|
US20060222647A1
(en)
*
|
1993-05-27 |
2006-10-05 |
Beavo Joseph A |
Methods and compositions for modulating the activity of PDE5
|
|
GB9311920D0
(en)
|
1993-06-09 |
1993-07-28 |
Pfizer Ltd |
Therapeutic agents
|
|
US6143746A
(en)
*
|
1994-01-21 |
2000-11-07 |
Icos Corporation |
Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
|
|
GB9514465D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9423911D0
(en)
*
|
1994-11-26 |
1995-01-11 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9423910D0
(en)
|
1994-11-26 |
1995-01-11 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9514473D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9514464D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
PL329875A1
(en)
*
|
1996-05-10 |
1999-04-12 |
Icos Corp |
Derivatives of carbolin
|
|
GB9612514D0
(en)
*
|
1996-06-14 |
1996-08-14 |
Pfizer Ltd |
Novel process
|
|
DE19642284A1
(de)
*
|
1996-10-14 |
1998-04-16 |
Merck Patent Gmbh |
Pyrazolinone zur Behandlung von Potenzstörungen
|
|
ID22834A
(id)
*
|
1997-04-25 |
1999-12-09 |
Pfizer |
Pirazolopimidinona untuk kelainan seksual
|
|
WO1998053819A1
(en)
*
|
1997-05-29 |
1998-12-03 |
Mochida Pharmaceutical Co., Ltd. |
Therapeutic agent for erection failure
|
|
AU742787B2
(en)
|
1997-07-09 |
2002-01-10 |
Androsolutions, Inc. |
Improved methods and compositions for treating male erectile dysfunction
|
|
US6103765A
(en)
|
1997-07-09 |
2000-08-15 |
Androsolutions, Inc. |
Methods for treating male erectile dysfunction
|
|
US6399618B1
(en)
|
1997-07-09 |
2002-06-04 |
Cardiome Pharma Corp |
Compositions and methods for modulating sexual activity
|
|
US20020025969A1
(en)
*
|
1997-07-09 |
2002-02-28 |
Wolf-Georg Forssmann |
Use of phosphordiesterase inhibitors in the treatment of prostatic diseases
|
|
US20030077229A1
(en)
*
|
1997-10-01 |
2003-04-24 |
Dugger Harry A. |
Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
|
|
US6593369B2
(en)
|
1997-10-20 |
2003-07-15 |
Vivus, Inc. |
Methods, compositions, and kits for enhancing female sexual desire and responsiveness
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
US6403597B1
(en)
|
1997-10-28 |
2002-06-11 |
Vivus, Inc. |
Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
|
|
US6127363A
(en)
*
|
1997-10-28 |
2000-10-03 |
Vivus, Inc. |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
AU734734B2
(en)
*
|
1997-10-28 |
2001-06-21 |
Vivus, Inc. |
Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
US6037346A
(en)
*
|
1997-10-28 |
2000-03-14 |
Vivus, Inc. |
Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
JP2001520999A
(ja)
|
1997-10-28 |
2001-11-06 |
アシビ, エルエルシー |
女性の性的機能不全の処置
|
|
US6548490B1
(en)
|
1997-10-28 |
2003-04-15 |
Vivus, Inc. |
Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
US6156753A
(en)
*
|
1997-10-28 |
2000-12-05 |
Vivus, Inc. |
Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
CA2309332C
(en)
|
1997-11-12 |
2002-12-03 |
Bayer Aktiengesellschaft |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
|
|
DE19752952A1
(de)
|
1997-11-28 |
1999-06-02 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
SK8782000A3
(en)
*
|
1997-12-16 |
2002-03-05 |
Pfizer Prod Inc |
Combination, composition and kits effective for the treatment of impotence
|
|
TW542719B
(en)
*
|
1998-02-23 |
2003-07-21 |
Pfizer Res & Dev |
Method of treating impotence due to spinal cord injury
|
|
PT1073658E
(pt)
*
|
1998-04-20 |
2003-12-31 |
Pfizer |
Inibidores de ogmp pdes de pirazolopirimidinona para o tratamento da disfuncao sexual
|
|
DE19819023A1
(de)
*
|
1998-04-29 |
