|
US6312700B1
(en)
*
|
1998-02-24 |
2001-11-06 |
Andrew D. Weinberg |
Method for enhancing an antigen specific immune response with OX-40L
|
|
TWI476001B
(zh)
|
2011-12-26 |
2015-03-11 |
Ind Tech Res Inst |
三倍體Ｆｃ融合蛋白及其用途
|
|
US20140050720A1
(en)
|
2012-01-09 |
2014-02-20 |
The Scripps Research Institute |
Ultralong complementarity determining regions and uses thereof
|
|
US10238698B2
(en)
|
2012-01-25 |
2019-03-26 |
Dnatrix, Inc. |
Biomarkers and combination therapies using oncolytic virus and immunomodulation
|
|
WO2013119202A1
(en)
|
2012-02-06 |
2013-08-15 |
Providence Health & Services - Oregon |
Cancer treatment and monitoring methods using ox40 agonists
|
|
US10329350B2
(en)
|
2012-12-26 |
2019-06-25 |
Industrial Technology Research Institute |
Method for producing a multivalent fab fragment with collagen-like peptide
|
|
US10259863B2
(en)
|
2013-01-11 |
2019-04-16 |
The California Institute For Biomedical Research |
Bovine fusion antibodies
|
|
EP2951209A4
(en)
|
2013-01-31 |
2016-06-22 |
Univ Jefferson |
CD40 OX40 AGONIST FUSION PROTEIN AND USES THEREOF
|
|
WO2015116178A1
(en)
*
|
2014-01-31 |
2015-08-06 |
Thomas Jefferson University |
Fusion proteins for modulating regulatory and effector t cells
|
|
EP2951199A4
(en)
|
2013-01-31 |
2016-07-20 |
Univ Jefferson |
Fusion proteins for the modulation of regulatory and effector T cells
|
|
MX385338B
(es)
|
2013-02-22 |
2025-03-18 |
CureVac SE |
Combinación de vacunación e inhibición de la trayectoria pd-1.
|
|
US9546203B2
(en)
*
|
2013-03-14 |
2017-01-17 |
Amgen Inc. |
Aglycosylated Fc-containing polypeptides with cysteine substitutions
|
|
PL2970427T3
(pl)
|
2013-03-15 |
2020-06-01 |
Geoffrey W. STONE |
Kompozycja składająca się z antygenu związanego z ligandem z nadrodziny TNF
|
|
CA2917814C
(en)
*
|
2013-07-11 |
2022-12-13 |
The California Institute For Biomedical Research |
Coiled coil immunoglobulin fusion proteins and compositions thereof
|
|
US20150038682A1
(en)
*
|
2013-08-02 |
2015-02-05 |
Jn Biosciences Llc |
Antibodies or fusion proteins multimerized via homomultimerizing peptide
|
|
KR20160137946A
(ko)
|
2013-11-22 |
2016-12-02 |
디엔에이트릭스, 인코포레이티드 |
면역 세포 자극성 수용체 작용제(들)를 발현하는 아데노바이러스
|
|
BR112016013963A2
(pt)
|
2013-12-17 |
2017-10-10 |
Genentech Inc |
terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1
|
|
ES2754239T3
(es)
|
2014-03-12 |
2020-04-16 |
Curevac Ag |
Combinación de vacunación y agonistas de OX40
|
|
KR20160146747A
(ko)
|
2014-03-31 |
2016-12-21 |
제넨테크, 인크. |
항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법
|
|
ES2774381T3
(es)
|
2014-04-03 |
2020-07-20 |
Univ Res Inst Inc Augusta |
Métodos para mejorar la eficacia de la respuesta inmune dirigida a tumores
|
|
WO2015183902A1
(en)
*
|
2014-05-29 |
2015-12-03 |
Medimmune, Llc |
Ox40l fusion proteins and uses thereof
|
|
CN113577081A
(zh)
|
2014-07-11 |
2021-11-02 |
吉利德科学公司 |
用于治疗hiv的toll样受体调节剂
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
TW201619200A
(zh)
|
2014-10-10 |
2016-06-01 |
麥迪紐有限責任公司 |
人類化抗－ｏｘ４０抗體及其用途
|
|
JP6877339B2
(ja)
|
2014-10-14 |
2021-05-26 |
ノバルティス アーゲー |
Ｐｄ−ｌ１に対する抗体分子およびその使用
|
|
EP3550019A1
(en)
|
2014-10-24 |
2019-10-09 |
Astrazeneca AB |
Combination
|
|
MX2017005750A
(es)
|
2014-11-03 |
2017-12-15 |
Genentech Inc |
Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso.
