AR011057A1 - Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos - Google Patents
Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestosInfo
- Publication number
- AR011057A1 AR011057A1 ARP980100032A ARP980100032A AR011057A1 AR 011057 A1 AR011057 A1 AR 011057A1 AR P980100032 A ARP980100032 A AR P980100032A AR P980100032 A ARP980100032 A AR P980100032A AR 011057 A1 AR011057 A1 AR 011057A1
- Authority
- AR
- Argentina
- Prior art keywords
- 4alkyl
- alkyl
- independently
- cycloalkyl
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003627 8 membered carbocyclic group Chemical group 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 abstract 1
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 abstract 1
- -1 C1-6 Chemical group 0.000 abstract 1
- 102000004274 CCR5 Receptors Human genes 0.000 abstract 1
- 108010017088 CCR5 Receptors Proteins 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se refiere al uso de bis-acridinas sustituidas de formula (I) o una sal farmacéuticamente aceptable del mismo: formula (I) en la que: los X sonindependientemente uno o más de H, alquilo C1-6 opcionalmente sustituido, cicloalquil C3-7-alquilo C0-4, AR-alquilo C0-4, CH2NR2, CH2OR, CN, COR,CONR2, CO2R,CF3, N(R)2, NRCOR, NRCONRR, NRCO2R, NRSO2R, NO2, OR, S(O)0-2R, S(O)0-2CF3, o halo; R1 es H, alquilo C1-6 opcionalmente sustituido,cicloalquil C3-7-alquilo C0-4 o Ar-alquilo C0-4; R es alquilo C1-6, cicloalquil C3-7-alquilo C0-4 o Ar-alquilo C0-4; D y Dson independientementeCX o N; V y V son independientemente C(R)2, NR1 O, S(O)0-2; los R1 son independientemente H, alquilo, C1-6, cicloalquil C3-7-alquilo C0-4 Ar-alquiloC0-4, -C(O)CF3, -C(O)R o -SO2R o, cuando V y V son -NR1, los dos grupos R1 tomados conjuntamente pueden ser (C(R)2)2-3 para formar un anillo heterocíclicode 5 a 9 miembros; n es 0, 1, 2 o 3; y los R son independientemente H, alquilo C1-6, cicloalquil C3-7-alquilo C0-4 o Ar-alquilo C0-4 o, cuando V y V sonindependientemente NR1, O o S (O)0-2, cualesquiera dos grupos R tomados conjuntamente pueden ser (C(R)2)2-4 para formar un anillo carbocíclico de 3hasta 8 miembros, para la preparacionde un medicamento util para tratar un estado de enfermedad mediado por CCR5 en mamíferos, que comprende una cantidadeficaz de dicho compuesto y al menos un vehículo farmacéuticamente aceptable. Estos compuestos afines son ligandos, en particular antagonistas del receptorCCR5, que incluyen, pero no se limitan a, asma y enfermedades atropicas (por ejemplo, dermatitis atopica y alergias), artritis reumatoide, aterosclerosis,psoriasis, enfermedades autoinmunitarias tales como la esclerosismultiple y el síndrome de intestino inflamatorio, todas ellas en mamíferos, por el uso de bis
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3514897P | 1997-01-08 | 1997-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011057A1 true AR011057A1 (es) | 2000-08-02 |
Family
ID=21880954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100032A AR011057A1 (es) | 1997-01-08 | 1998-01-05 | Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6242459B1 (es) |
| EP (1) | EP0979078A4 (es) |
| JP (1) | JP2001509152A (es) |
| AR (1) | AR011057A1 (es) |
| AU (1) | AU6020898A (es) |
| CA (1) | CA2276525A1 (es) |
| CO (1) | CO4920243A1 (es) |
| WO (1) | WO1998030218A1 (es) |
| ZA (1) | ZA9895B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
| US6514987B1 (en) * | 1997-01-06 | 2003-02-04 | Cerus Corporation | Frangible compounds for pathogen inactivation |
| ZA985542B (en) | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
| CN1279668A (zh) | 1997-11-18 | 2001-01-10 | 帝人株式会社 | 环胺衍生物及其作为药物的用途 |