1999-11-04 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
US6187790B1
(en)
|
1999-03-04 |
2001-02-13 |
Neal R. Cutler |
Use of cilostazol for treatment of sexual dysfunction
|
|
WO1999056666A1
(en)
*
|
1998-05-01 |
1999-11-11 |
Rt Alamo Ventures, Inc. |
The treatment of sexual dysfunction in certain patient groups
|
|
US6541487B1
(en)
|
1998-05-01 |
2003-04-01 |
R.T. Alamo Ventures I, Llc |
PDE III inhibitors for treating sexual dysfunction
|
|
US6426084B1
(en)
|
2000-06-19 |
2002-07-30 |
Neal R. Cutler |
Treatment of sexual dysfunction in certain patient groups
|
|
US6132753A
(en)
*
|
1998-05-01 |
2000-10-17 |
Neal R. Cutler |
Treatment of sexual dysfunction in certain patient groups
|
|
US6132757A
(en)
*
|
1998-05-01 |
2000-10-17 |
Neal R. Cutler |
Treatment of sexual dysfunction in certain patient groups
|
|
US6110489A
(en)
*
|
1998-05-01 |
2000-08-29 |
Cutler; Neal R. |
Use of quinolines and quinolones to treat male erectile dysfunction
|
|
US6194433B1
(en)
|
1998-10-05 |
2001-02-27 |
Neal R. Cutler |
Sexual dysfunction in females
|
|
WO1999059584A1
(en)
*
|
1998-05-20 |
1999-11-25 |
Schering Corporation |
Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction
|
|
EP0967284A1
(en)
*
|
1998-05-28 |
1999-12-29 |
Pfizer Limited |
Phosphodiesterases
|
|
TWI223598B
(en)
*
|
1998-06-22 |
2004-11-11 |
Pfizer Ireland Pharmaceuticals |
An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
|
|
HUP0103206A3
(en)
|
1998-06-25 |
2002-11-28 |
Lavipharm Lab Inc Piscataway |
A device and method for the treatment of erectile dysfunction and for its making
|
|
US7087240B1
(en)
|
1998-06-25 |
2006-08-08 |
Lavipharm Laboratories Inc. |
Device and method for the treatment of erectile dysfunction
|
|
WO2000000199A1
(en)
*
|
1998-06-26 |
2000-01-06 |
Nastech Pharmaceutical Company, Inc. |
Nasal delivery of sildenafil citrate
|
|
DE19837067A1
(de)
|
1998-08-17 |
2000-02-24 |
Bayer Ag |
Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern
|
|
US6974838B2
(en)
|
1998-08-24 |
2005-12-13 |
Sepracor Inc. |
Methods of treating or preventing pain using sibutramine metabolites
|
|
US6331571B1
(en)
|
1998-08-24 |
2001-12-18 |
Sepracor, Inc. |
Methods of treating and preventing attention deficit disorders
|
|
US6476078B2
(en)
|
1999-08-11 |
2002-11-05 |
Sepracor, Inc. |
Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
|
|
US6339106B1
(en)
|
1999-08-11 |
2002-01-15 |
Sepracor, Inc. |
Methods and compositions for the treatment and prevention of sexual dysfunction
|
|
ES2220109T3
(es)
*
|
1998-09-04 |
2004-12-01 |
Ortho-Mcneil Pharmaceutical, Inc. |
5-heterociclilpirazolo (4,3-d) pirimidin-7-onas para el tratamiento de la disfuncion erectil masculina.
|
|
JP2000178204A
(ja)
*
|
1998-10-05 |
2000-06-27 |
Eisai Co Ltd |
ホスフォジエステラ―ゼ阻害剤を含有する口腔内速崩壊性錠剤
|
|
CA2346350C
(en)
|
1998-10-05 |
2008-01-08 |
Eisai Co., Ltd. |
Intraoral quickly disintegrating tablets
|
|
JP2000191518A
(ja)
*
|
1998-10-19 |
2000-07-11 |
Eisai Co Ltd |
溶解性の改善された口腔内速崩壊性錠剤
|
|
UA67802C2
(uk)
|
1998-10-23 |
2004-07-15 |
Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. |
Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
|
|
GB9823101D0
(en)
*
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
GB9823102D0
(en)
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
GB9823103D0
(en)
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
KR100353014B1
(ko)
*
|
1998-11-11 |
2002-09-18 |
동아제약 주식회사 |
발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
|
|
RU2220145C2
(ru)
*
|
1998-11-11 |
2003-12-27 |
Донг А Фарм. Ко., Лтд. |
Производные пиразолопиримидинона для лечения импотенции и способ их получения
