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MX2017009950A - Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). - Google Patents

Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac).

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Publication number
MX2017009950A
MX2017009950A MX2017009950A MX2017009950A MX2017009950A MX 2017009950 A MX2017009950 A MX 2017009950A MX 2017009950 A MX2017009950 A MX 2017009950A MX 2017009950 A MX2017009950 A MX 2017009950A MX 2017009950 A MX2017009950 A MX 2017009950A
Authority
MX
Mexico
Prior art keywords
hdac
inhibitors
hydroxamics
deacetilasas
biciclico
Prior art date
Application number
MX2017009950A
Other languages
English (en)
Other versions
MX373137B (es
Inventor
W Martin Matthew
S Millan David
W Bair Kenneth
Lancia David Jr
Zheng Xiaozhang
Yee Ng Pui
Han Bingsong
R Thomason Jennifer
Margaret Zablocki Mary-
Liu Cuixian
Davis Heather
Rudnitskaya Aleksandra
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MX2017009950A publication Critical patent/MX2017009950A/es
Publication of MX373137B publication Critical patent/MX373137B/es

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Abstract

(ver Fórmula) La presente descripción hace referencia a inhibidores de histona desacetilasas (HDAC) dependientes de cinc útiles en el tratamiento de enfermedades o trastornos asociados con una HDAC, p. ej., HDAC6, con la fórmula I: en la que R, L, X1, X2, X3, X4, Y1, Y2, Y3 e Y4 se describen en la presente.
MX2017009950A 2015-02-02 2016-02-02 Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). MX373137B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562110716P 2015-02-02 2015-02-02
US201562205438P 2015-08-14 2015-08-14
PCT/US2016/016201 WO2016126725A1 (en) 2015-02-02 2016-02-02 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors

Publications (2)

Publication Number Publication Date
MX2017009950A true MX2017009950A (es) 2017-11-23
MX373137B MX373137B (es) 2020-04-20

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MX2017009950A MX373137B (es) 2015-02-02 2016-02-02 Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac).
MX2020003488A MX392538B (es) 2015-02-02 2016-02-02 Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac)

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MX2020003488A MX392538B (es) 2015-02-02 2016-02-02 Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac)

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US (32) US10214501B2 (es)
EP (3) EP3292116B8 (es)
JP (1) JP6668362B2 (es)
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