AR006705A1 - Compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida y 2-fenil-1-[4-(amino-1-il-alqu-1-inil)-bencil]-1h-indol-5-ol, metodo para preparar medicamentos y composiciones farmaceuticas que los contiene - Google Patents
Compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida y 2-fenil-1-[4-(amino-1-il-alqu-1-inil)-bencil]-1h-indol-5-ol, metodo para preparar medicamentos y composiciones farmaceuticas que los contieneInfo
- Publication number
- AR006705A1 AR006705A1 ARP970101579A ARP970101579A AR006705A1 AR 006705 A1 AR006705 A1 AR 006705A1 AR P970101579 A ARP970101579 A AR P970101579A AR P970101579 A ARP970101579 A AR P970101579A AR 006705 A1 AR006705 A1 AR 006705A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- alkyl
- compounds
- indol
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- -1 C1-C4 Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- QUMRWYOAAKRIDZ-UHFFFAOYSA-N 3-[4-[(2-phenylindol-1-yl)methyl]phenyl]prop-2-enamide Chemical class C1=CC(C=CC(=O)N)=CC=C1CN1C2=CC=CC=C2C=C1C1=CC=CC=C1 QUMRWYOAAKRIDZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Nuevos compuestos de 3-[4-(2-Fenil-Indol-1-ilmetil)-Fenil]-Acrilamida y nuevos compuestos de 2-Fenil-1-[4-(amino-1il-alqu-1-inil)bencil]-1H-indol-5-ol,que son útiles como agentes estrógenos, así como también con composiciones farmacéuticasy métodos de preparación de medicamentos utilizando estoscompuestos, teniendo los compuestos las fórmulas I y II, en donde R1 es seleccionado de H, OH o los alquil éteres o ésteres C1-C4 de los mismos, ohalógeno; R2, R3, R4, R5 y R6 sonindepe ndientemente seleccionados de H, OH o los alquil éteres o ésteres C1-C4 de los mismos, halógeno, ciano, alquilo C1-C6o trifluormetilo, con la condición de que, cuando R1 es H, R2 no es OH; n es 2 o 3 ; X es seleccionado de H, alquiloC1-C6, ciano, nitro trifluormetilo,halógeno; Z es seleccionado de la fórmula III a) la porción -NR7R8en donde R7 y R8 son independientemente seleccionados del grupo de H alquilo C1-C6 fenilo ocombinados por -(CH2)p, en donde p es un entero de desde2 a 6, de mane ra de formar un anillo, siendo el anillo opcionalmente substituido por hasta tressubstituyentes seleccionados del grupo de hidrógeno, hidróxilo, halo, alquilo C1-C4 trihalomelilo, alcoxi, C1-C4, trihalometoxi, alquiltioC1-C4alquilsulfinil C1-C4 , alquilsulfonil C1-C4, hidroxi alquilo (C1-C4)-CO2H-CN- CONHalquilo (C1-C4)-NH2, alquilamino C1-C4, dialquilamino C1-C4-NHOS2alquilo (C1-C4), -NHCOalquilo(C1-C4), y -NO2; b) un heterociclo de cinco, seis o sietemiembros saturado, insaturado o parcialmente insaturado, que contien hasta dosheteroátomos seleccionados del grupo que consiste en -O-, -NH-Nalquilo C1C4)-, N= y -S(O)m en donde m es un entero de desde 0-2 opcionalmente substituido con1-3substituyentes independientemente selecc ionados del grupo que consiste de hidrógeno, hidroxilo, halo, alquilo C1-C4, trihalomelilo, alcoxi C1-C4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63397296A | 1996-04-19 | 1996-04-19 | |
| US63397696A | 1996-04-19 | 1996-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006705A1 true AR006705A1 (es) | 1999-09-08 |
Family
ID=27092024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101579A AR006705A1 (es) | 1996-04-19 | 1997-04-18 | Compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida y 2-fenil-1-[4-(amino-1-il-alqu-1-inil)-bencil]-1h-indol-5-ol, metodo para preparar medicamentos y composiciones farmaceuticas que los contiene |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0802184B1 (es) |
| JP (1) | JPH1036347A (es) |
| KR (1) | KR970069986A (es) |
