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MX2016015398A - Moleculas de union tri-especificas y metodos de uso de las mismas. - Google Patents

Moleculas de union tri-especificas y metodos de uso de las mismas.

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Publication number
MX2016015398A
MX2016015398A MX2016015398A MX2016015398A MX2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A
Authority
MX
Mexico
Prior art keywords
epitopes
tri
binding
specific binding
binding molecules
Prior art date
Application number
MX2016015398A
Other languages
English (en)
Other versions
MX384781B (es
Inventor
s johnson Leslie
Huang Ling
Bonvini Ezio
Shah Kalpana
Reddy Chichili Gurunadh
Ying Kao LAM Chia-
James BURKE Stephen
Liu Liqin
Barat Bhaswati
A Moore Paul
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54699839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016015398(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX2016015398A publication Critical patent/MX2016015398A/es
Publication of MX384781B publication Critical patent/MX384781B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

La presente invención se relaciona con las Moléculas de Unión Tri-Específicas, que son Moléculas de Polipéptido de cadena múltiple que poseen tres Dominios de Unión y, son por tanto capaces de mediar la unión coordinada a los tres epítopos. Los Dominios de Unión pueden seleccionarse de manera que las Moléculas de Unión Tri-Específicas son capaces de unirse a cualquiera de los tres diferentes epítopos. Los epítopos pueden ser epítopos del mismo antígeno o epítopos de dos o tres diferentes antígenos. En una modalidad preferida, uno de los epítopos será capaz de unirse a CD3, el segundo de los epítopos será capaz de unirse a CD8, y el tercero de los epítopos será capaz de unirse a un epítopo de un Antígeno Asociado con la Enfermedad. La invención también proporciona también un anticuerpo de unión a ROR1 novedoso, así como derivados de los mismos y usos de tales composiciones.
MX2016015398A 2014-05-29 2015-05-29 Moleculas de union tri-especificas y metodos de uso de las mismas. MX384781B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462004571P 2014-05-29 2014-05-29
US201462008229P 2014-06-05 2014-06-05
US201562107824P 2015-01-26 2015-01-26
PCT/US2015/033076 WO2015184203A1 (en) 2014-05-29 2015-05-29 Tri-specific binding molecules and methods of use thereof

Publications (2)

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MX2016015398A true MX2016015398A (es) 2017-02-22
MX384781B MX384781B (es) 2025-03-14

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MX2016015479A MX384006B (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos.
MX2016015398A MX384781B (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas y metodos de uso de las mismas.
MX2020014221A MX2020014221A (es) 2014-05-29 2016-11-24 Moleculas de union tri-especificas y metodos de uso de las mismas.

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US (6) US10633440B2 (es)
EP (3) EP3152235B1 (es)
JP (5) JP6647222B2 (es)
KR (3) KR102355609B1 (es)
CN (4) CN113549153A (es)
AP (1) AP2016009586A0 (es)
AU (4) AU2015266880B2 (es)
BR (2) BR112016027893A2 (es)
CA (2) CA2950572C (es)
CL (2) CL2016003040A1 (es)
EA (1) EA035419B9 (es)
ES (2) ES2890079T3 (es)
IL (2) IL249266B (es)
MA (1) MA40069A (es)
MX (3) MX384006B (es)
NZ (2) NZ726520A (es)
PE (2) PE20170765A1 (es)
PH (2) PH12016502369A1 (es)
PL (2) PL3148580T3 (es)
RU (2) RU2020111366A (es)
SG (4) SG10201913680PA (es)
TN (1) TN2016000525A1 (es)
TW (5) TWI718098B (es)
WO (2) WO2015184203A1 (es)
ZA (1) ZA201607995B (es)

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US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10738132B2 (en) 2013-01-14 2020-08-11 Xencor, Inc. Heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
CN105283201B (zh) 2013-03-14 2019-08-02 斯克利普斯研究所 靶向剂抗体偶联物及其用途
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