|
|
US6225315B1
(en)
|
1998-11-30 |
2001-05-01 |
Pfizer Inc |
Method of treating nitrate-induced tolerance
|
|
GB9828340D0
(en)
*
|
1998-12-22 |
1999-02-17 |
Novartis Ag |
Organic compounds
|
|
US6455564B1
(en)
|
1999-01-06 |
2002-09-24 |
Pharmacia & Upjohn Company |
Method of treating sexual disturbances
|
|
WO2000043012A1
(en)
*
|
1999-01-22 |
2000-07-27 |
Selectus Pharmaceuticals, Inc. |
Controlling heart rate or blood pressure in patients co-medicated with phosphodiesterase inhibitors for treatment of impotence
|
|
EP1161255A4
(en)
*
|
1999-03-08 |
2002-07-17 |
Merck & Co Inc |
METHOD AND MEANS FOR TREATING ERECTILE DYSFUNCTION
|
|
KR20020015030A
(ko)
|
1999-03-22 |
2002-02-27 |
스티븐 비. 데이비스 |
cGMP 포스포디에스테라제의 접합된 피리도피리다진억제제
|
|
US6214849B1
(en)
|
1999-04-29 |
2001-04-10 |
Lupin Laboratories Limited |
Use of nicorandil in treatment of sexual dysfunction or for enhancement of sexual function in mammals including humans
|
|
IL135817A0
(en)
*
|
1999-04-30 |
2001-05-20 |
Lilly Icos Llc |
Phosphodiesterase enzyme inhibitors and their use in pharmaceutical articles
|
|
US6451807B1
(en)
*
|
1999-04-30 |
2002-09-17 |
Lilly Icos, Llc. |
Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
|
|
US7258850B2
(en)
*
|
1999-05-04 |
2007-08-21 |
Aradigm Corporation |
Methods and compositions for treating erectile dysfunction
|
|
JP3145364B2
(ja)
|
1999-06-04 |
2001-03-12 |
ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド |
新規化合物及び該化合物を含有する医薬組成物
|
|
AU5204800A
(en)
*
|
1999-06-21 |
2001-01-09 |
Biochemical Pharmaceutical Factory of Zhuhai Sez, The |
Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
|
|
US6303135B1
(en)
|
1999-07-08 |
2001-10-16 |
Neal R. Cutler |
Use of quinolines and quinolones to treat male erectile dysfunction
|
|
CN1077108C
(zh)
*
|
1999-07-13 |
2002-01-02 |
成都地奥制药集团有限公司 |
用于制备药物昔多芬的前体化合物
|
|
IL130968A
(en)
|
1999-07-15 |
2002-12-01 |
Shmuel Simon |
Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss
|
|
US6399826B1
(en)
|
1999-08-11 |
2002-06-04 |
Sepracor Inc. |
Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
|
|
DE19944161A1
(de)
*
|
1999-09-15 |
2001-03-22 |
Bayer Ag |
Neue Kombination zur Behandlung von sexueller Dysfunktion
|
|
CA2383466C
(en)
|
1999-09-16 |
2009-08-25 |
Tanabe Seiyaku Co., Ltd. |
Aromatic nitrogen-containing 6-membered cyclic compounds
|
|
US6436944B1
(en)
|
1999-09-30 |
2002-08-20 |
Pfizer Inc. |
Combination effective for the treatment of impotence
|
|
EA200200240A1
(ru)
*
|
1999-10-11 |
2002-10-31 |
Пфайзер Инк. |
5-(2-ЗАМЕЩЕННЫЕ-5-ГЕТЕРОЦИКЛИЛСУЛЬФОНИЛПИРИД-3-ИЛ)-ДИГИДРОПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
US20050070499A1
(en)
*
|
1999-11-08 |
2005-03-31 |
Pfizer Inc. |
Compounds for the treatment of female sexual dysfunction
|
|
WO2001047928A2
(de)
|
1999-12-24 |
2001-07-05 |
Bayer Aktiengesellschaft |
Imidazo 1,3,5 triazinone und ihre verwendung
|
|
KR100358083B1
(ko)
*
|
2000-02-17 |
2002-10-25 |
에스케이케미칼주식회사 |
피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
|
|
DE10010067A1
(de)
*
|
2000-03-02 |
2001-09-06 |
Bayer Ag |
Neue Imidazotriazinone und ihre Verwendung
|
|
GB0008694D0
(en)
*
|
2000-04-07 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
|
US7019136B2
(en)
|
2000-04-07 |
2006-03-28 |
Novartis, Ag |
8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors
|
|
DE10017947A1
(de)
*
|
2000-04-11 |
2001-10-25 |
Merck Patent Gmbh |
Verfahren zur Herstellung benzo-annelierter Heterocyclen
|
|
MXPA02010693A
(es)
|
2000-04-28 |
2003-03-10 |
Tanabe Seiyaku Co |
Compuestos ciclicos.
