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MX2019012360A - Composiciones y metodos mejorados de celulas t. - Google Patents

Composiciones y metodos mejorados de celulas t.

Info

Publication number
MX2019012360A
MX2019012360A MX2019012360A MX2019012360A MX2019012360A MX 2019012360 A MX2019012360 A MX 2019012360A MX 2019012360 A MX2019012360 A MX 2019012360A MX 2019012360 A MX2019012360 A MX 2019012360A MX 2019012360 A MX2019012360 A MX 2019012360A
Authority
MX
Mexico
Prior art keywords
methods
cells
compositions
improved
cell compositions
Prior art date
Application number
MX2019012360A
Other languages
English (en)
Inventor
Fernando Chaparro Riggers Javier
John Van Blarcom Thomas
Andre Boldajipour Bijan
Original Assignee
Allogene Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allogene Therapeutics Inc filed Critical Allogene Therapeutics Inc
Publication of MX2019012360A publication Critical patent/MX2019012360A/es

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
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  • Wood Science & Technology (AREA)
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  • Epidemiology (AREA)
  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
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  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
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Abstract

La presente invención proporciona composiciones y métodos que reducen la expresión de la superficie celular de la molécula de clase I de histocompatibilidad principal, y usos de tales composiciones y métodos para mejorar las actividades funcionales de células T aisladas (por ejemplo, células T específicas de antígeno modificadas por genes, tales como células T (CART) del receptor de antígeno quimérico). En particular, la presente invención proporciona métodos y composiciones para reforzar la eficacia terapéutica de células CAR-T.
MX2019012360A 2017-04-19 2018-04-18 Composiciones y metodos mejorados de celulas t. MX2019012360A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762487215P 2017-04-19 2017-04-19
PCT/IB2018/052698 WO2018193394A1 (en) 2017-04-19 2018-04-18 Improved t cell compositions and methods

Publications (1)

Publication Number Publication Date
MX2019012360A true MX2019012360A (es) 2019-11-28

Family

ID=62148430

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012360A MX2019012360A (es) 2017-04-19 2018-04-18 Composiciones y metodos mejorados de celulas t.

Country Status (13)

Country Link
US (1) US20200399343A1 (es)
EP (1) EP3612275A1 (es)
JP (2) JP2020517244A (es)
KR (1) KR20190141206A (es)
CN (1) CN110520196A (es)
AU (1) AU2018255926B9 (es)
BR (1) BR112019021857A2 (es)
CA (1) CA3057265A1 (es)
IL (1) IL269334A (es)
MX (1) MX2019012360A (es)
RU (1) RU2019136640A (es)
TW (1) TWI694149B (es)
WO (1) WO2018193394A1 (es)

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JP2023086732A (ja) 2023-06-22
AU2018255926B9 (en) 2023-10-19
BR112019021857A2 (pt) 2020-06-02
US20200399343A1 (en) 2020-12-24
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JP2020517244A (ja) 2020-06-18
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