MX2023000059A - Metodo de preparacion de compuesto de fenilisoxazolina. - Google Patents
Metodo de preparacion de compuesto de fenilisoxazolina.Info
- Publication number
- MX2023000059A MX2023000059A MX2023000059A MX2023000059A MX2023000059A MX 2023000059 A MX2023000059 A MX 2023000059A MX 2023000059 A MX2023000059 A MX 2023000059A MX 2023000059 A MX2023000059 A MX 2023000059A MX 2023000059 A MX2023000059 A MX 2023000059A
- Authority
- MX
- Mexico
- Prior art keywords
- phenylisoxazoline
- compound
- synthesizing
- preparation
- present
- Prior art date
Links
- -1 phenylisoxazoline compound Chemical class 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 4
- 230000002194 synthesizing effect Effects 0.000 abstract 3
- 229940035893 uracil Drugs 0.000 abstract 2
- UKFPAGCSDWQXFT-UHFFFAOYSA-N 3-phenyl-4,5-dihydro-1,2-oxazole Chemical compound O1CCC(C=2C=CC=CC=2)=N1 UKFPAGCSDWQXFT-UHFFFAOYSA-N 0.000 abstract 1
- KENAMMSVUHVEOL-UHFFFAOYSA-N 4-chloro-2-fluoro-5-methylaniline Chemical compound CC1=CC(N)=C(F)C=C1Cl KENAMMSVUHVEOL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 125000003971 isoxazolinyl group Chemical group 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención pertenece al campo de síntesis orgánica. La presente invención proporciona un método de síntesis de un compuesto de fenilisoxazolina. Se usa 2-fluoro-4-cloro-5-metilanil ina como material inicial para sintetizar primero un anillo de uracilo y luego sintetizar un anillo de isoxazolina para obtener un compuesto objetivo, compuesto de fenilisoxazolina (VII). (ver Fórmulas) La definición de cada grupo en la fórmula se explica en la descripción. El método de preparación proporcionado por la presente invención se puede usar ampliamente para la síntesis de uracilo que contiene fenilisoxazolina, mejora en gran medida el rendimiento, reduce efectivamente el costo y es fácil de producir industrialmente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010634286.4A CN113880774B (zh) | 2020-07-02 | 2020-07-02 | 一种苯基异恶唑啉类化合物的制备方法 |
| PCT/CN2021/103472 WO2022002116A1 (zh) | 2020-07-02 | 2021-06-30 | 一种苯基异恶唑啉类化合物的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023000059A true MX2023000059A (es) | 2023-02-01 |
Family
ID=79012822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023000059A MX2023000059A (es) | 2020-07-02 | 2021-06-30 | Metodo de preparacion de compuesto de fenilisoxazolina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230303545A1 (es) |
| EP (1) | EP4177250A4 (es) |
| JP (1) | JP7553689B2 (es) |
| CN (1) | CN113880774B (es) |
| AU (1) | AU2021302173B2 (es) |
| BR (1) | BR112023000029A2 (es) |
| CA (1) | CA3184706A1 (es) |
| IL (1) | IL299591A (es) |
| MX (1) | MX2023000059A (es) |
| WO (1) | WO2022002116A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116803991A (zh) * | 2022-03-18 | 2023-09-26 | 帕潘纳(北京)科技有限公司 | 一种制备苯嘧磺草胺中间体的方法 |
| CN115124476B (zh) * | 2022-07-08 | 2024-09-20 | 南京正荣医药化学有限公司 | 一种除草剂中间体的制备方法 |