| EP1179341B1 (en) | 1999-05-18 | 2005-11-09 | Teijin Limited | Remedies or preventives for diseases in association with chemokines |
| WO2000076982A1 (en) * | 1999-06-16 | 2000-12-21 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
| CA2378499A1 (en) | 1999-08-04 | 2001-02-15 | Teijin Limited | Cyclic amine ccr3 antagonists |
| ATE346042T1 (de) * | 1999-12-08 | 2006-12-15 | Teijin Ltd | Zyklische aminverbindungen als ccr5-rezeptor antagonisten |
| US6410566B1 (en) | 2000-05-16 | 2002-06-25 | Teijin Limited | Cyclic amine derivatives and their use as drugs |
| JP2004510706A (ja) | 2000-07-07 | 2004-04-08 | キャンサー・リサーチ・テクノロジー・リミテッド | 治療用アクリドン及びアクリジン化合物 |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| AU2003207646C1 (en) * | 2002-01-22 | 2008-09-18 | Vanderbilt University | Treating stress response with chemokine receptor CCR5 modulators |
| WO2004005464A2 (en) * | 2002-07-02 | 2004-01-15 | Uab Research Foundation | Compounds promoting delivery of genes |
| CA2559809A1 (en) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Antibodies against human g-protein chemokine receptor (ccr5) hdgnr10 |
| US20080108586A1 (en) * | 2006-09-06 | 2008-05-08 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
| WO2013024022A1 (en) | 2011-08-12 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| US10149830B2 (en) | 2016-06-03 | 2018-12-11 | Cushing Academy | Pharmaceutical agents and methods relating thereto |
| CN115443133B (zh) | 2020-02-19 | 2024-02-20 | 伊契洛夫科技有限公司 | 改进的抗抑郁疗法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
| WO2024119148A1 (en) * | 2022-12-02 | 2024-06-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Topoisomerase iii (top3) inhibitors and antiviral compounds based on bisacridines |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2503899A (en) * | 1945-08-29 | 1950-04-11 | Dow Chemical Co | Diacridyl diamine derivatives |
| FR2314165A1 (fr) | 1975-06-13 | 1977-01-07 | Anvar | Nouveaux bis (anthryl-9) alcanes et leur preparation |
| FR2588259B1 (fr) | 1985-10-04 | 1988-01-22 | Aix Marseille Universite | Bis-acridiniques monopontes et bis-acridiniques bipontes |
| JPH0688924B2 (ja) | 1986-05-28 | 1994-11-09 | ダイセル化学工業株式会社 | 光記憶材料 |
| DE4014421A1 (de) * | 1990-05-05 | 1991-11-07 | Merck Patent Gmbh | Aminosaeurederivate |
| JPH04226467A (ja) | 1990-09-13 | 1992-08-17 | Ricoh Co Ltd | 電子写真感光体の疲労回復方法 |
| ES2107557T3 (es) * | 1991-12-10 | 1997-12-01 | Shionogi & Co | Derivado de acido hidroxamico a base de sulfonamida aromatica. |
| DE4405378A1 (de) * | 1994-02-19 | 1995-08-24 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
-
1998
- 1998-01-05 AR ARP980100032A patent/AR011057A1/es unknown
- 1998-01-07 CO CO98000422A patent/CO4920243A1/es unknown
- 1998-01-07 ZA ZA9895A patent/ZA9895B/xx unknown
- 1998-01-08 JP JP53117498A patent/JP2001509152A/ja active Pending
- 1998-01-08 EP EP98903437A patent/EP0979078A4/en not_active Withdrawn
- 1998-01-08 US US09/341,171 patent/US6242459B1/en not_active Expired - Fee Related
- 1998-01-08 CA CA002276525A patent/CA2276525A1/en not_active Abandoned
- 1998-01-08 WO PCT/US1998/000489 patent/WO1998030218A1/en not_active Ceased
- 1998-01-08 AU AU60208/98A patent/AU6020898A/en not_active Abandoned
-
2001
- 2001-04-11 US US09/833,044 patent/US20010031763A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20010031763A1 (en) | 2001-10-18 |
| WO1998030218A1 (en) | 1998-07-16 |
| EP0979078A1 (en) | 2000-02-16 |
| US6242459B1 (en) | 2001-06-05 |
| EP0979078A4 (en) | 2000-06-21 |
| CA2276525A1 (en) | 1998-07-16 |
| ZA9895B (en) | 1998-07-08 |
| CO4920243A1 (es) | 2000-05-29 |
| AU6020898A (en) | 1998-08-03 |
| JP2001509152A (ja) | 2001-07-10 |
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