|
|
US7273868B2
(en)
|
2000-04-28 |
2007-09-25 |
Tanabe Seiyaku Co., Ltd. |
Pyrazine derivatives
|
|
AU2000254308A1
(en)
*
|
2000-05-17 |
2001-11-26 |
Sk Chemicals Co., Ltd. |
Pyrazolopyrimidinone derivatives, process for their preparation and their use
|
|
UA74826C2
(en)
*
|
2000-05-17 |
2006-02-15 |
Ortho Mcneil Pharm Inc |
?-carboline derivatives as phosphodiesterase inhibitors
|
|
UA72611C2
(uk)
*
|
2000-05-17 |
2005-03-15 |
Орто-Макнейл Фармацевтикал, Інк. |
Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
|
|
US6667398B2
(en)
|
2000-06-22 |
2003-12-23 |
Pfizer Inc |
Process for the preparation of pyrazolopyrimidinones
|
|
US6730786B2
(en)
*
|
2000-06-22 |
2004-05-04 |
Pfizer Inc |
Process for the preparation of pyrazolopyrimidinones
|
|
DE10031585A1
(de)
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
2-Aminoalkyl-thieno[2,3-d]pyrimidine
|
|
DE10031584A1
(de)
*
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
|
|
AU2001276403A1
(en)
*
|
2000-07-12 |
2002-01-21 |
Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts |
Use of inhibitors to multidrug resistance protein 5 (mrp5) to enhance intracellular levels of cyclic nucleotides
|
|
BRPI0003386B8
(pt)
*
|
2000-08-08 |
2021-05-25 |
Cristalia Produtos Quim Farmaceuticos Ltda |
pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas
|
|
PE20020394A1
(es)
|
2000-08-18 |
2002-06-21 |
Agouron Pharma |
Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
|
|
AU2000267375A1
(en)
*
|
2000-08-23 |
2002-03-04 |
Lg Life Sciences Ltd. |
Polyethoxylated pyrazolo pyrimidinone derivatives, process for preparation thereof and pharmaceutical compositions comprising the same for the treatment of impotence
|
|
US6503894B1
(en)
|
2000-08-30 |
2003-01-07 |
Unimed Pharmaceuticals, Inc. |
Pharmaceutical composition and method for treating hypogonadism
|
|
US7501409B2
(en)
|
2000-09-06 |
2009-03-10 |
Mitsubishi Tanabe Pharma Corporation |
Preparations for oral administration
|
|
US6821978B2
(en)
|
2000-09-19 |
2004-11-23 |
Schering Corporation |
Xanthine phosphodiesterase V inhibitors
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
GB0025782D0
(en)
*
|
2000-10-20 |
2000-12-06 |
Pfizer Ltd |
Use of inhibitors
|
|
DE60005024T2
(de)
*
|
2000-10-23 |
2004-06-24 |
The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co. Ltd. |
Verwendung von Sulfadiazin und Sulfadimidine zur Behandlung der erektilen Dysfunktion
|
|
DE10063108A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
|
|
SE0004780D0
(sv)
|
2000-12-22 |
2000-12-22 |
Jordanian Pharmaceutical Mfg & |
Novel compunds
|
|
JP3940290B2
(ja)
*
|
2000-12-22 |
2007-07-04 |
ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド |
新規化合物
|
|
WO2002062343A2
(en)
*
|
2001-02-02 |
2002-08-15 |
Merck Patent Gmbh |
PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO[4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS
|
|
AU2002230217B2
(en)
|
2001-02-15 |
2005-02-17 |
Tanabe Seiyaku Co., Ltd. |
Tablets quickly disintegrated in oral cavity
|
|
DE10107639A1
(de)
*
|
2001-02-15 |
2002-08-22 |
Bayer Ag |
2-Alkoxyphenyl-substituierte Imidazotriazinone
|
|
CA2438294C
(en)
|
2001-02-26 |
2008-10-21 |
Tanabe Seiyaku Co., Ltd. |
Pyridopyrimidine or naphthyridine derivative
|
|
EP1372656B1
(en)
*
|
2001-03-16 |
2005-06-22 |
Pfizer Limited |
Pyrazolo[4,3-d]pyrimidinone compounds as cgmp pde inhibitors
|
|
US6784185B2
(en)
|
2001-03-16 |
2004-08-31 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
US20050164220A1
(en)
*
|
2001-03-19 |
2005-07-28 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke: method of treatment
|
|
WO2004028341A2
(en)
*
|
2001-03-19 |
2004-04-08 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke; methods of treatment
|
|
US20040014099A1
(en)
*
|
2001-03-19 |
2004-01-22 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke; methods of treatment
|
|
US20030054531A1
(en)
*
|
2001-03-19 |
2003-03-20 |
Decode Genetics Ehf, |
Human stroke gene
|
|
US6794387B2
(en)
|
2001-03-28 |
2004-09-21 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
GB0107751D0
(en)
*
|
2001-03-28 |
2001-05-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
DE10118306A1
(de)
|
2001-04-12 |
2002-10-17 |
Bayer Ag |
Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
|
|
US6610887B2
(en)
|
2001-04-13 |
2003-08-26 |
Sepracor Inc. |
Methods of preparing didesmethylsibutramine and other sibutramine derivatives
|
|
KR100393160B1
(ko)
*
|
2001-06-14 |
2003-07-31 |
한국과학기술연구원 |
신규한 피라졸로피리미딘티온 유도체, 그의 제법 및발기부전 치료제로서의 용도
|
|
WO2002102385A1
(en)
*
|
2001-06-14 |
2002-12-27 |
Sampad Bhattacharya |
Compositions comprising cgmppde5 inhibitor for transdermal delivery to the erectile tissue of the penis
|
|
CN1127506C
(zh)
*
|
2001-06-29 |
2003-11-12 |
刘宝顺 |
一种治疗阳痿的新化合物
|
|
DE10135815A1
(de)
|
2001-07-23 |
2003-02-06 |
Bayer Ag |
Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
|
|
EP1790652A1
(en)
*
|
2001-08-28 |
2007-05-30 |
Schering Corporation |
Polycyclic guanine phosphodiesterase V inhibitors
|
|
CN1315835C
(zh)
|
2001-08-28 |
2007-05-16 |
先灵公司 |
多环鸟嘌呤磷酸二酯酶v抑制剂
|
|
US20030087963A1
(en)
|
2001-09-13 |
2003-05-08 |
Senanayake Chris H. |
Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites
|
|
US6943171B2
(en)
|
2001-11-09 |
2005-09-13 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase V inhibitors
|
|
BR0207215A
(pt)
*
|
2001-12-13 |
2004-02-10 |
Daiichi Suntory Pharma Co Ltd |
Derivados de pirazolopiriminona tendo ação de inibição de pde7
|
|
US7645878B2
(en)
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
EP1719772A1
(en)
|
2002-05-31 |
2006-11-08 |
Schering Corporation |
Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
|
|
CA2486174A1
(en)
*
|
2002-05-31 |
2003-12-11 |
Schering Corporation |
Xanthine phosphodiesterase v inhibitor polymorphs
|
|
ES2297217T3
(es)
|
2002-06-19 |
2008-05-01 |
Janssen Pharmaceutica Nv |
Derivados sustituidos de 2,4-dihidro-pirrolo(3,4-b)quinolin-9-ona utilizados como inhibidores de fosfodiesterasa.
|
|
DE10232113A1
(de)
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
|
WO2004072079A1
(en)
*
|
2003-02-11 |
2004-08-26 |
Pfizer Limited |
Hydrated and anhydrous sildenafil hemi-citrate compound
|
|
DE10325813B4
(de)
|
2003-06-06 |
2007-12-20 |
Universitätsklinikum Freiburg |
Prophylaxe und/oder Therapie bei der portalen Hypertonie
|
|
CN100374441C
(zh)
|
2003-06-06 |
2008-03-12 |
天津倍方科技发展有限公司 |
二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途
|
|
EP3342420A1
(en)
*
|
2003-06-13 |
2018-07-04 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
JP2007508365A
(ja)
*
|
2003-10-13 |
2007-04-05 |
ジェメック、ミカエル |
女性患者の性欲の促進及びオルガスム到達のための黄体形成ホルモンの使用
|
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
US20070287937A1
(en)
*
|
2003-12-02 |
2007-12-13 |
Hakuju Institute For Health Services |
Nonpharmacological Generative Function Control Method and Its Apparatus
|
|
CN100360531C
(zh)
*
|
2003-12-18 |
2008-01-09 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
|
|
JP2007532697A
(ja)
*
|
2004-04-19 |
2007-11-15 |
ストラテジック サイエンス アンド テクノロジーズ, エルエルシー |
局所的血流増大の有益な効果
|
|
US9226909B2
(en)
|
2004-04-19 |
2016-01-05 |
Strategic Science & Technologies, Llc |
Beneficial effects of increasing local blood flow
|
|
RU2436579C2
(ru)
|
2004-05-11 |
2011-12-20 |
Эмоушнл Брэйн Б.В. |
Фармацевтические композиции и их применение в лечении женской сексуальной дисфункции
