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AR045260A1 - Compuestos que contienen imidazo-oxima sustituidos - Google Patents

Compuestos que contienen imidazo-oxima sustituidos

Info

Publication number
AR045260A1
AR045260A1 ARP040102889A ARP040102889A AR045260A1 AR 045260 A1 AR045260 A1 AR 045260A1 AR P040102889 A ARP040102889 A AR P040102889A AR P040102889 A ARP040102889 A AR P040102889A AR 045260 A1 AR045260 A1 AR 045260A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
aryl
alkenyl
alkylene
Prior art date
Application number
ARP040102889A
Other languages
English (en)
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of AR045260A1 publication Critical patent/AR045260A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composiciones farmacéuticas que contienen los compuestos, intermediarios, y métodos de uso de estos compuestos como inmunomoduladores, para inducir la biosíntesis de citoquina en animales y en el tratamiento de enfermedades que incluyen enfermedades virales y neoplásticas. Reivindicación 1: Un compuesto de fórmula (1), en la cual: X está seleccionado del grupo que consiste en -CH(R9a)-alquileno- y -CH(R9a)-alquenileno-, donde el alquileno y el alquenileno están opcionalmente interrumpidos con uno o más grupos -O-; R1 y R' están independientemente seleccionados del grupo que consiste en: hidrógeno; alquilo; alquenilo; arilo; arilalquilenilo; heteroarilo; heteroarilalquilenilo; heterociclilo; heterociclilalquilenilo; y alquilo, alquenilo, arilo, arilalquilenilo, heteroarilo, heteroarilalquilenilo, heterociclilo, o heterociclilalquilenilo, sustituido con uno o más sustituyentes seleccionados del grupo que consiste en: hidroxilo; alquilo; haloalquilo; hidroxialquilo; alcoxi; dialquilamino; -S(O)0-2-alquilo; -S(O)0-2-arilo; -NH-S(O)2-alquilo; -NH-S(O)2-arilo; haloalcoxi; halógeno; nitrilo; nitro; arilo; heteroarilo; heterociclilo; ariloxi; arilalquilenoxi; -C(O)-O-alquilo; -C(O)-N(R8)2; -N(R8)-C(O)-alquilo; -O-C(O)-alquilo; y -C(O)-alquilo; o R1 y R' pueden unirse conjuntamente para formar un sistema de anillo seleccionado del grupo que consiste en: la fórmula (2), en la cual la cantidad total de átomo en el anillo es 4 a 9, y la fórmula (3), donde la cantidad total de átomos en el anillo es de 4 a 9; RA y RB están cada uno independientemente seleccionados del grupo que consiste en: hidrógeno; halógeno; alquilo; alquenilo; alcoxi; alquiltio; y -N(R9)2; o cuando se toman conjuntamente, RA y RB forman un anillo heteroarilo o un anillo arilo fusionado que contiene un heteroátomo seleccionado del grupo que consiste en N y S, donde el anillo arilo o heteroarilo está no sustituido o está sustituido con uno o más grupos R'''; o cuando se toman conjuntamente, RA y RB forman un anillo de 5 a 7 miembros saturado fusionado, que contiene opcionalmente un heteroátomo seleccionado del grupo que consiste en N y S; y está no sustituido o sustituido con uno o más grupos R; R está seleccionado del grupo que consiste en: halógeno; hidroxilo; alquilo; alquenilo; haloalquilo; alcoxi; alquiltio; y -N(R9a)2; A' está seleccionado del grupo que consiste en -O-, -S(O)0-2-, -N(-Q-R4)-, y -CH2-; Q está seleccionado del grupo que consiste en un enlace, -C(R6)-, -C(R6)-C(R6)-, -S(O)2-, -C(R6)-N(R8)-W-, -S(O)2-N(R8)-, -C(R6)-O-, y -C(R6)-N(OR9)-; W está seleccionado del grupo que consiste en un enlace, -C(O)-, y -S(O)2-; Rc y Rd están independientemente seleccionados del grupo que consiste en hidrógeno, halógeno, hidroxilo, alquilo, alquenilo, arilo, haloalquilo, alcoxi, alquiltio, y -N(R9)2; o Rc y Rd pueden unirse para formar un anillo arilo fusionado o un anillo heteroarilo de 5-10 miembros fusionado que contiene uno a cuatro heteroátomos; R4 están seleccionado del grupo que consiste en hidrógeno, alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo, alquilheteroarilenilo, y heterociclilo, donde los grupos alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo, alquilheteroarilenilo, y heterociclilo puedan estar no sustituidos o sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en alquilo, alcoxi, hidroxialquilo, haloalquilo, haloalcoxi, halógeno, nitro, hidroxilo, mercapto, ciano, arilo, ariloxi, arilalquilenoxi, heteroarilo, heteroariloxi, heteroarilalquilenoxi, heterociclilo, amino, alquilamino, dialquilamino, (dialquilamino)alquilenoxi, y en el caso de alquilo, alquenilo, alquinilo, y heterociclilo, oxo; cada R6 está independientemente seleccionado del grupo que consiste en =O y =S; cada R8 está independientemente seleccionado del grupo que consiste en hidrógeno, alquilo C1-10, alquenilo C2-10, alcoxi(C1-10)-alquilenilo(C1-10), y aril-alquilenilo(C1-10); cada R9 está independientemente seleccionado del grupo que consiste en hidrógeno y alquilo; R9a está seleccionado del grupo que consiste en hidrógeno y alquilo que está opcionalmente interrumpido con uno o más grupos -O-; cada R11 es independientemente alquileno C1-6 o alquenileno C2-6, donde el alquileno o alquenileno está opcionalmente interrumpido con un heteroátomo; R12 está seleccionado del grupo que consiste en un enlace, alquileno C1-5 y alquenileno C2-5, donde el alquileno o alquenileno está opcionalmente interrumpido con un heteroátomo; R'' es hidrógeno o un sustituyente que no interfiere; y cada R''' es un sustituyente que no interfiere, o una sal farmacéuticamente aceptable de los mismos.
ARP040102889A 2003-08-12 2004-08-12 Compuestos que contienen imidazo-oxima sustituidos AR045260A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49460503P 2003-08-12 2003-08-12
US49460803P 2003-08-12 2003-08-12