| CN (1) | CN1103756C (es) |
| AR (1) | AR006705A1 (es) |
| AT (1) | ATE219485T1 (es) |
| AU (1) | AU718888B2 (es) |
| BR (1) | BR9701879A (es) |
| CO (1) | CO4950540A1 (es) |
| CZ (1) | CZ293065B6 (es) |
| DE (1) | DE69713441T2 (es) |
| DK (1) | DK0802184T3 (es) |
| EA (1) | EA000815B1 (es) |
| ES (1) | ES2179273T3 (es) |
| HU (1) | HUP9700779A1 (es) |
| ID (1) | ID16618A (es) |
| IL (1) | IL120699A0 (es) |
| NO (1) | NO308214B1 (es) |
| NZ (1) | NZ314595A (es) |
| PT (1) | PT802184E (es) |
| SK (1) | SK282765B6 (es) |
| TW (1) | TW397821B (es) |
| UA (1) | UA47413C2 (es) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2331631A1 (en) * | 1998-05-12 | 1999-11-18 | American Home Products Corporation | Benzocarbazoles and indenoindoles as estrogenic agents |
| US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
| WO1999059969A1 (en) * | 1998-05-15 | 1999-11-25 | American Home Products Corporation | Compositions comprising 2-phenyl-indole compounds and estrogen formulations |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| JP2002515431A (ja) * | 1998-05-15 | 2002-05-28 | アメリカン・ホーム・プロダクツ・コーポレイション | エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール |
| US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| AU2004200099B2 (en) * | 1998-06-11 | 2006-11-02 | Endorecherche, Inc. | Medical Uses of A Selective Estrogen Receptor Modulator in Combination with Sex Steroid Precursors |
| US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| KR100653570B1 (ko) * | 1999-09-13 | 2006-12-05 | 와이어쓰 | 2-(4-하이드록시-페닐)-1-[4-(2-아민-1-일-에톡시)-벤질]-1ｈ-인돌-5-올의 글루코피라노시드 접합체 |
| WO2002003990A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted insole compounds for treating excessive intraocular pressure |
| US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| AR030064A1 (es) * | 2000-07-06 | 2003-08-13 | Wyeth Corp | Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos |
| US6369051B1 (en) | 2000-07-06 | 2002-04-09 | American Home Products Corporation | Combinations of SSRI and estrogenic agents |
| AR029539A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Combinaciones de estatinas y agentes estrogenicos |
| AU2001271781A1 (en) * | 2000-07-06 | 2002-01-21 | Wyeth | Use of substituted indole compounds for treating sphincter incontinence |
| WO2002003975A2 (en) | 2000-07-06 | 2002-01-17 | Wyeth | Combinations of ssri and estrogenic agents |
| US6358991B2 (en) | 2000-07-06 | 2002-03-19 | American Home Products Corporation | Methods of treating neuropeptide Y-related conditions |
| WO2002003992A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating prosthesis-related bone degeneration |
| US20020016318A1 (en) * | 2000-07-06 | 2002-02-07 | American Home Products Corporation | Methods of treating breast disorders |
| US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
| EP1656938A1 (en) | 2000-07-06 | 2006-05-17 | Wyeth | Combinations of SSRI and estrogenic agents |
| AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| CA2414111A1 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for increasing nitric oxide synthase activity |
| DE60124322T2 (de) * | 2000-08-24 | 2007-05-31 | University Of Tennessee Research Foundation, Knoxville | Selektive modulatoren des androgenrezeptors und methoden zu deren verwendung |
| ES2236536T3 (es) | 2001-05-22 | 2005-07-16 | Eli Lilly And Company | Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos. |
| ES2259376T3 (es) | 2001-05-22 | 2006-10-01 | Eli Lilly And Company | 1,2,3,4-tetrahidroquinolinas 2-sustituidas y sus derivados, composiciones y procedimientos. |
