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MX384006B - Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos. - Google Patents

Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos.

Info

Publication number
MX384006B
MX384006B MX2016015479A MX2016015479A MX384006B MX 384006 B MX384006 B MX 384006B MX 2016015479 A MX2016015479 A MX 2016015479A MX 2016015479 A MX2016015479 A MX 2016015479A MX 384006 B MX384006 B MX 384006B
Authority
MX
Mexico
Prior art keywords
tri
specific binding
methods
binding molecules
specifically bind
Prior art date
Application number
MX2016015479A
Other languages
English (en)
Other versions
MX2016015479A (es
Inventor
Ezio Bonvini
Jonathan C Li
Kalpana Shah
Leslie S Johnson
Paul A Moore
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54699839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX384006(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX2016015479A publication Critical patent/MX2016015479A/es
Publication of MX384006B publication Critical patent/MX384006B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/626—Diabody or triabody
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

La presente invención se refiere a Moléculas de Unión Tri-Específicas, las cuales son moléculas de polipéptidos en multi-cadena que poseen tres Dominios de Unión y de esta manera son capaces de mediar la unión coordinada a tres epítopos. La Molécula de Unión Tri-Específica se caracteriza de preferencia al poseer dominios de unión que le permiten unirse inmunoespecíficamente a: (1) un epítopo de un primer Antígeno de Cáncer, (2) un epítopo de un segundo Antígeno de Cáncer, y (3) un epítopo de una molécula que se expresa sobre la superficie de una célula efectora del sistema inmunológico, y de esta manera son capaces de ubicar una célula efectora del sistema inmunológico en una célula que expresa un Antígeno de Cáncer, para facilitar por consiguiente el exterminio de tales células cancerígenas.
MX2016015479A 2014-05-29 2015-05-29 Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos. MX384006B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462004571P 2014-05-29 2014-05-29
US201462008229P 2014-06-05 2014-06-05
US201562107824P 2015-01-26 2015-01-26
PCT/US2015/033081 WO2015184207A1 (en) 2014-05-29 2015-05-29 Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2016015479A MX2016015479A (es) 2017-03-23
MX384006B true MX384006B (es) 2025-03-14

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Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016015479A MX384006B (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos.
MX2016015398A MX384781B (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas y metodos de uso de las mismas.
MX2020014221A MX2020014221A (es) 2014-05-29 2016-11-24 Moleculas de union tri-especificas y metodos de uso de las mismas.

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MX2016015398A MX384781B (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas y metodos de uso de las mismas.
MX2020014221A MX2020014221A (es) 2014-05-29 2016-11-24 Moleculas de union tri-especificas y metodos de uso de las mismas.

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US (6) US10647768B2 (es)
EP (3) EP3148580B1 (es)
JP (5) JP6685934B2 (es)
KR (3) KR102364383B1 (es)
CN (4) CN113549153A (es)
AP (1) AP2016009586A0 (es)
AU (4) AU2015266880B2 (es)
BR (2) BR112016027912A2 (es)
CA (2) CA2950572C (es)
CL (2) CL2016003040A1 (es)
EA (1) EA035419B9 (es)
ES (2) ES2890079T3 (es)
IL (2) IL249266B (es)
MA (1) MA40069A (es)
MX (3) MX384006B (es)
NZ (2) NZ726520A (es)
PE (2) PE20170765A1 (es)
PH (2) PH12016502370A1 (es)
PL (2) PL3148580T3 (es)
RU (2) RU2718692C2 (es)
SG (4) SG11201609912TA (es)
TN (1) TN2016000525A1 (es)
TW (5) TWI707872B (es)
WO (2) WO2015184203A1 (es)
ZA (1) ZA201607995B (es)

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ES2790420T3 (es) 2013-03-14 2020-10-27 Scripps Research Inst Conjugados de anticuerpos y de agentes de focalización usos de los mismos
WO2014145907A1 (en) 2013-03-15 2014-09-18 Xencor, Inc. Targeting t cells with heterodimeric proteins
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US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
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