AR057061A1 - Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos - Google Patents
Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentosInfo
- Publication number
- AR057061A1 AR057061A1 ARP060102420A ARP060102420A AR057061A1 AR 057061 A1 AR057061 A1 AR 057061A1 AR P060102420 A ARP060102420 A AR P060102420A AR P060102420 A ARP060102420 A AR P060102420A AR 057061 A1 AR057061 A1 AR 057061A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- alkoxycarbonyl
- cycloalkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 20
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 piperidino, piperazino Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- VTKADNDBYHGLFR-UHFFFAOYSA-N 1-hydroxy-2-pyrrolidin-1-ylpyrrolidine Chemical group N1(CCCC1)C1N(CCC1)O VTKADNDBYHGLFR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente provee compuestos de la formula (1), compuestos derivados de espiro-bencimidazoles y su uso para preparar medicamentos. Los compuestos inhiben la secrecion de ácido gástrico, y por ende se utilizan en el tratamiento de enfermedades gastrointestinales. Reivindicacion 1: Un compuesto de la formula (1), en la cual: R1 es hidrogeno, alquilo C1-4, cicloalquilo C3-7, cicloalquilC3-7-alquiloC1-4, alcoxi C1-4, alcoxiC1-4-alquiloC1-4, alcoxicarbonilo C1-4, alquenilo C2-4, alquinilo C2- 4, fluoro-alquiloC1-4 o hidroxi-alquiloC1-4, R2 es hidrogeno, alquilo C1-4, alcoxi C1-4, cicloalquilo C3-7, cicloalquilC3-7-alquiloC1-4, hidroxi-alquiloC1-4, alcoxiC1-4-alquiloC1-4, alquenilo C2-4, alquinilo C2-4 o fluoro-alquiloC1-4, R3 es hidrogeno, halogeno, fluoro-alquilo C1-4, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, carboxilo, alcoxicarbonilo C1-4, hidroxi-alquiloC1-4, alcoxiC1-4-alquiloC1-4, alcoxiC1-4-alcoxiC1-4-alquiloC1-4, fluoro-alcoxiC1-4-alquiloC1-4 o el grupo -CO- NR31R32, donde R31 es hidrogeno, hidroxilo, alquilo C1-7, cicloalquilo C3-7, hidroxi-alquiloC1-4, alcoxiC1-4-alquiloC1-4, alquilcarbonilC1-4-alquilo C1-4, alquilcarbonilo C1-4 o alcoxicarbonilo C1-4; y R32 es hidrogeno, alquilo C1-7, hidroxi- alquiloC1-4, o alcoxiC1-4-alquilo C1-4, o donde R31 y R32 juntos, incluyendo el átomo de nitrogeno al cual ambos están unidos son un grupo pirrolidino, hidroxipirrolidino, piperidino, piperazino, azetidino, hidroxiazetidino, fluoroazetidino, aziridino, N-alquilpiperazinoC1-4 o morfolino, R4 y R5 son sustituyentes idénticos o diferentes seleccionados del grupo que consiste de hidrogeno, alquilo C1-4, hidroxi-alquiloC1-4, alcoxi C1-4, alcoxiC1-4-alquiloC1-4, hidroxi-alcoxiC1-4, alcoxiC1-4- alcoxiC1-4, alqueniloxi C2-4, alquilcarbonilC1-4, carboxilo, alcoxicarbonilo C1-4, carboxi-alquiloC1-4, alcoxicarbonilC1-4-alquiloC1-4, halogeno, hidroxilo, trifluorometilo, halo-alcoxiC1-4, nitro, amino, mono- o di-alquilaminoC1-4, alquilcarbonilamino C1-4, alcoxicarbonilamino C1-4, alcoxiC1-4-alcoxicarbonilaminoC1-4 o sulfonilo, y sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105330 | 2005-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057061A1 true AR057061A1 (es) | 2007-11-14 |
Family
ID=35276210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102420A AR057061A1 (es) | 2005-06-16 | 2006-06-09 | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090093473A1 (es) |
