AR041883A1 - Compuestos de piridopirimidinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Compuestos de piridopirimidinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR041883A1 AR041883A1 ARP030104026A ARP030104026A AR041883A1 AR 041883 A1 AR041883 A1 AR 041883A1 AR P030104026 A ARP030104026 A AR P030104026A AR P030104026 A ARP030104026 A AR P030104026A AR 041883 A1 AR041883 A1 AR 041883A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- term
- atom
- heterocycle
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de fórmula (1), su preparación y composiciones farmacéuticas que lo contienen. Reivindicación 1: Compuestos de fórmula (1), en la cual: R1 y R2, que son iguales o diferentes, representan un átomo de hidrógeno o un grupo alquilo, o junto con el átomo de nitrógeno que los lleva, forman un heterociclo; R3 representa un átomo de halógeno, un grupo alcoxi, un grupo arilo opcionalmente sustituido, o un grupo NR'1R'2 en el cual R'1 y R'2, que son iguales o diferentes, representan un átomo de hidrógeno o un grupo alquilo o junto con el átomo de nitrógeno que los lleva, forman un heterociclo; R4 representa un átomo de hidrógenos o un grupo NR''1R''2 en el cual R''1 y R''2, que son iguales o diferentes, representan un átomo de hidrógeno o un grupo alquilo o junto con el átomo de nitrógeno que los lleva, forman un heterociclo, sus enantiómeros, diastereoisómeros, tautómeros y también las sales de adición de los mismos con un ácido o con una base farmacéuticamente aceptable, y se entiende que: el término "alquilo" designa una cadena hidrocarbonada, lineal o ramificada C1-8; el término "alcoxi" designa un grupo alquilo-oxi en el cual la cadena alquilo es lineal o ramificada C1-8; el término "arilo" designa un grupo fenilo o naftilo; el término "heterociclo" designa un sistema mono o bicíclico C5-11 y que puede contener, además del átomo de nitrógeno al cual están enlazados R1R2, R'1R'2 o R''1R''2 uno o dos heteroátomos adicionales seleccionados entre oxígeno, azufre y nitrógeno, y de 1 a 7 átomos de halógeno, y el sistema heterocíclico puede ser sustituido por uno, dos o tres grupos alquilo; el término "sustituido" asociado a un grupo arilo, indica que el grupo fenilo o naftilo está sustituido por uno, dos o tres grupos idénticos o diferentes, seleccionados entre átomos de halógenos y grupos alquilo, alcoxi, polihaloalquilo e hidroxi, y se entiende por "polihaloalquilo" una cadena carbonada lineal o ramificada C1-3 y de 1 a 7 átomos de halógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0213804A FR2846657B1 (fr) | 2002-11-05 | 2002-11-05 | Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041883A1 true AR041883A1 (es) | 2005-06-01 |
Family
ID=32104442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104026A AR041883A1 (es) | 2002-11-05 | 2003-11-04 | Compuestos de piridopirimidinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7361662B2 (es) |
| EP (1) | EP1560826B1 (es) |
| JP (1) | JP2006512317A (es) |
| KR (1) | KR100717489B1 (es) |
| CN (1) | CN1330650C (es) |
| AR (1) | AR041883A1 (es) |
| AT (1) | ATE323092T1 (es) |
| AU (1) | AU2003292320B2 (es) |
| BR (1) | BR0315801A (es) |
| CA (1) | CA2503995A1 (es) |
| CY (1) | CY1105047T1 (es) |
| DE (1) | DE60304599T2 (es) |
| DK (1) | DK1560826T3 (es) |
| EA (1) | EA009043B1 (es) |
| ES (1) | ES2261978T3 (es) |
| FR (1) | FR2846657B1 (es) |
| GE (1) | GEP20084376B (es) |
| MA (1) | MA27410A1 (es) |
| MX (1) | MXPA05004789A (es) |
| MY (1) | MY140164A (es) |
| NO (1) | NO20052683D0 (es) |
| NZ (1) | NZ539598A (es) |
| PL (1) | PL376399A1 (es) |
| PT (1) | PT1560826E (es) |
| UA (1) | UA80578C2 (es) |
| WO (1) | WO2004043956A1 (es) |
| ZA (1) | ZA200503233B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009003673A (es) * | 2006-10-04 | 2009-04-22 | Pfizer Prod Inc | Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio. |
| CN101531638B (zh) * | 2008-03-13 | 2011-12-28 | 中国科学院广州生物医药与健康研究院 | 用作雌激素相关受体调节剂的化合物及其应用 |
| CN101619063B (zh) * | 2009-06-02 | 2011-08-10 | 华中师范大学 | 具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备 |