|
|
US20060030574A1
(en)
|
2004-08-04 |
2006-02-09 |
Shire Holdings Ag |
Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
|
|
US7700608B2
(en)
|
2004-08-04 |
2010-04-20 |
Shire Holdings Ag |
Quinazoline derivatives and their use in the treatment of thrombocythemia
|
|
AU2005277042A1
(en)
*
|
2004-08-23 |
2006-03-02 |
Mannkind Corporation |
Pulmonary delivery of inhibitors of phosphodiesterase type 5
|
|
CN100347174C
(zh)
*
|
2004-09-10 |
2007-11-07 |
上海特化医药科技有限公司 |
杂环并嘧啶酮衍生物、制备方法和用途
|
|
US8524274B2
(en)
|
2004-10-18 |
2013-09-03 |
Polymun Scientific Immunbiologische Forschung Gmbh |
Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof
|
|
DE102005009240A1
(de)
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
|
US20060235005A1
(en)
*
|
2005-04-14 |
2006-10-19 |
Oak Labs, Corp. |
Use of phosphodiesterase 5 (PDE5) inhibitors in the treatment of schizophrenia
|
|
UA84688C2
(uk)
*
|
2005-04-15 |
2008-11-25 |
Виктор Павлович Кутняк |
Засіб для лікування еректильної дисфункції
|
|
RU2336878C2
(ru)
*
|
2005-05-16 |
2008-10-27 |
Виктор Павлович Кутняк |
Средство для лечения эректильной дисфункции
|
|
CA2620333A1
(en)
|
2005-08-26 |
2007-03-01 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
|
SG166106A1
(en)
*
|
2005-09-29 |
2010-11-29 |
Bayer Schering Pharma Ag |
Pde inhibitors and combinations thereof for the treatment of urological disorders
|
|
AU2006304787A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by PDE inhibition
|
|
EP2314289A1
(en)
|
2005-10-31 |
2011-04-27 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
KR20080065704A
(ko)
|
2005-11-09 |
2008-07-14 |
콤비네이토릭스, 인코포레이티드 |
의학적 이상의 치료 방법들, 조성물들, 및 키트들
|
|
EP1790343A1
(en)
|
2005-11-11 |
2007-05-30 |
Emotional Brain B.V. |
Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
|
|
CN1966506A
(zh)
|
2005-11-17 |
2007-05-23 |
上海特化医药科技有限公司 |
吡唑并嘧啶酮衍生物及其制备方法和用途
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
WO2007124045A2
(en)
*
|
2006-04-20 |
2007-11-01 |
Ampla Pharmaceuticals, Inc. |
Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity
|
|
JP2009536667A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス,インコーポレイティド |
5ht受容体介在性の神経新生
|
|
EP2021000A2
(en)
|
2006-05-09 |
2009-02-11 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
|
ES2707548T3
(es)
*
|
2006-05-15 |
2019-04-04 |
United Therapeutics Corp |
Administración de treprostinil utilizando un inhalador de dosis medida
|
|
MX2009002496A
(es)
|
2006-09-08 |
2009-07-10 |
Braincells Inc |
Combinaciones que contienen un derivado de 4-acilaminopiridina.
|
|
DE102006043443A1
(de)
|
2006-09-15 |
2008-03-27 |
Bayer Healthcare Ag |
Neue aza-bicyclische Verbindungen und ihre Verwendung
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
EP1925307A1
(en)
|
2006-11-03 |
2008-05-28 |
Emotional Brain B.V. |
Use of 3-alpha-androstanediol in the treatment of sexual dysfunction
|
|
US7910597B2
(en)
|
2006-11-28 |
2011-03-22 |
Shire Llc |
Substituted quinazolines
|
|
CN101563348B
(zh)
|
2006-12-21 |
2011-08-24 |
上海特化医药科技有限公司 |
西地那非的制备方法及其中间体
|
|
ES2384481T3
(es)
*
|
2007-02-12 |
2012-07-05 |
Dmi Biosciences, Inc. |
Tratamiento de la eyaculación precoz y la disfunción eréctil co-morbidas
|
|
ES2384127T3
(es)
|
2007-02-12 |
2012-06-29 |
Dmi Biosciences, Inc. |
Reducción de los efectos secundarios del tramadol
|
|
WO2008100886A1
(en)
*
|
2007-02-12 |
2008-08-21 |
Auspex Pharmaceuticals, Inc. |
Preparation and use of deuterated udenafil analogues as highly selective pde5 modulators for the treatment of erectile dysfunction
|
|
ES2310144B1
(es)
|
2007-06-15 |
2010-01-12 |
Galenicum Health, S.L. |
Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5.
