[go: up one dir, main page]

MX2016014563A - Animales con il-4 e il-4r alfa humanizadas. - Google Patents

Animales con il-4 e il-4r alfa humanizadas.

Info

Publication number
MX2016014563A
MX2016014563A MX2016014563A MX2016014563A MX2016014563A MX 2016014563 A MX2016014563 A MX 2016014563A MX 2016014563 A MX2016014563 A MX 2016014563A MX 2016014563 A MX2016014563 A MX 2016014563A MX 2016014563 A MX2016014563 A MX 2016014563A
Authority
MX
Mexico
Prior art keywords
human
humanized
animals
gene
human animals
Prior art date
Application number
MX2016014563A
Other languages
English (en)
Other versions
MX370672B (es
Inventor
Stevens Sean
J Murphy Andrew
Hsien WANG Li-
Xue Yingzi
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016014563A publication Critical patent/MX2016014563A/es
Publication of MX370672B publication Critical patent/MX370672B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se proporcionan animales no humanos que comprenden una secuencia de ácido nucleico de IL-4 y/o lL-4R humanas o humanizadas. Se describen animales no humanos que comprenden una sustitución del gen endógeno de lL-4 y/o el gen endógeno de IL-4R con un gen de IL-4 humano y/o un gen de IL-4R humano en su totalidad o en parte, y métodos para obtener y usar los animales no humanos. Se proporcionan, además, animales no humanos que comprenden un gen de lL-4 humano o humanizado bajo el control de elementos reguladores de IL-4 no humanos, que incluyen animales no humanos que tienen una sustitución de una secuencia que codifica lL-4 no humana con una secuencia que codifica lL-4 humana en un locus endógeno de lL-4 no humano. Se proporcionan, además, animales no humanos que comprenden un gen de lL-4R humano o humanizado bajo el control de elementos reguladores de lL-4R no humanos, que incluyen animales no humanos que tienen una sustitución de una secuencia que codifica lL-4R no humana con una secuencia que codifica lL-4R humana o humanizada en un locus endógeno de C IL-4R no humano. Se proporcionan animales no humanos que comprenden secuencias génicas de lL-4 y/o lL-4R humanas o humanizadas, en donde los animales no humanos son roedores, por ejemplo, ratones o ratas.
MX2016014563A 2014-05-07 2015-05-07 Animales con il-4 e il-4r alfa humanizadas. MX370672B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Publications (2)

Publication Number Publication Date
MX2016014563A true MX2016014563A (es) 2017-02-23
MX370672B MX370672B (es) 2019-12-19

Family

ID=53284509

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014563A MX370672B (es) 2014-05-07 2015-05-07 Animales con il-4 e il-4r alfa humanizadas.

Country Status (26)