Publications (1)

Publication Number Publication Date
AR045260A1 true AR045260A1 (es) 2005-10-19

Family

ID=34221362

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP040102890A AR045261A1 (es) 2003-08-12 2004-08-12 Compuestos que contienen imidazo quinolina o imidazo piridina sustituidos; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos inmunomoduladores
ARP040102889A AR045260A1 (es) 2003-08-12 2004-08-12 Compuestos que contienen imidazo-oxima sustituidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP040102890A AR045261A1 (es) 2003-08-12 2004-08-12 Compuestos que contienen imidazo quinolina o imidazo piridina sustituidos; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos inmunomoduladores

Country Status (10)

Country Link
US (2) US7648997B2 (es)
EP (2) EP1653914A4 (es)
JP (2) JP2007502288A (es)
AR (2) AR045261A1 (es)
AU (2) AU2004266641A1 (es)
BR (2) BRPI0412902A (es)
CA (2) CA2535117A1 (es)
MX (2) MXPA06001669A (es)
TW (2) TW200524927A (es)
WO (2) WO2005018556A2 (es)

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MXPA06001669A (es) 2006-04-28
TW200524927A (en) 2005-08-01
MXPA06001674A (es) 2006-05-12
EP1653955A4 (en) 2009-07-29
WO2005018551A2 (en) 2005-03-03
TW200510412A (en) 2005-03-16
BRPI0412902A (pt) 2006-09-26
AU2004266658A1 (en) 2005-03-03
WO2005018551A3 (en) 2006-05-11
AR045261A1 (es) 2005-10-19
WO2005018556A3 (en) 2005-09-29
BRPI0413558A (pt) 2006-10-17
US20070066639A1 (en) 2007-03-22
EP1653955A2 (en) 2006-05-10
US7648997B2 (en) 2010-01-19
EP1653914A4 (en) 2008-10-29
JP2007502293A (ja) 2007-02-08

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