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MX2018003410A - Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso. - Google Patents

Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso.

Info

Publication number
MX2018003410A
MX2018003410A MX2018003410A MX2018003410A MX2018003410A MX 2018003410 A MX2018003410 A MX 2018003410A MX 2018003410 A MX2018003410 A MX 2018003410A MX 2018003410 A MX2018003410 A MX 2018003410A MX 2018003410 A MX2018003410 A MX 2018003410A
Authority
MX
Mexico
Prior art keywords
rhv
amino acid
acid sequence
sequence seq
human
Prior art date
Application number
MX2018003410A
Other languages
English (en)
Other versions
MX387662B (es
Inventor
Georges Guy
Kettenberger Hubert
Moessner Ekkehard
Schlothauer Tilman
Haas Alexander
Molhoj Michael
Ferrara Koller Claudia
Lariviere Laurent
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2018003410A publication Critical patent/MX2018003410A/es
Publication of MX387662B publication Critical patent/MX387662B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente descripción se describe de un anticuerpo que se une específicamente a CD19 humano, en el que el anticuerpo comprende: (a) una RHV-H1 que comprende la secuencia de aminoácidos SEC ID No. 03, (b) RHV-H2 que comprende la secuencia de aminoácido SEC ID No. 11, (c) RHV-H3 que comprende la secuencia de aminoácidos SEC ID No. 05, (d) RHV-L1 que comprende la secuencia de aminoácidos SEC ID No. 20 o 28, (e) RHV-L2 que comprende la secuencia de aminoácidos SEC ID No. 07, y (f) RHV-L3 que comprende la secuencia de aminoácidos SEC ID No. 08, así como métodos de uso de los mismos.
MX2018003410A 2015-10-01 2016-09-30 Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso. MX387662B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15187820 2015-10-01
PCT/EP2016/073412 WO2017055541A1 (en) 2015-10-01 2016-09-30 Humanized anti-human cd19 antibodies and methods of use

Publications (2)

Publication Number Publication Date
MX2018003410A true MX2018003410A (es) 2018-06-06
MX387662B MX387662B (es) 2025-03-18

Family

ID=54251433

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018003410A MX387662B (es) 2015-10-01 2016-09-30 Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso.
MX2021011167A MX2021011167A (es) 2015-10-01 2018-03-20 Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021011167A MX2021011167A (es) 2015-10-01 2018-03-20 Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso.

Country Status (31)

Country Link
US (3) US11286300B2 (es)
EP (2) EP3356408B1 (es)
JP (2) JP6629437B2 (es)
KR (1) KR20180056768A (es)
CN (2) CN108137696B (es)
AR (1) AR106188A1 (es)
AU (2) AU2016333511B2 (es)
BR (1) BR112018006579A2 (es)
CA (1) CA3000562A1 (es)
CL (1) CL2018000728A1 (es)
CO (1) CO2018002265A2 (es)
CR (1) CR20180141A (es)
DK (1) DK3356408T3 (es)
ES (1) ES2791989T3 (es)
HR (1) HRP20200767T1 (es)
HU (1) HUE049083T2 (es)
IL (2) IL257679B (es)
LT (1) LT3356408T (es)
MA (2) MA43024B1 (es)
MX (2) MX387662B (es)
MY (1) MY185171A (es)
PE (1) PE20181054A1 (es)
PH (1) PH12018500708A1 (es)
PL (1) PL3356408T3 (es)
PT (1) PT3356408T (es)
RS (1) RS60250B1 (es)
RU (2) RU2731156C1 (es)
SI (1) SI3356408T1 (es)
TW (2) TWI747842B (es)
UA (1) UA125285C2 (es)
WO (1) WO2017055541A1 (es)

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CN111246884A (zh) 2017-11-01 2020-06-05 豪夫迈·罗氏有限公司 新颖的含有tnf家族配体三聚体的抗原结合分子
MY203902A (en) 2018-10-01 2024-07-23 Hoffmann La Roche Bispecific antigen binding molecules comprising anti-fap clone 212
TWI861039B (zh) 2018-12-21 2024-11-11 瑞士商赫孚孟拉羅股份公司 靶向腫瘤之促效cd28抗原結合分子
JP7650802B2 (ja) * 2018-12-30 2025-03-25 エフ． ホフマン－ラ ロシュ アーゲー 抗ウサギｃｄ１９抗体および使用方法
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TWI829667B (zh) 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 結合gprc5d之抗體
TWI861039B (zh) 2018-12-21 2024-11-11 瑞士商赫孚孟拉羅股份公司 靶向腫瘤之促效cd28抗原結合分子

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