MX2018010128A - Toxina nueva y metodo de preparacion de un intermediario de la misma. - Google Patents
Toxina nueva y metodo de preparacion de un intermediario de la misma.Info
- Publication number
- MX2018010128A MX2018010128A MX2018010128A MX2018010128A MX2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A
- Authority
- MX
- Mexico
- Prior art keywords
- general formula
- new toxin
- present
- preparing
- iii
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000003053 toxin Substances 0.000 title abstract 3
- 231100000765 toxin Toxicity 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000006239 protecting group Chemical class 0.000 abstract 2
- 230000009435 amidation Effects 0.000 abstract 1
- 238000007112 amidation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
La presente invención se refiere a una toxina nueva y a un método para preparar un intermediario de la misma. En particular, la presente invención se refiere a una toxina nueva y a un método para preparar los compuestos intermediarios (III) y (IV) de la misma y a un método de preparación para sintetizar lo que se muestra en la fórmula general (I). El método comprende someter un compuesto quiral, mostrado en la fórmula general (III), a una serie de adición de grupo protector, eliminación de grupo protector y amidación para obtener un compuesto como se muestra en la fórmula general (I). El presente método tiene las ventajas de una condición de reacción suave, operación simple, pureza óptica alta y rendimiento sintético alto, y es adecuado para producción a gran escala. (ver fórmulas).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610107901 | 2016-02-26 | ||
| PCT/CN2017/074756 WO2017144015A1 (zh) | 2016-02-26 | 2017-02-24 | 一种新毒素及其中间体的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018010128A true MX2018010128A (es) | 2019-01-21 |
Family
ID=59685835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018010128A MX2018010128A (es) | 2016-02-26 | 2017-02-24 | Toxina nueva y metodo de preparacion de un intermediario de la misma. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10513510B2 (es) |
| EP (1) | EP3421463A4 (es) |
| JP (1) | JP2019510000A (es) |
| KR (1) | KR20180115743A (es) |
| CN (1) | CN107531680B (es) |
| AU (1) | AU2017223532A1 (es) |
| BR (1) | BR112018016983A2 (es) |
| CA (1) | CA3015098A1 (es) |
| HK (1) | HK1244805A1 (es) |
| MX (1) | MX2018010128A (es) |
| RU (1) | RU2018132749A (es) |
| TW (1) | TWI732826B (es) |
| WO (1) | WO2017144015A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201912626A (zh) * | 2017-09-04 | 2019-04-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種新毒素及其中間體的製備方法 |
| CN112390853A (zh) * | 2019-08-11 | 2021-02-23 | 复旦大学 | 海兔毒素10类似物及其制备方法 |
| CN115698079A (zh) | 2020-07-27 | 2023-02-03 | 上海拓界生物医药科技有限公司 | 抗cd79b抗体药物偶联物、其制备方法及其医药用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2861170B1 (fr) | 2003-10-16 | 2006-01-20 | Tijani Gharbi | Dispositif optique pour determiner au moins une caracteristique dimensionnelle d'une goutte de liquide |
| NZ547633A (en) * | 2003-11-06 | 2010-08-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| KR101270829B1 (ko) * | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| CL2007003827A1 (es) * | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras. |
| TWI476190B (zh) | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| AR086364A1 (es) | 2011-04-21 | 2013-12-11 | Bayer Ip Gmbh | Conjugados de principio activo-ligante (adc) y el uso de los mismos |
| KR101733853B1 (ko) | 2011-11-17 | 2017-05-08 | 화이자 인코포레이티드 | 세포독성 펩티드 및 그의 항체 약물 접합체 |
| CA2859255A1 (en) * | 2011-12-14 | 2013-06-20 | Seattle Genetics, Inc. | New antibody drug conjugates (adcs) and the use thereof |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| MX378281B (es) * | 2014-04-25 | 2025-03-10 | Pf Medicament | Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer. |
| US20180177890A1 (en) | 2015-02-15 | 2018-06-28 | Jiangsu Hengrui Medicine Co., Ltd. | Ligand-cytotoxic drug conjugate, preparation method thereof, and use thereof |
| CN106188293A (zh) * | 2015-04-17 | 2016-12-07 | 江苏恒瑞医药股份有限公司 | 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 |
-
2017
- 2017-02-24 US US16/078,396 patent/US10513510B2/en not_active Expired - Fee Related
- 2017-02-24 AU AU2017223532A patent/AU2017223532A1/en not_active Abandoned
- 2017-02-24 EP EP17755844.2A patent/EP3421463A4/en not_active Withdrawn
- 2017-02-24 CN CN201780001254.7A patent/CN107531680B/zh active Active
- 2017-02-24 WO PCT/CN2017/074756 patent/WO2017144015A1/zh not_active Ceased
- 2017-02-24 RU RU2018132749A patent/RU2018132749A/ru not_active Application Discontinuation
- 2017-02-24 KR KR1020187026912A patent/KR20180115743A/ko not_active Withdrawn
- 2017-02-24 TW TW106106404A patent/TWI732826B/zh not_active IP Right Cessation
- 2017-02-24 JP JP2018544080A patent/JP2019510000A/ja active Pending
- 2017-02-24 HK HK18104330.1A patent/HK1244805A1/zh unknown
- 2017-02-24 MX MX2018010128A patent/MX2018010128A/es unknown
- 2017-02-24 CA CA3015098A patent/CA3015098A1/en not_active Abandoned
- 2017-02-24 BR BR112018016983-8A patent/BR112018016983A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018016983A2 (pt) | 2018-12-26 |
| AU2017223532A1 (en) | 2018-08-30 |
| CA3015098A1 (en) | 2017-08-31 |
| JP2019510000A (ja) | 2019-04-11 |
| EP3421463A4 (en) | 2019-10-23 |
| US20190055223A1 (en) | 2019-02-21 |
| EP3421463A1 (en) | 2019-01-02 |
| RU2018132749A3 (es) | 2020-04-14 |
| US10513510B2 (en) | 2019-12-24 |
| CN107531680B (zh) | 2020-09-11 |
| TWI732826B (zh) | 2021-07-11 |
| KR20180115743A (ko) | 2018-10-23 |
| RU2018132749A (ru) | 2020-03-26 |
| TW201730185A (zh) | 2017-09-01 |
| CN107531680A (zh) | 2018-01-02 |
| HK1244805A1 (zh) | 2018-08-17 |
| WO2017144015A1 (zh) | 2017-08-31 |
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