| EP (1) | EP1899338A1 (es) |
| JP (1) | JP2008543808A (es) |
| KR (1) | KR20080020675A (es) |
| CN (1) | CN101193890A (es) |
| AR (1) | AR057061A1 (es) |
| AU (1) | AU2006259123A1 (es) |
| BR (1) | BRPI0612010A2 (es) |
| CA (1) | CA2627589A1 (es) |
| EA (1) | EA200702584A1 (es) |
| IL (1) | IL188011A0 (es) |
| MX (1) | MX2007015088A (es) |
| NO (1) | NO20080144L (es) |
| TW (1) | TW200720273A (es) |
| WO (1) | WO2006134111A1 (es) |
| ZA (1) | ZA200709852B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602007003312D1 (de) * | 2007-02-22 | 2009-12-31 | Indena Spa | Verfahren zur Herstellung von (2r,3s)-3-Phenylisoserin-Methylester-Acetatsalz |
| WO2008151927A2 (en) * | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
| JP5802898B2 (ja) | 2009-07-09 | 2015-11-04 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| AU2016215432B2 (en) | 2015-02-02 | 2020-07-30 | Valo Early Discovery, Inc. | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
| WO2016126726A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors |
| US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| AR043063A1 (es) * | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| JP2006522071A (ja) * | 2003-04-04 | 2006-09-28 | アルタナ ファルマ アクチエンゲゼルシャフト | 環式ベンゾイミダゾール |
| US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
-
2006
- 2006-06-09 AR ARP060102420A patent/AR057061A1/es unknown
- 2006-06-13 TW TW095120998A patent/TW200720273A/zh unknown
- 2006-06-13 KR KR1020087000646A patent/KR20080020675A/ko not_active Withdrawn
- 2006-06-13 US US11/921,508 patent/US20090093473A1/en not_active Abandoned
- 2006-06-13 JP JP2008516303A patent/JP2008543808A/ja active Pending
- 2006-06-13 EA EA200702584A patent/EA200702584A1/ru unknown
- 2006-06-13 CN CNA2006800207829A patent/CN101193890A/zh active Pending
- 2006-06-13 CA CA002627589A patent/CA2627589A1/en not_active Abandoned
- 2006-06-13 BR BRPI0612010-5A patent/BRPI0612010A2/pt not_active Application Discontinuation
- 2006-06-13 EP EP06763684A patent/EP1899338A1/en not_active Withdrawn
- 2006-06-13 WO PCT/EP2006/063163 patent/WO2006134111A1/en not_active Ceased
- 2006-06-13 AU AU2006259123A patent/AU2006259123A1/en not_active Abandoned
- 2006-06-13 MX MX2007015088A patent/MX2007015088A/es not_active Application Discontinuation
-
2007
- 2007-11-15 ZA ZA2007/09852A patent/ZA200709852B/en unknown
- 2007-12-10 IL IL188011A patent/IL188011A0/en unknown
-
2008
- 2008-01-09 NO NO20080144A patent/NO20080144L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2627589A1 (en) | 2006-12-21 |
| US20090093473A1 (en) | 2009-04-09 |
| TW200720273A (en) | 2007-06-01 |
| ZA200709852B (en) | 2008-10-29 |
| AU2006259123A1 (en) | 2006-12-21 |
| EA200702584A1 (ru) | 2008-06-30 |
| IL188011A0 (en) | 2008-03-20 |
| CN101193890A (zh) | 2008-06-04 |
| NO20080144L (no) | 2008-01-14 |
| KR20080020675A (ko) | 2008-03-05 |
| AU2006259123A8 (en) | 2008-04-03 |
| JP2008543808A (ja) | 2008-12-04 |
| BRPI0612010A2 (pt) | 2010-10-13 |
| EP1899338A1 (en) | 2008-03-19 |
| MX2007015088A (es) | 2008-01-24 |
| WO2006134111A1 (en) | 2006-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |