AR038864A1 - Inhibidores pirimidina y piridina biciclicos de la p38 quinasa - Google Patents
Inhibidores pirimidina y piridina biciclicos de la p38 quinasaInfo
- Publication number
- AR038864A1 AR038864A1 ARP030100718A ARP030100718A AR038864A1 AR 038864 A1 AR038864 A1 AR 038864A1 AR P030100718 A ARP030100718 A AR P030100718A AR P030100718 A ARP030100718 A AR P030100718A AR 038864 A1 AR038864 A1 AR 038864A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- quinasa
- pyrimidine
- bicycle
- aryl
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos y formulaciones farmacéuticas, métodos de fabricación y usos de los mismos en el tratamiento de enfermedades mediadas por la quinasa p38. Reivindicación 1: Un compuesto representado por la fórmula 1 en donde A es N o CH; R1 es H, alquilo o arilalquilo; R2 es alquilo, hidroxialquilo, (R´´)2NCO-alquileno- ( en donde cada R´´ es independientemente H o alquilo), cicloalquilo, heterociclilo, arilo, heteroarilo o heteroalquilo; X es O, NR3 o S, en donde R3 es H, alquilo, o arilo; y Y es un enlace, O, NR´, C(=O), CH(OR'), CH(R´), o S(O)n, en donde n es 0,1, o 2; y R´es H o alquilo y R es arilo o heteroarilo; o un isómero, una sal, un éster o un profármaco farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36237302P | 2002-03-07 | 2002-03-07 | |
| US43050802P | 2002-12-03 | 2002-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038864A1 true AR038864A1 (es) | 2005-02-02 |
Family
ID=27791709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100718A AR038864A1 (es) | 2002-03-07 | 2003-03-04 | Inhibidores pirimidina y piridina biciclicos de la p38 quinasa |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7091347B2 (es) |
| EP (1) | EP1485390B1 (es) |
| JP (1) | JP4187657B2 (es) |
| KR (1) | KR100714519B1 (es) |
| CN (1) | CN100386328C (es) |
| AR (1) | AR038864A1 (es) |
| AT (1) | ATE410429T1 (es) |
| AU (1) | AU2003210388B2 (es) |
| BR (1) | BR0308232A (es) |
| CA (1) | CA2477721A1 (es) |
| DE (1) | DE60323946D1 (es) |
| ES (1) | ES2314224T3 (es) |
| MX (1) | MXPA04008592A (es) |
| PA (1) | PA8568401A1 (es) |
| PE (1) | PE20040189A1 (es) |
| PL (1) | PL372886A1 (es) |
| RU (1) | RU2301233C2 (es) |
| TW (1) | TW200306194A (es) |
| WO (1) | WO2003074530A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005538118A (ja) | 2002-08-06 | 2005-12-15 | アストラゼネカ アクチボラグ | Ｔｉｅ２（ｔｅｋ）活性を持つ縮合したピリジン及びピリミジン |
| US7319102B1 (en) * | 2003-12-09 | 2008-01-15 | The Procter & Gamble Company | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors |
| ES2339670T3 (es) * | 2003-12-23 | 2010-05-24 | Novartis Ag | Inhibidores heterociclicos biciclicos de la quinasa p-38. |
| WO2005080393A1 (en) | 2004-02-14 | 2005-09-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| KR100844864B1 (ko) * | 2004-02-27 | 2008-07-09 | 에프. 호프만-라 로슈 아게 | 헤테로아릴-융합 피라졸로 유도체 |
| AU2005219525B2 (en) * | 2004-02-27 | 2011-08-18 | F. Hoffmann-La Roche Ag | Fused derivatives of pyrazole |
| WO2005085206A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Indazole derivatives and pharmaceutical compositions containing them |
| WO2005107760A1 (en) * | 2004-04-30 | 2005-11-17 | Irm Llc | Compounds and compositions as inducers of keratinocyte differentiation |
| CA2577588C (en) | 2004-10-29 | 2013-09-10 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting bicyclic pyrimidine derivatives |
| GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| JP2009506007A (ja) * | 2005-08-25 | 2009-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | ｐ３８ＭＡＰキナーゼ阻害剤及びその使用方法 |
| AU2007240568A1 (en) * | 2006-04-21 | 2007-11-01 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
| JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
| RU2540074C2 (ru) * | 2007-06-21 | 2015-01-27 | Кара Терапеутикс, Инк | Производные имидазопиразина или имидазодиазепина, активные в отношении рецептора св2 |
| RU2341527C1 (ru) * | 2007-07-17 | 2008-12-20 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ |
| RU2345996C1 (ru) * | 2007-07-17 | 2009-02-10 | Андрей Александрович Иващенко | Аннелированные азагетероциклические амиды, включающие пиримидиновый фрагмент, способ их получения и применения |
| NZ587271A (en) | 2008-02-06 | 2012-03-30 | Novartis Ag | Pyrrolo[2,3-d]pyrimidines containing a 7h-pyrrolo[2,3-d]pyrimidin-2-yl core and use thereof as tyrosine kinase inhibitors |
| TW201002713A (en) | 2008-04-09 | 2010-01-16 | Organon Nv | Pyrrolo[2,3-d]pyrimidin-2-yl-amine derivatives as PKC-theta inhibitors |
| CA2734802C (en) | 2008-08-22 | 2016-05-31 | Novartis Ag | Pyrrolopyrimidine compounds as cdk inhibitors |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
| US20130102601A1 (en) * | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
| GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
| CN103254194B (zh) * | 2013-05-17 | 2015-07-08 | 浙江师范大学 | 一种8-硫杂黄嘌呤化合物的制备方法 |
| GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
| EP3287463A4 (en) * | 2015-04-24 | 2018-07-11 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| GB201709840D0 (en) | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| RS63581B1 (sr) | 2017-10-05 | 2022-10-31 | Fulcrum Therapeutics Inc | Inhibitori p38 kinaze smanjuju ekspresiju dux4 i nizvodnih gena u cilju lečenja fshd |
| SG11202004966PA (en) * | 2017-12-21 | 2020-06-29 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| CN111655669A (zh) * | 2017-12-21 | 2020-09-11 | 格利亚制药股份公司 | 治疗包括运动神经元疾病的神经紊乱的组合物和方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
| AU2395095A (en) | 1994-04-29 | 1995-11-29 | G.D. Searle & Co. | Method of using (h+/k+) atpase inhibitors as antiviral agents |
| EP0766684A4 (en) | 1994-06-09 | 1997-07-16 | Smithkline Beecham Corp | ENDOTHELINE RECEPTOR ANTAGONISTS |
| JPH10510510A (ja) | 1994-06-09 | 1998-10-13 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗物質 |
| MX9709867A (es) * | 1995-06-07 | 1998-03-31 | Pfizer | Derivados de pirimidina condensados con un anillo heterociclico, composiciones que contienen los mismos, y uso de los mismos. |
| CA2259573A1 (en) | 1996-07-08 | 1998-01-15 | Ruth Richmond Wexler | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin |
| WO1998006715A1 (en) * | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
| JP2000516961A (ja) | 1996-08-30 | 2000-12-19 | イーライ・リリー・アンド・カンパニー | 非古典的ピロロ［２，３―ｄ］ピリミジン抗葉酸物質 |
| KR100378937B1 (ko) * | 1997-10-20 | 2003-05-09 | 에프. 호프만-라 로슈 아게 | 바이사이클릭 키나아제 억제제 |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| WO2000038683A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| DE60118521T2 (de) | 2000-01-07 | 2006-10-12 | Universitaire Instelling Antwerpen | Purin derivate, ihre herstellung und verwendung |
| DE60119124T2 (de) * | 2000-08-14 | 2006-11-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte pyrazole |
| AU2002333524A1 (en) * | 2001-09-11 | 2003-03-24 | Glaxosmithkline K.K. | Furo-and thienopyrimidine derivatives as angiogenesis inhibitors |
-
2003
- 2003-02-28 AT AT03743361T patent/ATE410429T1/de not_active IP Right Cessation
- 2003-02-28 KR KR1020047013677A patent/KR100714519B1/ko not_active Expired - Fee Related
- 2003-02-28 BR BR0308232-6A patent/BR0308232A/pt not_active IP Right Cessation
- 2003-02-28 ES ES03743361T patent/ES2314224T3/es not_active Expired - Lifetime
- 2003-02-28 CN CNB038054191A patent/CN100386328C/zh not_active Expired - Fee Related
- 2003-02-28 PL PL03372886A patent/PL372886A1/xx not_active Application Discontinuation
- 2003-02-28 DE DE60323946T patent/DE60323946D1/de not_active Expired - Fee Related
- 2003-02-28 RU RU2004129768/04A patent/RU2301233C2/ru active
- 2003-02-28 EP EP03743361A patent/EP1485390B1/en not_active Expired - Lifetime
- 2003-02-28 WO PCT/EP2003/002090 patent/WO2003074530A1/en not_active Ceased
- 2003-02-28 CA CA002477721A patent/CA2477721A1/en not_active Abandoned
- 2003-02-28 AU AU2003210388A patent/AU2003210388B2/en not_active Ceased