Country Link
US (7) US9565841B2 (es)
EP (3) EP3906781A1 (es)
JP (5) JP6640740B2 (es)
KR (2) KR102473565B1 (es)
CN (2) CN110269047B (es)
AU (3) AU2015255977B2 (es)
BR (1) BR112016025745A2 (es)
CA (2) CA3207834C (es)
CY (2) CY1119773T1 (es)
DK (2) DK3281521T3 (es)
ES (2) ES2887852T3 (es)
HR (2) HRP20211455T1 (es)
HU (2) HUE038028T2 (es)
IL (3) IL297105B2 (es)
LT (2) LT3281521T (es)
MX (1) MX370672B (es)
NO (1) NO2785538T3 (es)
PH (1) PH12016502058A1 (es)
PL (2) PL3027015T3 (es)
PT (2) PT3281521T (es)
RS (2) RS57073B1 (es)
RU (1) RU2703139C2 (es)
SG (2) SG10201912354PA (es)
SI (2) SI3027015T1 (es)
SM (2) SMT201800018T1 (es)
WO (1) WO2015171861A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2785538T3 (es) 2014-05-07 2018-08-04
PL3157956T3 (pl) 2014-06-19 2020-06-29 Regeneron Pharmaceuticals, Inc. Zwierzęta inne niż człowiek mające humanizowany gen zaprogramowanej śmierci komórkowej 1
KR102422356B1 (ko) * 2014-09-17 2022-07-18 오를리콘 서피스 솔루션스 아크티엔게젤샤프트, 페피콘 내마모성이 향상된 이중층 코팅 절삭 공구의 제조 방법
RU2726446C2 (ru) 2014-11-24 2020-07-14 Регенерон Фармасьютикалз, Инк. Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3
SG11201703463WA (en) 2014-12-05 2017-05-30 Regeneron Pharma Non-human animals having a humanized cluster of differentiation 47 gene
CN113412818B (zh) 2014-12-09 2022-11-04 瑞泽恩制药公司 具有人源化分化簇274基因的非人动物
RS61866B1 (sr) 2015-11-20 2021-06-30 Regeneron Pharma Ne-humane životinje koje imaju humanizovani gen za aktivaciju limfocita 3
US10582702B2 (en) 2016-02-04 2020-03-10 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered ANGPTL8 gene
ES2886958T3 (es) 2016-02-29 2021-12-21 Regeneron Pharma Roedores que tienen un gen TMPRSS humanizado
TWI784988B (zh) 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
IL314591A (en) 2017-04-13 2024-09-01 Regeneron Pharma Treatment and prevention of inflammatory lung diseases in patients with risk alleles in the genes encoding IL33 and IL1RL1
WO2018231827A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
US20190098879A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use
KR102709884B1 (ko) 2017-11-30 2024-09-26 리제너론 파마슈티칼스 인코포레이티드 인간화된 trkb 유전자좌를 포함하는 비인간 동물
CN116420679B (zh) 2018-03-26 2025-10-03 瑞泽恩制药公司 用于测试治疗剂的人源化啮齿动物
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
JP7048051B2 (ja) 2018-07-11 2022-04-05 正徳 染井 痒みを軽減するアトピー性皮膚炎治療剤
US11589562B2 (en) * 2018-07-16 2023-02-28 Regeneran Pharmaceuticals, Inc. Mouse model of DITRA disease and uses thereof
WO2020074005A1 (en) * 2018-10-12 2020-04-16 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric genes
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
IL286905B2 (en) 2019-04-04 2024-06-01 Regeneron Pharma Non-human animals containing the human coagulation factor 12 locus
KR20220016869A (ko) 2019-06-04 2022-02-10 리제너론 파마슈티칼스 인코포레이티드 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법
US11622547B2 (en) 2019-06-07 2023-04-11 Regeneran Pharmaceuticals, Inc. Genetically modified mouse that expresses human albumin
CN112300265B (zh) * 2019-07-29 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il33基因人源化的非人动物的构建方法和应用
CN112430621B (zh) * 2019-08-09 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il2ra基因人源化的非人动物的构建方法及应用
WO2021093790A1 (en) * 2019-11-11 2021-05-20 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes
US20220354097A1 (en) * 2019-12-25 2022-11-10 Gempharmatech Co., Ltd. Il-15 humanized mouse model and use thereof
CN115175559A (zh) * 2020-01-28 2022-10-11 瑞泽恩制药公司 包含人源化pnpla3基因座的非人动物及其使用方法
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113527485B (zh) 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN111808882B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 Il7r基因人源化改造的动物模型的构建方法及其应用
CN111793646B (zh) * 2020-09-08 2021-01-15 北京百奥赛图基因生物技术有限公司 Il1r1基因人源化改造的非人动物的构建方法及其应用
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
WO2022140221A1 (en) * 2020-12-21 2022-06-30 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene
WO2022247936A1 (en) * 2021-05-28 2022-12-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric cd36
WO2024067796A1 (zh) * 2022-09-28 2024-04-04 百奥赛图(北京)医药科技股份有限公司 一种il5和/或il5ra基因人源化修饰的非人动物
KR20250135248A (ko) * 2023-01-11 2025-09-12 리제너론 파아마슈티컬스, 인크. 규제 준수 자동화된 검정을 위한 시스템 및 방법
WO2025175099A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. A rodent copd model