|
|
EP3215637B1
(en)
|
2014-11-03 |
2019-07-03 |
F. Hoffmann-La Roche AG |
Methods and biomarkers for predicting efficacy and valuation of an ox40 agonist treatment
|
|
WO2016073282A1
(en)
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
SG11201703605QA
(en)
|
2014-11-17 |
2017-06-29 |
Genentech Inc |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
MA41460A
(fr)
|
2015-02-03 |
2017-12-12 |
Oncomed Pharm Inc |
Agents de liaison à la tnfrsf et leurs utilisations
|
|
US10046047B2
(en)
*
|
2015-02-06 |
2018-08-14 |
Heat Biologics, Inc. |
Vector co-expressing vaccine and costimulatory molecules
|
|
WO2016156291A1
(en)
*
|
2015-03-31 |
2016-10-06 |
F. Hoffmann-La Roche Ag |
Antigen binding molecules comprising a trimeric tnf family ligand
|
|
EP3280736A1
(en)
|
2015-04-07 |
2018-02-14 |
F. Hoffmann-La Roche AG |
Antigen binding complex having agonistic activity and methods of use
|
|
CN115109158A
(zh)
|
2015-05-07 |
2022-09-27 |
阿吉纳斯公司 |
抗ox40抗体及其使用方法
|
|
US20160347848A1
(en)
|
2015-05-28 |
2016-12-01 |
Medimmune Limited |
Therapeutic combinations and methods for treating neoplasia
|
|
AU2016291817A1
(en)
|
2015-07-16 |
2018-02-22 |
Biolinerx Ltd. |
Compositions and methods for treating cancer
|
|
EP3964528A1
(en)
|
2015-07-29 |
2022-03-09 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
|
WO2017019896A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
CA2994346A1
(en)
*
|
2015-08-12 |
2017-02-16 |
Medimmune Limited |
Gitrl fusion proteins and uses thereof
|
|
JP2018527366A
(ja)
|
2015-09-15 |
2018-09-20 |
ギリアード サイエンシーズ， インコーポレイテッド |
ＨＩＶを処置するためのｔｏｌｌ様レセプターのモジュレーター
|
|
US20190022092A1
(en)
|
2015-09-15 |
2019-01-24 |
Acerta Pharma B.V. |
Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist
|
|
NZ739750A
(en)
|
2015-09-25 |
2019-11-29 |
Genentech Inc |
Anti-tigit antibodies and methods of use
|
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
|
EP3356403A2
(en)
|
2015-10-02 |
2018-08-08 |
H. Hoffnabb-La Roche Ag |
Bispecific antibodies specific for a costimulatory tnf receptor
|
|
TW202134282A
(zh)
|
2015-12-02 |
2021-09-16 |
美商艾吉納斯公司 |
抗體和使用彼之方法
|
|
EP4424322A3
(en)
|
2015-12-17 |
2025-04-16 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
|
ES3041885T3
(en)
|
2016-01-08 |
2025-11-17 |
Replimune Ltd |
Engineered virus
|
|
KR20180098671A
(ko)
|
2016-01-11 |
2018-09-04 |
인히브릭스, 인크. |
다가 및 다중특이적 ox40-결합 융합 단백질
|
|
EP3426271B1
(en)
|
2016-03-10 |
2025-08-27 |
CG Oncology, Inc. |
Methods of treating solid tumors by combination therapy
|
|
DE102016105069A1
(de)
|
2016-03-18 |
2017-09-21 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Antivirale Immuntherapie durch Membranrezeptorligation
|
|
EP3231813A1
(en)
|
2016-03-29 |
2017-10-18 |
F. Hoffmann-La Roche AG |
Trimeric costimulatory tnf family ligand-containing antigen binding molecules
|
|
EP3243836A1
(en)
*
|
2016-05-11 |
2017-11-15 |
F. Hoffmann-La Roche AG |
C-terminally fused tnf family ligand trimer-containing antigen binding molecules
|
|
WO2018027204A1
(en)
|
2016-08-05 |
2018-02-08 |
Genentech, Inc. |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
|
CA3040123A1
(en)
|
2016-10-11 |
2018-04-19 |
University Of Miami |
Vectors and vaccine cells for immunity against zika virus
|
|
TWI788307B
(zh)
|
