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MX2019004708A - Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores. - Google Patents

Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores.

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Publication number
MX2019004708A
MX2019004708A MX2019004708A MX2019004708A MX2019004708A MX 2019004708 A MX2019004708 A MX 2019004708A MX 2019004708 A MX2019004708 A MX 2019004708A MX 2019004708 A MX2019004708 A MX 2019004708A MX 2019004708 A MX2019004708 A MX 2019004708A
Authority
MX
Mexico
Prior art keywords
aapcs
presenting cells
antigen presenting
tumor infiltrating
artificial antigen
Prior art date
Application number
MX2019004708A
Other languages
English (en)
Inventor
T Lotze Michael
Veerapathran Anand
Gokuldass Aishwarya
Rabinovich Brian
Original Assignee
Iovance Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of MX2019004708A publication Critical patent/MX2019004708A/es

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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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Abstract

En algunas modalidades, se describen composiciones y métodos relacionados con células aisladas que presentan antígeno artificial (aAPCs), incluyendo aAPCs que comprenden una célula mieloide transducida con uno o varios vectores virales, tales como una célula mieloide MOLM-14 o EM-3, en donde la célula mieloide expresa endógenamente HLA-A/B/C, ICOS-L y CD58 y en donde los uno o varios vectores virales comprenden un ácido nucleico que codifica CD86 y un ácido nucleico que codifica 4-1BBL y/u OX40L y transduce la célula mieloide para expresar proteínas CD86 y 4-1BBL y/u OX40L. En algunas modalidades, se describen métodos de expansión de linfocitos infiltrantes de tumores (TILs) con aAPCs y métodos de tratamiento de cánceres usando TILs después de la expansión con aAPCs.
MX2019004708A 2016-10-31 2017-10-31 Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores. MX2019004708A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662415274P 2016-10-31 2016-10-31
US201662438600P 2016-12-23 2016-12-23
US201762475053P 2017-03-22 2017-03-22
US201762481831P 2017-04-05 2017-04-05
PCT/US2017/059271 WO2018081789A1 (en) 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

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MX2019004708A true MX2019004708A (es) 2019-08-29

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MX2019004708A MX2019004708A (es) 2016-10-31 2017-10-31 Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores.
MX2022012409A MX2022012409A (es) 2016-10-31 2019-04-23 Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores.

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US (4) US10415015B2 (es)
EP (1) EP3532608A1 (es)
JP (2) JP7576912B2 (es)
KR (2) KR20190071802A (es)
CN (2) CN110312790A (es)
AU (2) AU2017347942A1 (es)
BR (1) BR112019008560A2 (es)
CA (1) CA3041673A1 (es)
IL (1) IL266221B1 (es)
MA (1) MA46668A (es)
MX (2) MX2019004708A (es)
SG (1) SG11201903825SA (es)
TW (1) TWI788307B (es)
WO (1) WO2018081789A1 (es)

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KR20240150531A (ko) 2016-10-26 2024-10-15 이오반스 바이오테라퓨틱스, 인크. 냉동보존된 종양 침윤 림프구의 재자극
TWI788307B (zh) * 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
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