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (en) * 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
PL2767161T3 (pl) 2004-10-19 2018-09-28 Regeneron Pharmaceuticals, Inc. Sposób wytwarzania zwierzęcia homozygotycznego pod względem modyfikacji genetycznej
JP2007252370A (ja) * 2006-02-22 2007-10-04 Institute Of Physical & Chemical Research Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
CN102725400A (zh) * 2009-06-29 2012-10-10 麻省理工学院 制造人源化的非人类哺乳动物的方法
KR20120097483A (ko) * 2009-07-24 2012-09-04 시그마-알드리치 컴퍼니., 엘엘씨 게놈 편집을 위한 방법
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
ES2591107T3 (es) 2009-10-06 2016-11-24 Regeneron Pharmaceuticals, Inc. Ratones modificados genéticamente e injerto
SG192606A1 (en) 2011-02-15 2013-09-30 Regeneron Pharma Humanized m-csf mice
MX376167B (es) 2011-10-28 2025-03-07 Regeneron Pharma Ratones con complejo principal de histocompatibilidad modificado genéticamente.
SG10201510056SA (en) 2011-10-28 2016-01-28 Regeneron Pharma Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
HUE033400T2 (en) * 2011-10-28 2017-12-28 Regeneron Pharma Humanized IL-6 and IL-6 receptor
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
KR102502640B1 (ko) * 2012-08-21 2023-02-23 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
RU2768282C2 (ru) 2012-09-07 2022-03-23 Йель Юниверсити Генетически модифицированные не принадлежащие к человеческому роду животные и способ их использования
ES2748662T3 (es) 2012-11-05 2020-03-17 Institute For Res In Biomedicine Irb Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos
CN111484999B (zh) 2013-02-20 2024-10-25 瑞泽恩制药公司 人源化的t细胞共受体的小鼠
EP3421490B1 (en) 2013-02-22 2020-04-01 Regeneron Pharmaceuticals, Inc. Method of generating non-human animals expressing humanized major histocompatibility complex
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
TR201901782T4 (tr) 2013-09-23 2019-03-21 Regeneron Pharma İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar.
MX2016004781A (es) 2013-10-15 2016-07-26 Regeneron Pharma Il-15 humanizada en animales.
MY183188A (en) 2013-11-19 2021-02-18 Regeneron Pharma Non-human animals having a humanized b-cell activating factor gene
MY183189A (en) 2013-11-19 2021-02-18 Regeneron Pharma Non-human animals having a humanized a proliferation-inducing ligand gene
AU2015243865C1 (en) 2014-04-08 2020-11-26 Regeneron Pharmaceuticals, Inc. Non-human animals having humanized Fc-gamma receptors
SG10202003996YA (en) 2014-05-05 2020-06-29 Regeneron Pharma Humanized c5 and c3 animals
NO2785538T3 (es) 2014-05-07 2018-08-04