2016-10-31 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
|
|
CA3041340A1
(en)
|
2016-11-09 |
2018-05-17 |
Agenus Inc. |
Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
|
|
AU2018205234B2
(en)
|
2017-01-06 |
2024-09-19 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists
|
|
WO2018187260A1
(en)
|
2017-04-04 |
2018-10-11 |
Heat Biologics, Inc. |
Intratumoral vaccination
|
|
AU2018251987B2
(en)
|
2017-04-14 |
2024-11-28 |
Cg Oncology, Inc. |
Methods of treating bladder cancer
|
|
US11377490B2
(en)
*
|
2017-05-31 |
2022-07-05 |
Sichuan Clover Biopharmaceuticals, Inc |
Method for treating cancer using disulfide-linked trimeric 4-1BBL
|
|
TW201919662A
(zh)
|
2017-06-05 |
2019-06-01 |
美商艾歐凡斯生物治療公司 |
對雙重難治性黑色素瘤使用腫瘤浸潤性淋巴細胞之方法
|
|
BR112020009663A2
(pt)
|
2017-11-17 |
2020-11-10 |
Iovance Biotherapeutics, Inc. |
método para a expansão de linfócitos infiltrantes de tumor (tils) em uma população terapêutica de tils, método para o tratamento de um indivíduo com câncer, composição
|
|
SG11202006541UA
(en)
|
2018-01-08 |
2020-08-28 |
Iovance Biotherapeutics Inc |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
|
WO2019136459A1
(en)
|
2018-01-08 |
2019-07-11 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
|
US11713446B2
(en)
|
2018-01-08 |
2023-08-01 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
|
JP2021512962A
(ja)
|
2018-02-13 |
2021-05-20 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ
|
|
WO2019184909A1
(zh)
|
2018-03-27 |
2019-10-03 |
信达生物制药(苏州)有限公司 |
新型抗体分子、其制备方法及其用途
|
|
CN110305210B
(zh)
|
2018-03-27 |
2023-02-28 |
信达生物制药(苏州)有限公司 |
新型抗体分子、其制备方法及其用途
|
|
MA52533A
(fr)
|
2018-04-27 |
2021-03-03 |
Iovance Biotherapeutics Inc |
Procédé en circuit fermé pour l'amplification et l'edition de gènes de lymphocytes d'infiltration des tumeurs et leurs utilisations en immunothérapie
|
|
CA3104218A1
(en)
|
2018-06-25 |
2020-01-02 |
Immodulon Therapeutics Limited |
Cancer therapy
|
|
CA3105891A1
(en)
|
2018-07-24 |
2020-01-30 |
Inhibrx, Inc. |
Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
|
|
US11447556B2
(en)
|
2018-08-13 |
2022-09-20 |
Inhibex, Inc. |
OX40-binding polypeptides and uses thereof
|
|
TW202031273A
(zh)
|
2018-08-31 |
2020-09-01 |
美商艾歐凡斯生物治療公司 |
抗ｐｄ－１抗體難治療性之非小細胞肺癌（ｎｓｃｌｃ）病患的治療
|
|
AU2019342749B2
(en)
|
2018-09-20 |
2025-07-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tils from cryopreserved tumor samples
|
|
EP3864045A2
(en)
|
2018-10-11 |
2021-08-18 |
Inhibrx, Inc. |
Dll3 single domain antibodies and therapeutic compositions thereof
|
|
EP3864049A1
(en)
|
2018-10-11 |
2021-08-18 |
Inhibrx, Inc. |
Pd-1 single domain antibodies and therapeutic compositions thereof
|
|
BR112021008266A2
(pt)
|
2018-11-05 |
2022-01-04 |
Iovance Biotherapeutics Inc |
Métodos para expandir linfócitos infiltrantes de tumor em uma população terapêutica de linfócitos infiltrantes de tumor e para tratar um sujeito com câncer, e, população terapêutica de linfócitos infiltrantes de tumor
|
|
KR20210091213A
(ko)
|
2018-11-05 |
2021-07-21 |
이오반스 바이오테라퓨틱스, 인크. |
종양 침윤 림프구의 생성 방법 및 면역치료법에서 이의 용도
|
|
CA3118634A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients refractory for anti-pd-1 antibody
|
|
JP2022506508A
(ja)
|
2018-11-05 |
2022-01-17 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