| TW202502761A (zh) * | 2023-07-06 | 2025-01-16 | 瑞士商先正達農作物保護股份公司 | 除草組成物 |
| CN120271582A (zh) * | 2023-12-28 | 2025-07-08 | 南通江山农药化工股份有限公司 | 异噁唑啉脲嘧啶类化合物的新晶型、制备方法与应用 |
| CN120271581A (zh) * | 2023-12-28 | 2025-07-08 | 南通江山农药化工股份有限公司 | 一种异噁唑啉脲嘧啶类化合物的结晶方法及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5336663A (en) * | 1991-11-13 | 1994-08-09 | Ciba-Geigy Corporation | 3-aryluracil derivatives and their use for weed control |
| DE19524623A1 (de) * | 1995-07-06 | 1997-01-09 | Basf Ag | 5-Pyrazolylbenzoesäure-Derivate |
| KR100282153B1 (ko) * | 1997-07-02 | 2001-02-15 | 김충섭 | 3-알킬피롤록3,2-씨퀴놀린유도체 |
| MX2010010366A (es) * | 2008-03-31 | 2010-11-30 | C & C Res Lab | Derivados heterociclicos. |
| FR2934265B1 (fr) * | 2008-07-23 | 2010-07-30 | Sanofi Aventis | Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique |
| WO2014111871A1 (en) * | 2013-01-17 | 2014-07-24 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
| CN105272973B (zh) * | 2014-06-10 | 2019-02-01 | 华中师范大学 | 一种含有苯并噁嗪环的嘧啶二酮类化合物及其应用 |
| CN105753853B (zh) | 2014-12-16 | 2020-08-04 | 沈阳中化农药化工研发有限公司 | 一种含异恶唑啉的脲嘧啶类化合物及其用途 |
| CN105777733B (zh) * | 2014-12-16 | 2018-12-14 | 沈阳中化农药化工研发有限公司 | 一种含异恶唑啉的四氢邻苯二甲酰亚胺类化合物及其用途 |
| JP2018526372A (ja) * | 2015-08-28 | 2018-09-13 | グレンマーク・ファーマシューティカルズ・エスエー | Ｒｏｒガンマ調節剤としての新規の炭素環化合物 |
| CN108570041B (zh) | 2017-03-14 | 2024-02-09 | 沈阳中化农药化工研发有限公司 | 一种含异恶唑啉脲嘧啶类化合物的制备方法 |
| JP7198279B2 (ja) * | 2018-06-11 | 2022-12-28 | 住友化学株式会社 | ウラシル化合物及びその用途 |
| CN110818644B (zh) * | 2018-08-08 | 2022-08-23 | 沈阳中化农药化工研发有限公司 | 一种异恶唑啉羧酸酯类化合物和应用 |
| CN110818699B (zh) * | 2018-08-08 | 2022-08-02 | 沈阳中化农药化工研发有限公司 | 一种异恶唑啉类化合物及其用途 |
| CN110964001B (zh) * | 2018-09-29 | 2022-07-22 | 沈阳中化农药化工研发有限公司 | 一种甲基化制备含异恶唑啉脲嘧啶类化合物的方法 |
-
2020
- 2020-07-02 CN CN202010634286.4A patent/CN113880774B/zh active Active
-
2021
- 2021-06-30 CA CA3184706A patent/CA3184706A1/en active Pending
- 2021-06-30 AU AU2021302173A patent/AU2021302173B2/en active Active
- 2021-06-30 US US18/003,906 patent/US20230303545A1/en active Pending
- 2021-06-30 MX MX2023000059A patent/MX2023000059A/es unknown
- 2021-06-30 EP EP21833201.3A patent/EP4177250A4/en active Pending
- 2021-06-30 JP JP2023500281A patent/JP7553689B2/ja active Active
- 2021-06-30 IL IL299591A patent/IL299591A/en unknown
- 2021-06-30 WO PCT/CN2021/103472 patent/WO2022002116A1/zh not_active Ceased
- 2021-06-30 BR BR112023000029A patent/BR112023000029A2/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113880774A (zh) | 2022-01-04 |
| IL299591A (en) | 2023-03-01 |
| AU2021302173A1 (en) | 2023-02-09 |
| EP4177250A4 (en) | 2024-07-10 |
| JP2023532362A (ja) | 2023-07-27 |
| BR112023000029A2 (pt) | 2023-01-31 |
| US20230303545A1 (en) | 2023-09-28 |
| CA3184706A1 (en) | 2022-01-06 |
| WO2022002116A1 (zh) | 2022-01-06 |
| CN113880774B (zh) | 2023-12-08 |
| AU2021302173B2 (en) | 2024-03-21 |
| EP4177250A1 (en) | 2023-05-10 |
| JP7553689B2 (ja) | 2024-09-18 |
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