Also Published As

Publication number Publication date
CA2947307A1 (en) 2015-11-12
EP3281521B1 (en) 2021-06-30
RU2016143376A3 (es) 2018-11-22
LT3281521T (lt) 2021-09-27
RU2016143376A (ru) 2018-06-09
RS57073B1 (sr) 2018-06-29
CA3207834C (en) 2025-10-14
IL297105A (en) 2022-12-01
HRP20180242T1 (hr) 2018-03-09
IL297105B1 (en) 2023-09-01
IL248358A0 (en) 2016-11-30
HUE038028T2 (hu) 2018-09-28
LT3027015T (lt) 2018-01-25
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
ES2887852T3 (es) 2021-12-28
US11963521B2 (en) 2024-04-23
PH12016502058A1 (en) 2017-01-09
KR20160150637A (ko) 2016-12-30
JP2021087434A (ja) 2021-06-10
KR20220165814A (ko) 2022-12-15
PL3281521T3 (pl) 2022-01-03
AU2015255977B2 (en) 2021-09-02
RU2019131253A (ru) 2019-12-06
NZ725615A (en) 2024-05-31
AU2021218060A1 (en) 2021-09-09
IL304841B1 (en) 2025-09-01
SMT201800018T1 (it) 2018-03-08
PT3027015T (pt) 2018-02-09
CN106470545A (zh) 2017-03-01
AU2015255977A1 (en) 2016-11-17
RU2703139C2 (ru) 2019-10-15
SG10201912354PA (en) 2020-02-27
US20150320022A1 (en) 2015-11-12
US20200022344A1 (en) 2020-01-23
US20230027494A1 (en) 2023-01-26
JP7145250B2 (ja) 2022-09-30
US20170311580A1 (en) 2017-11-02
JP6838131B2 (ja) 2021-03-03
IL304841B2 (en) 2026-01-01
KR102473565B1 (ko) 2022-12-02
CA2947307C (en) 2023-09-26
NO2785538T3 (es) 2018-08-04
PL3027015T3 (pl) 2018-04-30
NZ763861A (en) 2024-05-31
IL297105B2 (en) 2024-01-01
EP3906781A1 (en) 2021-11-10
JP2024159985A (ja) 2024-11-08
US20210368753A1 (en) 2021-12-02
IL248358B2 (en) 2023-03-01
CA3207834A1 (en) 2015-11-12
SG11201608570YA (en) 2016-11-29
JP2017514501A (ja) 2017-06-08
KR102517112B1 (ko) 2023-04-03
SMT202100560T1 (it) 2021-11-12
EP3027015B1 (en) 2017-11-08
SI3027015T1 (en) 2018-02-28
AU2024204694A1 (en) 2024-09-05
JP7755699B2 (ja) 2025-10-16
US20150320021A1 (en) 2015-11-12
WO2015171861A1 (en) 2015-11-12
IL304841A (en) 2023-09-01
EP3281521A1 (en) 2018-02-14
US12310340B2 (en) 2025-05-27
US20180000056A1 (en) 2018-01-04
JP2020058379A (ja) 2020-04-16
AU2021218060C1 (en) 2024-11-07
RS62345B1 (sr) 2021-10-29
CY1124605T1 (el) 2022-07-22
ES2656529T3 (es) 2018-02-27
PT3281521T (pt) 2021-09-16
EP3027015A1 (en) 2016-06-08
IL248358B (en) 2022-11-01
HUE055860T2 (hu) 2021-12-28
SI3281521T1 (sl) 2021-11-30
US9565841B2 (en) 2017-02-14
AU2021218060B2 (en) 2024-04-11
DK3027015T3 (en) 2018-01-22
CY1119773T1 (el) 2018-06-27
BR112016025745A2 (pt) 2018-01-16
MX370672B (es) 2019-12-19
JP6640740B2 (ja) 2020-02-05
CN110269047B (zh) 2021-11-02
HRP20211455T1 (hr) 2022-01-07
DK3281521T3 (da) 2021-09-20
CN110269047A (zh) 2019-09-24
JP2022171841A (ja) 2022-11-11
US10588298B2 (en) 2020-03-17
US9743647B2 (en) 2017-08-29
CN106470545B (zh) 2019-08-20

Similar Documents

Publication Publication Date Title
PH12016502058A1 (en) Humanized il-4 and il-4r alpha animals
MX2016014504A (es) Animales c5 y c3 humanizados.
PH12016502170A1 (en) Humanized dipeptidyl peptidase iv (dpp4) animals
HK1203761A1 (en) Humanized il-7 rodents
PH12016500342A1 (en) Non-human animals having a humanized signal-regulatory protein gene
MY172726A (en) Humanized il-6 and il-6 receptor
MX2016016903A (es) Animales no humanos que tienen un gen de muerte celular programada 1 humanizado.
EP3392337A4 (en) GENETIC CHANGE OF NON-HUMAN ORGANISM, EGGS, BURIED EGGS AND METHOD OF MODIFYING TARGET GENES
MY183188A (en) Non-human animals having a humanized b-cell activating factor gene
MY183189A (en) Non-human animals having a humanized a proliferation-inducing ligand gene
EP3507373A4 (en) GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERAL PD-L1
AR102888A1 (es) Animales no humanos que tienen un gen humanizado de agrupamiento de diferenciación 47
MX2016004781A (es) Il-15 humanizada en animales.
MX2017007636A (es) Animales no humanos que tienen un gen del grupo de diferenciacion 274 humanizado.
AU2018338790A8 (en) Non-human animals comprising a humanized TTR locus and methods of use
MX2016013241A (es) Animales no humanos que tienen receptores fc gamma humanizados.
EP4249502A3 (en) Rodents expressing humanized c1q complex
HK1244511A1 (zh) 与嗜酸细胞食管炎相关的基因改变的诊断和治疗
NZ763861B2 (en) Humanized il-4 and il-4r alpha animals

Legal Events

Date Code Title Description
FG Grant or registration