| PA8629201A1 (es) | 2004-04-07 | 2005-11-25 | Wyeth Corp | Polimorfo cristalino de acetato de bazedoxifeno |
| US7683051B2 (en) | 2004-04-07 | 2010-03-23 | Wyeth | Crystalline polymorph of bazedoxifene acetate |
| MXPA06011686A (es) | 2004-04-08 | 2006-12-14 | Wyeth Corp | Ascorbato de bazedoxifeno como modulador del receptor de estrogeno selectivo. |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| KR20070083484A (ko) | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | Ｃ형 간염 치료 방법 |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
| CN106138065A (zh) | 2004-10-20 | 2016-11-23 | 恩多研究公司 | 性甾体前体单独或与选择性雌激素受体调节剂联合用于预防和治疗绝经后女性的性功能障碍 |
| AP2007004234A0 (en) | 2005-04-22 | 2007-12-31 | Alantos Pharm Holding | Dipeptidyl peptidase-IV inhibitors |
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| US20100317635A1 (en) | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| KR20140089402A (ko) | 2010-06-16 | 2014-07-14 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
| US9744177B2 (en) | 2014-03-10 | 2017-08-29 | Endorecherche, Inc. | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM |
| HRP20211542T1 (hr) | 2015-05-29 | 2022-01-07 | Eisai R&D Management Co., Ltd. | Tetrasupstituirani spojevi alkena i njihova uporaba |
| IL310489A (en) | 2015-10-01 | 2024-03-01 | Olema Pharmaceuticals Inc | TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS AND COMPOSITIONS COMPRISING SAME FOR USE IN TREATING CANCER |
| LT3386500T (lt) | 2015-12-09 | 2022-12-27 | The Board Of Trustees Of The University Of Illinois | Selektyvūs estrogenų receptorių slopintojai benzotiofeno pagrindu |
| JP6790222B2 (ja) * | 2016-03-25 | 2020-11-25 | 羅欣薬業（上海）有限公司Ｌｕｏｘｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ （Ｓｈａｎｇｈａｉ） Ｃｏ．， Ｌｔｄ． | エストロゲン受容体ダウンレギュレーターとしての置換インドール化合物 |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN109789143A (zh) | 2016-07-01 | 2019-05-21 | G1治疗公司 | 基于嘧啶的抗增殖剂 |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| IL266003B (en) | 2016-11-28 | 2022-08-01 | Eisai R&D Man Co Ltd | Salts of indazole derivative and crystals thereof |
| CA3048057A1 (en) | 2017-01-06 | 2018-07-12 | G1 Therapeutics, Inc. | Combination therapy for the treatment of cancer |
| WO2018148576A1 (en) | 2017-02-10 | 2018-08-16 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| ES2988261T3 (es) | 2017-06-29 | 2024-11-19 | G1 Therapeutics Inc | Formas mórficas de GIT38 y métodos de fabricación de las mismas |
| EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN BREAKDOWN |
| KR20220034129A (ko) | 2019-07-07 | 2022-03-17 | 올레마 파마슈티컬스 인코포레이티드 | 에스트로겐 수용체 길항제 요법 |
| EP4003996B1 (en) | 2019-07-22 | 2025-05-21 | Radius Pharmaceuticals, Inc. | Estrogen receptor-modulating compounds |
| PE20221724A1 (es) | 2019-12-20 | 2022-11-04 | C4 Therapeutics Inc | Compuestos de isoindolinona e indazol para la degradacion del receptor del factor de crecimiento epidermico (egfr) |
| CN119823124A (zh) | 2020-03-05 | 2025-04-15 | C4医药公司 | 用于brd9的靶向降解的化合物 |
| WO2022032026A1 (en) | 2020-08-05 | 2022-02-10 | C4 Therapeutics, Inc. | Compounds for targeted degradation of ret |
| KR20240018446A (ko) | 2021-06-08 | 2024-02-13 | 씨4 테라퓨틱스, 인코포레이티드 | 돌연변이 braf의 분해를 위한 요법 |
| JP2025525917A (ja) | 2022-08-03 | 2025-08-07 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｅｔタンパク質を調節するための化合物 |
| CN120530116A (zh) | 2022-11-04 | 2025-08-22 | 百时美施贵宝公司 | Ret-ldd蛋白抑制剂 |
| EP4611901A1 (en) | 2022-11-04 | 2025-09-10 | Bristol-Myers Squibb Company | Ret-ldd protein degraders |
| WO2025006753A2 (en) | 2023-06-30 | 2025-01-02 | Merck Patent Gmbh | Heterobifunctional compounds for the degradation of kras protein |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3232968A1 (de) * | 1981-09-10 | 1983-06-09 | Degussa Ag, 6000 Frankfurt | Neue 2-(hydroxy-phenyl)-indole und verfahren zu deren herstellung |
