AR035665A1 - Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos - Google Patents
Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestosInfo
- Publication number
- AR035665A1 AR035665A1 ARP010105727A ARP010105727A AR035665A1 AR 035665 A1 AR035665 A1 AR 035665A1 AR P010105727 A ARP010105727 A AR P010105727A AR P010105727 A ARP010105727 A AR P010105727A AR 035665 A1 AR035665 A1 AR 035665A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- aryl
- alkenyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- JDQVYSWJFCKKPX-UHFFFAOYSA-N 6,7,8,9-tetrahydro-3h-imidazo[4,5-h]quinoline Chemical class C1CCNC2=C1C=CC1=C2N=CN1 JDQVYSWJFCKKPX-UHFFFAOYSA-N 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940124669 imidazoquinoline Drugs 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Imidazoquinolina y 6,7,8,9-tetrahidroimidazoquinolinas de fórmula (1) en donde: los enlaces representados por las líneas punteadas están presente o ausentes; X es -CHR3-, -CHR3-alquilo-, ó -CHR3-alquenilo-; R1 se selecciona del grupo que consiste de alquenilo, arilo, R4-arilo, y (CH2)1-10-C:::C-R10; R2 se selecciona del grupo que consiste de hidrógeno, alquilo, alquenilo, arilo, heteroarilo, heterociclilo, alquil-Y-alquilo, alquil-Y-alquenilo, alquil-Y-arilo, y alquilo o alquenilo sustituido con uno o más sustituyentes seleccionados del grupo que consiste de OH, halógeno, N(R3)2, CO-N(R3)2, CO-alquilo C1-10, CO-O-alquilo C1-10, N3, arilo, heteroarilo, heterociclilo, CO-arilo, y CO-heteroarilo; cada R3 es en forma independiente H o alquilo C1-10; R4 es alquilo o alquenilo, que pueden estar interrumpidos por uno o más grupos -O-; R10 se selecciona a partir del grupo formado por H, alquilo, alquenilo y arilo; cada Y es en forma independiente -O- ó -S(O)0-2-; n es de 0 a 4; y cada R presente se selecciona, en forma independiente, del grupo que consiste de alquilo C1-10, alcoxi C1-10, hidroxi, halógeno, y trifluormetilo; o sales farmacéuticamente aceptables de las mismas. Estos compuestos son útiles como modificadores de la respuesta inmunitaria. Dichos compuestos pueden inducir la biosíntesis de varias citocinas y son útiles en el tratamiento de una variedad de trastornos que incluyen enfermedades virales y enfermedades neoplásicas. También se dan a conocer: composiciones farmacéuticas que los comprende, el uso de dichos compuestos en la preparación de medicamentos, e intermediarios útiles en la síntesis de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25421800P | 2000-12-08 | 2000-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035665A1 true AR035665A1 (es) | 2004-06-23 |
Family
ID=22963391
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105730A AR035668A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105726A AR035664A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105728A AR035666A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105731A AR035669A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones que las comprenden, y usos de dichos compuestos en la preparacion de medicamentos |
| ARP010105729A AR035667A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105727A AR035665A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105730A AR035668A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105726A AR035664A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105728A AR035666A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105731A AR035669A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones que las comprenden, y usos de dichos compuestos en la preparacion de medicamentos |
| ARP010105729A AR035667A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
Country Status (31)
| Country | Link |
|---|---|
| US (8) | US6683088B2 (es) |
| EP (6) | EP1341791B1 (es) |
| JP (7) | JP2004515501A (es) |
| KR (6) | KR20030070050A (es) |
| CN (6) | CN1894244A (es) |
| AR (6) | AR035668A1 (es) |
| AT (3) | ATE296301T1 (es) |
| AU (12) | AU2002239517B2 (es) |
| BR (6) | BR0116470A (es) |
| CA (6) | CA2430844A1 (es) |
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| UA (2) | UA74852C2 (es) |
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| CA2488801A1 (en) | 2002-06-07 | 2003-12-18 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
| ES2355819T3 (es) | 2002-08-15 | 2011-03-31 | 3M Innovative Properties Company | Composiciones inmunoestimuladoras y métodos para estimular una respuesta inmune. |
| AU2003299082A1 (en) | 2002-09-26 | 2004-04-19 | 3M Innovative Properties Company | 1h-imidazo dimers |
| AU2003287324A1 (en) | 2002-12-11 | 2004-06-30 | 3M Innovative Properties Company | Gene expression systems and recombinant cell lines |
| AU2003287316A1 (en) | 2002-12-11 | 2004-06-30 | 3M Innovative Properties Company | Assays relating to toll-like receptor activity |
| NZ540826A (en) * | 2002-12-20 | 2008-07-31 | 3M Innovative Properties Co | Aryl / hetaryl substituted imidazoquinolines |
| WO2004060319A2 (en) | 2002-12-30 | 2004-07-22 | 3M Innovative Properties Company | Immunostimulatory combinations |
| EP1592302A4 (en) | 2003-02-13 | 2007-04-25 | 3M Innovative Properties Co | METHODS AND COMPOSITIONS ASSOCIATED WITH IMMUNE RESPONSE MODIFIER COMPOUNDS AND TOLL-LIKE RECEPTOR 8 |
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| JP2006519866A (ja) | 2003-03-04 | 2006-08-31 | スリーエム イノベイティブ プロパティズ カンパニー | Ｕｖ誘発性の表皮の新形成の予防的治療 |
| MXPA05009488A (es) | 2003-03-07 | 2005-12-14 | 3M Innovative Properties Co | 1-amino 1h-imidazoquinolinas. |
| US7699057B2 (en) | 2003-03-13 | 2010-04-20 | 3M Innovative Properties Company | Methods for treating skin lesions |
| CA2518445A1 (en) | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Method of tattoo removal |
| ATE556711T1 (de) | 2003-03-13 | 2012-05-15 | 3M Innovative Properties Co | Verfahren zur verbesserung der hautqualität |
| JP2006523452A (ja) | 2003-03-25 | 2006-10-19 | スリーエム イノベイティブ プロパティズ カンパニー | 共通のＴｏｌｌ様受容体を通じて媒介される細胞活性の選択的活性化 |
| US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
| AU2004244962A1 (en) | 2003-04-10 | 2004-12-16 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
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