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SV2005002083A - Derivados de la 1-amino-ftalazina, su preparacion y aplicacion en terapeutica - Google Patents

Derivados de la 1-amino-ftalazina, su preparacion y aplicacion en terapeutica

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Publication number
SV2005002083A
SV2005002083A SV2005002083A SV2005002083A SV2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A
Authority
SV
El Salvador
Prior art keywords
rent
aryl
alkylene
alquileno
rarbn
Prior art date
Application number
SV2005002083A
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English (en)
Inventor
Jean Michel Augereau
Michel Geslin
Original Assignee
Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of SV2005002083A publication Critical patent/SV2005002083A/es

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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

LA INVENCION SE REFIERE A DERIVADOS DE LA 1-AMINO-FTALAZINA, DE FORMULA GENERAL (I): VER FORMULA, EN DONDE A, B= ALQUILENO-C1-4 EVENTUALMENTE SUSTITUIDO; L= ENLACE SIMPLE O ALQUILENO-C1-2, -CH=CH- EVENTUALMENTE SUSTITUIDOS, O -C=C-, O CICLOPROP-1,2-DIILO; R1=ARILO O HETEROARILO EVENTUALMENTE SUSTITUIDOS; R2, R3=H, ALQUILO C1-C3, FLUOROALQUILO-C1-C3 O R2 Y R3 FORMAN JUNTOS, CON EL ATOMO DE CARBONO QUE LOS LLEVA, UN CICLOPROP-1,1-DIILO; R3=H, ALQUILO-C1-C5, FLUOROALQUILO-C1-C3, CICLOALQUILO-C3-6, CICLOALQUILO-C3-C6-ALQUILENO-C1-3, ALQUILO-C1-3-O-ALQUILENO-C1-3, HO-ALQUILENO-C1-3, ALQUILO-C1-3-X-ALQUILENO-C1-3 EN DONDE X=S, SO O SO2; O R4=RARBN-ALQUILENO-C1-3, ARILO, ARILO-ALQUILENO- C1-3, ARILO-O, ARILO-O-ALQUILENO-C1-3; ARILO-ALQUILENO-C1-3-O- ALQUILENO-C1-3, HETEROARILO O HETEROARILO-ALQUILENO-C1-3; R5=H, HALOGENO, ALQUILO-C1-5, FLUOROALQUILO-C1-3, ALCOXI-C1-5, FLUOROALCOXI-C1-3, HO-ALQUILENO-C1-3, HO-ALQUILENO-C1-3, -CN, ALQUILO-C1-3-X- EN DONDE X=S, SO O SO2; O R5=RARBN-, RARBN-ALQUILENO-C1-3, ARILO, ARILO-ALQUILENO-C1-3, ARILO-O- O HETEROARILO; R6=H, HALOGENO, ALQUILO-C1,5, FLUOROALQUILO-C1-3, ALCOXI-C1-5, FLUOROALCOXI-C1-3, -CN, RARBN-, RARBN-ALQUILENO-C1-3, ARILO O HETEROARILO; R7=H, HALOGENO, ALQUILO-C1,5, FLUOROALQUILO-C1-3, ALCOXI-C1-5, FLUOROALCOXI-C1-3, HO-ALQUILENO-C1-3, -CN, ALQUILO-C1-3-X-EN DONDE X=S, SO O SO2; O RARBN-, RARBN-ALQUILENO-C1-3, RARBNC(O)-, ALQUILO-C1-3-C(O)-, ARILO, ARILO- O HETEROARILO; R8=H, HALOGENO, ALQUILO-C1-5, ALCOXI-C1-5, FLUOROALCOXI-C1-3; EN EL ESTADO DE BASE O DE SAL DE ADICION DE UN ACIDO, COMO ASI TAMBIEN EN EL ESTADO DE HIDRATO O DE SOLVATO. PROCEDIMIENTO DE PREPARACION Y APLICACION EN TERAPEUTICA
SV2005002083A 2004-04-13 2005-04-13 Derivados de la 1-amino-ftalazina, su preparacion y aplicacion en terapeutica SV2005002083A (es)