- 2003-02-28 JP JP2003572998A patent/JP4187657B2/ja not_active Expired - Fee Related
- 2003-02-28 MX MXPA04008592A patent/MXPA04008592A/es active IP Right Grant
- 2003-03-04 PE PE2003000209A patent/PE20040189A1/es not_active Application Discontinuation
- 2003-03-04 AR ARP030100718A patent/AR038864A1/es not_active Application Discontinuation
- 2003-03-04 TW TW092104537A patent/TW200306194A/zh unknown
- 2003-03-06 US US10/383,392 patent/US7091347B2/en not_active Expired - Fee Related
- 2003-03-06 PA PA20038568401A patent/PA8568401A1/es unknown
-
2005
- 2005-08-12 US US11/202,611 patent/US7449472B2/en not_active Expired - Fee Related
- 2005-11-30 US US11/292,217 patent/US7439247B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW200306194A (en) | 2003-11-16 |
| AU2003210388A1 (en) | 2003-09-16 |
| PL372886A1 (en) | 2005-08-08 |
| US7449472B2 (en) | 2008-11-11 |
| CN100386328C (zh) | 2008-05-07 |
| JP4187657B2 (ja) | 2008-11-26 |
| US20060084803A1 (en) | 2006-04-20 |
| RU2301233C2 (ru) | 2007-06-20 |
| PE20040189A1 (es) | 2004-05-01 |
| CA2477721A1 (en) | 2003-09-12 |
| CN1639168A (zh) | 2005-07-13 |
| EP1485390B1 (en) | 2008-10-08 |
| MXPA04008592A (es) | 2004-12-06 |
| JP2005526057A (ja) | 2005-09-02 |
| ES2314224T3 (es) | 2009-03-16 |
| DE60323946D1 (de) | 2008-11-20 |
| PA8568401A1 (es) | 2003-12-10 |
| US7439247B2 (en) | 2008-10-21 |
| EP1485390A1 (en) | 2004-12-15 |
| WO2003074530A1 (en) | 2003-09-12 |
| US20050288312A1 (en) | 2005-12-29 |
| BR0308232A (pt) | 2004-12-28 |
| KR20040091084A (ko) | 2004-10-27 |
| US7091347B2 (en) | 2006-08-15 |
| ATE410429T1 (de) | 2008-10-15 |
| RU2004129768A (ru) | 2005-08-27 |
| US20030207900A1 (en) | 2003-11-06 |
| AU2003210388B2 (en) | 2007-05-17 |
| KR100714519B1 (ko) | 2007-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR038864A1 (es) | Inhibidores pirimidina y piridina biciclicos de la p38 quinasa | |
| RU2004132204A (ru) | Имидазоконденсированные соединения | |
| RU2007134380A (ru) | Антибактериальные производные пиперидина | |
| NO20062713L (no) | 2,6 bisheteroaryl-4-aminopyrimidiner som adenosin reseptor antagonister | |
| AR047076A1 (es) | Compuestos de pirrolotriazina como inhibidores de tirosina quinasas, composiciones farmaceuticas | |
| DK1678166T3 (da) | Proteinkinaseinhibitorer | |
| AR045595A1 (es) | Composiciones utiles como inhibidores de proteinas quinasas | |
| AR035665A1 (es) | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos | |
| MY143400A (en) | 2-pyridone derivatives as neutrophil elastase inhibitors and their use | |
| RU2004109812A (ru) | Ингибиторы цистеинпротеазы 2-циано-4-аминопиримидинового строения с ингибирующим действием на катепсин к для лечения воспалительных и других заболеваний | |
| SE0402735D0 (sv) | Novel compounds | |
| CA2455181A1 (en) | Benzimidazo[4,5-f]isoquinolinone derivatives | |
| PL378136A1 (pl) | Pirymidyny i triazyny hamujące replikacją wirusa HIV | |
| RU2003132687A (ru) | Лечение диабета типа 2 ингибиторами дипептидилпептидазы iv | |
| MA28270A1 (fr) | Pyrido [2, 3-D] pyrimidine-2, 4-diamines servant d'inhibiteurs de PDE 2 | |
| CA2523261A1 (en) | Fused pyrimidine derivatives with crf activity | |
| DK1261602T3 (da) | Imidazol-2-carboxamidderivater som Raf-kinaseinhibitorer | |
| DE60316013D1 (de) | Heteroaryl-pyrimidinderivate als jak-inhibitoren | |
| MEP13408A (en) | Cdk inhibiting pyrimidines, production thereof and their use as medicaments | |
| EA200501332A1 (ru) | Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38 | |
| CY1110831T1 (el) | Αντι-ιικα μεσα τυπου διαζαινδολο-δικαρβονυλο-πιπεραζινυλιου | |
| MXPA04002338A (es) | Derivados de carbazol y su uso como antagonistas receptores del npy5. | |
| NO20070837L (no) | Pyrido-pyrido pyrimidinderivater, fremstilling derav samt terapeutisk anvendelse for behandling av cancer. | |
| UY29312A1 (es) | Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones | |
| ATE372995T1 (de) | Benzo(b)(1,4)dioxepinderivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |