AR035664A1 - Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos - Google Patents
Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestosInfo
- Publication number
- AR035664A1 AR035664A1 ARP010105726A ARP010105726A AR035664A1 AR 035664 A1 AR035664 A1 AR 035664A1 AR P010105726 A ARP010105726 A AR P010105726A AR P010105726 A ARP010105726 A AR P010105726A AR 035664 A1 AR035664 A1 AR 035664A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- alkenyl
- quinolin
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- HLFGXPKPTDQYBN-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1h-imidazo[4,5-c]quinolin-4-amine Chemical class NC1N=C2C=CC=CC2=C2C1NCN2 HLFGXPKPTDQYBN-UHFFFAOYSA-N 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- -1 N 3 Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- WUUCVVFSWNXYRD-UHFFFAOYSA-N chembl19191 Chemical class C1=CC=C2C3=NC=NC3=C(N)NC2=C1 WUUCVVFSWNXYRD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract
Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas de fórmula (1), en donde: los enlaces representados por las líneas punteadas están presentes o ausentes; X es -CHR5-, -CHR5-alquilo, ó -CHR5-alquenilo; R1 está seleccionado del grupo que consiste en R4-CR3-Z-R6-alquilo, R4-CR3-Z-R6-alquenilo, R4-CR3-Z-R6-arilo, R4-CR3-Z-R6-heteroarilo, R4-CR3-Z-R6-heterociclilo, R4-CR3-Z-H, R4-NR7-CR3-R6-alquilo, R4-NR7-CR3-R6-alquenilo, R4-NR7-CR3-R6-arilo, R4-NR7-CR3-R6-heteroarilo, R4-NR7-CR3-R6-heterociclilo, y R4-NR7-CR3-R8; cada Z es independientemente -NR5-, -O-, ó -S-; R2 está seleccionado del grupo que consiste en hidrógeno, alquilo, alquenilo, arilo, heteroarilo, heterociclilo, alquil-Y-alquilo, alquil-Y-alquenilo, alquil-Y-arilo, y alquilo o alquenilo sustituido con uno o más sustituyentes seleccionados del grupo que consiste en OH, halógeno, N(R5)2, CO-N(R5)2, CO-alquilo C1-10, CO-O-alquilo C1-10, N3, arilo, heteroarilo, heterociclilo, CO-arilo, y CO-heteroarilo; cada R3 es =O ó =S; cada R4 es independientemente alquilo o alquenilo, que puede estar interrumpido por uno o más grupos -O-; cada R5 es independientemente H o alquilo C1-10; R6 es un enlace, alquilo, o alquenilo, que puede estar interrumpido con uno o más grupos -O-; R7 es H, alquilo C1-10, o arilalquilo; o R4 y R7 pueden estar unidos para formar un anillo; R8 es H o alquilo C1-10; o R7 y R8 pueden unirse para formar un anillo; cada Y es independientemente -O- ó -S(O)0-2-; n es 0 a 4; y cada R presente está independientemente seleccionado del grupo que consiste en alquilo C1-10, alcoxi C1-10, hidroxi, halógeno y triflúormetilo; o sales farmacéuticamente aceptables de las mismas. Estos compuestos son útiles como modificadores de la respuesta inmunitaria. Dichos compuestos pueden inducir la biosíntesis de varias citoquinas y son útiles en el tratamiento de una variedad de trastornos que incluyen enfermedades virales y enfermedades neoplásicas. También se dan a conocer: composiciones farmacéuticas que los comprenden, el uso de dichos compuestos en la preparación de medicamentos, e intermediarios útiles en la síntesis de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25421800P | 2000-12-08 | 2000-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035664A1 true AR035664A1 (es) | 2004-06-23 |
Family
ID=22963391
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105730A AR035668A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105726A AR035664A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105728A AR035666A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105731A AR035669A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones que las comprenden, y usos de dichos compuestos en la preparacion de medicamentos |
| ARP010105729A AR035667A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105727A AR035665A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105730A AR035668A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105728A AR035666A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105731A AR035669A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones que las comprenden, y usos de dichos compuestos en la preparacion de medicamentos |
| ARP010105729A AR035667A1 (es) | 2000-12-08 | 2001-12-10 | Imidazo[4,5-c]quinolin-4-aminas y tetrahidroimidazo[4,5-c]quinolin-4-aminas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
| ARP010105727A AR035665A1 (es) | 2000-12-08 | 2001-12-10 | Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos |
Country Status (31)
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| US (8) | US6683088B2 (es) |
| EP (6) | EP1341791B1 (es) |
| JP (7) | JP2004515501A (es) |
| KR (6) | KR20030070050A (es) |
| CN (6) | CN1894244A (es) |
| AR (6) | AR035668A1 (es) |
| AT (3) | ATE296301T1 (es) |
| AU (12) | AU2002239517B2 (es) |
| BR (6) | BR0116470A (es) |
| CA (6) | CA2430844A1 (es) |
| CY (2) | CY1105586T1 (es) |
| CZ (6) | CZ20031563A3 (es) |
| DE (3) | DE60117859T2 (es) |
| DK (3) | DK1343784T3 (es) |
| EE (6) | EE200300272A (es) |
| ES (3) | ES2281456T3 (es) |
| HR (6) | HRP20030464A2 (es) |
| HU (6) | HUP0600600A2 (es) |
| IL (6) | IL155904A0 (es) |
| MX (6) | MXPA03004972A (es) |
| NO (6) | NO20032452L (es) |
| NZ (6) | NZ526086A (es) |
| PL (7) | PL365995A1 (es) |
| PT (2) | PT1341790E (es) |
| RU (6) | RU2315049C2 (es) |
| SI (1) | SI1341790T1 (es) |
| SK (6) | SK287264B6 (es) |
| TW (3) | TWI293300B (es) |
| UA (2) | UA74852C2 (es) |
| WO (6) | WO2002046192A2 (es) |
| ZA (6) | ZA200305270B (es) |
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