| DE3821148A1 (de) * | 1988-06-23 | 1989-12-28 | Erwin Von Dr Angerer | Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| GB9108811D0 (en) * | 1991-04-24 | 1991-06-12 | Erba Carlo Spa | N-imidazolyl derivatives of substituted indole |
| RU2061694C1 (ru) * | 1991-09-11 | 1996-06-10 | Е.Р.Сквибб энд Санз, Инк., | Производные индола |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| WO1993023374A1 (fr) * | 1992-05-08 | 1993-11-25 | Otsuka Pharmaceutical Factory, Inc. | Derive d'indole |
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| NZ281431A (en) * | 1994-02-22 | 1997-09-22 | Merrell Pharma Inc | Alkylamide-substituted indole derivatives |
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-
1997
- 1997-04-09 TW TW086104511A patent/TW397821B/zh active
- 1997-04-14 NZ NZ314595A patent/NZ314595A/xx unknown
- 1997-04-15 EP EP97302577A patent/EP0802184B1/en not_active Expired - Lifetime
- 1997-04-15 AT AT97302577T patent/ATE219485T1/de not_active IP Right Cessation
- 1997-04-15 DE DE69713441T patent/DE69713441T2/de not_active Expired - Fee Related
- 1997-04-15 ES ES97302577T patent/ES2179273T3/es not_active Expired - Lifetime
- 1997-04-15 SK SK471-97A patent/SK282765B6/sk unknown
- 1997-04-15 PT PT97302577T patent/PT802184E/pt unknown
- 1997-04-15 DK DK97302577T patent/DK0802184T3/da active
- 1997-04-17 AU AU18921/97A patent/AU718888B2/en not_active Ceased
- 1997-04-17 UA UA97041832A patent/UA47413C2/uk unknown
- 1997-04-17 CZ CZ19971176A patent/CZ293065B6/cs not_active IP Right Cessation
- 1997-04-17 ID IDP971302A patent/ID16618A/id unknown
- 1997-04-17 CO CO97020214A patent/CO4950540A1/es unknown
- 1997-04-18 IL IL12069997A patent/IL120699A0/xx unknown
- 1997-04-18 HU HU9700779A patent/HUP9700779A1/hu unknown
- 1997-04-18 CN CN97111251A patent/CN1103756C/zh not_active Expired - Fee Related
- 1997-04-18 EA EA199700043A patent/EA000815B1/ru not_active IP Right Cessation
- 1997-04-18 JP JP9101557A patent/JPH1036347A/ja active Pending
- 1997-04-18 AR ARP970101579A patent/AR006705A1/es not_active Application Discontinuation
- 1997-04-18 KR KR1019970014302A patent/KR970069986A/ko not_active Ceased
- 1997-04-18 NO NO971814A patent/NO308214B1/no not_active IP Right Cessation
- 1997-04-22 BR BR9701879A patent/BR9701879A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA199700043A1 (ru) | 1997-12-30 |
| HUP9700779A1 (hu) | 1999-09-28 |
| SK282765B6 (sk) | 2002-12-03 |
| EP0802184A1 (en) | 1997-10-22 |
| CZ117697A3 (en) | 1997-12-17 |
| CO4950540A1 (es) | 2000-09-01 |
| CN1168373A (zh) | 1997-12-24 |
| ID16618A (id) | 1997-10-23 |
| NO971814L (no) | 1997-10-20 |
| ES2179273T3 (es) | 2003-01-16 |
| AU1892197A (en) | 1997-10-23 |
| AU718888B2 (en) | 2000-04-20 |
| DE69713441D1 (de) | 2002-07-25 |
| KR970069986A (ko) | 1997-11-07 |
| UA47413C2 (uk) | 2002-07-15 |
| NO308214B1 (no) | 2000-08-14 |
| ATE219485T1 (de) | 2002-07-15 |
| CN1103756C (zh) | 2003-03-26 |
| CZ293065B6 (cs) | 2004-02-18 |
| JPH1036347A (ja) | 1998-02-10 |
| HK1002862A1 (en) | 1998-09-25 |
| EA000815B1 (ru) | 2000-04-24 |
| BR9701879A (pt) | 1998-09-29 |
| IL120699A0 (en) | 1997-08-14 |
| DE69713441T2 (de) | 2002-11-07 |
| HU9700779D0 (en) | 1997-06-30 |
| NZ314595A (en) | 2000-04-28 |
| SK47197A3 (en) | 1997-11-05 |
| EP0802184B1 (en) | 2002-06-19 |
| PT802184E (pt) | 2002-09-30 |
| NO971814D0 (no) | 1997-04-18 |
| DK0802184T3 (da) | 2002-09-16 |
| TW397821B (en) | 2000-07-11 |
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