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MX2015010934A - Metodo para producir un compuesto triciclico, y un compuesto triciclico capaz de producirse por dicho metodo de produccion. - Google Patents

Metodo para producir un compuesto triciclico, y un compuesto triciclico capaz de producirse por dicho metodo de produccion.

Info

Publication number
MX2015010934A
MX2015010934A MX2015010934A MX2015010934A MX2015010934A MX 2015010934 A MX2015010934 A MX 2015010934A MX 2015010934 A MX2015010934 A MX 2015010934A MX 2015010934 A MX2015010934 A MX 2015010934A MX 2015010934 A MX2015010934 A MX 2015010934A
Authority
MX
Mexico
Prior art keywords
tricyclic compound
producing
produced
compound capable
production method
Prior art date
Application number
MX2015010934A
Other languages
English (en)
Inventor
Tadashi Shimamura
Takao Uno
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2013/054615 external-priority patent/WO2013125709A1/ja
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of MX2015010934A publication Critical patent/MX2015010934A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un objeto de la presente invención es proporcionar un método para producir de forma que se pueda reproducir un compuesto tricíclico que contiene un anillo pirrolopirimidina con alto rendimiento con formación reducida de subproductos y proporcionar un compuesto tricíclico novedoso capaz de obtenerse por este método de producción; la presente invención proporciona un método para producir un compuesto representado por la fórmula (1) o una sal del mismo, el método que comprende los pasos de; (I) provocar que un reactivo borano orgánico actúe sobre un compuesto representado por la fórmula (2) o una sal del mismo, y (II) realizar una reacción de ciclización intramolecular de la reacción del paso (I) anterior utilizando un catalizador de paladio de valencia cero en presencia de un hidróxido de metal alcalino.
MX2015010934A 2013-02-22 2014-02-21 Metodo para producir un compuesto triciclico, y un compuesto triciclico capaz de producirse por dicho metodo de produccion. MX2015010934A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/JP2013/054615 WO2013125709A1 (ja) 2012-02-23 2013-02-22 キノリルピロロピリミジル縮合環化合物又はその塩
JP2013033886 2013-02-22
TW102106272A TWI496783B (zh) 2012-02-23 2013-02-22 Quinolylpyrrolopyrimidine condensed cyclic compounds or salts thereof
JP2013169200 2013-08-16
PCT/JP2014/054218 WO2014129596A1 (ja) 2013-02-22 2014-02-21 三環性化合物の製造方法及び当該製造方法により得ることができる三環性化合物

Publications (1)

Publication Number Publication Date
MX2015010934A true MX2015010934A (es) 2015-10-29

Family

ID=51391376

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015010934A MX2015010934A (es) 2013-02-22 2014-02-21 Metodo para producir un compuesto triciclico, y un compuesto triciclico capaz de producirse por dicho metodo de produccion.

Country Status (11)

Country Link
US (2) US9845329B2 (es)
EP (1) EP2960241A4 (es)
JP (1) JP5851068B2 (es)
KR (1) KR20150119401A (es)
CN (1) CN105073752B (es)
AU (1) AU2014219754B2 (es)
BR (1) BR112015018222A2 (es)
CA (1) CA2898274A1 (es)
MX (1) MX2015010934A (es)
TW (1) TWI558706B (es)
WO (1) WO2014129596A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3037424B1 (en) 2013-08-22 2017-11-08 Taiho Pharmaceutical Co., Ltd. Novel quinoline-substituted compound
JOP20190073A1 (ar) 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
CN108101905A (zh) * 2016-11-24 2018-06-01 中国科学院上海药物研究所 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
SG11202001861WA (en) 2017-09-01 2020-04-29 Taiho Pharmaceutical Co Ltd Selective inhibitor of exon 18 and/or exon 21 mutant egfr
EP3960743A4 (en) * 2019-04-24 2022-05-04 Shanghai Institute of Materia Medica, Chinese Academy of Sciences PYRIMIDO[5,4-B]PYRROLIZIN COMPOUND, ITS OPTICAL ISOMER, ITS PREPARATION METHOD AND ITS USE
CN115785107B (zh) * 2022-12-15 2024-11-12 南京雷正医药科技有限公司 一种取代8,9-二氢嘧啶并[5,4-b]吲嗪类化合物、药物组合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1871773A1 (en) 2005-03-17 2008-01-02 Novartis AG N-[3-(1-amino-5,6,7,8-tetrahydro-2,4,4b-triazafluoren-9-yl)-phenyl]benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
US20080299113A1 (en) * 2005-12-19 2008-12-04 Arnold Lee D Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents
CA2909277A1 (en) 2006-04-04 2007-10-11 Kevan M. Shokat Kinase antagonists
WO2008018881A1 (en) 2006-08-10 2008-02-14 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors
ES2585902T3 (es) 2006-09-22 2016-10-10 Pharmacyclics Llc Inhibidores de tirosina cinasa de Bruton
BRPI0810086B1 (pt) 2007-03-28 2021-11-09 Pharmacyclics Llc Composto inibidor de tirosina quinase de bruton, uso do referido composto e composição farmacêutica
US7718662B1 (en) * 2009-10-12 2010-05-18 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
CN102146059A (zh) 2010-02-08 2011-08-10 上海艾力斯医药科技有限公司 喹唑啉衍生物、制备方法及其应用
BR122014012788B1 (pt) 2010-06-23 2022-04-19 Hanmi Science Co., Ltd Derivados de pirimidina fundidos, seus usos, e composição farmacêutica para inibição da atividade de tirosina quinase
JP5957460B2 (ja) 2010-11-01 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド 複素環式化合物またはその使用
DK2722332T3 (en) * 2012-02-23 2016-06-20 Taiho Pharmaceutical Co Ltd Quinolylpyrrolopyrimidylforbindelse with concentrated ring or salt thereof.

Also Published As

Publication number Publication date
CN105073752A (zh) 2015-11-18
BR112015018222A2 (pt) 2017-07-18
EP2960241A4 (en) 2016-07-13
US9845329B2 (en) 2017-12-19
AU2014219754A1 (en) 2015-07-23
TW201444840A (zh) 2014-12-01
HK1215809A1 (zh) 2016-09-15
WO2014129596A1 (ja) 2014-08-28
TWI558706B (zh) 2016-11-21
CA2898274A1 (en) 2014-08-28
US20180086770A1 (en) 2018-03-29
CN105073752B (zh) 2017-08-15
JP5851068B2 (ja) 2016-02-03
US20160115172A1 (en) 2016-04-28
JPWO2014129596A1 (ja) 2017-02-02
AU2014219754B2 (en) 2016-05-05
EP2960241A1 (en) 2015-12-30
KR20150119401A (ko) 2015-10-23

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