
DE602005002470T2 (de) 2008-06-12
FR2868780A1 (fr) 2005-10-14
CN1953972A (zh) 2007-04-25
SV2005002083A (es) 2005-12-01
AU2005235766A1 (en) 2005-11-03

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