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NO905201L - Fremgangsmaate for fremstilling av terapeutisk aktive benzofuran-derivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive benzofuran-derivater.

Info

Publication number
NO905201L
NO905201L NO90905201A NO905201A NO905201L NO 905201 L NO905201 L NO 905201L NO 90905201 A NO90905201 A NO 90905201A NO 905201 A NO905201 A NO 905201A NO 905201 L NO905201 L NO 905201L
Authority
NO
Norway
Prior art keywords
group
alkyl
alkenyl
constitutes
alkoxy
Prior art date
Application number
NO90905201A
Other languages
English (en)
Other versions
NO905201D0 (no
Inventor
Barry Clive Ross
David Middlemiss
David Ian Carter Scopes
Torquil Iain Maclean Jack
Kevin Stuart Cardwell
Michael Dennis Dowle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898929071A external-priority patent/GB8929071D0/en
Priority claimed from GB909011186A external-priority patent/GB9011186D0/en
Priority claimed from GB909019436A external-priority patent/GB9019436D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO905201D0 publication Critical patent/NO905201D0/no
Publication of NO905201L publication Critical patent/NO905201L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives forbindelser med den generelle formel (I). eller et fysiologisk akseptabelt salt, solvat eller en ugiftig metabolsk labil ester derav, hvor1 utgjør et hydrogen- eller halogenatom eller en gruppe valgt fra Calkyl, C.alkenyl, f luorCj-ealkyl, C.alkoksy, -CHO, -O,eller -COR; Ar utgjør gruppenR utgjør en gruppe valgt fra c.alkyl, C.alkenyl, C_alkoksy eller gruppen -NR10Rn;3 utgjør en gruppe valgt fra -C0H, -NHS0CFeller en C-bundet tetirazolylgruppe; Rog Rsom kan være like eller forskjellige, utgjør et hydrogen- eller halogenatom eller en C_alkylgruppe; Het utgjør en N-bundet imidazolylgruppe som i 2-stillingen eventuelt er substituert med en C_alkyl-, C.alkenyl- eller Calkyltiogruppe, hvor imidazolylgruppen eventuelt kan være substituert i 4- og 5-stillingen med én eller to ytterligere substituenter valgt fra et halogenatom eller en gruppe valgt fra cyano, nitro, C.alkyl, C.alkenyl, fluorC^alkyl, -(CH)R, -(CH)„COReller - (CH2) pNRBCOR9 ; Rutgjør en hydroksy- eller Calkoksygruppe;. Rutgjør et hydrogenatom eller en gruppe valgt fra hydroksy, C^alkyl, C^alkoksy, fenyl, fenoksy eller gruppen -NRl0R11 ;. Rs utgjør et hydrogenatom eller en Calkylgruppe; Rutgjør. et hydrogenatom eller en gruppe valgt fra C.alkyl, Calkoksy, fenyl, fenoksy eller gruppen -N101og11 som kan være like eller forskjellige, utgjør uavhengig av hverandre, et hydrogenatom eller en C.alkylgruppe, eller -NRRdanner en mettet heterocyklisk ring som har 5 eller 6 ring-ledd og hvor ringen eventuelt kan inneholde et oksygenatom; m utgjør et heltall fra 1 til 4; n utgjør et heltall fra 0 til'4; og p utgjør et heltall fra 1 til 4.
NO90905201A 1989-12-01 1990-11-30 Fremgangsmaate for fremstilling av terapeutisk aktive benzofuran-derivater. NO905201L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB898927277A GB8927277D0 (en) 1989-12-01 1989-12-01 Chemical compounds
GB898929071A GB8929071D0 (en) 1989-12-22 1989-12-22 Chemical compounds
GB909011186A GB9011186D0 (en) 1990-05-18 1990-05-18 Chemical compounds
GB909019436A GB9019436D0 (en) 1990-09-06 1990-09-06 Chemical compounds
OA60008A OA10044A (en) 1989-12-01 1991-05-28 Benzofuran derivatives

Publications (2)

Publication Number Publication Date
NO905201D0 NO905201D0 (no) 1990-11-30
NO905201L true NO905201L (no) 1991-06-03

Family

ID=33314473

Family Applications (1)

Application Number Title Priority Date Filing Date
NO90905201A NO905201L (no) 1989-12-01 1990-11-30 Fremgangsmaate for fremstilling av terapeutisk aktive benzofuran-derivater.

Country Status (16)

Country Link
EP (1) EP0434249A3 (no)
JP (1) JPH04217975A (no)
CN (1) CN1052672A (no)
AU (1) AU638077B2 (no)
CA (1) CA2031324A1 (no)
CZ (1) CZ597190A3 (no)
FI (1) FI905908A7 (no)
GB (1) GB8927277D0 (no)
HU (1) HUT61751A (no)
IE (1) IE904333A1 (no)
IL (1) IL96516A0 (no)
NO (1) NO905201L (no)
NZ (1) NZ236297A (no)
OA (1) OA10044A (no)
PL (1) PL288039A1 (no)
PT (1) PT96042A (no)

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US5449682A (en) * 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element
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Also Published As

Publication number Publication date
FI905908A0 (fi) 1990-11-30
NZ236297A (en) 1992-10-28
EP0434249A3 (en) 1992-02-12
IL96516A0 (en) 1991-08-16
JPH04217975A (ja) 1992-08-07
AU6763290A (en) 1991-06-06
CN1052672A (zh) 1991-07-03
PL288039A1 (en) 1991-08-12
GB8927277D0 (en) 1990-01-31
HU908016D0 (en) 1991-06-28
CA2031324A1 (en) 1991-06-02
FI905908A7 (fi) 1991-06-02
AU638077B2 (en) 1993-06-17
HUT61751A (en) 1993-03-01
NO905201D0 (no) 1990-11-30
EP0434249A2 (en) 1991-06-26
IE904333A1 (en) 1991-06-05
PT96042A (pt) 1991-09-13
OA10044A (en) 1996-10-14
CZ597190A3 (en) 1995-02-15

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