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MX2007010141A - Procesos para la preparacion de intermedios de linezolid. - Google Patents

Procesos para la preparacion de intermedios de linezolid.

Info

Publication number
MX2007010141A
MX2007010141A MX2007010141A MX2007010141A MX2007010141A MX 2007010141 A MX2007010141 A MX 2007010141A MX 2007010141 A MX2007010141 A MX 2007010141A MX 2007010141 A MX2007010141 A MX 2007010141A MX 2007010141 A MX2007010141 A MX 2007010141A
Authority
MX
Mexico
Prior art keywords
linezolid
processes
preparation
oxazolidinyl
fluorophenyl
Prior art date
Application number
MX2007010141A
Other languages
English (en)
Inventor
Viviana Braude
Serguei Fine
Tamar Nidam
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of MX2007010141A publication Critical patent/MX2007010141A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invencion proporciona metodos mejorados para convertir R-N-(4-morfolinil-3-fluorofenil)-2-oxo-5-oxazolidinil- metil azida (III) en el intermedio de S-N-(4-morfolinil-3- fluorofenil)-2-oxo-5-oxazolidinil-metil amina (II) que implica la produccion de menos subproductos que los metodos previos. La amina (II) luego se convierte en linezolid (I) de alta pureza quimica con respecto al enantiomero R inactivo y a bis-linezolid (IV) y tiene alto rendimiento, sin necesidad de pasos de purificacion tediosos y complicados, tales como la cromatografia.
MX2007010141A 2005-02-24 2006-02-23 Procesos para la preparacion de intermedios de linezolid. MX2007010141A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65664605P 2005-02-24 2005-02-24
US65677805P 2005-02-24 2005-02-24
US69082205P 2005-06-14 2005-06-14
PCT/US2006/006414 WO2006091731A2 (en) 2005-02-24 2006-02-23 Processes for the preparation of linezolid intermediate

Publications (1)

Publication Number Publication Date
MX2007010141A true MX2007010141A (es) 2007-09-27

Family

ID=36498839

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2007010141A MX2007010141A (es) 2005-02-24 2006-02-23 Procesos para la preparacion de intermedios de linezolid.
MX2007010136A MX2007010136A (es) 2005-02-24 2006-02-24 Bis-linezolid aislado, preparacion de el, y su uso como estandar de referencia.
MX2007010143A MX2007010143A (es) 2005-02-24 2006-02-24 Formas cristalinas de intermedio de linezolid.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2007010136A MX2007010136A (es) 2005-02-24 2006-02-24 Bis-linezolid aislado, preparacion de el, y su uso como estandar de referencia.
MX2007010143A MX2007010143A (es) 2005-02-24 2006-02-24 Formas cristalinas de intermedio de linezolid.

Country Status (8)

Country Link
US (4) US7291614B2 (es)
EP (3) EP1866295A2 (es)
JP (2) JP2008530028A (es)
CA (2) CA2602073A1 (es)
IL (3) IL183380A0 (es)
MX (3) MX2007010141A (es)
TW (1) TW200640886A (es)
WO (3) WO2006091731A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011114210A2 (en) 2010-03-15 2011-09-22 Jubilant Life Sciences Limited Processes for the preparation of linezolid
BR112012027901A2 (pt) 2010-04-30 2015-09-08 Univ Indiana Res & Tech Corp processos para preparar linezolida
EP2690100A1 (en) 2010-08-11 2014-01-29 Synhton B.V. Process for making linezolid
WO2012019632A1 (en) 2010-08-11 2012-02-16 Synthon B.V. Process for making linezolid
US9567307B2 (en) 2011-01-07 2017-02-14 The Regents Of The University Of California Amination of aryl alcohol derivatives
WO2013111048A1 (en) 2012-01-24 2013-08-01 Jubilant Life Sciences Limited Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
ES2603252T3 (es) 2012-11-09 2017-02-24 Synthon Bv Proceso para preparar linezolid
US9586913B2 (en) 2013-04-25 2017-03-07 Symed Labs Limited Processes for the preparation of linezolid using novel intermediates
CR20160222U (es) 2013-11-15 2016-08-26 Akebia Therapeutics Inc Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas
CN109265407B (zh) * 2018-10-23 2020-05-29 扬子江药业集团北京海燕药业有限公司 一种双利奈唑胺的合成方法
CN109444294B (zh) * 2018-12-27 2021-06-22 苏州莱奥生物技术有限公司 一种分离利奈唑胺和其手性异构体的高效液相色谱方法
GB202013383D0 (en) * 2020-08-26 2020-10-07 Givaudan Sa Process

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
KR100257418B1 (ko) 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5750717A (en) * 1994-03-02 1998-05-12 Daicel Chemical Industries, Ltd. 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same
JP3831954B2 (ja) * 1995-05-19 2006-10-11 ダイソー株式会社 ４−ヒドロキシ−２−ピロリドンの製法
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
DE19827282A1 (de) * 1998-06-19 1999-12-23 Bayer Ag Verfahren zur Herstellung von cycloaliphatischen Aminen
US6444813B2 (en) 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
US6514529B2 (en) * 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
YU52403A (sh) * 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
US6982274B2 (en) * 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
AU2001100437A4 (en) 2001-10-03 2001-11-01 Pfizer Limited Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
AU2003224345A1 (en) * 2002-04-30 2003-11-17 Orchid Chemicals & Pharmaceuticals Antibacterial agents
AU2002339721A1 (en) 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
EP1673370B1 (en) * 2003-10-16 2009-09-09 Symed Labs Limited Crystalline form of linezolid
CA2572207A1 (en) * 2004-06-29 2006-10-19 Teva Pharmaceutical Industries Ltd. Solid forms of linezolid and processes for preparation thereof

Also Published As

Publication number Publication date
US20080045707A1 (en) 2008-02-21
US7291614B2 (en) 2007-11-06
US20060252932A1 (en) 2006-11-09
IL184038A0 (en) 2007-10-31
EP1866295A2 (en) 2007-12-19
US20060258655A1 (en) 2006-11-16
IL183379A0 (en) 2007-09-20
JP2008530144A (ja) 2008-08-07
WO2006091848A2 (en) 2006-08-31
WO2006091731A3 (en) 2006-10-19
MX2007010143A (es) 2007-09-27
EP1861383A2 (en) 2007-12-05
TW200640886A (en) 2006-12-01
EP1853571A1 (en) 2007-11-14
JP2008530028A (ja) 2008-08-07
IL183380A0 (en) 2007-09-20
WO2006091848A3 (en) 2006-12-28
WO2006091848A9 (en) 2006-11-09
WO2006091731A2 (en) 2006-08-31
CA2602073A1 (en) 2006-08-31
CA2588876A1 (en) 2006-08-31
WO2006091777A1 (en) 2006-08-31
US20070021417A1 (en) 2007-01-25
MX2007010136A (es) 2007-09-27

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