Ａｋｔ経路阻害剤を利用したｔｉｌの拡大培養
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
EP3898949A1
(en)
|
2018-12-19 |
2021-10-27 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
|
CA3131700A1
(en)
|
2019-02-27 |
2020-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of malat1 expression
|
|
JP7760374B2
(ja)
|
2019-03-29 |
2025-10-27 |
ターンストーン バイオロジクス コーポレイション |
Ｔ細胞治療薬を生成するためのエクスビボ方法ならびに関連する組成物および方法
|
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
EP4037693A1
(en)
|
2019-09-30 |
2022-08-10 |
Astrazeneca AB |
Combination treatment for cancer
|
|
WO2021081378A1
(en)
|
2019-10-25 |
2021-04-29 |
Iovance Biotherapeutics, Inc. |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
EP4065229A1
(en)
|
2019-11-27 |
2022-10-05 |
Myst Therapeutics, LLC |
Method of producing tumor-reactive t cell composition using modulatory agents
|
|
WO2021118990A1
(en)
|
2019-12-11 |
2021-06-17 |
Iovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
|
AU2021226903A1
(en)
|
2020-02-27 |
2022-10-20 |
Turnstone Biologics Corp. |
Methods for ex vivo enrichment and expansion of tumor reactive T cells and related compositions thereof
|
|
WO2021226061A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
US20230293685A1
(en)
|
2020-05-04 |
2023-09-21 |
Iovance Biotherapeutics, Inc. |
Selection of improved tumor reactive t-cells
|
|
US20230372397A1
(en)
|
2020-10-06 |
2023-11-23 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
WO2022096896A1
(en)
|
2020-11-06 |
2022-05-12 |
Immodulon Therapeutics Limited |
Mycobacterial immunotherapy for treating cancer
|
|
WO2022101619A1
(en)
|
2020-11-10 |
2022-05-19 |
Immodulon Therapeutics Limited |
A mycobacterium for use in cancer therapy
|
|
WO2022125941A1
(en)
|
2020-12-11 |
2022-06-16 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
|
|
US20240123067A1
(en)
|
2020-12-17 |
2024-04-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocyte therapies
|
|
CA3202483A1
(en)
|
2020-12-17 |
2022-06-23 |
Maria Fardis |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
EP4326287A2
(en)
|
2021-04-19 |
2024-02-28 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
|
AU2022288058A1
(en)
|
2021-06-07 |
2023-11-16 |
Agonox, Inc. |
Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
|
|
WO2023007107A1
(en)
|
2021-07-27 |
2023-02-02 |
Immodulon Therapeutics Limited |
A mycobacterium for use in cancer therapy
|
|
CA3226942A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
|
EP4423755A2
(en)
|
2021-10-27 |
2024-09-04 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
AU2022388729A1
(en)
|
2021-11-10 |
2024-05-16 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
|
WO2023147486A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Tumor infiltrating lymphocytes engineered to express payloads
|
|
EP4507704A1
(en)
|
2022-04-15 |
2025-02-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
|
EP4565683A1
(en)
|
2022-08-01 |
2025-06-11 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
|
WO2024151885A1
(en)
|
2023-01-13 |
2024-07-18 |
Iovance Biotherapeutics, Inc. |
Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
CN119390782B
(zh)
*
|
2024-09-29 |
2025-09-16 |
中国人民解放军总医院 |
一种自组装三聚体蛋白及其制备方法
|
|
CN120718109A
(zh)
*
|
2024-09-29 |
2025-09-30 |
中国人民解放军总医院 |
一类具备自组装聚性能的蛋白及其制备方法
|