| US8981087B2 (en) | 2009-07-29 | 2015-03-17 | Karus Therapeutics Limited | Benzo [E] [1,3] oxazin-4-one derivatives as phosphoinositide 3-kinase inhibitors |
| EP2467387B1 (en) | 2009-08-20 | 2015-01-07 | Karus Therapeutics Limited | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors. |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| SG11201502301YA (en) | 2012-09-28 | 2015-04-29 | Cancer Rec Tech Ltd | Azaquinazoline inhibitors of atypical protein kinase c |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| AU2015340215B2 (en) | 2014-10-29 | 2018-11-15 | Dong-A St Co., Ltd | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (KDMs) |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| US20170057955A1 (en) * | 2015-08-26 | 2017-03-02 | Dong-A Socio Holdings Co., Ltd. | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) |
| CN105616420A (zh) * | 2016-01-16 | 2016-06-01 | 赵国良 | 一种降血脂的药物组合物 |
| SMT202200134T1 (it) | 2018-03-08 | 2022-05-12 | Incyte Corp | Composti di amminopirazindiolo come inibitori di pi3k-y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| JP7665615B2 (ja) * | 2019-11-22 | 2025-04-21 | センダ バイオサイエンシーズ， インコーポレイテッド | Ａｈｒアンタゴニストとしてのピリドピリミジノン誘導体 |
| WO2024008722A2 (en) * | 2022-07-04 | 2024-01-11 | Muna Therapeutics Aps | Trem2 modulators |
| US12459952B2 (en) | 2024-01-04 | 2025-11-04 | Muna Therapeutics Aps | TREM2 modulators |
| US12459953B2 (en) | 2024-01-04 | 2025-11-04 | Muna Therapeutics Aps | TREM2 modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6348310B1 (en) * | 1994-03-04 | 2002-02-19 | Promega Corporation | Quantitation of individual protein kinase activity |
| US6060477A (en) * | 1995-06-07 | 2000-05-09 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives |
| ZA9756B (en) * | 1996-01-16 | 1997-07-17 | Warner Lambert Co | Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| PL331602A1 (en) * | 1996-08-06 | 1999-08-02 | Pfizer | Pyrido- or pyrimido-substituted 6,6- or 6,7-bicyclic derivatives |
| US6962922B2 (en) * | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| AUPS019702A0 (en) * | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
-
2002
- 2002-11-05 FR FR0213804A patent/FR2846657B1/fr not_active Expired - Fee Related
-
2003
- 2003-04-11 UA UAA200505315A patent/UA80578C2/uk unknown
- 2003-10-09 MY MYPI20033854A patent/MY140164A/en unknown
- 2003-11-04 US US10/533,697 patent/US7361662B2/en not_active Expired - Fee Related
- 2003-11-04 GE GEAP20038824A patent/GEP20084376B/en unknown
- 2003-11-04 AU AU2003292320A patent/AU2003292320B2/en not_active Expired - Fee Related
- 2003-11-04 CN CNB2003801027139A patent/CN1330650C/zh not_active Expired - Fee Related
- 2003-11-04 AR ARP030104026A patent/AR041883A1/es unknown
- 2003-11-04 EA EA200500690A patent/EA009043B1/ru not_active IP Right Cessation
- 2003-11-04 JP JP2004550726A patent/JP2006512317A/ja active Pending
- 2003-11-04 DE DE60304599T patent/DE60304599T2/de not_active Expired - Fee Related
- 2003-11-04 AT AT03767886T patent/ATE323092T1/de not_active IP Right Cessation
- 2003-11-04 PL PL03376399A patent/PL376399A1/xx not_active Application Discontinuation
- 2003-11-04 KR KR1020057007994A patent/KR100717489B1/ko not_active Expired - Fee Related
- 2003-11-04 PT PT03767886T patent/PT1560826E/pt unknown
- 2003-11-04 EP EP03767886A patent/EP1560826B1/fr not_active Expired - Lifetime
- 2003-11-04 MX MXPA05004789A patent/MXPA05004789A/es active IP Right Grant
- 2003-11-04 WO PCT/FR2003/003274 patent/WO2004043956A1/fr not_active Ceased
- 2003-11-04 CA CA002503995A patent/CA2503995A1/fr not_active Abandoned
- 2003-11-04 NZ NZ539598A patent/NZ539598A/en unknown
- 2003-11-04 BR BR0315801-2A patent/BR0315801A/pt not_active IP Right Cessation
- 2003-11-04 DK DK03767886T patent/DK1560826T3/da active
- 2003-11-04 ES ES03767886T patent/ES2261978T3/es not_active Expired - Lifetime
-
2005
- 2005-04-19 MA MA28232A patent/MA27410A1/fr unknown
- 2005-04-21 ZA ZA200503233A patent/ZA200503233B/en unknown
- 2005-06-03 NO NO20052683A patent/NO20052683D0/no not_active Application Discontinuation
-
2006
- 2006-06-08 CY CY20061100767T patent/CY1105047T1/el unknown
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |