NO950606L - Adhesjonsreseptor-antagonister - Google Patents
Adhesjonsreseptor-antagonisterInfo
- Publication number
- NO950606L NO950606L NO950606A NO950606A NO950606L NO 950606 L NO950606 L NO 950606L NO 950606 A NO950606 A NO 950606A NO 950606 A NO950606 A NO 950606A NO 950606 L NO950606 L NO 950606L
- Authority
- NO
- Norway
- Prior art keywords
- gly
- ala
- ch2nhco
- cox
- coor5
- Prior art date
Links
- 102000019997 adhesion receptor Human genes 0.000 title 1
- 108010013985 adhesion receptor Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- PPRGXYWEHFENBY-UHFFFAOYSA-N 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine Chemical class C1CCCN2C=CN=C21 PPRGXYWEHFENBY-UHFFFAOYSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000000010 osteolytic effect Effects 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4405378A DE4405378A1 (de) | 1994-02-19 | 1994-02-19 | Adhäsionsrezeptor-Antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO950606D0 NO950606D0 (no) | 1995-02-17 |
| NO950606L true NO950606L (no) | 1995-08-21 |
Family
ID=6510687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO950606A NO950606L (no) | 1994-02-19 | 1995-02-17 | Adhesjonsreseptor-antagonister |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5614531A (zh) |
| EP (1) | EP0668278A1 (zh) |
| JP (1) | JPH07252254A (zh) |
| KR (1) | KR950032197A (zh) |
| CN (1) | CN1111630A (zh) |
| AU (1) | AU1230795A (zh) |
| CA (1) | CA2142741A1 (zh) |
| CZ (1) | CZ42495A3 (zh) |
| DE (1) | DE4405378A1 (zh) |
| HU (1) | HUT71806A (zh) |
| NO (1) | NO950606L (zh) |
| PL (1) | PL307328A1 (zh) |
| RU (1) | RU95102323A (zh) |
| SK (1) | SK22195A3 (zh) |
| ZA (1) | ZA951345B (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040084945A (ko) * | 1996-07-25 | 2004-10-06 | 바이오겐 아이덱 엠에이 인코포레이티드 | 세포 유착 억제제 |
| DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| AR011057A1 (es) * | 1997-01-08 | 2000-08-02 | Smithkline Beecham Corp | Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos |
| US5902797A (en) * | 1997-11-10 | 1999-05-11 | Beth Israel Deaconess Medical Center | Nutritional supplement for use in the treatment of attention deficit |
| IL143901A0 (en) | 1998-12-23 | 2002-04-21 | Searle & Co | Use of cyclooxygenase-2- inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia |
| DE10117184A1 (de) * | 2001-04-05 | 2002-10-17 | Gruenenthal Gmbh | Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen |
| DE10117183A1 (de) * | 2001-04-05 | 2002-10-10 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel |
| PT2484365E (pt) | 2004-06-04 | 2013-12-12 | Scripps Research Inst | Composições e métodos para o tratamento de doenças neovasculares |
| US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| KR20070101226A (ko) * | 2004-09-07 | 2007-10-16 | 아케믹스 코포레이션 | 앱타머의 약화학 |
| SG156618A1 (en) | 2004-09-07 | 2009-11-26 | Archemix Corp | Aptamers to von willebrand factor and their use as thrombotic disease therapeutics |
| US7919519B2 (en) * | 2005-11-23 | 2011-04-05 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| JP2009520688A (ja) * | 2005-11-23 | 2009-05-28 | エピックス デラウェア， インコーポレイテッド | Ｓ１ｐ受容体調節化合物およびそれらの使用 |
| US20080293947A1 (en) * | 2005-11-28 | 2008-11-27 | Halvachs Robert E | Method of Preparation for Imidazolepyridines |
| WO2007109330A2 (en) * | 2006-03-21 | 2007-09-27 | Epix Delaware, Inc. | S1p receptor modulating compounds |
| WO2008027812A2 (en) * | 2006-08-28 | 2008-03-06 | Forest Laboratories Holdings Limited | Imidazopyridine and imidazopyrimidine derivatives |
| EP1964840A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridines and their use as pharmaceuticals |
| MX2009010060A (es) * | 2007-03-21 | 2010-01-20 | Epix Pharm Inc | Compuestos moduladores del receptor de esfingosin-1-fosfato y uso de los mismos. |
| US20090203766A1 (en) * | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
| ES2360929T3 (es) * | 2007-09-20 | 2011-06-10 | Amgen Inc. | Derivados del ácido 1-(4-(4-bencilbenzamido)-bencil)azetidin-3-carboxílico y compuestos relacionados como moduladores del receptor s1p para el tratamiento de trastornos inmunitarios. |
| US7868001B2 (en) * | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2593818B1 (fr) * | 1986-02-05 | 1988-04-29 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique |
| ATE62687T1 (de) * | 1986-01-22 | 1991-05-15 | Synthelabo | Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung. |
| US4990506A (en) * | 1986-02-05 | 1991-02-05 | Synthelabo | 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and their application in therapy |
| US4791117A (en) * | 1986-09-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers |
| FR2606410B1 (fr) * | 1986-11-07 | 1989-02-24 | Synthelabo | Imidazopyridines, leur preparation et leur application en therapeutique |
| US5053393A (en) * | 1988-07-20 | 1991-10-01 | Monsanto Company | Novel platelet-aggregation inhibitor |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
| DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
| US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| FI934894A7 (fi) * | 1991-05-07 | 1993-11-05 | Merck & Co Inc | Fibrinogeenireseptorin antagonisteja |
| DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| AU3648993A (en) * | 1992-03-17 | 1993-10-21 | Nippon Shinyaku Co. Ltd. | Imidazopyridine derivative and medicine |
| DE4327027A1 (de) * | 1993-02-15 | 1994-08-18 | Bayer Ag | Imidazoazine |
-
1994
- 1994-02-19 DE DE4405378A patent/DE4405378A1/de not_active Withdrawn
-
1995
- 1995-02-14 EP EP95101992A patent/EP0668278A1/de not_active Withdrawn
- 1995-02-15 CN CN95101977A patent/CN1111630A/zh active Pending
- 1995-02-16 AU AU12307/95A patent/AU1230795A/en not_active Abandoned
- 1995-02-17 RU RU95102323/04A patent/RU95102323A/ru unknown
- 1995-02-17 NO NO950606A patent/NO950606L/no unknown
- 1995-02-17 HU HU9500479A patent/HUT71806A/hu unknown
- 1995-02-17 JP JP7029649A patent/JPH07252254A/ja active Pending
- 1995-02-17 ZA ZA951345A patent/ZA951345B/xx unknown
- 1995-02-17 PL PL95307328A patent/PL307328A1/xx unknown
- 1995-02-17 CZ CZ95424A patent/CZ42495A3/cs unknown
- 1995-02-17 US US08/390,669 patent/US5614531A/en not_active Expired - Fee Related
- 1995-02-17 CA CA002142741A patent/CA2142741A1/en not_active Abandoned
- 1995-02-17 SK SK221-95A patent/SK22195A3/sk unknown
- 1995-02-18 KR KR1019950003141A patent/KR950032197A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR950032197A (ko) | 1995-12-20 |
| SK22195A3 (en) | 1995-09-13 |
| EP0668278A1 (de) | 1995-08-23 |
| RU95102323A (ru) | 1997-03-20 |
| AU1230795A (en) | 1995-08-31 |
| ZA951345B (en) | 1995-10-24 |
| CA2142741A1 (en) | 1995-08-20 |
| HU9500479D0 (en) | 1995-04-28 |
| CZ42495A3 (en) | 1995-10-18 |
| PL307328A1 (en) | 1995-08-21 |
| NO950606D0 (no) | 1995-02-17 |
| CN1111630A (zh) | 1995-11-15 |
| JPH07252254A (ja) | 1995-10-03 |
| US5614531A (en) | 1997-03-25 |
| DE4405378A1 (de) | 1995-08-24 |
| HUT71806A (en) | 1996-02-28 |
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