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FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique

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US (1) US7423030B2 (es)
EP (1) EP1737840B1 (es)
JP (1) JP4918477B2 (es)
KR (1) KR20070007361A (es)
CN (1) CN1953972A (es)
AR (1) AR049543A1 (es)
AT (1) ATE372998T1 (es)
AU (1) AU2005235766A1 (es)
BR (1) BRPI0509910A (es)
CA (1) CA2562100A1 (es)
DE (1) DE602005002470T2 (es)
DO (1) DOP2005000062A (es)
FR (1) FR2868780B1 (es)
GT (1) GT200500089A (es)
IL (1) IL178402A0 (es)
MA (1) MA28575B1 (es)
MX (1) MXPA06011829A (es)
NO (1) NO20065184L (es)
PE (1) PE20060336A1 (es)
RU (1) RU2006139952A (es)
SV (1) SV2005002083A (es)
TW (1) TW200607800A (es)
UY (1) UY28855A1 (es)
WO (1) WO2005103033A1 (es)

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US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
MX2007003329A (es) * 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y biciclicos y su uso como inhibidores de estearoil-coa-desaturasa (scd).
WO2006034441A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AR051094A1 (es) * 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
EP2540296A1 (en) 2005-06-03 2013-01-02 Xenon Pharmaceuticals Inc. Arminothiazole derivatives as human stearoyl-coa desaturase inhibitors
FR2891825B1 (fr) * 2005-10-12 2007-12-14 Sanofi Aventis Sa Derives de la 1-amino-isoquinoline, leur preparation et leur application en therapeutique
FR2891828B1 (fr) * 2005-10-12 2007-12-21 Sanofi Aventis Sa Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
KR20120060207A (ko) 2009-08-26 2012-06-11 사노피 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
WO2012120057A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683701B1 (de) 2011-03-08 2014-12-24 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
GB201311953D0 (en) * 2013-07-03 2013-08-14 Redx Pharma Ltd Compounds
KR20210130843A (ko) 2013-07-31 2021-11-01 노파르티스 아게 1,4-이치환된 피리다진 유사체 및 smn-결핍-관련 상태를 치료하기 위한 그의 용도
KR102507847B1 (ko) * 2016-10-28 2023-03-08 서울대학교병원 페닐 프탈라진 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물
JP2024529839A (ja) * 2021-06-29 2024-08-14 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター
CN118234730A (zh) * 2021-11-17 2024-06-21 豪夫迈·罗氏有限公司 杂环nlrp3抑制剂

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EP1737840B1 (fr) 2007-09-12
JP4918477B2 (ja) 2012-04-18
NO20065184L (no) 2007-01-11
ATE372998T1 (de) 2007-09-15
US7423030B2 (en) 2008-09-09
MA28575B1 (fr) 2007-05-02
MXPA06011829A (es) 2007-01-16
TW200607800A (en) 2006-03-01
EP1737840A1 (fr) 2007-01-03
CA2562100A1 (fr) 2005-11-03
UY28855A1 (es) 2005-11-30
KR20070007361A (ko) 2007-01-15
GT200500089A (es) 2005-10-31
WO2005103033A1 (fr) 2005-11-03
AR049543A1 (es) 2006-08-16
BRPI0509910A (pt) 2007-09-18
US20070099895A1 (en) 2007-05-03
RU2006139952A (ru) 2008-05-20
DE602005002470D1 (de) 2007-10-25
IL178402A0 (en) 2007-02-11
DOP2005000062A (es) 2006-10-15
PE20060336A1 (es) 2006-05-15
FR2868780B1 (fr) 2008-10-17
DE602005002470T2 (de) 2008-06-12
FR2868780A1 (fr) 2005-10-14
CN1953972A (zh) 2007-04-25
AU2005235766A1 (en) 2005-11-03

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