|
|
DE102007028869A1
(de)
|
2007-06-22 |
2008-12-24 |
Ratiopharm Gmbh |
Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
|
|
WO2009091777A1
(en)
*
|
2008-01-15 |
2009-07-23 |
Forest Laboratories Holdings Limited |
Nebivolol in the treatment of sexual dysfunction
|
|
ES2553897T3
(es)
|
2008-05-02 |
2015-12-14 |
Gilead Sciences, Inc. |
El uso de partículas de vehículo sólido para mejorar la procesabilidad de un agente farmacéutico
|
|
CA2722578C
(en)
|
2008-05-14 |
2014-02-11 |
Sbi Alapromo Co., Ltd. |
Use of .delta.-amino levulinic acid to treat male infertility
|
|
CN101747282A
(zh)
|
2008-12-10 |
2010-06-23 |
上海特化医药科技有限公司 |
一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
|
|
BRPI0823356A2
(pt)
*
|
2008-12-12 |
2015-06-16 |
Rhein Siegfried Sa De Cv |
Composição de liberação pulsátil de sildenafil e processo para prepará-la
|
|
DE102008063992A1
(de)
|
2008-12-19 |
2010-09-02 |
Lerner, Zinoviy, Dipl.-Ing. |
Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
|
|
WO2010070617A1
(en)
|
2008-12-19 |
2010-06-24 |
Shimoda Biotech (Pty) Ltd |
Inclusion complexes of alpha-cyclodextrin and sildenafil salt
|
|
RU2391095C1
(ru)
*
|
2009-02-05 |
2010-06-10 |
Закрытое акционерное общество "Березовский фармацевтический завод" |
Фармацевтическая композиция, включающая холина альфосцерат и гопантеновую кислоту (или ее соль), для лечения недостаточности кровообращения мозга и эректильной дисфункции
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
US20100261737A1
(en)
*
|
2009-04-10 |
2010-10-14 |
Medtronic Vascular, Inc. |
Method of Treating Erectile Dysfunction
|
|
AU2010261510A1
(en)
|
2009-06-19 |
2012-02-09 |
Nanoform Hungary Ltd. |
Nanostructured Sildenafil base, its pharmaceutically acceptable salts and co-crystals, compositions of them, process for the preparation thereof and pharmaceutical compositions containing them
|
|
US12138268B2
(en)
|
2009-06-24 |
2024-11-12 |
Strategic Science & Technologies, Llc |
Treatment of erectile dysfunction and other indications
|
|
US11684624B2
(en)
|
2009-06-24 |
2023-06-27 |
Strategic Science & Technologies, Llc |
Treatment of erectile dysfunction and other indications
|
|
DE102009033396A1
(de)
|
2009-07-16 |
2011-01-20 |
Ratiopharm Gmbh |
Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung
|
|
DE102009035211A1
(de)
|
2009-07-29 |
2011-02-17 |
Ratiopharm Gmbh |
Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung
|
|
EP2493434A1
(en)
|
2009-10-30 |
2012-09-05 |
Medispec Ltd |
Method and apparatus for treatment of erectile dysfunction with extracorporeal shockwaves
|
|
KR101861981B1
(ko)
|
2009-11-27 |
2018-05-28 |
아드베리오 파마 게엠베하 |
제약상 물질로서 사용하기 위한 메틸-(4,6-디아미노-2-(1-(2-플루오로벤질)-1h-피라졸로(3,4-b)피리디노-3-일)피리미디노-5-일)메틸카르바메이트의 제조 방법 및 그의 정제
|
|
UY33041A
(es)
|
2009-11-27 |
2011-06-30 |
Bayer Schering Pharma Aktienegesellschaft |
Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
|
|
JP5806231B2
(ja)
|
2009-12-21 |
2015-11-10 |
アセフ エス.アー. |
勃起障害の治療における血管拡張剤としてのクベビン、ジベンジルブチルロラクトリンリグナン、その半合成誘導体および合成誘導体、ならびに他のリグナンおよびネオリグナン
|
|
ES2635340T3
(es)
|
2010-02-27 |
2017-10-03 |
Bayer Intellectual Property Gmbh |
Ariltriazolonas ligadas a bis-arilo y su uso
|
|
KR101508047B1
(ko)
|
2010-03-15 |
2015-04-06 |
유나이티드 세러퓨틱스 코오포레이션 |
폐고혈압의 치료
|
|
DE102010021637A1
(de)
|
2010-05-26 |
2011-12-01 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
|
|
WO2012000634A1
(de)
|
2010-06-29 |
2012-01-05 |
Georg Bambach |
Pharmazeutische zusammensetzung zur behandlung von erektiler dysfunktion
|
|
CN101891747B
(zh)
*
|
2010-07-02 |
2012-04-25 |
张南 |
抑制5型磷酸二酯酶的化合物及制备方法
|
|
TW201210584A
(en)
|
2010-08-18 |
2012-03-16 |
Alcon Res Ltd |
Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma
|
|
DE102010040187A1
(de)
|
2010-09-02 |
2012-03-08 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung
|
|
DE102010040924A1
(de)
|
2010-09-16 |
2012-03-22 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung
|
|
JP2014504592A
(ja)
|
2010-12-29 |
2014-02-24 |
ストラテジック サイエンス アンド テクノロジーズ, エルエルシー |
勃起不全および他の適応症の処置
|
|
PL2670401T3
(pl)
|
2011-02-02 |
2015-11-30 |
Novartis Ag |
Sposoby stosowania inhibitorów ALK
|
|
EP2731599B1
(en)
|
2011-07-15 |
2018-10-31 |
NuSirt Sciences, Inc. |
Compositions and methods for modulating metabolic pathways
|
|
AT512084A1
(de)
|
2011-10-20 |
2013-05-15 |
Univ Wien Tech |
Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
|
|
WO2013067309A1
(en)
|
2011-11-04 |
2013-05-10 |
Xion Pharmaceutical Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
JP5941558B2
(ja)
|
2012-02-28 |
2016-06-29 |
株式会社ソウル製薬Seoul Pharma. Co., Ltd. |
シルデナフィルを有効成分として含有し、且つ、苦味の隠蔽された高含量速溶フィルム
|
|
US9198454B2
(en)
|
2012-03-08 |
2015-12-01 |
Nusirt Sciences, Inc. |
Compositions, methods, and kits for regulating energy metabolism
|
|
CN108452311A
(zh)
|
2012-11-13 |
2018-08-28 |
纽斯尔特科学公司 |
用于增强能量代谢的组合物和方法
|
|
US9750743B2
(en)
|
2012-12-04 |
2017-09-05 |
Aribio Inc. |
Composition comprising phosphodiesterase type 5 inhibitor for inhibiting apoptosis of nerve cells
|
|
KR101953735B1
(ko)
|
2012-12-14 |
2019-03-04 |
한미약품 주식회사 |
포스포다이에스터라제-5 억제제를 포함하는 츄정
|
|
JP6386478B2
(ja)
|
2013-02-21 |
2018-09-05 |
アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
メチル{4,6−ジアミノ−2−[1−(2−フルオロベンジル)−1h−ピラゾロ[3,4−b]ピリジノ−3−イル]ピリミジノ−5−イル}メチルカルバメートの形態
|
|
CN105228627B
(zh)
|
2013-03-15 |
2018-07-13 |
纽斯尔特科学公司 |
亮氨酸和烟酸降低脂质水平
|
|
SG11201607075TA
(en)
|
2014-02-27 |
2016-09-29 |
Nusirt Sciences Inc |
Compositions and methods for the reduction or prevention of hepatic steatosis
|
|
KR101645652B1
(ko)
|
2014-11-03 |
2016-08-08 |
(주)퓨젠바이오농업회사법인 |
세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
|
|
WO2016071212A1
(en)
|
2014-11-03 |
2016-05-12 |
Bayer Pharma Aktiengesellschaft |
Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
|
|
CN104650093B
(zh)
*
|
2015-02-02 |
2017-01-25 |
王靖林 |
一种西地那非类似物的合成方法
|
|
WO2017168174A1
(en)
|
2016-04-02 |
2017-10-05 |
N4 Pharma Uk Limited |
New pharmaceutical forms of sildenafil
|
|
US9988367B2
(en)
|
2016-05-03 |
2018-06-05 |
Bayer Pharma Aktiengesellschaft |
Amide-substituted pyridinyltriazole derivatives and uses thereof
|
|
EP3522920A2
(en)
|
2016-10-10 |
2019-08-14 |
Transgene SA |
Immunotherapeutic product and mdsc modulator combination therapy
|
|
US10568847B2
(en)
*
|
2016-12-13 |
2020-02-25 |
James J. Caprio |
Compositions and methods for treatment of erectile dysfunction
|
|
WO2018134848A1
(en)
|
2017-01-20 |
2018-07-26 |
Laila Nutraceuticals |
Dietary supplements for inhibiting pde5 and increasing cgmp levels
|
|
JP7334124B2
(ja)
|
2017-06-21 |
2023-08-28 |
トランジェーヌ |
個別化ワクチン
|
|
WO2019007299A1
(zh)
*
|
2017-07-07 |
2019-01-10 |
中国科学院上海药物研究所 |
一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途
|
|
WO2019170820A1
(en)
|
2018-03-07 |
2019-09-12 |
Transgene |
Parapoxvirus vectors
|
|
CA3103695A1
(en)
|
2018-06-14 |
2019-12-19 |
Astrazeneca Uk Limited |
Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition
|
|
CN112997258A
(zh)
*
|
2018-06-14 |
2021-06-18 |
阿斯利康(英国)有限公司 |
用cGMP特异性磷酸二酯酶5抑制剂药物组合物治疗勃起功能障碍的方法
|
|
SE542968C2
(en)
|
2018-10-26 |
2020-09-22 |
Lindahl Anders |
Treatment of osteoarthritis
|
|
WO2020136235A1
(en)
|
2018-12-28 |
2020-07-02 |
Transgene Sa |
M2-defective poxvirus
|
|
CN113493459B
(zh)
*
|
2020-04-07 |
2022-12-13 |
广州白云山医药集团股份有限公司白云山制药总厂 |
Pde5抑制剂化合物及其制备方法和应用
|
|
CN111732593A
(zh)
*
|
2020-07-07 |
2020-10-02 |
黄泳华 |
哌嗪氧化物衍生物及其组合物、制备方法与用途
|
|
CN115785101B
(zh)
*
|
2022-11-23 |
2023-10-13 |
西安市食品药品检验所 |
一种含有苯基哌嗪结构的那非类化合物及其制备方法
|
|
CN120641103A
(zh)
|
2023-01-25 |
2025-09-12 |
阿丽派欧株式会社 |
包含5型磷酸二酯酶抑制剂作为有效成分用于预防或治疗创伤后应激障碍的组合物
|